BGC0001630: kasumigamide biosynthetic gene cluster from uncultured Candidatus Entotheonella sp.
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Location: 1 - 36,804 nt. (total: 36,804 nt).
This entry is originally from NCBI GenBank LC160290.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001630
Short description kasumigamide biosynthetic gene cluster from uncultured Candidatus Entotheonella sp.
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: LC160290.1
Compounds
  • kasumigamide
Species uncultured Candidatus Entotheonella sp. [taxonomy]
References
Chemical products information
kasumigamide
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C40H50N8O9
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAW32320.1
  • ORF1
 46 - 963 (+) putative transferase
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  • BAW32321.1
  • kasD
 1173 - 2762 (-) hydroxylase
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  • BAW32322.1
  • kasA
 3403 - 7548 (+) nonribosomal peptide synthetase
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  • BAW32323.1
  • kasB
 7582 - 18666 (+) hybrid cis-AT polyketide synthase - nonribosomal peptide synthetase
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  • BAW32324.1
  • kasC
 18901 - 29634 (+) nonribosomal peptide synthetase
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  • BAW32325.1
  • kasE
 29677 - 31299 (-) transporter
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  • BAW32326.1
  • kasF
 32208 - 32714 (-) transcriptional regulator
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  • BAW32327.1
  • kasG
 33330 - 33977 (+) methyltransferase
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  • BAW32328.1
  • kasH
 34100 - 34612 (+) chorismate synthase
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  • BAW32329.1
  • kasI
 34674 - 35699 (-) hypothetical protein
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  • BAW32330.1
  • ORF2
 35872 - 36789 (-) putative transferase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
kasA
Module ?
Specificity: phenylpyruvic acid
Evidence for specificity:
  • Structure-based inference
  • Homology
kasB
Module ?
Specificity: beta-alanine
Evidence for specificity:
  • Structure-based inference
  • Homology
Module ?
Specificity: tryptophan
Evidence for specificity:
  • Structure-based inference
  • Homology
kasC
Module ?
Specificity: arginine
Evidence for specificity:
  • Structure-based inference
  • Homology
Module ?
Specificity: R-beta-hydroxyphenylalanine
Evidence for specificity:
  • Structure-based inference
  • Homology
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added NRP substrate specificities
Detailed domain annotation
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