LOCUS       BGC0001637             18579 bp    DNA     linear   BCT 17-OCT-2017
DEFINITION  Klebsiella oxytoca kleboxymycin biosynthetic gene cluster, complete
            sequence.
ACCESSION   BGC0001637
VERSION     BGC0001637
KEYWORDS    .
SOURCE      Klebsiella oxytoca
  ORGANISM  Klebsiella oxytoca
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 15:57:54
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 18579
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..18579
                     /db_xref="taxon:571"
                     /mol_type="genomic DNA"
                     /organism="Klebsiella oxytoca"
                     /strain="MH43-1"
     protocluster    1..18579
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[12631:17002]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      12632..17002
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..18579
                     /SMILES="N1C(CCC1)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..18579
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001637"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..18579
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            642..1874
                     /gene="mfsX"
     CDS             642..1874
                     /codon_start=1
                     /gene="mfsX"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 108.4; E-value:
                     4.9e-33)"
                     /gene_kind="transport"
                     /product="MFS transporter"
                     /protein_id="ATJ04402.1"
                     /transl_table=11
                     /translation="MRPKEVPAPTASTMYRDESRGLLSRKVVIVLGLLSAVAALSTDMY
                     LPLFPAIASDLHTTPDKVQLSITAFMVGLGIGQLFIGPLSDHYGRRKLLLGGMTLLTIA
                     SLAGAISTNIQLLIVTRFFQGLGGAAGIVLSRAIISDLCPGTKAARYFNLVLAIQGIAP
                     VIAPLLGGVAAWFIWPVVFVFMAAISLVSTLLSSHFISETLPRHQRLPFNLNEFISQFI
                     ELLSHKKYIGYTLIFAIQFGALFAYISASPFIYQSAFDLSSGEFAVIFSINAAVMMFGS
                     IVSARYVTKFGEDNLIIVGVISTLVISILLCIVNYISHFQFEIAAVLLLIMMFTMALTF
                     GNAASMAMAASSHLKGTGSAILGVFQFGIAAITPLLLGFGDPLSLLPMSLIIAGCCLIA
                     IMALLLTGKKG"
     misc_feature    642..18043
                     /note="kleboxymycin biosynthetic gene cluster"
     gene            1879..4140
                     /gene="uvrX"
     CDS             1879..4140
                     /codon_start=1
                     /gene="uvrX"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 58.5; E-value:
                     1.4e-17)"
                     /gene_kind="transport"
                     /product="UvrA-like transporter (ABC)"
                     /protein_id="ATJ04403.1"
                     /transl_table=11
                     /translation="MNTHDAIKIIGARQNNLQDIDLEVPKNKITVFTGVSGSGKSSLVF
                     GTIAAESQRQLNDTFPPFIRHRLPHYGNPEVDDIENLSVAIIIDQKRIGGNARSTVGTA
                     SDIYTLLRLLFSRVGEPFVGYSNVFSFNHPAGMCATCDGLGIASTIDIDQLIDSNLSLN
                     AGAIRYPSFAPGSWRWKRYVYSGLFDADKKIADYSKEEREILLYADNLTPEAPLAGWPK
                     SAKFEGVITRFTRSYLKQETKDTKTEEFQRVVSLQVCPSCQGMRLNEKILSCRIRGKNI
                     GECATLPVTELKLFVEKLDYPEVRPLLEALLERLDAMCAVGLGYLDLNRTTPSLSGGES
                     QRLKMVRHLGSSLTGIVYIIDEPSTGLHPADIVKLNVLISKLRDKGNTILMVEHDPDMI
                     AIAEHVIDLGPGAGKQGGNIVFEGDLSALKQSQTLTGRYFSSRAEINNRPRCAKGYISV
                     RNATLHNLHNLSVDVPLSVMVAVTGVAGSGKSSFVMGALAPQCPDAIVIDQKPIHTSIR
