LOCUS       BGC0001631             26273 bp    DNA     linear   BCT 08-DEC-2016
DEFINITION  Microcystis aeruginosa NIES-87 DNA, Kasumigamide biosynthetic gene
            cluster, partial and complete cds, strain: NIES-87.
ACCESSION   BGC0001631
VERSION     BGC0001631
KEYWORDS    .
SOURCE      Microcystis aeruginosa NIES-87
  ORGANISM  Microcystis aeruginosa NIES-87
            Bacteria; Cyanobacteria; Oscillatoriophycideae; Chroococcales;
            Microcystaceae; Microcystis.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 03:02:51
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 26273
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            <1..198
                     /gene="ORFM1"
     CDS             <1..198
                     /codon_start=1
                     /gene="ORFM1"
                     /product="transferase"
                     /protein_id="BAW32331.1"
                     /transl_table=11
                     /translation="IAFLFHTVLDLVNHTYQKIRELLVTRTSFFNDIRTLLKFIWFKNW
                     SEFFSFILTEYVPFKKVNSS"
     source          1..26273
                     /db_xref="taxon:449440"
                     /mol_type="genomic DNA"
                     /organism="Microcystis aeruginosa NIES-87"
                     /strain="NIES-87"
     protocluster    1..26273
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[11727:24075]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      11728..24075
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     protocluster    1..26273
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[5347:24075]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      5348..24075
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="2"
     cand_cluster    1..26273
                     /SMILES="NC([*])C(=O)NC([*])C(=O)NC([*])C(=O)NC([*])C(=O)NC
                     (Cc1ccccc1)C(=O)CC(O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="chemical_hybrid"
                     /product="NRPS"
                     /product="T1PKS"
                     /protoclusters="2"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..26273
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001631"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..26273
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="True"
                     /product="NRPS"
                     /product="T1PKS"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /subregion_numbers="1"
                     /tool="antismash"
     protocluster    <1..24075
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[1284:5337]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="3"
                     /tool="antismash"
     proto_core      1285..5337
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="3"
     cand_cluster    <1..24075
                     /SMILES="NC([*])C(=O)NC([*])C(=O)NC([*])C(=O)NC([*])C(=O)NC
                     (Cc1ccccc1)C(=O)CC(O)C(=O)O"
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="3"
                     /tool="antismash"
     gene            1285..5337
                     /gene="makasA"
     CDS             1285..5337
                     /NRPS_PKS="Domain: AMP-binding (197-600). E-value: 1e-58.
                     Score: 190.7. Matches aSDomain:
                     nrpspksdomains_makasA_AMP-binding.1"
                     /NRPS_PKS="Domain: PKS_KR (953-1130). E-value: 8.4e-17.
                     Score: 53.5. Matches aSDomain:
                     nrpspksdomains_makasA_PKS_KR.1"
                     /NRPS_PKS="Domain: PCP (1259-1322). E-value: 1.9e-16.
                     Score: 51.9. Matches aSDomain: nrpspksdomains_makasA_PCP.1"
                     /codon_start=1
                     /gene="makasA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     221.3; E-value: 3e-67)"
                     /gene_kind="biosynthetic"
                     /product="nonribosomal peptide synthetase"
                     /protein_id="BAW32332.1"
                     /sec_met_domain="AMP-binding (E-value: 2.5e-67, bitscore:
                     215.9, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 6.2e-11, bitscore:
                     31.5, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVFGHSLCRSMVSGDCEEYGDIELALLAYPGIVEARVLDMRSVCR
                     KEMSVKRIAYVAGPGACRLSNKSLPLRWQLDALVPVNRLGNDTELEYLPVWTAQELDQI
                     RHELISLSDVEDVAVVSVPNSVRKHIRQSLLVPNRVKASTPFSLREPSGVSKPVKSVEV
                     GHSLSEQLAVLHGPSLVFPKNFPRTIGEGIQRAASNDKTVIYGALNGTHRHEKYASLYQ
                     RALSILGGLQNAQIGKGDCVLLDSSNAEDFMGALWACILGGIIVTPIGVPEANSNPATF
                     ERLNAAWQLLDHPTVLTKATLPSSFGNDTKSVKTLDISRLQCPEACNLVSCESVDSVLI
                     LLTSGSTGIPKGVHLSHAAILAMAVGFGIDGLKVNETDIFFNWMPLDHVGALVWSSLVP
                     MLAGCDQIHTSTDYILADSSRWLDFVSDFRVSRTWAPNFAYSLIARAALAQSKPWDVSS
                     LRTVLNAGEAVNEESLKQFLEVLKIYGVERDDIIVPTFGMSETCSGIVLGKLGQTLGSL
                     SSLGSPVAGSSLRIVNSQQQVVKEGEIGNLQIASPQLFSRYHGFPDRASNCHAARDWFD
                     TGDAGLIANGNLYLTGRSNDKININGVTIFAFEVEQIVASLSGIDSNCVAAVPFRSQNS
                     TTDEIVLFFSMIPEMATDDDSIVAELVKAIRNTLSLQLGLVIETLLLLSARDFPRTGIG
                     KISKTKLRQNWEAGVYDAIQERVNGLLGSSDYSEIPLHRQIWVERPVRLKEPTVINPAN
                     IDLIFVGNQEQLQWLVPNPHDYQVQIIRSSETKRLSNNTWAIASDDAIGHGKVIDAIAT
                     LDGKHYTILHAWGYNDSADSTVHATRSLLSLARAIATRGKKTYSVVVLTYGAVATNPDE
                     RINYNHALLPGLIRSLALELPEVRWQLIDLPMPSFNDVSVILKGVCGFEPVVAWRDGKA
                     LVPRFEVVEPPLATLQEAITPGSLWLISGGLGGLGSLICERLLSHGANVLLIGRTDNID
                     LSPERAARLKQLERLGDVQYIKADVADLDQLRDAVHERECALGQSLSGILHAAGSGRAV
                     RLADDNGVDLETMQRTSLGGLAALATLLETRPAAQLLVIGSIVGQVGGRVMGYAAVHAA
                     LSEAAHKLTMSGARVSLLSCSSWMDIGLSKGQTNEALVRSDGLVPLDAETGLLVIEAAL
                     LRPGTHWLVGLNDQHPANAAFALTTPAPLNRPTAWVKGKQSAVVLSYPDNLSRQAWVLV
                     RNAPEILRDAQGQVDIAGMISHATDRWVAPRDGVERLVAETFSSILGIDQPSIYDNFFM
                     LGGTSLLASQLSSQLSELFFVELSSASIFQNPTIESLTIELYAIEKQEGLVSAVAKHLE
                     SLRSKTN"
     aSDomain        1876..3084
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_makasA_AMP-binding.1"
                     /evalue="1.00E-58"
                     /label="makasA_AMP-binding.1"
                     /locus_tag="makasA"
                     /protein_end="600"
                     /protein_start="197"
                     /score="190.7"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="SNDKTVIYGALNGTHRHEKYASLYQRALSILGGLQNAQIGKGDCV
                     LLDSSNAEDFMGALWACILGGIIVTPIGVPEANSNPATFERLNAAWQLLDHPTVLTKAT
                     LPSSFGNDTKSVKTLDISRLQCPEACNLVSCESVDSVLILLTSGSTGIPKGVHLSHAAI
                     LAMAVGFGIDGLKVNETDIFFNWMPLDHVGALVWSSLVPMLAGCDQIHTSTDYILADSS
                     RWLDFVSDFRVSRTWAPNFAYSLIARAALAQSKPWDVSSLRTVLNAGEAVNEESLKQFL
                     EVLKIYGVERDDIIVPTFGMSETCSGIVLGKLGQTLGSLSSLGSPVAGSSLRIVNSQQQ
                     VVKEGEIGNLQIASPQLFSRYHGFPDRASNCHAARDWFDTGDAGLIANGNLYLTGRSND
                     KINI"
     aSModule        1876..5250
                     /complete
                     /domains="nrpspksdomains_makasA_AMP-binding.1"
                     /domains="nrpspksdomains_makasA_PKS_KR.1"
                     /domains="nrpspksdomains_makasA_PCP.1"
                     /locus_tags="makasA"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       2302..2355
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasA_0001"
                     /evalue="9.90E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="makasA"
                     /protein_end="357"
                     /protein_start="339"
                     /score="18.3"
                     /tool="antismash"
                     /translation="ILLTSGSTGIPKGVHLSH"
     aSDomain        4144..4674
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_makasA_PKS_KR.1"
                     /evalue="8.40E-17"
                     /label="makasA_PKS_KR.1"
                     /locus_tag="makasA"
                     /protein_end="1130"
                     /protein_start="953"
                     /score="53.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="LWLISGGLGGLGSLICERLLSHGANVLLIGRTDNIDLSPERAARL
                     KQLERLGDVQYIKADVADLDQLRDAVHERECALGQSLSGILHAAGSGRAVRLADDNGVD
                     LETMQRTSLGGLAALATLLETRPAAQLLVIGSIVGQVGGRVMGYAAVHAALSEAAHKLT
                     MSGARVSLLSCSSW"
     CDS_motif       4150..4236
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasA_0002"
                     /evalue="2.70E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="makasA"
                     /protein_end="984"
                     /protein_start="955"
                     /score="20.0"
                     /tool="antismash"
                     /translation="LISGGLGGLGSLICERLLSHGANVLLIGR"
     aSDomain        5062..5250
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_makasA_PCP.1"
                     /evalue="1.90E-16"
                     /label="makasA_PCP.1"
                     /locus_tag="makasA"
                     /protein_end="1322"
                     /protein_start="1259"
                     /score="51.9"
                     /tool="antismash"
                     /translation="ERLVAETFSSILGIDQPSIYDNFFMLGGTSLLASQLSSQLSELFF
                     VELSSASIFQNPTIESLT"
     gene            5348..11731
                     /gene="makasB"
     CDS             5348..11731
                     /NRPS_PKS="Domain: Condensation_LCL (40-325). E-value:
                     3.6e-50. Score: 162.5. Matches aSDomain:
                     nrpspksdomains_makasB_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (486-890). E-value: 6.1e-85.
                     Score: 277.1. Matches aSDomain:
                     nrpspksdomains_makasB_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1001-1067). E-value: 1.4e-12.
                     Score: 39.5. Matches aSDomain: nrpspksdomains_makasB_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1087-1375). E-value:
                     3.7e-58. Score: 188.7. Matches aSDomain:
                     nrpspksdomains_makasB_Condensation_LCL.2"
                     /NRPS_PKS="Domain: AMP-binding (1542-1922). E-value:
                     3.7e-92. Score: 300.8. Matches aSDomain:
                     nrpspksdomains_makasB_AMP-binding.2"
                     /NRPS_PKS="Domain: PCP (2041-2109). E-value: 2.5e-19.
