BGC0001636 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001636 (Curvularia clavata)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS	1	75,000	High	KK-1	NRPS:Type I

BGC0001636 - Region 1 - NRPS

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Location: 1 - 75,000 nt. (total: 75,000 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 75,001
Label		BGC0001636

Tailoring functions

Oxidoreductases: dehydrogenase

TRAF068007: dehydrogenase

smcogs: SMCOG1072: dehydrogenase

Transferases: methyltransferase

TRAF135002: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Hydrolases: amidase

TRAF068002: amidase

smcogs: SMCOG1105: amidase

Ligases: ligase

TRAF135001: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001636.4	0.87	NRPS	KK-1	Curvularia clavata
BGC0000307.4	0.76	NRPS	AbT1	Aureobasidium pullulans
BGC0001833.4	0.69	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.66	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000393.5	0.45	NRPS, PKS	myxoprincomide-c506	Myxococcus xanthus DK 1622
BGC0001565.4	0.44	NRPS	cyclosporin C	Beauveria felina
BGC0001834.4	0.41	NRPS	argyrin	Cystobacter sp. SBCb004
BGC0000334.4	0.40	NRPS	cyclosporin A	Tolypocladium inflatum NRRL 8044
BGC0000423.5	0.40	NRPS	scabichelin	Streptomyces scabiei 87.22
BGC0002198.3	0.40	NRPS	nanangelenin B, terreazepine	Aspergillus terreus var. terreus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001636.4	0.98	NRPS	KK-1	Curvularia clavata
BGC0000307.4	0.76	NRPS	AbT1	Aureobasidium pullulans
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002710.2	0.46	NRPS	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0000393.5	0.46	NRPS, PKS	myxoprincomide-c506	Myxococcus xanthus DK 1622
BGC0000321.4	0.45	NRPS	chaetocin	Collariella virescens
BGC0002188.3	0.44	NRPS, PKS	W493 B, W493 A	Fusarium pseudograminearum CS3096
BGC0001565.4	0.43	NRPS	cyclosporin C	Beauveria felina
BGC0001820.3	0.43	NRPS	verticillin	Gliocladium sp.

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 66678:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - Hpr - NMe-Val - Val - NMe-Asp - NMe-Val - NMe-Ile - Gly - NMe-Val - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

TRAF135001: X - Hpr - Val - Val - Asp - Val - Ile - Gly - Val - X

Search NORINE for peptide: strict or relaxed

AMP-binding (267..663): X

nrpys: Lac

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A