                     SHIASWCGAFDTIRLLFAEKNHVSASWFSANAKGACPECHGLGVIQTDLAFMDTVTLPC
                     EACQGQRYSPQALKYRYQGKNIAEVLSLSINDAGDFFLNEPQLRPIFRSLVEVGLGYLR
                     LGESLNHLSGGECQRLKLASQLNHDSDMYIFDEPTTGLHPSDVASLLKLFNRLVDRGNT
                     VIIIEHNMELIAQADWIIDIGPYAGQEGGKLLFSGTPESMLACRHSLTAEWLRKHCQVE
                     "
     gene            complement(4228..5742)
                     /gene="hmoX"
     CDS             complement(4228..5742)
                     /codon_start=1
                     /gene="hmoX"
                     /product="anthranilate 3-monooxygenase"
                     /protein_id="ATJ04404.1"
                     /transl_table=11
                     /translation="MGNKSVSLPTGNDFLAGLNDGREIWAYGEKVDNVITHPAFRNSAL
                     SIAKLYDALHDEKYQAILTTPCDTGSGGVTHPFFRVPHSVDDLIRDRDAIAQWAKLSYG
                     WLGRSPDFKASFLTTLGANPEAYGEYADNARHWYKRSQEELLYWNHAIINPPIDRNLPP
                     DQIEDICIHVEKECDDGVIVSGAKVVATGSALTHYNFIAHYGLPVKKREFALVCTLPMN
                     APGLKLVCRPSYSLAAEKIGSPFDYPLSSRYDENDMIFILDKVKIPWENIFIYGDTAKA
                     ATFLPSSGFLHRSTFHGVTRLAVKIDFICGLFIKGVEATGVADFRGIQTRVGEMLAWRN
                     LFWAISDAMAKSPNPWHNGALLPNLDYGLAYRWFMSLGYPRIREIIEQDLGSALIYINS
                     HAKDFAAPELEPYLKKYMRGSNGMDAVERVKLMKLIWDSVGTEFASRHELYERNYTGSH
                     ENVRIELLLAAQMSGQVQEYKGFAEQCMMDYDLDGWLDRDYHWPVD"
     gene            complement(5781..7736)
                     /gene="adsX"
     CDS             complement(5781..7736)
                     /codon_start=1
                     /gene="adsX"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018:isochorismate synthase (Score: 258.9; E-value:
                     2e-78)"
                     /gene_kind="biosynthetic-additional"
                     /product="anthranilate synthase"
                     /protein_id="ATJ04405.1"
                     /transl_table=11
                     /translation="MMMLSKGTAKPDELSAHLANLDRPFACIYRPQCEPIKAVLFLEGD
                     IELNQSLSELALDPPLDGKGKNSFNKLILLPFNQLKEKGYACIDDGEQTIVMHIERQDY
                     YPIDSFIAAINDYDIKPRNLHFDLDDQTYGDIVDTVIDQEISSGEGSNFVISRSLEGDI
                     TDFSIRHALTLYKRLLQSECGSYWTWMIFTGSRYFIGSSPEQHIQVDEQNVAMNPISGT
                     LKYPDSGNMAHVLDDFLQDKKERDELFMVVDEELKMMSSICQHDIQVTGPKLKAMSHIA
                     HTEYFIHGSSDRSLKEIIRQSLFAPTVTGSPIESACKVIARRERRGRGYYSGIVAITGA
                     QEGKRYLDSAIMIRTADITAQGHFRLTAGSTIVRSSIAQNEAGETRAKLQGLMHSFFSD
                     TSAGTPNRTGLSAELRHRADQILAKRNACASAFWLDNSQLGPCALLSRHTITLIDMEDN
                     FTAMIAYQLRSAGCAVTLIPWYDCLSKLTQLTDRDIVFIGPGPGDPTNIQLEKIRVGRK
                     IIAQRLREQRPLIGTCLGHQLICAELGIPIERLINNRQGSQHQISIQGKSHTVGFYNSF
                     SALHQRPCWYSPEHDKTVQLERLPSGEIVALSSGNVASIQFHNESFLTQDAFSIYQWLI
                     QNALTTTVTLSQQDAV"
     gene            complement(7760..8392)
                     /gene="icmX"
     CDS             complement(7760..8392)
                     /codon_start=1
                     /gene="icmX"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:isochorismatase (Score: 267.7; E-value: 1.4e-81)"
                     /gene_kind="biosynthetic-additional"
                     /product="isochorismatase-like family protein"
                     /protein_id="ATJ04406.1"
                     /transl_table=11
                     /translation="MEKIQPYPLPTERQLPKSMADWRPNSSRAALLIHDMQRYFLDFYT
                     ADAPPIAQVIDNIYRLLSVARRLHVPVFYTAQPGDMTPQQRGLLHSLWGSGMNGSQEHK