                     Score: 61.1. Matches aSDomain: nrpspksdomains_makasB_PCP.2"
                     /codon_start=1
                     /gene="makasB"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     277.7; E-value: 3.5e-84)"
                     /gene_kind="biosynthetic"
                     /product="nonribosomal peptide synthetase"
                     /protein_id="BAW32333.1"
                     /sec_met_domain="Condensation (E-value: 8.1e-48, bitscore:
                     151.6, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 2.3e-103, bitscore:
                     334.5, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.5e-19, bitscore:
                     58.4, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVFDERSSLAELLKKDGFTILDANLSNRSEKSSRCDRLAGSAQYR
                     FWLQERTEGIPGLNTLGCLVRFSRSLSASSLNLAFEKLFQRHEALRTRFEETSDGVFER
                     IDVVAPKDVEYLEGDSSDCGLLERQLARRLRMNEGPLWRASIFSDPTAANTLLLVFHHA
                     IIDWTGIGRLVEELEQLLSNPDDTNLLLDDPFQPADYYYWRTATSNEVKIKADQSYWLE
                     RLAGELPVLDLPAARRSGRGLGRRSTYTALTFAPQLVRDIRQFAVANGTTPFFVFLAAY
                     AGVLGRFALSEDVSIGTAIDNRDTPGSETIVGCLSDLVVLRCDLSGEPSFKVLVQKLQR
                     VCSTDFKHTTIGYADVVALVKPQRRAGVAPLFQALFNFLPARGGADLPTLMPLPSPDAR
                     ADIALELVDDGVGISGQIEVREDLVPKSVAIAITTAISTTLQSAMARPDIAFNRLPLID
                     SQAAAALTQRLNPSHLETINQSLGDLLLERARLHSNKIALCEGDRTLDYKTLIKQATAL
                     AHFLVAQTPVEKPTVGFPIAICLDRSIDLVIAAVAVVLAGGAVLFLEPDLPEERLASLL
                     ADSGATRLIARQRPVWLPESAAVTIVTLTDYDTKNTAKALVSLPRVSPEDPAYLIYTSG
                     STGRPKVVVGLHKGMVNRILWMERQWPVQPDEAICLKTSLMFVDCIGEIFGPLIWGLRA
                     VVADRDTALNPRALATLIARERISRIVMVPSLLRAMLDRVPDIESKLRSLRLCVSSGET
                     LPVQLVQRFYTVVPDAALVNFYGSSEVSADATWHRVDISDTAPIPIGVPIQGNRIFVLD
                     RAGQVLPVGAPGQIAISGVGVARGYLHGNSSAFQRNLNDDKPTEKPIDEPIFATGDLGL
                     WDGDGRLVYLGRMDRQVKIQGVRVEPTEIEATLEDHPGVDAAYVSATVAPPEDNMVLTA
                     YVAAEAGVTVASLRAWLSHRLPRALIPASFMILDALPLNASGKIDLAALPSPARDLDTD
                     AEIPKTDILDPLEELVANVWSEMLAQPINSPDDDFFDCGGGSLQAIMAINQISELMDSA
                     IAVSTLFETPSLRAFVRRIITPDVEGLPPPCPSLETGLAPATSNQRWLWTHYQDDPNSS
                     AYNLCIAYELNGSLDVPQLESAIRHLVTRHDALRTHLAIQNDELVQVVTSEELELFRHD
                     VSAAVDPLAVLESLLADIRCRPFALERELPLRVHLVKLEPVRHVLIWVNHHVACDGWSG
                     QVLVKELAALWSVHSTTALPPPLLQLGDIARWQQTVCPAIAKQLKDYQQSLMGGESPRV
                     SGIATDKTWGGQVAVDQVVIGTDTLTAFEALAQEERVTRFISMLTIWAVLLTRFGDTEH
                     PLLGFPQAGRNTPGLQSVVGFLANTVLLKVDLADAPTFRQAFKATKTALLTAMRYQDVP
                     LPWLQATGMGWPTQPDSEAIRSMVIVEDASDWDLRLPELSSRLFAMPNSPEARVDLAFV
                     VTQMTNGPRLVIEYATRRVPRAVAERLARGLEQLMAAAATEPDTQIERLPLLSIDNPDC
                     GAVLTAEAASSPIATRLDAVLAHVALTSPAATAVWDLTSSLSYAELNQRASVTAQRLQG
                     LGVGTGDRVGLLAQPSPLQLASLFGVWRLGAVAVPLDPTYPRERIAATLMDAGVVAVLT
                     DIPLDYPCPQLSLDSILGAVPSAPIAGLVSSPDPDDVAAIIYTSGTTGTPKGVMITQAA
                     LCRLGCALSMAYDLGQGDRVLQVVSPAFDVALSDIAMAVSAVATLVVPPHVDVMPGKHL
                     NRTLAMANITHMQVPAAVLAATQPGTLPKLRTVSVGGEVCSPETANAWSCDRRLFIAYG
                     PTEATVTVALATYQKGARPGTIGRPFGGASLTVVDPTGHLVPIGVAGELIIGGPGVALG
                     YLGLPDLTAERFEQTAQGRRYRTGDRVRMEADGTVTFLGRIDRQLKLRGFRIEPGEVET
                     HLMNCDGVAQALVSVCPDQIGEPQLVAWVVGEPGAKLDSLTLRQALKQHLPNHLVPSAI
                     VQIVAVPLTANRKVDWSSLKAEFHRLNVPDMNISEMAQCSLVERDSTTVERDLSTIWSE
                     LLGRNQVGLDISFFDLGGHSIQLVRLQTRIEDHFGIELPIGEMFANPTLRSMTSLVQRL
                     LRTAASDEENDWEEFTL"
     aSDomain        5468..6322
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_makasB_Condensation_LCL.1"
                     /domain_subtype="Condensation_LCL"
                     /evalue="3.60E-50"
                     /label="makasB_Condensation_LCL.1"
                     /locus_tag="makasB"
                     /protein_end="325"
                     /protein_start="40"
                     /score="162.5"
                     /tool="antismash"
                     /translation="SAQYRFWLQERTEGIPGLNTLGCLVRFSRSLSASSLNLAFEKLFQ
                     RHEALRTRFEETSDGVFERIDVVAPKDVEYLEGDSSDCGLLERQLARRLRMNEGPLWRA
                     SIFSDPTAANTLLLVFHHAIIDWTGIGRLVEELEQLLSNPDDTNLLLDDPFQPADYYYW
                     RTATSNEVKIKADQSYWLERLAGELPVLDLPAARRSGRGLGRRSTYTALTFAPQLVRDI
                     RQFAVANGTTPFFVFLAAYAGVLGRFALSEDVSIGTAIDNRDTPGSETIVGCLSDLVVL
                     RCDL"
     aSModule        5468..8548
                     /complete
                     /domains="nrpspksdomains_makasB_Condensation_LCL.1"
                     /domains="nrpspksdomains_makasB_AMP-binding.1"
                     /domains="nrpspksdomains_makasB_PCP.1"
                     /locus_tags="makasB"
                     /monomer_pairings="X -> X"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       5537..5629
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasB_0001"
                     /evalue="3.90E-07"
                     /label="C2_LCL_024-062"
                     /locus_tag="makasB"
                     /protein_end="94"
                     /protein_start="63"
                     /score="22.5"
                     /tool="antismash"
                     /translation="LVRFSRSLSASSLNLAFEKLFQRHEALRTRF"
     CDS_motif       5825..5881
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasB_0002"
                     /evalue="7.90E-03"
                     /label="C3_dual_135-156"
                     /locus_tag="makasB"
                     /protein_end="178"
                     /protein_start="159"
                     /score="9.4"
                     /tool="antismash"
                     /translation="FHHAIIDWTGIGRLVEELE"
     CDS_motif       6224..6313
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasB_0003"
                     /evalue="1.20E-05"
                     /label="C5_LCL_267-296"
                     /locus_tag="makasB"
                     /protein_end="322"
                     /protein_start="292"
                     /score="17.8"
                     /tool="antismash"
                     /translation="DVSIGTAIDNRDTPGSETIVGCLSDLVVLR"
     CDS_motif       6410..6481
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasB_0004"
                     /evalue="2.60E-06"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="makasB"
                     /protein_end="378"
                     /protein_start="354"
                     /score="19.7"
                     /tool="antismash"
                     /translation="DVVALVKPQRRAGVAPLFQALFNF"
     aSDomain        6806..8017
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_makasB_AMP-binding.1"
                     /evalue="6.10E-85"
                     /label="makasB_AMP-binding.1"
                     /locus_tag="makasB"
                     /protein_end="890"
                     /protein_start="486"
                     /score="277.1"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="ERARLHSNKIALCEGDRTLDYKTLIKQATALAHFLVAQTPVEKPT
                     VGFPIAICLDRSIDLVIAAVAVVLAGGAVLFLEPDLPEERLASLLADSGATRLIARQRP
                     VWLPESAAVTIVTLTDYDTKNTAKALVSLPRVSPEDPAYLIYTSGSTGRPKVVVGLHKG
                     MVNRILWMERQWPVQPDEAICLKTSLMFVDCIGEIFGPLIWGLRAVVADRDTALNPRAL
                     ATLIARERISRIVMVPSLLRAMLDRVPDIESKLRSLRLCVSSGETLPVQLVQRFYTVVP
                     DAALVNFYGSSEVSADATWHRVDISDTAPIPIGVPIQGNRIFVLDRAGQVLPVGAPGQI
                     AISGVGVARGYLHGNSSAFQRNLNDDKPTEKPIDEPIFATGDLGLWDGDGRLVYLGRMD
                     RQVKI"
     CDS_motif       7001..7036
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasB_0005"
                     /evalue="1.30E+01"
                     /label="NRPS-A_a2"
                     /locus_tag="makasB"
                     /protein_end="563"
                     /protein_start="551"
                     /score="0.3"
                     /tool="antismash"
                     /translation="AVVLAGGAVLFL"
     CDS_motif       7229..7288
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasB_0006"
                     /evalue="2.00E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="makasB"
                     /protein_end="647"
                     /protein_start="627"
                     /score="23.4"
                     /tool="antismash"
                     /translation="AYLIYTSGSTGRPKVVVGLH"
     CDS_motif       7802..7864
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasB_0007"
                     /evalue="1.90E-07"
                     /label="NRPS-A_a6"
                     /locus_tag="makasB"
                     /protein_end="839"
                     /protein_start="818"
                     /score="23.4"
                     /tool="antismash"
                     /translation="PVGAPGQIAISGVGVARGYLH"
     CDS_motif       7985..8050
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasB_0008"
                     /evalue="1.70E-09"
                     /label="NRPS-A_a8"
                     /locus_tag="makasB"
                     /protein_end="901"
                     /protein_start="879"
                     /score="29.8"
                     /tool="antismash"
                     /translation="YLGRMDRQVKIQGVRVEPTEIE"
     aSDomain        8351..8548
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_makasB_PCP.1"
                     /evalue="1.40E-12"
                     /label="makasB_PCP.1"
                     /locus_tag="makasB"
                     /protein_end="1067"
                     /protein_start="1001"
                     /score="39.5"
                     /tool="antismash"
                     /translation="EELVANVWSEMLAQPINSPDDDFFDCGGGSLQAIMAINQISELMD
                     SAIAVSTLFETPSLRAFVRRI"
     aSDomain        8609..9472
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_makasB_Condensation_LCL.2"
                     /domain_subtype="Condensation_LCL"
                     /evalue="3.70E-58"
                     /label="makasB_Condensation_LCL.2"
                     /locus_tag="makasB"
                     /protein_end="1375"
                     /protein_start="1087"
                     /score="188.7"
                     /tool="antismash"
                     /translation="PATSNQRWLWTHYQDDPNSSAYNLCIAYELNGSLDVPQLESAIRH
                     LVTRHDALRTHLAIQNDELVQVVTSEELELFRHDVSAAVDPLAVLESLLADIRCRPFAL
                     ERELPLRVHLVKLEPVRHVLIWVNHHVACDGWSGQVLVKELAALWSVHSTTALPPPLLQ
                     LGDIARWQQTVCPAIAKQLKDYQQSLMGGESPRVSGIATDKTWGGQVAVDQVVIGTDTL
                     TAFEALAQEERVTRFISMLTIWAVLLTRFGDTEHPLLGFPQAGRNTPGLQSVVGFLANT
                     VLLKVDL"
     aSModule        8609..11674
                     /complete
                     /domains="nrpspksdomains_makasB_Condensation_LCL.2"
                     /domains="nrpspksdomains_makasB_AMP-binding.2"
                     /domains="nrpspksdomains_makasB_PCP.2"
                     /locus_tags="makasB"
                     /monomer_pairings="X -> X"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       8666..8776
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasB_0009"
                     /evalue="3.80E-15"
                     /label="C2_LCL_024-062"
                     /locus_tag="makasB"
                     /protein_end="1143"
                     /protein_start="1106"
                     /score="48.2"
                     /tool="antismash"
                     /translation="SAYNLCIAYELNGSLDVPQLESAIRHLVTRHDALRTH"
     CDS_motif       8993..9052
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasB_0010"
                     /evalue="1.10E-08"
                     /label="C3_LCL_132-143"
                     /locus_tag="makasB"
                     /protein_end="1235"
                     /protein_start="1215"
                     /score="27.6"
                     /tool="antismash"
                     /translation="HHVACDGWSGQVLVKELAAL"
     CDS_motif       9383..9460
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasB_0011"
                     /evalue="5.80E-08"
                     /label="C5_LCL_267-296"
                     /locus_tag="makasB"
                     /protein_end="1371"
                     /protein_start="1345"
                     /score="25.2"
                     /tool="antismash"
                     /translation="LGFPQAGRNTPGLQSVVGFLANTVLL"
     aSDomain        9974..11113
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_makasB_AMP-binding.2"
                     /evalue="3.70E-92"
                     /label="makasB_AMP-binding.2"
                     /locus_tag="makasB"
                     /protein_end="1922"
                     /protein_start="1542"
                     /score="300.8"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="HVALTSPAATAVWDLTSSLSYAELNQRASVTAQRLQGLGVGTGDR
                     VGLLAQPSPLQLASLFGVWRLGAVAVPLDPTYPRERIAATLMDAGVVAVLTDIPLDYPC
                     PQLSLDSILGAVPSAPIAGLVSSPDPDDVAAIIYTSGTTGTPKGVMITQAALCRLGCAL
                     SMAYDLGQGDRVLQVVSPAFDVALSDIAMAVSAVATLVVPPHVDVMPGKHLNRTLAMAN
                     ITHMQVPAAVLAATQPGTLPKLRTVSVGGEVCSPETANAWSCDRRLFIAYGPTEATVTV
                     ALATYQKGARPGTIGRPFGGASLTVVDPTGHLVPIGVAGELIIGGPGVALGYLGLPDLT
                     AERFEQTAQGRRYRTGDRVRMEADGTVTFLGRIDRQLKLR"
     CDS_motif       10154..10195
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasB_0012"
                     /evalue="3.20E-02"
                     /label="NRPS-A_a2"
                     /locus_tag="makasB"
                     /protein_end="1616"
                     /protein_start="1602"
                     /score="8.1"
                     /tool="antismash"
                     /translation="FGVWRLGAVAVPLD"
     CDS_motif       10373..10429
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasB_0013"
                     /evalue="2.30E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="makasB"
                     /protein_end="1694"
                     /protein_start="1675"
                     /score="26.2"
                     /tool="antismash"
                     /translation="AAIIYTSGTTGTPKGVMIT"
     CDS_motif       10916..11005
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasB_0014"
                     /evalue="1.10E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="makasB"
                     /protein_end="1886"
                     /protein_start="1856"
                     /score="49.6"
                     /tool="antismash"
                     /translation="PIGVAGELIIGGPGVALGYLGLPDLTAERF"
     CDS_motif       11078..11143
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasB_0015"
                     /evalue="9.80E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="makasB"
                     /protein_end="1932"
                     /protein_start="1910"
                     /score="33.7"
                     /tool="antismash"
                     /translation="FLGRIDRQLKLRGFRIEPGEVE"
     aSDomain        11471..11674
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_makasB_PCP.2"
                     /evalue="2.50E-19"
                     /label="makasB_PCP.2"
                     /locus_tag="makasB"
                     /protein_end="2109"
                     /protein_start="2041"
                     /score="61.1"
                     /tool="antismash"
                     /translation="ERDLSTIWSELLGRNQVGLDISFFDLGGHSIQLVRLQTRIEDHFG
                     IELPIGEMFANPTLRSMTSLVQR"
     gene            11728..24075
                     /gene="makasC"
     CDS             11728..24075
                     /NRPS_PKS="Domain: Condensation_LCL (73-363). E-value:
                     7.1e-84. Score: 273.1. Matches aSDomain:
                     nrpspksdomains_makasC_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (530-929). E-value: 4.6e-74.
                     Score: 241.2. Matches aSDomain:
                     nrpspksdomains_makasC_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1033-1098). E-value: 7.8e-20.
