BGC0001635 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001635 (Nonomuraea sp. ATCC 55076)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,T3PKS	1	49,434	kistamicin A	NRPS:Type I+PKS	100%

BGC0001635 - Region 1 - NRPS,T3PKS

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Location: 1 - 49,434 nt. (total: 49,434 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 49,435
Label		BGC0001635

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001635	1.44	NRP, Polyketide	kistamicin A	Nonomuraea sp. ATCC 55076
BGC0002341	0.68	Other	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002127	0.67	Polyketide	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0001831	0.67	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0002608	0.66	NRP, Polyketide	ochratoxin A	Aspergillus steynii
BGC0002631	0.66	RiPP	myxarylin	Pyxidicoccus fallax
BGC0002099	0.64	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0002084	0.64	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0002643	0.63	Alkaloid	aetokthonotoxin	Aetokthonos hydrillicola Thurmond2011
BGC0000902	0.60	Polyketide	flaviolin	Saccharopolyspora erythraea NRRL 2338

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001635	1.00	NRP, Polyketide	kistamicin A	Nonomuraea sp. ATCC 55076
BGC0000322	0.71	NRP	chloroeremomycin	Amycolatopsis orientalis
BGC0001050	0.71	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001133	0.70	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0000351	0.68	NRP	exochelin	Mycolicibacterium smegmatis MC2 155
BGC0002341	0.67	Other	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002017	0.67	NRP	potensibactin	Nocardiopsis potens DSM 45234
BGC0002127	0.67	Polyketide	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0001831	0.67	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0002608	0.66	NRP, Polyketide	ochratoxin A	Aspergillus steynii

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 49434:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Trp) + (D-Dhpg) + (Hpg - D-Hpg - Tyr) + (Hpg)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 18928 - 49434:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Hpg - D-Hpg - Tyr) + (Hpg)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

BKM31_54135

Search NORINE for peptide: strict or relaxed

AMP-binding (457..841): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVGIVGEITK
Nearest Stachelhaus code(s):: Trp DVGIVGEITK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

BKM31_54140

Search NORINE for peptide: strict or relaxed

AMP-binding (448..832): Dhpg

nrpys: Dhpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: dhpg (Dhpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DAHQAGTLYK
Nearest Stachelhaus code(s):: Dhpg DAHQAGTLYK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

BKM31_54145

Search NORINE for peptide: strict or relaxed

AMP-binding (458..842): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DIYHLGLLCK
Nearest Stachelhaus code(s):: Hpg DIYHLGLLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1488..1878): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DIYHLGMLCK
Nearest Stachelhaus code(s):: Hpg DIYHLGMLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2992..3376): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DASTVAAVCK
Nearest Stachelhaus code(s):: Tyr DASTVAAVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

BKM31_54150

Search NORINE for peptide: strict or relaxed

AMP-binding (451..848): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DAYHLGLLCK
Nearest Stachelhaus code(s):: Hpg DAYHLGLLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)