                     QIVPPLTPLENEWVLTKWRYSAFFNSPLLSTLHELKCDQLIVCGVYAHIGCLCTAQEAY
                     SNDIETFFIADALADFSEEKHRLALEIAAETSSVVLSTRQAIDALEH"
     gene            complement(8411..9196)
                     /gene="dhbX"
     CDS             complement(8411..9196)
                     /NRPS_PKS="Domain: PKS_KR (9-168). E-value: 1.8e-13. Score:
                     42.7. Matches aSDomain: nrpspksdomains_dhbX_PKS_KR.1"
                     /codon_start=1
                     /gene="dhbX"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) EntA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     220.8; E-value: 3.4e-67)"
                     /gene_kind="biosynthetic-additional"
                     /product="2,3-DHB dehydrogenase"
                     /protein_id="ATJ04407.1"
                     /sec_met_domain="EntA (E-value: 2.3e-97, bitscore: 315.2,
                     seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 4.1e-37, bitscore:
                     117.6, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFDKDYIAVITGACGGIGESVAHALAKEGVSLALLDNNASQLAT
                     LVATLQNNHPQPIAGFNVDVADDRSVAEAFTAIGRQLGPVGYLVNGAGVLCHASVAETQ
                     PQDWTKTFAVNATGVFNTSRHAANLMMAQRKGSIVTIASNAARVPRATMAAYCASKAAA
                     QAFTYALGLEVAPYGIRCNVVAPGSTDTPMLRGMWHSESDRQNTLNGNPQQFRIGIPLN
                     KVATAEEIAAAVCFYLCEESGQTTLSTLLVDGGAALGSC"
     aSDomain        complement(8693..9169)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_dhbX_PKS_KR.1"
                     /evalue="1.80E-13"
                     /label="dhbX_PKS_KR.1"
                     /locus_tag="dhbX"
                     /protein_end="168"
                     /protein_start="9"
                     /score="42.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VITGACGGIGESVAHALAKEGVSLALLDNNASQLATLVATLQNNH
                     PQPIAGFNVDVADDRSVAEAFTAIGRQLGPVGYLVNGAGVLCHASVAETQPQDWTKTFA
                     VNATGVFNTSRHAANLMMAQRKGSIVTIASNAARVPRATMAAYCASKAAAQAFTY"
     CDS_motif       complement(9107..9169)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_dhbX_0001"
                     /evalue="1.60E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="dhbX"
                     /protein_end="30"
                     /protein_start="9"
                     /score="14.3"
                     /tool="antismash"
                     /translation="VITGACGGIGESVAHALAKEG"
     gene            complement(9186..10355)
                     /gene="aroX"
     CDS             complement(9186..10355)
                     /codon_start=1
                     /gene="aroX"
                     /product="class-II DAHP synthetase"
                     /protein_id="ATJ04408.1"
                     /transl_table=11
                     /translation="MTSFPGNKSNWQQPFWSDKDMLALVISELDTLPELLSFEEISEFN
                     KALAAVYAGKAMIFQAGDCAERICESDALHVRKKLTFLEQMSRELSTLMGLPILTVGRI
                     AGQYAKPRSQHNEVDGDRVLPVWRGDSVNRPEATPEARRNDPQRMLLSYHAAAETLAEI
                     KRYEREYPRDVHPIWTSHEALLLDYETTQIRTNPHGESYLASTHWPWIGIRTLAPDSPH
                     IAMLANIANPVACKIDATVTPSFIATLCRQLNPQRIPGRLTFISRFGRSHIHRLGALIQ
                     AAQATETPVLWMCDPMHGNTGKTQAGNKRRELSDMMAEISGFLRQVKTHNACAAGLHLE
                     ATPNPVIECFCENNHPEEHELKQILCDPRLNVTQTQMLLTHWKERQNDL"
     gene            10813..12333
                     /gene="npsA"
     CDS             10813..12333
                     /NRPS_PKS="Domain: AMP-binding (16-411). E-value: 4.6e-76.