                     Score: 62.7. Matches aSDomain: nrpspksdomains_makasC_PCP.1"
                     /NRPS_PKS="Domain: Epimerization (1111-1406). E-value:
                     1.7e-74. Score: 242.7. Matches aSDomain:
                     nrpspksdomains_makasC_Epimerization.1"
                     /NRPS_PKS="Domain: Condensation_DCL (1551-1850). E-value:
                     7.4e-103. Score: 335.6. Matches aSDomain:
                     nrpspksdomains_makasC_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (2012-2406). E-value:
                     1.6e-98. Score: 321.8. Matches aSDomain:
                     nrpspksdomains_makasC_AMP-binding.2"
                     /NRPS_PKS="Domain: PCP (2532-2595). E-value: 7.9e-17.
                     Score: 53.1. Matches aSDomain: nrpspksdomains_makasC_PCP.2"
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (2626-3049). E-value:
                     1.8e-150. Score: 493.4. Matches aSDomain:
                     nrpspksdomains_makasC_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (3157-3434). E-value: 1.3e-89.
                     Score: 292.3. Matches aSDomain:
                     nrpspksdomains_makasC_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_KR (3756-3945). E-value: 5.4e-42.
                     Score: 135.6. Matches aSDomain:
                     nrpspksdomains_makasC_PKS_KR.1"
                     /NRPS_PKS="Domain: PCP (4043-4110). E-value: 2.7e-15.
                     Score: 48.2. Matches aSDomain: nrpspksdomains_makasC_PCP.3"
                     /codon_start=1
                     /gene="makasC"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     hyb_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     305.9; E-value: 9.4e-93)"
                     /gene_kind="biosynthetic"
                     /product="hybrid cis-AT polyketide synthase - nonribosomal
                     peptide synthetase"
                     /protein_id="BAW32334.1"
                     /sec_met_domain="Condensation (E-value: 6.9e-67, bitscore:
                     214.2, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 4.4e-107, bitscore:
                     346.8, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3.3e-16, bitscore:
                     48.4, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 1.5e-90, bitscore: 292.3,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="hyb_KS (E-value: 4.2e-154, bitscore:
                     502.1, seeds: 33, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 4.4e-36, bitscore:
                     113.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPKNRPVDQLLHDLEQAGISLAIEGELLRVRGPVKAISQDLRVE
                     LTARKQELMAILRMPASPAASRASLAVEAPVTHNQRRLWFLNKLENTSAVFRMMAAWEL
                     VGPLDIDAFNQAIASLTARHPILRSTIRERGEDVFLTPMDSPFEEVIPKRGSPNEIEQI
                     IHEQAEASFDLANGPLFLVRLVEFSQTHRLLVIDIHHIISDRWSMGLLFRDLSAFMRAE
                     VTGEDAALPVLPIQFSDFALSQHALLDQPTLEGRVRYWRETLTGGTAELALPLDRPRPR
                     TRGMRGASLRFPLGQDANLSHLASHYRATAFMAYLAVYSALLVRWTGQDEVVVGCPIGG
                     RERHETHDLVGFFVNTVALRLDLSDDPSFITLLERVKRVSLEAMTHQDVPFDRVVDALN
                     PPRYLNRNPLFQAMFVLQNAPLSELAWPGIEARSLTVPAMAPEVDLNLALELSATPDTP
                     FTGYLEYDPDLFEPSTVERFVQHFVSFCQAVSRAPEQSISQIVIADETRAVWQGPQRAR
                     PNQTLDEMLITRLAGNPNAIALMTTEGEAVSAGQLLHRARLLSDRLSWDTDVVQLVGIW
                     LPRSPELVVSMLAIWLAGKAFVVLPVDAPLTYLEGLIESVGLTHVIVAPDFGSDSGRPL
                     PTGVNPIVPILPAPTEVIISPVSVSNRSRQDLAYICFTSGSSGQPKGVEVSHAALVNHT
                     LAIIEAFDLSHQDRVLQFAAPNFDVALEEIWPSLLAGGTVVIPSPAVTDSLHAFENEIT
                     ASGVTVVNLPAPFWHAWVSKLDEETTSPPTNLRLVVTGSDRVYTSAVRRWMMLAPTVRL
                     LSGYGPTETTITATIFDCGRDILPITASTVPLGLPLANVQVYLVDSQGNSVPVGVVGEI
                     VIEGAGIAQGYVHTREKSGFRPRVPGGTLAFWTGDRGRCRPDGTLMFEGRDDEQVKVRG
                     VRIEPAGVETLLASCPGIALAAVVARPDGASGTLLRAFYSGTAALADVRSWLSHNVPAA
                     LVPGLIERLDELPQTPSGKLDRRTLAARPIPLSPPPVRPLDDRHEQIIGEIFADVLQVT
                     EIGPDSNFFELGGDSISSLKIVTRARRAGLLITVRTVFEHQTISAIAKAATPIYNDSEQ
                     SNGSGPLPLTPITAWFHEFITVDSHHFNQAVVLAVPKAVDAQALQTALTALVRCHDILG
                     LTVSGTSEQLRHAIPETIPAPTLITLDLSTFPNEERLERRAQAFASAQSSLDPGQGRNL
                     AAVLLADEGRLLVCIHHLCVDVLSWDVLLTDLETAYEEVSRGRQPRLSPSGTPFRMWAE
                     RMNELAAGPALDDISFWLKRLAHPADRLLPEAGDQPGCDGAGASVRRTLNPIDTKYIVR
                     TAPVLFAVRSDEVILAALLKVLRQRNGNRLRVDLERNGRVSPFGDFDLSRTVGWFTTVI
                     PLLLNQKHEDIAELLGDIGRAVTETPQDGLSYGLLRYLSSQTGQVLAALPPAEILVNFV
                     GILPGWNEADFRPVDDDCGPTISPRSPRSHILELNAGVIEGHLRLELGYPGAAGCHEEA
                     AALLDDIVAALSEIASVARATKIGVEKPQGIEEILPLTPLQTGIFFHSNRQEETYFNQL
                     HLVLEGSLNTSAFRSAWCQLIKRHKLLRASFHTADDGTPLQFIHKHVDPTWVERDWTGF
                     DRTHQSQRLAALMAADRATNFELHQAPLLRFHLLKTGDERHDLIWSSHHLLLDGWSVSV
                     VMEELLALYREACGGMAAALGSAPDFSEYLTWLDTVDKQAAEHFWQQELSGIAEPTCLI
                     GSGLAPNEQEPNAPAHHHLELPANDVQAIEELARTSGVTVGLVLQAAWGLLLSRYTGLD
                     DVLFGLTVSGRPPDLAGVNRMVGMLINTLPIRIQIPDDTTVRSWLKTLATRGLDRDAYA
                     MLPLPQAIAAAVMAEGKLPFDSLVLIQNYPRTTNLDVEGLRVSIAQVSESTSFAVTLVA
                     EWAERPRLTIVRDRHLVAVAASNQLLRHLHQILQSLVRCADKPLDNISIYTPDELQHRL
                     LLGLGERLDVGHSLAHETIAAWAELSPDMPAVISKEETLTYGQLVEQANTLAAHLITSA
                     GIRPGSLIAMALPRSSAAIVAILAIWRVGAAVIPIDVGYPAERVHFMLLDCTPDLVLTN
                     TVHRSSLPLDEGNAIFLIDTLSDAPLSVSRDEAWPRIELDTPAYVIYTSGSTGKPKGVL
                     SSHRGLVSLIRSQRELFSLAPGDRVLQFASLSFDASIWETVMALASGAALYIPNREDAL
                     AGPELGTYLRTYRITAATLPPSLLAVLPEGNYPDLKLLVSAGEACPVALARRWKQGRRF
                     FNAYGPSEATVCATVFEGSVEGTSLPIGRAIPNVSTHVVDSHLRPVPAGCEGELVIGGL
                     GVALGYLGQPALTAKRFVKVPALDHPSETNKLFYRTGDRVRLDIDGTLTYLGRLDRQVK
                     LDGFRIELGEIEATLLNYPGVAQALSTVRQDRRGEQRLFAWVLPKPGVTLIIEDLRASI
                     RQTLPGYMVPSGLMLITGVPLTPNGKVDWSGLPATEIESSEQQTATAAEAAQQAGDKGD
                     SKSAALSRCLKAIWSELLGRTVINPNDNFFDIGGSSLLLVQMQGLIHSRLGVSLSSSKL
                     FRHPTLDSLVELLLPQEVTLTLEERSPTIEGGTAERIPTARAEPIAVVGAAGRFPGSPN
                     LEAFWELLIEGREGISRFDKESLLQSGMPLDLINNPAWVPVGGVIDDAEAFDPTVFGIG
                     ARDALILDPQHRVFLECAWHALEHAGYAPKATDRSIGLFASSGQNTWLHDVLLPAGETI
                     TGSTGFHLLTANDKDFLASQAAYRLDLKGPVVTIQTACSSSLVAVSMAIDALRTGRCEM
                     ALAGGVSIRFPQNRGYLYEPEMILSPDGHCRAFSADANGTVPGSGVGVVVLKPLSQAKT
                     DGDRILAVVRGIAVNNDGSNKMGYTAPGVAGQAQVIRAALEDAGLTADDVDYVEAHGTG
                     TPLGDPVEVTALGRVYTGRREPLLLGSVKTNIGHADAAAGIAGFLKVVLALERGQLPAS
                     LHAQPLNPRIDYSVGPFEVVDRTRSWPERGRPLRGAISSFGIGGTNVHAILEASPCARP
                     VPNKSLAAPVNVNQAVILSAQTAAVLHCQTERLITHLRAHPELPIADVAFTLQCGRTVL
                     PHRRAVVANSSLEAALALEAVLLNSYQTPLNNKPIERSSMVALLLPGQGSQHLGMGQQL
                     YEAGGVFRRELDTYSEILRPLIDFSIVELLFSGGEDKAKVLQTTQLAQPLVFALDVALA
                     RHWQGLGIQPVGFLGHSLGEYAAAHLAGVFSTEDALALVVERGRLLGELPPGVMLAVPR
                     SEVEIHGWLSDDLALAAVNNSTNCVVSGSFDAIEAFEARLKEMGCISRRLHTSHAFHSP
                     MMTAAAEPLAAAVARFSPKRPQGRFISNVTGTWITPEDAIDPNYWARHLLQTVRFADGL
                     ATLQNDGITLAIECGPGQTLTILAKGTDIAVQPSLAHAAEIPTGGSRITDAAANLWVEG
                     ASINWSALHPEPRRRVDVPLYPFERLPFKPKACLSPSQLSERSESAEQVLPGKRRCMDE
                     WFYRPGWQPALPSPSEPLAGPVMILSDRGGIGEALANLLPYPAILVEQGAGYAALGDNR
                     FTVRPAQDEDYYQLFKALPTLPLRFLHLWGLDDANADTLEEIGVHAVLSLVRSLGGISS
                     SQALRLDLVTHGAAAITGTEVLRPELAAAIGAARVLPYEYPNLTVRAIDVEPESPRSMA
                     AAILSEIMRKGEHVVIGLRGERRWTPTFWPLALPASSNGNSIRNGLGKIRPKAVVWITG
                     GFGGVGSAVARDLAKEQGIQLVLTGRTALGENGADSPTRKDRLQLVREIEAMGAIVMTA
                     ALDLADERAVKALVNQVETRLGAITGVFHCAGVADLAGVVQMRSRSDTEHVLAPKVAGT
                     RAIERALSQHSLDFLVLCSSLSSFLPIAKFGQVGYAAANEYMDLAAVAIARRTGWRTVT
                     INWDDWVEAGMTVEAYQSWSIPAPTADEGLTAAEGVTVLRRILTSDQTRVAVSVRPLES
                     LVAGSDHLFSTKRFSQLLQCHNRPTEGIVSTVSGSDDVSQDTVTRLLLEAFRRILDDPT
                     TVVDSNFFERGGHSLLAMNLLNFIRETFSVGIALLDLFEHPTPPTLADIIKERQTDRE"
     aSDomain        11947..12816
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_makasC_Condensation_LCL.1"
                     /domain_subtype="Condensation_LCL"
                     /evalue="7.10E-84"
                     /label="makasC_Condensation_LCL.1"
                     /locus_tag="makasC"
                     /protein_end="363"
                     /protein_start="73"
                     /score="273.1"
                     /tool="antismash"
                     /translation="APVTHNQRRLWFLNKLENTSAVFRMMAAWELVGPLDIDAFNQAIA
                     SLTARHPILRSTIRERGEDVFLTPMDSPFEEVIPKRGSPNEIEQIIHEQAEASFDLANG
                     PLFLVRLVEFSQTHRLLVIDIHHIISDRWSMGLLFRDLSAFMRAEVTGEDAALPVLPIQ
                     FSDFALSQHALLDQPTLEGRVRYWRETLTGGTAELALPLDRPRPRTRGMRGASLRFPLG
                     QDANLSHLASHYRATAFMAYLAVYSALLVRWTGQDEVVVGCPIGGRERHETHDLVGFFV
                     NTVALRLDL"
     aSModule        11947..15945
                     /complete
                     /domains="nrpspksdomains_makasC_Condensation_LCL.1"
                     /domains="nrpspksdomains_makasC_AMP-binding.1"
                     /domains="nrpspksdomains_makasC_PCP.1"
                     /domains="nrpspksdomains_makasC_Epimerization.1"
                     /locus_tags="makasC"
                     /monomer_pairings="X -> D-X"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       12019..12120
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0001"
                     /evalue="1.10E-11"
                     /label="C2_LCL_024-062"
                     /locus_tag="makasC"
                     /protein_end="131"
                     /protein_start="97"
                     /score="37.2"
                     /tool="antismash"
                     /translation="MMAAWELVGPLDIDAFNQAIASLTARHPILRSTI"
     CDS_motif       12319..12381
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0002"
                     /evalue="2.60E-09"
                     /label="C3_LCL_132-143"
                     /locus_tag="makasC"
                     /protein_end="218"
                     /protein_start="197"
                     /score="29.6"
                     /tool="antismash"
                     /translation="IHHIISDRWSMGLLFRDLSAF"
     CDS_motif       12718..12807
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0003"
                     /evalue="3.20E-13"
                     /label="C5_LCL_267-296"
                     /locus_tag="makasC"
                     /protein_end="360"
                     /protein_start="330"
                     /score="42.0"
                     /tool="antismash"
                     /translation="EVVVGCPIGGRERHETHDLVGFFVNTVALR"
     CDS_motif       12856..12975
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0004"
