BGC0001635: kistamicin A biosynthetic gene cluster from Nonomuraea sp. ATCC 55076
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Location: 11,980,264 - 12,029,697 nt. (total: 49,434 nt).
This entry is originally from NCBI GenBank CP017717.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001635
Short description kistamicin A biosynthetic gene cluster from Nonomuraea sp. ATCC 55076
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
CP017717.1
11980264 - 12029697
via
Compounds
  • kistamicin A
Species Nonomuraea sp. ATCC 55076 [taxonomy]
References
  • [1] . Nazari B et al., Medchemcomm (2017) PMID:28626548
Chemical products information
kistamicin A Evidence:
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C61H51Cl1N8O15
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BKM31_54095
  • AQZ69220.1
 11980264 - 11981403 (+) prephenate dehydrogenase
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    • BKM31_54100
    • AQZ69221.1
    		 11981410 - 11982063 (+) DNA-binding response regulator
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      • BKM31_54105
      • AQZ69222.1
      		 11982177 - 11982674 (+) hypothetical protein
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        • BKM31_54110
        • AQZ69223.1
        		 11982704 - 11983729 (+) hypothetical protein
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          • BKM31_54115
          • AQZ69224.1
          		 11983726 - 11984463 (+) ABC transporter ATP-binding protein
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            • BKM31_54120
            • AQZ69225.1
            		 11984460 - 11985710 (+) ABC transporter permease
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              • BKM31_54125
              • AQZ69226.1
              		 11985723 - 11986904 (-) two-component sensor histidine kinase
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                • BKM31_54130
                • AQZ71346.1
                		 11987134 - 11989041 (+) ABC transporter
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                  • BKM31_54135
                  • AQZ71347.1
                  		 11989581 - 11994080 (+) hypothetical protein
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                    • BKM31_54140
                    • AQZ69227.1
                    		 11994291 - 11998691 (+) hypothetical protein
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                      • BKM31_54145
                      • AQZ69228.1
                      		 11998733 - 12009577 (+) hypothetical protein
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                        • BKM31_54150
                        • AQZ69229.1
                        		 12009574 - 12014871 (+) hypothetical protein
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                          • BKM31_54155
                          • AQZ69230.1
                          		 12014882 - 12015112 (+) MbtH family protein
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                            • BKM31_54160
                            • AQZ69231.1
                            		 12015208 - 12016371 (+) hypothetical protein
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                              • BKM31_54165
                              • AQZ69232.1
                              		 12016439 - 12017719 (+) cytochrome
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                                • BKM31_54170
                                • AQZ69233.1
                                		 12017688 - 12019010 (-) GntR family transcriptional regulator
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                                  • BKM31_54175
                                  • AQZ69234.1
                                  		 12019192 - 12020280 (+) type III polyketide synthase
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                                    • BKM31_54180
                                    • AQZ69235.1
                                    		 12020274 - 12020951 (+) enoyl-CoA hydratase
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                                      • BKM31_54185
                                      • AQZ71348.1
                                      		 12021029 - 12022237 (+) enoyl-CoA hydratase
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                                        • BKM31_54190
                                        • AQZ69236.1
                                        		 12022234 - 12023049 (+) enoyl-CoA hydratase
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                                          • BKM31_54195
                                          • AQZ69237.1
                                          		 12023141 - 12024625 (+) tryptophan halogenase
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                                            • BKM31_54200
                                            • AQZ69238.1
                                            		 12024622 - 12025902 (+) cation/H(+) antiporter
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                                              • BKM31_54205
                                              • AQZ69239.1
                                              		 12026051 - 12027133 (+) 4-hydroxyphenylpyruvate dioxygenase
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                                                • BKM31_54210
                                                • AQZ69240.1
                                                		 12027130 - 12028278 (+) alpha-hydroxy-acid oxidizing enzyme
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                                                  • BKM31_54215
                                                  • AQZ71349.1
                                                  		 12028876 - 12029697 (+) streptomycin biosynthesis protein
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                                                    Biosynthesis information

                                                    Biosynthetic modules

                                                    Name
                                                    Unk01
                                                    Type
                                                    nrps-type1
                                                    Genes
                                                    BKM31_54140
                                                    Substrates
                                                    3,5-dihydroxyphenylglycine (evidence: Structure-based inference, Homology)
                                                    Integrated Monomers
                                                    Domains
                                                    adenylation
                                                    Name
                                                    Unk02
                                                    Type
                                                    nrps-type1
                                                    Genes
                                                    BKM31_54145
                                                    Substrates
                                                    4-hydroxyphenylglycine (evidence: Structure-based inference, Homology)
                                                    Integrated Monomers
                                                    Domains
                                                    adenylation
                                                    Name
                                                    Unk03
                                                    Type
                                                    nrps-type1
                                                    Genes
                                                    BKM31_54145
                                                    Substrates
                                                    4-hydroxyphenylglycine (evidence: Structure-based inference, Homology)
                                                    Integrated Monomers
                                                    Domains
                                                    adenylation
                                                    Name
                                                    Unk04
                                                    Type
                                                    nrps-type1
                                                    Genes
                                                    BKM31_54145
                                                    Substrates
                                                    tyrosine (evidence: Structure-based inference [1])
                                                    Integrated Monomers
                                                    Domains
                                                    adenylation
                                                    Name
                                                    Unk05
                                                    Type
                                                    nrps-type1
                                                    Genes
                                                    BKM31_54150
                                                    Substrates
                                                    4-hydroxyphenylglycine (evidence: Structure-based inference, Homology)
                                                    Integrated Monomers
                                                    Domains
                                                    adenylation
                                                    Name
                                                    Unk06
                                                    Type
                                                    nrps-type1
                                                    Genes
                                                    BKM31_54135
                                                    Substrates
                                                    tryptophan (evidence: Structure-based inference [1])
                                                    Integrated Monomers
                                                    Domains
                                                    adenylation
                                                    Annotation changelog

                                                    Entry version: 3

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2022-09-15
                                                    Added NRP substrate specificities
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 2

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2019-10-16
                                                    Migrated from v1.4
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    2019-10-16
                                                    Updated compound(s) information (NPAtlas curation)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 1

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2018-08-06
                                                    Submitted
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    Detailed domain annotation
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