                     Score: 247.8. Matches aSDomain:
                     nrpspksdomains_npsA_AMP-binding.1"
                     /codon_start=1
                     /gene="npsA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     257.7; E-value: 2.8e-78)"
                     /gene_kind="biosynthetic-additional"
                     /note="similar to TomA"
                     /product="NRPS"
                     /protein_id="ATJ04409.1"
                     /sec_met_domain="AMP-binding (E-value: 6.9e-77, bitscore:
                     248.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHSAYVNQLKAVPDIFDEISQRFPDRVALIFDQRQITYRELAEQ
                     CSALAAVLQNNCLIKGDIVAIKIERSPELYIFMLALMKIGAVMVPVNSNSPERYIGEVL
                     SAAGARYLISDDVTSVPGGSWQVLSSRTLIQNCAQQRSGNYPVLSADDPALILMTSGST
                     GKPKSVLIAHRGIARLSLPVPALGNSERDCYLQIADVSFAASANEIWMALLTGACLTIA
                     PPGLPDLMALVRQIESDNVTMLFLSGGLFRLFVEVSLETLHIPACVVVSGDFVNPRLFS
                     VAAQAGKAKIFNGLGCTENSAISSLYHVQSEGQLSSDSPVPVGTALPLVEMVVFNERLQ
                     PCACGEYGELFIAGAGVALGYSDPQLTAERFISIPYQGTDVLFYRTDDRATCDQDSNIV
                     LVGRGNHICKIRGFRVNLAGIEHLLRLHHAVEDVLIVVEETPDEPRLHACYVTQDDALS
                     VADLKNHLAMHAPAWMIPEKFSRLAVLPMTANGKKDRLRLKNILLEQV"
     aSDomain        10861..12045
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_npsA_AMP-binding.1"
                     /evalue="4.60E-76"
                     /label="npsA_AMP-binding.1"
                     /locus_tag="npsA"
                     /protein_end="411"
                     /protein_start="16"
                     /score="247.8"
                     /specificity="substrate consensus: diOH-Bz"
                     /tool="antismash"
                     /translation="FDEISQRFPDRVALIFDQRQITYRELAEQCSALAAVLQNNCLIKG
                     DIVAIKIERSPELYIFMLALMKIGAVMVPVNSNSPERYIGEVLSAAGARYLISDDVTSV
                     PGGSWQVLSSRTLIQNCAQQRSGNYPVLSADDPALILMTSGSTGKPKSVLIAHRGIARL
                     SLPVPALGNSERDCYLQIADVSFAASANEIWMALLTGACLTIAPPGLPDLMALVRQIES
                     DNVTMLFLSGGLFRLFVEVSLETLHIPACVVVSGDFVNPRLFSVAAQAGKAKIFNGLGC
                     TENSAISSLYHVQSEGQLSSDSPVPVGTALPLVEMVVFNERLQPCACGEYGELFIAGAG
                     VALGYSDPQLTAERFISIPYQGTDVLFYRTDDRATCDQDSNIVLVGRGNHICKIR"
     CDS_motif       11272..11331
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_npsA_0001"
                     /evalue="9.90E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="npsA"
                     /protein_end="173"
                     /protein_start="153"
                     /score="21.3"
                     /tool="antismash"
                     /translation="ALILMTSGSTGKPKSVLIAH"
     CDS_motif       11845..11925
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_npsA_0002"
                     /evalue="1.90E-10"
                     /label="NRPS-A_a6"
                     /locus_tag="npsA"
                     /protein_end="371"
                     /protein_start="344"
                     /score="33.0"
                     /tool="antismash"
                     /translation="GEYGELFIAGAGVALGYSDPQLTAERF"
     CDS_motif       12013..12075
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_npsA_0003"
                     /evalue="1.80E-05"
                     /label="NRPS-A_a8"
                     /locus_tag="npsA"
                     /protein_end="421"