                     /evalue="6.40E-20"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="makasC"
                     /protein_end="416"
                     /protein_start="376"
                     /score="63.6"
                     /tool="antismash"
                     /translation="KRVSLEAMTHQDVPFDRVVDALNPPRYLNRNPLFQAMFVL"
     aSDomain        13318..14514
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_makasC_AMP-binding.1"
                     /evalue="4.60E-74"
                     /label="makasC_AMP-binding.1"
                     /locus_tag="makasC"
                     /protein_end="929"
                     /protein_start="530"
                     /score="241.2"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="AGNPNAIALMTTEGEAVSAGQLLHRARLLSDRLSWDTDVVQLVGI
                     WLPRSPELVVSMLAIWLAGKAFVVLPVDAPLTYLEGLIESVGLTHVIVAPDFGSDSGRP
                     LPTGVNPIVPILPAPTEVIISPVSVSNRSRQDLAYICFTSGSSGQPKGVEVSHAALVNH
                     TLAIIEAFDLSHQDRVLQFAAPNFDVALEEIWPSLLAGGTVVIPSPAVTDSLHAFENEI
                     TASGVTVVNLPAPFWHAWVSKLDEETTSPPTNLRLVVTGSDRVYTSAVRRWMMLAPTVR
                     LLSGYGPTETTITATIFDCGRDILPITASTVPLGLPLANVQVYLVDSQGNSVPVGVVGE
                     IVIEGAGIAQGYVHTREKSGFRPRVPGGTLAFWTGDRGRCRPDGTLMFEGRDDEQVKVR
                     "
     CDS_motif       13489..13527
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0005"
                     /evalue="9.90E-01"
                     /label="NRPS-A_a2"
                     /locus_tag="makasC"
                     /protein_end="600"
                     /protein_start="587"
                     /score="3.6"
                     /tool="antismash"
                     /translation="LAIWLAGKAFVVL"
     CDS_motif       13729..13788
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0006"
                     /evalue="1.10E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="makasC"
                     /protein_end="687"
                     /protein_start="667"
                     /score="24.2"
                     /tool="antismash"
                     /translation="AYICFTSGSSGQPKGVEVSH"
     CDS_motif       14173..14199
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0007"
                     /evalue="6.70E-02"
                     /label="NRPS-A_a5"
                     /locus_tag="makasC"
                     /protein_end="824"
                     /protein_start="815"
                     /score="6.4"
                     /tool="antismash"
                     /translation="YGPTETTIT"
     CDS_motif       14317..14391
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0008"
                     /evalue="7.20E-09"
                     /label="NRPS-A_a6"
                     /locus_tag="makasC"
                     /protein_end="888"
                     /protein_start="863"
                     /score="28.0"
                     /tool="antismash"
                     /translation="PVGVVGEIVIEGAGIAQGYVHTREK"
     CDS_motif       14482..14544
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0009"
                     /evalue="1.20E-06"
                     /label="NRPS-A_a8"
                     /locus_tag="makasC"
                     /protein_end="939"
                     /protein_start="918"
                     /score="21.0"
                     /tool="antismash"
                     /translation="EGRDDEQVKVRGVRIEPAGVE"
     aSDomain        14827..15021
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_makasC_PCP.1"
                     /evalue="7.80E-20"
                     /label="makasC_PCP.1"
                     /locus_tag="makasC"
                     /protein_end="1098"
                     /protein_start="1033"
                     /score="62.7"
                     /tool="antismash"
                     /translation="EQIIGEIFADVLQVTEIGPDSNFFELGGDSISSLKIVTRARRAGL
                     LITVRTVFEHQTISAIAKAA"
     aSDomain        15061..15945
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_makasC_Epimerization.1"
                     /evalue="1.70E-74"
                     /label="makasC_Epimerization.1"
                     /locus_tag="makasC"
                     /protein_end="1406"
                     /protein_start="1111"
                     /score="242.7"
                     /tool="antismash"
                     /translation="GPLPLTPITAWFHEFITVDSHHFNQAVVLAVPKAVDAQALQTALT
                     ALVRCHDILGLTVSGTSEQLRHAIPETIPAPTLITLDLSTFPNEERLERRAQAFASAQS
                     SLDPGQGRNLAAVLLADEGRLLVCIHHLCVDVLSWDVLLTDLETAYEEVSRGRQPRLSP
                     SGTPFRMWAERMNELAAGPALDDISFWLKRLAHPADRLLPEAGDQPGCDGAGASVRRTL
                     NPIDTKYIVRTAPVLFAVRSDEVILAALLKVLRQRNGNRLRVDLERNGRVSPFGDFDLS
                     RTVGWFTTVIPLLL"
     CDS_motif       15127..15222
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0010"
                     /evalue="2.40E-05"
                     /label="C2_DCL_024-062"
                     /locus_tag="makasC"
                     /protein_end="1165"
                     /protein_start="1133"
                     /score="16.6"
                     /tool="antismash"
                     /translation="FNQAVVLAVPKAVDAQALQTALTALVRCHDIL"
     CDS_motif       15433..15498
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0011"
                     /evalue="3.30E-06"
                     /label="NRPS-E2"
                     /locus_tag="makasC"
                     /protein_end="1257"
                     /protein_start="1235"
                     /score="19.7"
                     /tool="antismash"
                     /translation="LLVCIHHLCVDVLSWDVLLTDL"
     CDS_motif       15760..15810
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0012"
                     /evalue="7.60E+00"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="makasC"
                     /protein_end="1361"
                     /protein_start="1344"
                     /score="0.7"
                     /tool="antismash"
                     /translation="APVLFAVRSDEVILAAL"
     CDS_motif       15895..15945
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0013"
                     /evalue="2.10E-07"
                     /label="NRPS-E5"
                     /locus_tag="makasC"
                     /protein_end="1406"
                     /protein_start="1389"
                     /score="23.1"
                     /tool="antismash"
                     /translation="DLSRTVGWFTTVIPLLL"
     CDS_motif       16006..16047
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0014"
                     /evalue="1.00E-03"
                     /label="NRPS-E6"
                     /locus_tag="makasC"
                     /protein_end="1440"
                     /protein_start="1426"
                     /score="11.7"
                     /tool="antismash"
                     /translation="TPQDGLSYGLLRYL"
     aSDomain        16381..17277
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_makasC_Condensation_DCL.1"
                     /domain_subtype="Condensation_DCL"
                     /evalue="7.40E-103"
                     /label="makasC_Condensation_DCL.1"
                     /locus_tag="makasC"
                     /protein_end="1850"
                     /protein_start="1551"
                     /score="335.6"
                     /tool="antismash"
                     /translation="EEILPLTPLQTGIFFHSNRQEETYFNQLHLVLEGSLNTSAFRSAW
                     CQLIKRHKLLRASFHTADDGTPLQFIHKHVDPTWVERDWTGFDRTHQSQRLAALMAADR
                     ATNFELHQAPLLRFHLLKTGDERHDLIWSSHHLLLDGWSVSVVMEELLALYREACGGMA
                     AALGSAPDFSEYLTWLDTVDKQAAEHFWQQELSGIAEPTCLIGSGLAPNEQEPNAPAHH
                     HLELPANDVQAIEELARTSGVTVGLVLQAAWGLLLSRYTGLDDVLFGLTVSGRPPDLAG
                     VNRMVGMLINTLPIRIQI"
     aSModule        16381..19512
                     /complete
                     /domains="nrpspksdomains_makasC_Condensation_DCL.1"
                     /domains="nrpspksdomains_makasC_AMP-binding.2"
                     /domains="nrpspksdomains_makasC_PCP.2"
                     /locus_tags="makasC"
                     /monomer_pairings="phe -> phe"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       16450..16560
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0015"
                     /evalue="1.70E-10"
                     /label="C2_DCL_024-062"
                     /locus_tag="makasC"
                     /protein_end="1611"
                     /protein_start="1574"
                     /score="33.1"
                     /tool="antismash"
                     /translation="YFNQLHLVLEGSLNTSAFRSAWCQLIKRHKLLRASFH"
     CDS_motif       16783..16845
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0016"
                     /evalue="8.30E-10"
                     /label="C3_DCL_135-156"
                     /locus_tag="makasC"
                     /protein_end="1706"
                     /protein_start="1685"
                     /score="31.1"
                     /tool="antismash"
                     /translation="HHLLLDGWSVSVVMEELLALY"
     CDS_motif       17173..17268
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0017"
                     /evalue="9.00E-17"
                     /label="C5_DCL_263-294"
                     /locus_tag="makasC"
                     /protein_end="1847"
                     /protein_start="1815"
                     /score="53.5"
                     /tool="antismash"
                     /translation="DVLFGLTVSGRPPDLAGVNRMVGMLINTLPIR"
     aSDomain        17764..18945
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_makasC_AMP-binding.2"
                     /evalue="1.60E-98"
                     /label="makasC_AMP-binding.2"
                     /locus_tag="makasC"
                     /protein_end="2406"
                     /protein_start="2012"
                     /score="321.8"
                     /specificity="consensus: phe"
                     /tool="antismash"
                     /translation="AWAELSPDMPAVISKEETLTYGQLVEQANTLAAHLITSAGIRPGS
                     LIAMALPRSSAAIVAILAIWRVGAAVIPIDVGYPAERVHFMLLDCTPDLVLTNTVHRSS
                     LPLDEGNAIFLIDTLSDAPLSVSRDEAWPRIELDTPAYVIYTSGSTGKPKGVLSSHRGL
                     VSLIRSQRELFSLAPGDRVLQFASLSFDASIWETVMALASGAALYIPNREDALAGPELG
                     TYLRTYRITAATLPPSLLAVLPEGNYPDLKLLVSAGEACPVALARRWKQGRRFFNAYGP
                     SEATVCATVFEGSVEGTSLPIGRAIPNVSTHVVDSHLRPVPAGCEGELVIGGLGVALGY
                     LGQPALTAKRFVKVPALDHPSETNKLFYRTGDRVRLDIDGTLTYLGRLDRQVKL"
     CDS_motif       17947..17988
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0018"
                     /evalue="4.90E-02"
                     /label="NRPS-A_a2"
                     /locus_tag="makasC"
                     /protein_end="2087"
                     /protein_start="2073"
                     /score="7.6"
                     /tool="antismash"
                     /translation="LAIWRVGAAVIPID"
     CDS_motif       18184..18243
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0019"
                     /evalue="2.90E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="makasC"
                     /protein_end="2172"
                     /protein_start="2152"
                     /score="28.9"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGKPKGVLSSH"
     CDS_motif       18598..18624
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0020"
                     /evalue="1.10E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="makasC"
                     /protein_end="2299"
                     /protein_start="2290"
                     /score="5.8"
                     /tool="antismash"
                     /translation="YGPSEATVC"
     CDS_motif       18727..18816
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0021"
                     /evalue="1.30E-13"
                     /label="NRPS-A_a6"
                     /locus_tag="makasC"
                     /protein_end="2363"
                     /protein_start="2333"
                     /score="43.1"
                     /tool="antismash"
                     /translation="PAGCEGELVIGGLGVALGYLGQPALTAKRF"
     CDS_motif       18913..18978
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0022"
                     /evalue="1.80E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="makasC"
                     /protein_end="2417"
                     /protein_start="2395"
                     /score="32.9"
                     /tool="antismash"
                     /translation="YLGRLDRQVKLDGFRIELGEIE"
     aSDomain        19324..19512
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_makasC_PCP.2"
                     /evalue="7.90E-17"
                     /label="makasC_PCP.2"
                     /locus_tag="makasC"
                     /protein_end="2595"
                     /protein_start="2532"
                     /score="53.1"
                     /tool="antismash"
                     /translation="LKAIWSELLGRTVINPNDNFFDIGGSSLLLVQMQGLIHSRLGVSL
                     SSSKLFRHPTLDSLVELL"
     aSDomain        19606..20874
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_makasC_PKS_KS.1"
                     /domain_subtype="Hybrid-KS"
                     /evalue="1.80E-150"
                     /label="makasC_PKS_KS.1"
                     /locus_tag="makasC"
                     /protein_end="3049"
                     /protein_start="2626"
                     /score="493.4"
                     /tool="antismash"
                     /translation="IAVVGAAGRFPGSPNLEAFWELLIEGREGISRFDKESLLQSGMPL
                     DLINNPAWVPVGGVIDDAEAFDPTVFGIGARDALILDPQHRVFLECAWHALEHAGYAPK
                     ATDRSIGLFASSGQNTWLHDVLLPAGETITGSTGFHLLTANDKDFLASQAAYRLDLKGP
                     VVTIQTACSSSLVAVSMAIDALRTGRCEMALAGGVSIRFPQNRGYLYEPEMILSPDGHC
                     RAFSADANGTVPGSGVGVVVLKPLSQAKTDGDRILAVVRGIAVNNDGSNKMGYTAPGVA
                     GQAQVIRAALEDAGLTADDVDYVEAHGTGTPLGDPVEVTALGRVYTGRREPLLLGSVKT
                     NIGHADAAAGIAGFLKVVLALERGQLPASLHAQPLNPRIDYSVGPFEVVDRTRSWPERG
                     RPLRGAISSFGIGGTNVHAILEAS"
     aSModule        19606..24057
                     /complete
                     /domains="nrpspksdomains_makasC_PKS_KS.1"
                     /domains="nrpspksdomains_makasC_PKS_AT.1"
                     /domains="nrpspksdomains_makasC_PKS_KR.1"
                     /domains="nrpspksdomains_makasC_PCP.3"
                     /locus_tags="makasC"
                     /monomer_pairings="mal -> ohmal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       20089..20136
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0023"
                     /evalue="1.50E-05"
                     /label="PKSI-KS_m3"
                     /locus_tag="makasC"
                     /protein_end="2803"
                     /protein_start="2787"
                     /score="17.1"
                     /tool="antismash"
                     /translation="GPVVTIQTACSSSLVA"
     CDS_motif       20512..20559
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0024"
                     /evalue="5.50E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="makasC"
                     /protein_end="2944"
                     /protein_start="2928"
                     /score="12.2"
                     /tool="antismash"
                     /translation="YVEAHGTGTPLGDPVE"
     CDS_motif       20611..20655
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0025"
                     /evalue="4.20E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="makasC"
                     /protein_end="2976"
                     /protein_start="2961"
                     /score="9.9"
                     /tool="antismash"
                     /translation="GSVKTNIGHADAAAG"
     CDS_motif       21196..21246
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0026"
                     /evalue="2.30E-04"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="makasC"
                     /protein_end="3173"
                     /protein_start="3156"
                     /score="13.8"
                     /tool="antismash"
                     /translation="LLPGQGSQHLGMGQQLY"
     aSDomain        21199..22029
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_makasC_PKS_AT.1"
                     /evalue="1.30E-89"
                     /label="makasC_PKS_AT.1"
                     /locus_tag="makasC"
                     /protein_end="3434"
                     /protein_start="3157"
                     /score="292.3"
                     /specificity="consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LPGQGSQHLGMGQQLYEAGGVFRRELDTYSEILRPLIDFSIVELL
                     FSGGEDKAKVLQTTQLAQPLVFALDVALARHWQGLGIQPVGFLGHSLGEYAAAHLAGVF
                     STEDALALVVERGRLLGELPPGVMLAVPRSEVEIHGWLSDDLALAAVNNSTNCVVSGSF
                     DAIEAFEARLKEMGCISRRLHTSHAFHSPMMTAAAEPLAAAVARFSPKRPQGRFISNVT
                     GTWITPEDAIDPNYWARHLLQTVRFADGLATLQNDGITLAIECGPGQTLTILAKG"
     CDS_motif       21376..21432
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0027"
                     /evalue="5.60E-04"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="makasC"
                     /protein_end="3235"
                     /protein_start="3216"
                     /score="13.2"
                     /tool="antismash"
                     /translation="QLAQPLVFALDVALARHWQ"
     CDS_motif       21439..21558
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0028"
                     /evalue="4.60E-21"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="makasC"
                     /protein_end="3277"
                     /protein_start="3237"
                     /score="67.1"
                     /tool="antismash"
                     /translation="GIQPVGFLGHSLGEYAAAHLAGVFSTEDALALVVERGRLL"
     CDS_motif       21904..21939
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0029"
                     /evalue="3.80E-04"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="makasC"
                     /protein_end="3404"
                     /protein_start="3392"
                     /score="13.9"
                     /tool="antismash"
                     /translation="YWARHLLQTVRF"
     CDS_motif       22996..23094
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0030"
                     /evalue="3.50E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="makasC"
                     /protein_end="3789"
                     /protein_start="3756"
                     /score="22.9"
                     /tool="antismash"
                     /translation="VVWITGGFGGVGSAVARDLAKEQGIQLVLTGRT"
     aSDomain        22996..23562
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_makasC_PKS_KR.1"
                     /evalue="5.40E-42"
                     /label="makasC_PKS_KR.1"
                     /locus_tag="makasC"
                     /protein_end="3945"
                     /protein_start="3756"
                     /score="135.6"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: (unknown)"
                     /tool="antismash"
                     /translation="VVWITGGFGGVGSAVARDLAKEQGIQLVLTGRTALGENGADSPTR
                     KDRLQLVREIEAMGAIVMTAALDLADERAVKALVNQVETRLGAITGVFHCAGVADLAGV
                     VQMRSRSDTEHVLAPKVAGTRAIERALSQHSLDFLVLCSSLSSFLPIAKFGQVGYAAAN
                     EYMDLAAVAIARRTGWRTVTINWDDW"
     CDS_motif       23401..23496
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_makasC_0031"
                     /evalue="2.10E-08"
                     /label="PKSI-KR_m4"
                     /locus_tag="makasC"
                     /protein_end="3923"
                     /protein_start="3891"
                     /score="26.7"
                     /tool="antismash"
                     /translation="LDFLVLCSSLSSFLPIAKFGQVGYAAANEYMD"
     aSDomain        23857..24057
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_makasC_PCP.3"
                     /evalue="2.70E-15"
                     /label="makasC_PCP.3"
                     /locus_tag="makasC"
                     /protein_end="4110"
                     /protein_start="4043"
                     /score="48.2"
                     /tool="antismash"
                     /translation="LLLEAFRRILDDPTTVVDSNFFERGGHSLLAMNLLNFIRETFSVG
                     IALLDLFEHPTPPTLADIIKER"
     gene            24134..25735
                     /gene="makasD"
     CDS             24134..25735
                     /codon_start=1
                     /gene="makasD"
                     /product="hydroxylase"
                     /protein_id="BAW32335.1"
                     /transl_table=11
                     /translation="MKSPSYYLRPDVVVEPLIARWHAWSGLISPVTAALNVVHRHLDIM
                     TSYVSMPQVHAAAARDPALLGGPFIDLEGGRVDEVRALLDWTRLCQQPAIQLAEDLAKV
                     WTMLKYEADGHGMTNLYKQLPDSLRGAVELVYTPSGSPDIRPIEPLLYQSPCYNPDIQG
                     AMIRRVRSDHRAFALSTPRLDLPDAIYLDRPFRDPVYDKLASLRFIPQPLSTITDIFQV
                     RSEKKPLLESFLTSEAPARTPKSSELRWRYFGHACVLVETFGGQSVLVDPVIAYESGAE
                     PERFTVADLPSHIDFVVITHNHPDHVLIETLLSLRHKISTVLVPTAGGSLVDPSLKLVL
                     EAIGFETVREVSCMEDVIAGDLRIQALPFLGEHADLDIRCKAAWLVEAESMRLLFAADS
                     NNLDPVLYDRLTPLIGRVDTLFIGMECRGAPMSWMYGTLLPESVERSKDQSRRLDGSNC
                     ERAKAIISSLDIEQVCVYAMGMEPWLKFISSLDPTADSPALQESQALIDHCNHLGLPAE
                     RLYGRSESLFLTEYYL"
     gene            complement(25908..>26237)
                     /gene="ORFM2"
     CDS             complement(25908..>26237)
                     /codon_start=1
                     /gene="ORFM2"
                     /product="transferase"
                     /protein_id="BAW32336.1"
                     /transl_table=11
                     /translation="MLAYYVEWHLKQSLAPLLFEDEEIDDSCLNVIKANRSESVQSKER
                     KKRNQENFTVHSFRTLLEDLGTICLNTVECTIREGSYRFSKITRPTQLQQKALDLLGVS
                     LICSQ"
ORIGIN
        1 atagcttttt tatttcatac cgttttagat ttagttaatc atacttatca aaagattcgt
       61 gagctattag taactcggac ttcttttttt aatgatattc gtaccctatt aaaatttatt