                     /protein_start="400"
                     /score="17.4"
                     /tool="antismash"
                     /translation="VGRGNHICKIRGFRVNLAGIE"
     gene            12336..12566
                     /gene="thdA"
     CDS             12336..12566
                     /NRPS_PKS="Domain: PCP (4-73). E-value: 1.9e-21. Score:
                     67.9. Matches aSDomain: nrpspksdomains_thdA_PCP.1"
                     /codon_start=1
                     /gene="thdA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /note="PP-binding site"
                     /product="truncated NRPS"
                     /protein_id="ATJ04410.1"
                     /sec_met_domain="PP-binding (E-value: 2.7e-17, bitscore:
                     52.8, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNVEQQLLSIWQEIIHSEAINPQDNFLDQGGNSLHFIKLASMVS
                     KTFHLAVSPADIFTAGTIAALAQTIRQRQQL"
     aSDomain        12348..12554
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_thdA_PCP.1"
                     /evalue="1.90E-21"
                     /label="thdA_PCP.1"
                     /locus_tag="thdA"
                     /protein_end="73"
                     /protein_start="4"
                     /score="67.9"
                     /tool="antismash"
                     /translation="EQQLLSIWQEIIHSEAINPQDNFLDQGGNSLHFIKLASMVSKTFH
                     LAVSPADIFTAGTIAALAQTIRQR"
     gene            12632..17002
                     /gene="npsB"
     CDS             12632..17002
                     /NRPS_PKS="Domain: Condensation_LCL (27-318). E-value:
                     8.9e-65. Score: 210.5. Matches aSDomain:
                     nrpspksdomains_npsB_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (482-883). E-value: 9.7e-86.
                     Score: 279.7. Matches aSDomain:
                     nrpspksdomains_npsB_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (996-1061). E-value: 1.6e-18. Score:
                     58.5. Matches aSDomain: nrpspksdomains_npsB_PCP.1"
                     /NRPS_PKS="Domain: TD (1099-1338). E-value: 6.3e-78. Score:
                     253.2. Matches aSDomain: nrpspksdomains_npsB_TD.1"
                     /codon_start=1
                     /gene="npsB"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     285.2; E-value: 1.8e-86)"
                     /gene_kind="biosynthetic"
                     /product="NRPS, TomB binding"
                     /protein_id="ATJ04411.1"
                     /sec_met_domain="Condensation (E-value: 2.2e-53, bitscore:
                     170.9, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 5.6e-93, bitscore:
                     301.3, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 5.6e-17, bitscore:
                     51.8, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.5e-07,
                     bitscore: 20.4, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 4.6e-62, bitscore:
                     199.0, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSFNSGESNKGCLNKACGESAVTYLAATPGQQAMWWLDNTLDQP
                     QCYNVPVLLTVNATLDAEIMQRAVAELTLRHEIFRTRFVYLDGKLQQRIGADGYLSFSH
                     RQPEQTETPESVTAQLAASRLSLAEGPLSIINMLSSDSGTTWLACCFHHIIIDAPSVRI
                     VLHDLLRIYCALDEKRALPAFNDTGSYQEFTRWQAASLAAAECEDMRDYWRQALHPAPP
                     LSDLPVDFPRRLREDTKAAYTMLALNEQEADSLQRHARSLSMTPFMYMSMCWQFFLSRM