      121 tggtttaaga attggtcgga atttttctca tttattctca ctgaatatgt cccatttaaa
      181 aaagtaaatt ctagttgaaa atgtcagaac tcttgaagga gaaaaaagaa agttgtttat
      241 aaaaaaacta aaaattttgt taaaatttta tccagattta tgagttgaaa tcgatttttt
      301 aatggacaag gttattaaaa cctgtctatc tccagggttg gatgataatt atctgtcaaa
      361 gaataatgct tctacacaag ttctctattt aaataagaga attttatctg atttttttca
      421 aaatgagaat tgctggtgat taggggccag catagctatt gatatttgaa taggttactg
      481 tttctattat acgctattta gatgctgaac agcttagctg tagaaaatgc taatcgctgt
      541 ttaaaaatct tcaaaattct ctcttacccc tatcgaaatc gccgatataa atttggatta
      601 agaagtcatt taatcgctgg aatttacaat aacgatttag gttcaaaagc ctaagcaaaa
      661 aactaactat agcgtttctg attcagaaga ggtacatttc cgatcctgaa cagcttaatc
      721 ggcaaaggtt taagtgtgcc gcacaaatgc gagaaccgct atatattctt ttaatttagc
      781 tgagaataac aagctagata tctttgtcgt gcgaataatg tattgagagt tgattaaccg
      841 tatctgtgga aaaataatgg tggaaagatc ataaatttag aagttcaaag acgaaataga
      901 taaaccgtcc atcataccat aaaaaacttt tgcaagaggt ctattgatgg cacggtctgc
      961 gccgtgcgga agctatcgct cgtcgtggat gtcggcaaat atccgctcgc cttacgaagg
     1021 agcgatttta tctccctggg cgaacgcctg ttctcaggga tttaaacgta aagttttatg
     1081 tataaattca actctgtatg cgaaccttaa attttattaa aaaaatacct gaagtgctct
     1141 aagtaagcta tcctgaccat taagctgtta gtcatctagg tttctagggt aatccaagca
     1201 tagcaagggg ttcagccccc gaaaccagcg atttaaatta cggacagctt aacagactaa
     1261 acttaacaaa ctaaaagagt ttaaatggta ttcggtcata gtttatgtag gtcgatggtt
     1321 tcgggggatt gtgaggagta tggtgatatt gagttggctt tgctcgccta tccgggcatt
     1381 gtcgaagctc gggtcttgga tatgagatct gtgtgtcgta aagaaatgtc tgtcaaacgg
     1441 attgcttatg ttgctggtcc aggggcttgc cgattatcga acaaatctct gcctttgcgc
     1501 tggcagctag atgcccttgt accagtgaac cgtttgggaa acgacacgga acttgagtat
     1561 ttaccagtat ggacagcgca ggagctagac cagattcggc atgaactcat tagtctgtca
     1621 gatgttgaag atgtggcagt agtttctgtg ccaaacagtg ttcgtaaaca tatccgacaa
     1681 tccttgctgg tgccgaatcg agtcaaagcc tctacgccat ttagccttcg tgagccatcc
     1741 ggtgttagta agccagtcaa gtcggttgag gttggccaca gtctatccga gcagttagct
     1801 gtgctccatg gaccctcgtt agtatttccc aagaattttc ccagaacaat tggtgaaggc
     1861 attcaacggg ctgcctctaa tgacaaaacc gtaatctacg gtgcattgaa tggaacccac
     1921 cggcatgaaa aatatgcatc actgtatcag cgagcactct ctatcctcgg tggtcttcag
     1981 aatgcccaga ttggtaaagg agattgcgtt ctacttgaca gttccaatgc tgaggacttt
     2041 atgggggcgc tgtgggcctg catacttggc ggcatcatcg tgacccccat cggcgtacca
     2101 gaagctaatt ctaatcctgc cactttcgag cgcctgaacg cagcttggca actgctcgac
     2161 catcccacag ttttaactaa agctactttg ccaagttcat ttggcaacga tactaaatct
     2221 gtgaagaccc tagacatttc tcgcttacag tgcccagaag cctgcaactt ggtgagctgt
     2281 gagtcggtgg attcagtttt aattttactg acatcaggta gtaccggcat ccccaagggg
     2341 gtgcatctgt cccatgccgc gatactggca atggcggttg ggtttgggat cgatggattg
     2401 aaagtaaacg agacggacat tttctttaac tggatgcccc tggatcatgt gggcgcgctg
     2461 gtatggtcaa gtttagtgcc gatgcttgca ggttgtgacc agatccacac aagtacagac
     2521 tacattcttg ccgactcatc acggtggtta gacttcgtct ccgattttcg tgttagcaga
     2581 acttgggcac cgaatttcgc ctatagtttg attgctagag cagcgttagc ccagtccaag
     2641 ccatgggatg tgtcttccct gcgaaccgtt ttaaatgctg gtgaggcagt caatgaggag
     2701 tctttgaagc agtttctaga ggtattgaaa atatacggtg tggagcgcga cgacatcata
     2761 gttcctacat tcggtatgtc agaaacttgc tcgggtattg ttttaggcaa gctgggtcaa
     2821 acgctaggat cgctttccag tttaggcagt ccagttgctg gcagctctct acgcattgtt
     2881 aacagccagc agcaagtcgt gaaggaagga gaaattggca acctgcagat tgccagtcct
     2941 cagctgtttt ctcggtatca tgggtttcca gatcgagcca gcaattgcca cgctgctagg
     3001 gattggtttg atacgggtga tgctggtctt atcgccaatg gcaatctata tctgacaggg
     3061 cgttcaaatg acaaaatcaa catcaacgga gtaacaatat tcgcctttga ggtcgagcaa
     3121 attgtggcct ccttgtctgg aatagatagt aactgcgtag ccgctgtacc atttcgttcg
     3181 cagaactcaa ccaccgacga gattgtgctg ttcttcagta tgattccgga aatggctact
     3241 gatgacgaca gcatagtagc agagcttgtc aaggcaatta ggaatacgtt atccctacaa
     3301 cttgggttgg taatcgagac cttactgctc ttatcggcta gggattttcc tcgaaccgga
     3361 atcggtaaga tttctaaaac aaagttgaga caaaattggg aagcgggtgt ttatgatgca
     3421 atccaggagc gagtgaacgg ccttttgggt agctcggact attctgagat accactgcat
     3481 cgtcagatct gggtcgagcg accagtgcga ttgaaggagc caactgtcat taatccagcg
     3541 aacatcgatc tgatatttgt cggcaaccaa gaacagcttc agtggttagt tcctaacccc
     3601 catgattacc aagttcagat cataagatct tctgaaacga agcgtttgag caataataca
     3661 tgggcaatag cctcggatga cgcgatcggt cacggtaagg tgatagacgc gattgcgact
     3721 cttgacggta agcactatac aattctccat gcctggggct ataatgactc cgccgattcg
     3781 actgttcatg ctactcgctc tcttctttcc ttagctcggg ctatagccac gagaggcaaa
     3841 aaaacttact ctgtcgttgt tctgacctac ggtgcggtgg caactaatcc tgacgagcgc
     3901 atcaattaca atcacgccct tttacctggg ctaattcgtt cgctggcctt ggaattacca
     3961 gaagtgcggt ggcaattaat tgacctaccg atgccgagtt ttaatgatgt gagcgtcatc
     4021 ctgaagggtg tttgtggctt tgagccggtc gttgcgtggc gggacggcaa ggcacttgtt
     4081 cctcgttttg aagttgttga gccgccgctg gctacgttgc aggaagcgat cacgcctggc
     4141 agcctctggc tcattagtgg tggtttggga ggactgggta gcttgatctg tgagcggcta
     4201 ctgagccacg gggcaaacgt tcttctcatt ggtcgcacgg ataatatcga tttatcgccg
     4261 gaacgggctg ctcgattgaa gcagcttgaa cgcttggggg atgtccaata cataaaggcc
     4321 gatgttgccg atctcgatca actacgggat gctgtgcatg agcgagaatg tgcattgggt
     4381 caatctcttt caggtatttt acatgcggcg ggctcgggcc gtgctgttcg gttagctgat
     4441 gataatggcg tcgatcttga gaccatgcaa cgtactagcc ttggtggtct cgccgcactg
     4501 gcgacactgt tggaaacaag accagccgcc caactgctag tgataggatc gatcgttggt
     4561 caggtggggg gtcgggttat gggatatgct gccgtgcatg ccgctctatc tgaggcagca
     4621 cataagctaa cgatgagcgg tgctcgggtc tcactattat cttgttcttc ctggatggat
     4681 attgggttaa gcaagggtca aaccaatgaa gctttagtgc gctcagatgg gcttgtccca
     4741 cttgatgctg aaactggttt gttagtcatc gaagctgccc tcttgcgtcc gggcactcac
     4801 tggctcgtcg gtctcaacga ccagcacccc gctaatgccg ccttcgcact gacaacaccc
     4861 gcgccactga accgaccgac ggcttgggtg aaagggaaac aatctgctgt tgtgctcagc
     4921 tatccggata atctgtcgcg ccaggcttgg gtcttagtgc gcaatgcgcc agaaattcta
     4981 cgggatgcac aagggcaagt tgacattgct gggatgatat cacacgcaac cgatcgatgg
     5041 gtggctcccc gtgatggggt ggagcgttta gtggccgaaa ctttctcgtc tattctcggc
     5101 atcgatcaac cgagcatcta tgacaacttt tttatgctgg ggggaacatc tttgctggct
     5161 agccagctct ctagtcaatt gtcagagtta ttctttgttg agctatcgtc tgcctctata
     5221 tttcaaaacc ctaccattga atcgttaacc atcgaattat atgcgattga gaagcaggaa
     5281 ggactggtgt ctgcagttgc caaacattta gaaagcttga gatcaaaaac gaattaggat
     5341 taaaagaatg gtatttgatg aacgctcttc gctcgcagaa cttttaaaga aagacggatt
     5401 caccatcctg gatgccaacc tgtcaaatcg ttccgaaaaa tctagccgtt gtgatcgtct
     5461 agctggctca gctcaatatc gcttctggct tcaagagcgt actgaaggta ttcctgggct
     5521 aaatacctta ggttgtctgg taaggtttag tcgatccctc tccgcatctt cactcaattt
     5581 ggcttttgag aagttgtttc agcgtcatga agctctgcgc accagatttg aggagacctc
     5641 cgatggtgtg ttcgagcgaa tagatgtcgt tgcgccaaaa gatgtggagt atcttgaggg
     5701 agattctagt gattgcggtc tcctcgaacg ccaacttgcc aggcgtttga gaatgaatga
     5761 ggggccactc tggcgtgcgt ctatcttcag cgatcccact gcggctaata cgctactgct
     5821 agtctttcat catgccatca ttgattggac tgggatcggg cgtttggttg aggagctaga
     5881 gcagctactc agtaatccag atgacacgaa cctcctgctc gacgatccct ttcagccagc
     5941 tgactattac tattggcgaa cggctacatc aaacgaggtg aagattaagg ctgatcagtc
     6001 ctattggtta gaaagattgg caggtgagct gcctgtactt gacttgcccg cggctcgtcg
     6061 ttctggtcgc ggactgggga gacgttctac atatactgca ctaacctttg ccccccagct
     6121 ggttagggat attcgccagt ttgcggtagc gaacggaaca acaccgtttt tcgtcttcct
     6181 agcagcctat gctggggttt tgggtcgttt tgccctgagt gaagacgtta gcattggtac
     6241 cgctatcgac aatcgcgata cacctggatc cgaaactatt gtcggctgtc tctcagactt
     6301 agtggtactg cgctgcgatc tatctggtga gccgagtttt aaggtgcttg tccaaaagct
     6361 acagcgcgtt tgttcgacag attttaagca cacgaccatc ggctacgcgg atgttgtagc
     6421 actcgtcaaa cctcagcgtc gtgctggggt tgctcctcta tttcaggctc tttttaactt
     6481 tttgcccgct agggggggag cggatttacc aacgctgatg ccactcccta gccctgacgc
     6541 tcgagctgat atcgctctgg aactggtgga cgacggtgtt gggatttctg gccagattga
     6601 ggttcgtgag gatttagttc ctaagtccgt cgcgatcgct attactaccg ccatcagcac
     6661 aacactacag tccgccatgg caaggcctga catcgcgttt aataggctgc cgctaatcga
     6721 ttcccaagca gcggcggccc tgacccagcg actcaaccca tcccatctag aaaccatcaa
     6781 tcagtctttg ggggatttgt tgctggaacg tgctcggctt cattccaata agattgctct
     6841 gtgtgaaggc gatcgcaccc ttgactataa gaccttaatc aagcaggcca cagcccttgc
     6901 acattttctg gtagcccaga ctccagtgga gaaacccacg gttggtttcc cgatcgctat
     6961 ctgtctcgat cgatcaatcg acttggtgat tgcggctgtt gcagtggtgt tagctggagg
     7021 agcggtgtta tttctagagc cagatttgcc tgaagagcgg cttgccagcc tgctagcgga
     7081 cagtggtgcc acccgattga tcgcgcgaca gcgaccagta tggctgcccg agtcagccgc
     7141 cgtcaccatt gtgacgctaa cggactacga tacgaaaaac acggcaaaag ctctagtatc
     7201 cttaccacgc gtcagccctg aggatcctgc ttatttaatc tatacatcgg gatccaccgg
     7261 tcgccccaag gtagtcgtgg gactccataa gggtatggtc aatcgtattc tttggatgga
     7321 acgtcagtgg cctgtccaac ctgatgaggc gatttgcctg aagacatcgc tgatgtttgt
     7381 cgattgcatc ggggagattt ttggccctct catttggggg cttcgggctg ttgtggcgga
     7441 tagggatacg gcccttaacc ctagggcatt agcgacactg attgcccgag agcgaatttc
     7501 acgtattgta atggtgccgt cgctactgcg ggctatgctc gacagggtac cagacataga
     7561 aagtaaattg cgaagtctac ggctgtgtgt cagcagcgga gaaaccttgc cggttcaact
     7621 cgttcagcgt ttttacacgg ttgtacctga tgcggctctg gtaaatttct atggttcttc
     7681 cgaggtgtcg gcggatgcaa cctggcatag ggtcgacatc tcagacacag ccccgatccc
     7741 cattggtgtg cccatacaag gaaaccgcat cttcgttttg gatcgcgctg gtcaggtgct
     7801 gccagtcggt gcacctggcc agatcgccat cagtggggta ggggtagcgc gaggctatct
     7861 ccacggcaat tcttcggctt tccagcggaa tttaaacgac gacaaaccta cagaaaaacc
     7921 tatagacgaa ccaatatttg ccacgggtga tttaggtctg tgggatggcg atggacggct
     7981 tgtgtatctg ggtcggatgg atcgccaagt caaaattcag ggggtacggg ttgaacccac
     8041 tgaaattgag gctaccctgg aggatcatcc tggggtagat gccgcctatg tcagcgcgac
     8101 agtagcaccg ccagaggata atatggtgct gacagcctac gtcgctgctg aagcgggtgt
     8161 gacagtagcc tccttaagag cttggctttc ccaccgattg cctcgggctc taattccggc
     8221 ctcatttatg attttggatg cgttgccgct taatgcgagt ggcaaaattg acctggcagc
     8281 cttgccgagt cctgccaggg atctggatac agacgcggag attcctaaga ctgatatcct
     8341 agatccgtta gaagagctgg tagctaatgt gtggtctgag atgctggcgc agccgatcaa
     8401 tagccctgac gacgatttct ttgattgtgg cggcggctct ttgcaagcga tcatggccat
     8461 caaccagatc agcgagctga tggattctgc gatcgcagtt tctaccctct ttgaaacacc
     8521 gagcctcaga gcattcgtcc gtcgtattat cacccctgat gttgaggggt taccgccacc
     8581 ctgtccatcg ttggaaaccg ggttagcccc tgccactagt aatcagcgct ggctctggac
     8641 tcactatcag gacgatccca acagtagtgc ctacaatctc tgcattgcct atgagttaaa
     8701 tggatcgctc gatgtccccc agcttgagag cgctatcagg catttagtga cccgtcacga
     8761 cgcgttacgc acccacctag caattcaaaa tgatgagcta gtacaagtag ttacctcgga
     8821 agagctagaa ctctttcgtc acgacgtatc agccgctgtc gatcccttag cggtcttaga
     8881 gtctttgctg gcagatatcc gttgtcgccc ttttgctttg gagagggaat taccactgcg
     8941 ggttcatttg gtcaaactcg aaccggttcg ccatgtcttg atttgggtaa accaccatgt
     9001 ggcctgcgat ggctggtcgg ggcaggttct ggttaaagaa ctggcagccc tgtggtctgt
     9061 ccatagcacc accgccttac cgccgcctct cctacaactg ggagatatcg ctcggtggca
     9121 gcagaccgtc tgtcccgcga tcgcgaagca gttgaaggat tatcaacaaa gcctcatggg
     9181 aggtgaatcc ccccgagtgt caggtatcgc gacagataag acctggggtg gacaagtcgc
     9241 cgtggatcag gtggtgatcg gtacagatac tctcacagcc tttgaagcct tagctcagga
     9301 agaacgggtc acccgtttta tatcaatgct aacaatctgg gcggttttgc tgacgcgctt
     9361 cggcgatacc gaacatcctc ttctaggctt tcctcaagct ggcagaaata caccgggatt
     9421 acagtctgtg gttggatttt tagccaacac ggttctgctc aaggtcgatc ttgccgatgc
     9481 cccaacgttt cggcaggcct ttaaggcgac taagactgcc ctgctgacag cgatgcggta
     9541 tcaggatgtt ccactccctt ggctccaagc cacaggtatg ggctggccta ctcaaccaga
     9601 tagtgaggcg attcgtagca tggtgattgt tgaagatgcc agcgattggg atctccgctt
     9661 gccggagctt tcgagccgtc tcttcgctat gcctaactct cccgaggcgc gagttgatct
     9721 tgcttttgtg gtcactcaga tgactaacgg accgcgcttg gttattgaat atgccacccg
     9781 acgcgtgccg agggcagtgg ctgaacgctt agcgcggggt ctggagcaat taatggcggc
     9841 agcggctact gagccagaca cacaaatcga acgactgccg ctcttgagta ttgataatcc
     9901 agattgtgga gccgtgctga ctgctgaagc ggcttctagc cccattgcaa ctcgtctaga
     9961 cgcagtcttg gctcatgtgg cactaacctc tccggccgcg acggcagtgt gggacttgac
    10021 ctcatccctg tcctatgccg agctgaatca gcgggcaagt gtcacggctc aacgacttca
    10081 aggtctaggt gtagggacgg gagaccgagt agggctactg gcgcagcctt cccccctaca
    10141 gctcgccagt ttattcgggg tgtggcggct aggagcagtt gctgttccgc tcgaccccac
    10201 ctatccgcgg gagaggatcg ccgctacgct catggacgcg ggggtggtag cggtactgac
    10261 ggatattccg ctcgactatc cctgtccaca gctaagtctt gatagtatct tgggtgccgt
    10321 accgtccgca ccgatagcag gactagtttc ttcccccgac cctgatgacg tggccgctat
    10381 catctacacc tccggaacga ccggcacccc taaaggcgtg atgattactc aggccgccct
    10441 ttgccgctta ggatgtgcgt tgtcgatggc ctatgacttg ggtcaaggtg atcgggtatt
    10501 acaggtggtt tccccagctt tcgatgtggc gctttcggat attgctatgg cagtcagtgc
    10561 ggtggcaaca ttggtggtac ccccgcacgt ggatgtgatg ccagggaagc acttgaaccg
    10621 tactcttgca atggccaaca ttacccatat gcaagtgcca gcagccgtgc ttgcagcaac
    10681 ccagcccggt actctcccaa aattgagaac tgtctcggtc ggtggagagg tttgctcgcc
    10741 ggaaacagca aacgcgtggt catgcgatcg ccgtttgttc attgcctatg gccccaccga
    10801 agcaacagta accgtagcat tggcaactta tcagaaagga gctaggccag gcaccatcgg
    10861 tcgcccattc ggcggagctt ccctaaccgt tgtggatcca acgggacacc tagtgccgat
    10921 aggagtagct ggggaactga ttattggcgg gcccggtgtc gcgctgggct acctagggtt
    10981 gcccgatctc accgccgaac ggtttgagca aacagcgcag gggcgtcgct accgaacggg
    11041 tgatcgagtc aggatggaag ccgatggcac ggtgactttt ctggggcgaa tcgatcgtca
    11101 attaaaacta cgcggtttcc gcatcgagcc gggcgaggtc gaaactcatt tgatgaattg
    11161 tgatggcgtt gcacaggccc tggtgtcggt ttgcccggat cagatcggag aaccccagtt
    11221 ggtggcttgg gtagtgggtg agcctggtgc caaattggat agtttgacgc ttcgtcaagc
    11281 actcaaacaa catttgccaa atcatttggt accctcagcc atcgtccaaa ttgttgcagt
    11341 acctctgacg gccaatcgaa aagttgattg gtcgtctctt aaagcagagt tccatcgtct
    11401 caatgtccct gacatgaaca tttcagagat ggctcagtgc tctttagtag aaagggatag
    11461 cactacggtt gagcgggatc tttcaaccat ttggagtgag ctactgggca gaaaccaggt
    11521 gggacttgac atcagtttct tcgatttagg cggacattcc atccagttgg ttcggcttca
    11581 gacgcgaata gaagaccatt ttggaattga gttgcccatc ggggaaatgt ttgccaaccc
    11641 tacgcttcgc tctatgacct cgctggtaca gcgcttgctt cgcacagctg catccgatga
    11701 agaaaatgac tgggaggaat ttacgctatg agtccaaaaa atagacccgt tgaccagctt
    11761 ttgcatgacc ttgagcaggc tggtattagt ttagccatag aaggggaact actcagggta
    11821 aggggtccag taaaggccat tagccaagat ttacgagtgg aactgacagc ccgtaagcag
    11881 gaactgatgg cgattttacg gatgcccgca tcgccagccg catctcgggc tagtctagcg
    11941 gttgaagccc cggtaacgca taaccaacgg cggttgtggt ttttgaataa gcttgagaac
    12001 accagtgccg tgttccggat gatggcagcc tgggaactgg tgggtccttt agatattgat
    12061 gcctttaacc aggcgatcgc ctccctaacg gcccgccacc caatcctgcg ttcgaccatt
    12121 cgagagcggg gtgaggatgt ctttttaacg cccatggatt ccccctttga agaggttatc
    12181 ccaaagcgcg gctcccctaa tgaaattgag cagattatcc acgagcaggc agaagcgtct
    12241 ttcgatctgg ctaatggtcc gttattcctc gttcgactgg tggaattctc ccagactcac
    12301 cgtctgcttg tcattgatat ccatcacatc atctccgacc gctggtctat gggtctattg
    12361 tttcgcgatt tgagtgcgtt catgcgggcg gaggttacag gtgaagatgc ggcactgcca
    12421 gtgctaccaa tacagttttc tgactttgct ctctcccaac acgcgctgct ggatcagccg
    12481 accttggagg gcagggttag gtattggcgc gagacgttga ctggaggaac agctgaatta
    12541 gccctacctt tggatcggcc acgacctcga acgcggggaa tgcgcggcgc atccttgcgg
    12601 tttccgttag ggcaagatgc taatctatcg catcttgcca gtcactaccg agcaacagcg
    12661 tttatggctt acctagccgt atattcggct ctgctcgttc gttggacagg gcaagatgag
    12721 gtggtagtag gctgcccgat cgggggtcgt gagcgtcacg aaacccacga tctggttggt
    12781 ttttttgtaa atacggtagc cttgcgcttg gatctatctg acgatccgag cttcattact
    12841 ttgctggagc gggttaagcg cgtcagtcta gaggcgatga cccaccagga tgtgcccttt
    12901 gaccgggtag tggatgcact caatccgccc cgctacttga accgcaatcc cctgttccag
    12961 gcgatgttcg ttctgcaaaa cgcgcccctc tccgagctag cttggcctgg cattgaagcg
    13021 cgttcgctga cggtgccagc tatggcaccg gaggtggatc tcaatctggc actggagcta
    13081 tccgccacgc cagacacccc gtttacagga tatcttgaat acgatccaga tctgttcgag
    13141 ccgtccaccg ttgagcgttt tgtccagcat tttgtgagct tttgtcaagc cgtctcccgg
    13201 gctccagagc aatccatctc ccaaattgta atcgcggatg aaacgcgtgc cgtatggcaa
    13261 ggtccccagc gagcgcgacc caatcagacg ctggatgaga tgctgataac tcgtcttgct
    13321 ggcaatccga atgcgatcgc cctaatgacc acggaaggag aggctgtttc ggcgggtcaa
    13381 ctgctgcacc gggcacgcct gctctctgac cggctatcct gggacaccga tgtcgttcag
    13441 ttagtgggga tctggcttcc acgcagtccg gaactggtgg tctccatgct ggcgatctgg
    13501 ttagcgggta aagcgtttgt tgttctgcct gtggacgcac ccttaacgta tcttgaaggc
    13561 ttgattgagt cggtagggtt aactcacgtc atcgtagctc ccgatttcgg gtcggattcc
    13621 ggtcgcccac ttccgactgg ggtcaaccct attgtgccga tattaccagc acctacagaa
    13681 gtaataatat ctcctgtgtc cgtttccaat cggtctcgtc aggatctcgc ctatatctgt
    13741 tttacctcgg gttcaagcgg tcaacccaaa ggggtggaag tctcccacgc ggctctggtc
    13801 aatcatacct tagccatcat tgaagccttt gatttgagtc accaagatcg agtactacag
    13861 tttgcagcgc caaactttga tgtggcgttg gaggaaatct ggccgtcgct gcttgccgga
    13921 ggcaccgtgg taataccatc tccagcggta acagactctc tccacgcttt tgagaatgaa
    13981 attaccgcca gcggtgttac cgtagtgaac ttaccagccc cgttctggca cgcttgggtc
    14041 agcaaattgg acgaggagac aacgtctccc ccaactaacc tgcgcttggt ggtgactggc
    14101 agtgatcggg tgtatacctc tgccgtcaga cgttggatga tgctcgcacc caccgtacgg
    14161 ttgttgagcg gctatggtcc tacagagact accatcacgg caacaatctt cgattgcggg
    14221 cgagatattt tacccattac tgcatccacc gtaccgctag gcttaccact tgccaatgtt
    14281 caggtttatc tagtcgattc ccaaggtaat tctgtccctg taggtgtggt tggtgagatt
    14341 gtgattgaag gtgctggaat tgcccaaggg tatgttcaca ctcgcgaaaa atcaggattt
    14401 cgccctcgcg ttcccggagg aaccctcgcg ttctggaccg gcgatcgggg gcgatgtcgg
    14461 cccgatggca ccctgatgtt cgaggggcgt gacgatgaac aggttaaagt gcgcggggta
    14521 cggattgaac cggcgggcgt tgaaaccttg ttagcatcct gtcctggtat cgcgctggca
    14581 gcggtggtgg ctcgcccgga tggggccagt ggtactctat tacgcgcttt ctatagcggc
    14641 acggcagctc tggctgatgt gcgcagttgg ttaagtcaca atgtccccgc cgccctggtg
    14701 cctgggttga ttgagcggct agatgaactg cctcaaaccc cttcagggaa actcgatcgc
    14761 cgaactctcg cggcacgccc cattccactg tctcccccgc ctgtgcggcc ccttgatgat
    14821 cggcacgagc aaatcatcgg cgagattttt gcagatgtac tgcaggttac tgaaattgga
    14881 ccggacagca acttttttga attggggggg gattctatca gcagccttaa gattgttacc
    14941 cgcgcccggc gagctggtct tttaatcacc gtgcggacag tttttgagca tcagacgatt
    15001 tctgcgatcg ctaaagcggc cactcccatt tacaacgaca gcgaacaaag caatggttcc
    15061 ggcccattac cgctaacccc tatcactgct tggtttcacg aattcatcac cgtcgattct
    15121 caccatttta atcaggctgt agtgctcgcc gttcccaaag cagttgacgc acaagcacta
    15181 caaacagcct tgacagcatt ggttcgctgc catgacattc tgggtctaac ggtctctggt
    15241 acctcagagc agctccgtca tgctattcca gaaacgatcc cagcaccaac attaatcacc
    15301 ctagatctat ctaccttccc caacgaggag aggttagagc ggcgagccca ggcatttgcc
    15361 tcagcgcagt ctagccttga cccaggtcaa ggacgtaatc tagcggcggt tttgctggca
    15421 gacgaagggc gcttgctggt gtgcattcac catctctgtg tagatgtcct atcttgggat
    15481 gttctcctca ctgacctcga aaccgcctac gaagaggtga gtcggggcag acagcctcgg
    15541 ttgagtccct cgggtactcc cttcagaatg tgggcggagc ggatgaacga gttggccgca
    15601 ggaccggccc tagacgatat ttcgttttgg ttaaagcggc tggcacatcc tgcagatcga
    15661 ttgttgcccg aagcaggcga tcagcctggc tgtgatggcg caggtgcatc tgttagacgg
    15721 acactaaacc ctatagatac caagtatatt gtgcgcacgg cacctgtgct gttcgcagtt
    15781 cgttccgatg aggtgattct agcggcgttg ttaaaagtac tgcgtcagcg taacggcaat
    15841 cgactgcggg tggatctaga aagaaatggt cgggtttccc cctttggaga tttcgatttg
    15901 tcccgcactg tcggctggtt tacgacagtg ataccgctac ttctgaacca gaagcacgaa
    15961 gatattgccg aacttttggg tgatattgga cgagcggtga cagaaacccc tcaagacggg
    16021 ctgagttacg gtctcttgcg ctatcttagc agtcagactg gtcaggtgct ggccgcccta
    16081 ccacccgctg aaattctagt caattttgtg ggtattctac cggggtggaa cgaagcggat
    16141 tttcggccag tggatgatga ctgcggtcct acaatttctc cccgtagtcc ccgcagtcac
    16201 atacttgagc taaatgccgg tgtaattgaa ggacatctgc ggttggaatt gggctatccc
    16261 ggtgcagcgg gctgccatga agaagctgcc gccctgctag acgatattgt cgcggctcta
    16321 agcgaaattg catcggtagc ccgtgcgacc aaaattggcg ttgagaaacc tcaaggaatt
    16381 gaagagattc tgcccctcac ccctttacaa actgggatat ttttccatag caaccgtcag
    16441 gaagagacgt attttaatca acttcacttg gtcttagagg gttccctcaa cactagcgct
    16501 tttcgctccg cctggtgtca acttattaag cgccacaagt tgctacgagc ttctttccac
    16561 accgccgatg atggcacacc gcttcagttt attcacaagc acgttgatcc cacgtgggtc
    16621 gagagagatt ggacaggctt tgacagaacc catcagtccc agagactcgc ggctctcatg
    16681 gcagctgacc gagccactaa ctttgaactg catcaggctc cgctactacg ttttcacctg
    16741 ctgaaaactg gcgatgaacg ccatgatctg atctggagtt cccatcatct gctcctggat
    16801 gggtggtcgg tttcggtagt gatggaggaa ttgctggcac tctaccgaga agcctgcggt
    16861 gggatggcag cggcactcgg cagtgccccc gacttttcag aatatttaac ttggctagat
    16921 acggtggaca aacaggctgc agagcatttc tggcagcagg aactgagtgg catagccgag
    16981 cccacttgtt tgatcggatc tggtctagca ccaaatgagc aggaaccgaa tgcgccggcc
    17041 catcaccatc tggaactgcc tgccaacgat gtgcaggcca ttgaggaact ggcacgcacc
    17101 agcggtgtga cggtgggact agtacttcag gcggcctggg gtctgctgct ttctcgttac
    17161 actggccttg acgatgttct gtttggcctg acagtctcgg ggcgaccacc cgatctggcg
    17221 ggggtgaatc gaatggtcgg catgctgatc aacacattac cgatacggat ccaaatccct
    17281 gacgacacta ctgtaaggtc ttggttgaag actttagcga cgcggggact agaccgcgat
    17341 gcttatgcca tgctgccatt accgcaggcg atcgctgcgg cggtaatggc agaaggaaaa
    17401 ttgccgttcg acagtctggt actaatccaa aactatccta gaaccacgaa tctagatgtg
    17461 gaggggctac gagtttcgat cgcacaagta agcgagtcca ccagctttgc cgtcaccctt
    17521 gtagctgaat gggccgaacg cccgcggctg accatcgtcc gagatcggca cttagtggcc