                     SGQNDITVGVPFTLRDRSEFAETPGYMINTLPVRVQVNEDDTVRTLAAKVRQSFIGAHF
                     NKLLPFNEIVALSRENAGQDSPLFRTLLVMPDTRGDIFNDLPFKVMLDDYFSQMAKYDL
                     TLFFEAQPQWKLTLEYKTALYHPQTIDYWLKIFRHLLSAMGEDGEVLLSSLKLLDAPLS
                     RELVVRSSLKPCAEAWRFDALAAFNQHAVNHSADTALITANGTRSYGWLAERSGQIAAY
                     LQQQFNIAPGKRVALLLERNAEAIATLFGVLKTGAAYIPVDPQYPQERIGYMLQDAKVD
                     CIATTRSLVARFPVSASVPLLLIDDIPPEYPGEWSYIKRMPDDELYIIYTSGSTGQPKG
                     VRLLNKTLNNLIKWQQDVSECGQGDCTLHFMSLSFDVSVQEIFGTLACGGRLYIASEEE
                     RRDLDHLQEVIQEQGINRLYFPYVALQQFAHLSALANRQFPSLKEVYSTGEQLVLTADI
                     KHFFRQPVRLINLYGPSESHVCSAYVLPPESDKWGDAASIGYPLPGFTLLVVDEHLQLV
                     PAGVAGELLIVSDSLSPGYHNKSEESARRFISAEGFAAQSCHAYRTGDLVRLEHDDRFS
                     YLGRIDNQLKIRGFRIEPSEVEAAINALEGVQVSAVVGRADNSGSKQLIAFIAGLLDDK
                     GNQKDKIKRGLRLVLPEYMVPTELVFVDKLPTTPSGKIDRKALLKVDIIVESSTQMPER
                     PLTKTQEQVKALWETLFPGRHIALHDDFFAIGGHSLLATQLVFLLRKAFDCDIPLRLLF
                     NHPTLSAMAESIDGYIASEKGPVDAVDRSFVQDGYERIHWQGGVRSTPGLTLLTGATGF
                     LGIYLLRSLLLAGTQSVLCMVRARTDEQALARLRENAMRYGIADEIDFSRVEVCLGDIG
                     QRNLGLSSEAYSRLAERVDTVFHAAAQINFLLSYSSVKQSNVQGTLNILAFCGCGGRKT
                     LHYLSTIAVFSPRYPQSPIVEHCVPGHPEALSIGYTQSKWVAERYVIQAREQGLDANVF
                     RIGRIGGDSRSGACQSDDFLWRQIKSFIQMGLAPDPSALSTDLLPVDFVAEAIVALARS
                     EATRQENFHIFHPQSTRFDPVYRAIRSLGYPLETTSDGEWLQQLELCVTQGREVALGPV
                     IHLFKENLLDTGDNVYGNPETTKRIAQLGLRFPELSEETFKRMIVYFQRQNEIV"
     aSDomain        12713..13585
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_npsB_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="8.90E-65"
                     /label="npsB_Condensation_LCL.1"
                     /locus_tag="npsB"
                     /protein_end="318"
                     /protein_start="27"
                     /score="210.5"
                     /tool="antismash"
                     /translation="ATPGQQAMWWLDNTLDQPQCYNVPVLLTVNATLDAEIMQRAVAEL
                     TLRHEIFRTRFVYLDGKLQQRIGADGYLSFSHRQPEQTETPESVTAQLAASRLSLAEGP
                     LSIINMLSSDSGTTWLACCFHHIIIDAPSVRIVLHDLLRIYCALDEKRALPAFNDTGSY
                     QEFTRWQAASLAAAECEDMRDYWRQALHPAPPLSDLPVDFPRRLREDTKAAYTMLALNE
                     QEADSLQRHARSLSMTPFMYMSMCWQFFLSRMSGQNDITVGVPFTLRDRSEFAETPGYM
                     INTLPVRVQV"
     aSModule        12713..16645
                     /complete
                     /domains="nrpspksdomains_npsB_Condensation_LCL.1"
                     /domains="nrpspksdomains_npsB_AMP-binding.1"
                     /domains="nrpspksdomains_npsB_PCP.1"
                     /domains="nrpspksdomains_npsB_TD.1"
                     /final_module
                     /locus_tags="npsB"
                     /monomer_pairings="Pro -> Pro"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       12773..12883
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_npsB_0001"
                     /evalue="1.60E-11"
                     /label="C2_LCL_024-062"
                     /locus_tag="npsB"
                     /protein_end="84"
                     /protein_start="47"
                     /score="36.6"
                     /tool="antismash"
                     /translation="YNVPVLLTVNATLDAEIMQRAVAELTLRHEIFRTRFV"
     CDS_motif       13082..13147
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_npsB_0002"
                     /evalue="9.30E-06"
                     /label="C3_DCL_135-156"
                     /locus_tag="npsB"
                     /protein_end="172"
                     /protein_start="150"
                     /score="18.3"
                     /tool="antismash"
                     /translation="FHHIIIDAPSVRIVLHDLLRIY"
     CDS_motif       13487..13576
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_npsB_0003"
                     /evalue="6.10E-10"
                     /label="C5_LCL_267-296"
                     /locus_tag="npsB"
                     /protein_end="315"
                     /protein_start="285"
                     /score="31.5"
                     /tool="antismash"
                     /translation="DITVGVPFTLRDRSEFAETPGYMINTLPVR"
     aSDomain        14078..15280
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_npsB_AMP-binding.1"
                     /evalue="9.70E-86"
                     /label="npsB_AMP-binding.1"
                     /locus_tag="npsB"
                     /protein_end="883"
                     /protein_start="482"
                     /score="279.7"
                     /specificity="substrate consensus: Pro"
                     /tool="antismash"
                     /translation="NQHAVNHSADTALITANGTRSYGWLAERSGQIAAYLQQQFNIAPG
                     KRVALLLERNAEAIATLFGVLKTGAAYIPVDPQYPQERIGYMLQDAKVDCIATTRSLVA
                     RFPVSASVPLLLIDDIPPEYPGEWSYIKRMPDDELYIIYTSGSTGQPKGVRLLNKTLNN
                     LIKWQQDVSECGQGDCTLHFMSLSFDVSVQEIFGTLACGGRLYIASEEERRDLDHLQEV
                     IQEQGINRLYFPYVALQQFAHLSALANRQFPSLKEVYSTGEQLVLTADIKHFFRQPVRL
                     INLYGPSESHVCSAYVLPPESDKWGDAASIGYPLPGFTLLVVDEHLQLVPAGVAGELLI
                     VSDSLSPGYHNKSEESARRFISAEGFAAQSCHAYRTGDLVRLEHDDRFSYLGRIDNQLK
                     IR"
     CDS_motif       14264..14305
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_npsB_0004"
                     /evalue="6.30E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="npsB"
                     /protein_end="558"
                     /protein_start="544"
                     /score="13.2"
                     /tool="antismash"
                     /translation="FGVLKTGAAYIPVD"
     CDS_motif       14495..14542
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_npsB_0005"
                     /evalue="1.10E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="npsB"
                     /protein_end="637"
                     /protein_start="621"
                     /score="24.2"
                     /tool="antismash"
                     /translation="YIIYTSGSTGQPKGVR"
     CDS_motif       15068..15157
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_npsB_0006"
                     /evalue="2.20E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="npsB"
                     /protein_end="842"
                     /protein_start="812"
                     /score="26.4"
                     /tool="antismash"
                     /translation="PAGVAGELLIVSDSLSPGYHNKSEESARRF"
     CDS_motif       15245..15310
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_npsB_0007"
                     /evalue="9.80E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="npsB"
                     /protein_end="893"
                     /protein_start="871"
                     /score="33.7"