    17581 gtggctgcca gcaaccaact gctacgccac ctccatcaga tactgcaatc cctggttcgt
    17641 tgtgcggaca aacccctcga taacatttcc atctataccc ctgatgaact gcagcaccgt
    17701 ctgttgcttg gtcttggaga acgattggat gtgggtcaca gccttgccca cgaaactatt
    17761 gcggcttggg ccgagctgtc gccagatatg ccagcggtca tttccaagga ggagacacta
    17821 acctatggac agttggtcga acaggcgaat acgctggcag cccatctaat tactagtgca
    17881 gggattcgac ccggtagcct gatagccatg gcactgcccc ggtcatcagc cgccatagtg
    17941 gcgatattgg cgatttggag agtaggagct gctgtaatac ccattgatgt gggctatcct
    18001 gccgaacggg tgcactttat gctccttgat tgtactccgg acttggtact cacgaacaca
    18061 gttcaccgct cgtctctgcc tctcgacgaa ggtaacgcca tcttcctaat agatacgctg
    18121 tcggatgcac cgttatcagt gtccagggat gaagcatggc cgcgaattga actagacaca
    18181 cctgcctatg ttatttacac ttctggctca acgggtaaac ccaagggggt gctttcatcc
    18241 caccgtggtc tggtgtcttt gatacgatct caacgcgagc tcttctccct agcccccggg
    18301 gatcgtgtcc tacagtttgc ttcgctgtct ttcgacgcgt ccatctggga aacagtaatg
    18361 gctctggcca gtggagccgc tttgtacatc ccgaatcgag aggatgcctt ggccggtcca
    18421 gaactaggca cctatctgcg aacctatcgc attaccgccg caactctgcc cccatcattg
    18481 ctggccgtac ttcccgaggg aaattatccc gatcttaaac tgctggtcag tgcgggggaa
    18541 gcctgtccgg tagctctggc gcgccgttgg aagcagggca gacggttttt caatgcctac
    18601 ggtccgagcg aggcaaccgt atgtgccacg gtttttgagg gtagtgttga gggaacgtct
    18661 ctccccattg gtcgagcaat accgaatgtt tcaacccatg tcgtagattc ccatctcagg
    18721 ccagtacccg ccggatgtga gggcgagcta gtcattggcg gtctaggggt agcactgggg
    18781 tatctcggtc aacccgcact cacggcgaag cgattcgtga aggttcctgc cctcgatcat
    18841 ccaagcgaaa ctaacaagct gttttaccgc acaggcgatc gggtcagatt agatattgac
    18901 ggtaccctca cctatttggg ccgccttgac aggcaagtca agctcgacgg gtttcgcata
    18961 gaactaggtg agatcgaggc cacactgctc aactaccccg gcgtggccca agctcttagc
    19021 acggtgcgcc aggatcggcg tggagaacag cggttgttcg cctgggtgtt acccaaaccc
    19081 ggcgttactc tcatcattga ggatctacgg gcttccatta ggcaaaccct tccgggctat
    19141 atggtcccat caggtttgat gctcattaca ggagttccac tgactcccaa tggaaaggtg
    19201 gattggtctg ggttaccagc caccgaaata gaatcatcgg aacagcaaac agcgacggcg
    19261 gctgaagcgg cgcagcaggc tggcgataaa ggtgactcga aatccgccgc ccttagccgc
    19321 tgcctcaagg caatatggag cgagctactt ggccgtaccg ttatcaatcc taacgataac
    19381 tttttcgaca tcggaggctc ttccttgcta ctggttcaaa tgcaggggct gatccatagt
    19441 cgtttgggcg tgtcactttc ctcgtcaaag ctattccgcc atccaacatt agatagtttg
    19501 gtggagcttc tcctacctca agaggtcacg cttactttgg aggaacgctc accaacaatt
    19561 gaaggtggca cggcggaacg cataccgact gcccgcgctg aaccgatcgc tgttgttggc
    19621 gcagccggtc gctttcctgg atcacccaac ttggaagcct tttgggagct attgatcgaa
    19681 ggacgggagg gcatttctcg ctttgataag gaaagcctgc ttcagtcggg tatgcctctc
    19741 gatctcatca ataatcccgc ttgggtgccg gtggggggag ttattgatga tgccgaggcg
    19801 tttgacccca ctgtgttcgg cattggtgct agggatgcct tgattcttga tccacagcac
    19861 cgcgtgtttc tagagtgtgc ttggcatgcc ctcgaacacg ctggctacgc accaaaagcc
    19921 accgatcgtt ccatcggatt gttcgcgagc agcggtcaaa atacttggct ccatgacgtg
    19981 ctgttgcccg ccggtgaaac gattaccggg tctacgggct tccatctgtt gacggcaaac
    20041 gataaagact ttctcgcatc ccaggccgct taccgacttg atctgaaagg gccagtggtg
    20101 acgattcaaa cagcttgctc ttcatcgtta gtcgcggttt caatggcgat cgatgccctg
    20161 aggacgggac ggtgtgagat ggcactggcc ggtggagttt ctatcaggtt tccgcaaaat
    20221 cgtggctacc tctacgaacc tgaaatgatt ctgtcacctg atggtcactg tcgtgccttc
    20281 tctgctgacg ctaacggaac ggttccgggc tcgggagtag gtgttgttgt gctaaaaccc
    20341 ctttctcaag ctaaaaccga tggtgatcgc attctcgcgg tcgttcgggg tatcgctgtc
    20401 aataacgatg gcagtaacaa aatgggatac accgctccgg gtgttgcagg acaagcccaa
    20461 gtcatccggg ctgcccttga ggatgctgga ttgacagcgg acgatgttga ctatgtggaa
    20521 gcgcatggga ctggtactcc tctaggcgac cccgtcgaag tcaccgcgtt gggacgggtc
    20581 tacaccgggc gaagagaacc actactgctg ggttccgtga agaccaatat cggtcatgcc
    20641 gatgctgccg ctggtattgc tggattccta aaagtagttc tggcactcga acgtggccaa
    20701 ctgccagcta gtctgcacgc gcaaccgctc aatccccgaa ttgattactc cgtcgggccg
    20761 tttgaagtgg ttgatcgaac ccgctcttgg cctgaacggg gtcgtcccct tagaggggct
    20821 attagttcct tcggcattgg aggaaccaac gtacatgcta ttttggaagc cagcccctgc
    20881 gctcgccccg tcccgaataa atcgctggct gcacctgtga atgttaacca agcagtaatt
    20941 ttgtccgctc agacggctgc cgtgcttcat tgtcagactg agcgtttgat tactcacctg
    21001 cgcgctcatc ccgagctacc tattgccgat gttgccttta cccttcagtg tggccgaact
    21061 gttctgcccc atcgtcgtgc ggtggtagcg aacagttcgc ttgaggctgc cctcgcctta
    21121 gaagcagtat tgcttaatag ttatcaaacc cccttgaaca ataaaccgat agaacggtct
    21181 tctatggtcg ctctgttgtt gccggggcag ggtagccagc atctaggcat gggacaacaa
    21241 ctgtacgagg caggaggagt ttttcgtcgt gaacttgaca cctattcaga aattctgcgt
    21301 ccattgatcg atttctctat tgttgagtta ctttttagcg gcggcgaaga caaggcgaag
    21361 gtactacaaa ctacccaact ggctcagccc ttagtctttg cactggatgt tgccttggca
    21421 cggcattggc aggggcttgg cattcagccc gtcggattct taggtcattc cctgggcgaa
    21481 tacgcagcag cccaccttgc tggggtattt tcgaccgaag atgcactagc actggttgtc
    21541 gaacggggcc gtttgctcgg agagcttccc cccggtgtaa tgctagccgt tccccgctcg
    21601 gaggttgaga ttcacggctg gctgagcgat gacttagctc tagcagcggt aaacaatagc
    21661 acgaactgtg tcgtatcagg ctcctttgac gcgattgagg ctttcgaggc gcgcttgaaa
    21721 gagatgggct gtattagtcg gcgtttacat acgtctcatg ccttccactc accgatgatg
    21781 acggcggcgg cagaacccct ggcagcggcg gtcgctcgct tttctcccaa gcggccgcag
    21841 gggcgcttta tctcaaacgt cactggaaca tggatcaccc cagaagatgc tatagatccg
    21901 aactattggg cacgccattt gctacaaaca gttcgctttg ccgatggttt ggcaacattg
    21961 caaaatgatg gaattacgct ggcgatcgag tgtggtccgg ggcaaacctt aacgatattg
    22021 gccaagggta ctgatatcgc tgtccagcct agtctagccc atgcggctga gatccctact
    22081 ggtggctcgc ggataacgga tgctgccgcc aatctctggg tggaaggagc ttcgatcaac
    22141 tggagtgctc tccacccgga accacgtcgg cgtgttgatg ttcctctcta tccgtttgaa
    22201 cgtttgccat ttaaaccaaa ggcctgtcta agtccgtccc aactatcgga gcggtctgaa
    22261 tccgctgagc aagttttgcc tggcaaacgc aggtgtatgg acgagtggtt ctatcggcca
    22321 ggttggcagc ctgcccttcc ctccccgtcc gaacccttgg cgggtccagt gatgatcttg
    22381 tccgaccgtg ggggcatcgg agaggcgctc gcgaatcttc ttccataccc cgcgattctt
    22441 gtggaacagg gagcgggtta cgccgccctc ggcgacaaca gattcacggt acggccagca
    22501 caggatgagg attattatca actgtttaaa gcgttaccaa cgctgccttt gcgctttctt
    22561 catctgtggg gattggatga tgccaatgcg gatactttgg aagaaatagg tgtacatgct
    22621 gttctatctc tggtgcgatc actaggaggt atctcgtcaa gccaagcgct gcgccttgac
    22681 ctcgtcactc atggagcggc tgcaatcacc gggacagagg tgctgcggcc tgagctggct
    22741 gccgctattg gtgctgcccg tgtgttgccc tatgaatatc cgaatttaac ggtgagagcc
    22801 atcgatgttg agccagagtc acctcggagc atggctgctg ctattctcag cgaaataatg
    22861 cgcaagggtg agcatgttgt tattggttta cggggtgaga gacgctggac tcctacattt
    22921 tggccgcttg ccttgcctgc ttcctccaac ggcaatagta tccgtaacgg tcttggcaag
    22981 attagaccga aggctgttgt ttggattact ggaggttttg ggggggtagg ctcagctgta
    23041 gcccgtgatt tagctaagga acagggtatt cagctggtgt tgactggtcg cactgctcta
    23101 ggggagaacg gtgccgactc tccgactcgg aaggatcgtc tccagttagt tcgtgagatt
    23161 gaagcgatgg gggcgattgt gatgaccgct gcactcgacc tggctgatga gcgggctgtt
    23221 aaagccttgg tcaaccaagt tgagacccgc cttggcgcga ttactggcgt ttttcattgt
    23281 gctggagtag ccgatttagc aggtgtggta cagatgcgat cgaggtctga tacagagcat
    23341 gtgcttgcgc ctaaagtggc aggcacacgg gccatagaac gcgcactctc tcaacactct
    23401 ttggattttc tggtgttatg ttcgagcctc agctcgtttc tgccgatcgc taagtttggc
    23461 caggtaggtt acgcggccgc caatgaatat atggatttgg ctgcagttgc aatagcacgc
    23521 cgcacgggtt ggcgcaccgt taccattaac tgggacgact gggttgaagc ggggatgacc
    23581 gtagaagcgt atcagtcatg gagcataccc gctcccaccg ctgatgaagg gctaacggcg
    23641 gcagaaggcg tgactgtttt acgacgtatt cttacctcgg atcagacgcg ggtagctgtt
    23701 tctgtacgac ctctagaatc tctcgttgct gggtcagacc atcttttcag taccaaacgg
    23761 tttagccagc ttttacagtg ccataaccgc cccaccgagg gtatagtttc cacagtttca
    23821 gggtccgacg acgtcagcca agatactgtc actaggttgt tgctagaagc ctttcgccgc
    23881 attctggatg atccgacaac agttgtagac agtaactttt ttgagcgtgg tggtcattct
    23941 ctcctggcta tgaatctatt aaactttatt cgcgagacgt tttcagtcgg tatagcctta
    24001 cttgacttgt ttgaacatcc gacgccccca accttggctg atataattaa ggagcgccag
    24061 actgatcggg aatagcacgt ctgttaattt catctaaacc aaatttcaac cagtcataag
    24121 tagagctttt tgtatgaaat ctcccagtta ctaccttcgc cccgatgtcg tcgtcgagcc
    24181 tctaattgct cgctggcatg cttggtcagg gttgatttca cctgtgactg cggctctgaa
    24241 tgtggttcac cgacacctag atattatgac ctcctacgtg tcaatgcccc aagtacatgc
    24301 cgccgccgca cgcgatcctg ccttgctagg gggccctttt atagatcttg agggaggccg
    24361 ggtagatgaa gtccgtgcgc tcctcgattg gacaagactg tgtcagcagc cagcgattca
    24421 gctcgcagag gatttagcta aagtctggac aatgctaaag tatgaggccg atggccatgg
    24481 gatgaccaat ctttataagc agcttccaga ctccctccga ggcgcggttg aattggttta
    24541 cactccttct ggatctcctg atatacgccc aattgagcct ttactttacc aatctccctg
    24601 ttacaatcca gatatccaag gagctatgat ccgtcgcgtc aggagtgacc atcgggcgtt
    24661 cgcgttaagc acgccccggc tcgatttgcc cgatgccatt tacttagatc ggccttttag
    24721 agatcctgtt tacgacaagt tggcatctct gcggtttatt cctcaaccgc tatccacgat
    24781 tacagatatt tttcaggtca gatcagaaaa gaaaccacta cttgaatcct ttctcacatc
    24841 cgaggcacca gcaagaactc ctaagtcatc tgaactgcgc tggcgatatt ttggacatgc
    24901 ctgtgtgtta gttgaaacct tcggcggtca atctgtactc gttgacccag tgattgccta
    24961 tgagagtggt gcggagcctg agcggtttac cgtggcggat ctaccgagtc acatcgattt
    25021 tgtggtcatt acccacaacc atcccgacca tgtgctaatc gaaacccttc tttctctacg
    25081 tcacaaaatt tctacagttt tagtcccaac tgcgggtggc agcctggtgg atccttcgtt
    25141 gaaactagtg ctggaggcaa tcggctttga gactgtacga gaggtcagtt gtatggagga
    25201 tgtcattgcc ggtgatttgc gcatccaggc actaccgttc ttaggtgaac atgctgatct
    25261 tgatattcgc tgcaaggccg catggttagt agaggcagag tcaatgcgcc tgctctttgc
    25321 cgctgactcg aacaacctcg atcctgtcct ctacgatcgg ctcacaccgt tgataggccg
    25381 tgtggacaca ttatttattg gaatggagtg ccgtggtgcg cctatgagct ggatgtatgg
    25441 cactttactg cctgagtctg ttgaacgttc taaagatcaa tcccgtcgtc tggatggttc
    25501 taactgtgaa cgggcgaaag ccattatttc cagtttggat atcgagcaag tttgtgtcta
    25561 cgccatgggc atggaaccct ggctcaagtt catttccagt ctggatccca ccgccgatag
    25621 tccagcactc caagaatctc aggcattgat tgaccattgc aatcatcttg gtctccccgc
    25681 agaacgatta tatggccgtt cagaatctct tttcttgaca gagtactacc tctagttttt
    25741 atcgacccat gaaatgtgca acgagcgggg aaatgtatgg ttctgttgca aagtttttgg
    25801 ctcttctcga ctttgtgtga taatttttgc ttataattgg acttccccgt tgacaaaaag
    25861 gcataagctg tgctgtagaa gggattaaga gaatttccgc cgccccgtta ctggctacaa
    25921 attagggaaa ctcccaataa atctaacgct ttttgttgca gttgagtcgg tcgagttatc
    25981 ttagaaaaac gataacttcc ctccctaatc gtacattcca ctgtattcaa gcaaattgtc
    26041 cccaggtctt ccaacaaagt ccgaaaacta tgcacggtaa agttctcttg attccgtttt
    26101 tttctctctt tagattgcac cgattcactc cgattggctt taatcacatt cagacaacta
    26161 tcatcaattt cttcatcctc aaataacaaa ggagccaaag actgttttaa atgccattcc
    26221 acataataag ccaacataca taaaaaagat atgagctttg acttctatca acc
//