                     /tool="antismash"
                     /translation="YLGRIDNQLKIRGFRIEPSEVE"
     aSDomain        15620..15814
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_npsB_PCP.1"
                     /evalue="1.60E-18"
                     /label="npsB_PCP.1"
                     /locus_tag="npsB"
                     /protein_end="1061"
                     /protein_start="996"
                     /score="58.5"
                     /tool="antismash"
                     /translation="QVKALWETLFPGRHIALHDDFFAIGGHSLLATQLVFLLRKAFDCD
                     IPLRLLFNHPTLSAMAESID"
     aSDomain        15929..16645
                     /aSDomain="TD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_npsB_TD.1"
                     /evalue="6.30E-78"
                     /label="npsB_TD.1"
                     /locus_tag="npsB"
                     /protein_end="1338"
                     /protein_start="1099"
                     /score="253.2"
                     /tool="antismash"
                     /translation="LLTGATGFLGIYLLRSLLLAGTQSVLCMVRARTDEQALARLRENA
                     MRYGIADEIDFSRVEVCLGDIGQRNLGLSSEAYSRLAERVDTVFHAAAQINFLLSYSSV
                     KQSNVQGTLNILAFCGCGGRKTLHYLSTIAVFSPRYPQSPIVEHCVPGHPEALSIGYTQ
                     SKWVAERYVIQAREQGLDANVFRIGRIGGDSRSGACQSDDFLWRQIKSFIQMGLAPDPS
                     ALSTDLLPVDFVAEAIV"
     gene            17039..17431
                     /gene="npsC"
     CDS             17039..17431
                     /codon_start=1
                     /gene="npsC"
                     /product="polyketide hydroxylase/cyclase"
                     /protein_id="ATJ04412.1"
                     /transl_table=11
                     /translation="MVPALFDKYISAVMEKSSDKLASLFSVNGRLSLPFRRNREVIVGR
                     ENIRLHYANGFGVAPLRFTSIEDERFHYTNNPDVVIVEYKLHGNTLPDGKHFSLLYVNV
                     IEINNGEIIELIDYEDVLNREYIFQD"
     gene            17546..18043
                     /gene="marR"
     CDS             17546..18043
                     /codon_start=1
                     /gene="marR"
                     /gene_functions="regulatory (smcogs) SMCOG1135:MarR family
                     transcriptional regulator (Score: 69.9; E-value: 2.7e-21)"
                     /gene_kind="regulatory"
                     /product="MarR transciptional regulator"
                     /protein_id="ATJ04413.1"
                     /transl_table=11
                     /translation="MEMNKKVASGSEREISLNRQFEDALGNLQCVLVARRSLINPDGIN
                     WPQYDTLYILRQFQPMTPSAIGEKLGFARSKMSKILRMLKDKHFVEQESAESDKREMLT
                     RITEKGIEFLHSAESSRRIMAEQVASCMSQGEIAIFAELCTRAANILHENIKGKLEDTS
                     EN"
ORIGIN
        1 taccttcttt aacgagttag atttgtgtcg aaattattcc ggcaagatat ccgactcgtt
       61 gttttaggat agttgaggag agtgattcag gaaattcgat ggtaaatgtt gaaaacaaag
      121 catcattata ttctgcaata tcaaactcaa gcttacagac acattattaa tgcttcttgt
      181 ataacatccc ccgttttgaa agagcggatg aatatccctg ggaaacattt ttgtcaaaca
      241 ttaacataat gctgcacccc tttaaaagcg cctttttcta gtacccgggc atagactcaa
      301 tacgcttcaa gttgcatgtt cgggcaacag tgcagcccaa accttatggg cataaagcaa
      361 cacgcgcaac atgcgacgcc tggtatggcg agtattgggt tttctggcat agattattga
      421 tattacaact ttatttagga tatccatgga agtgagtaat cagttttgta atgcccttaa
      481 agaaattaaa acacaataaa attttattca atattttgta tgctattgat ttttattgat
      541 ttattatctt gttgttattt taattgattt cgtttttgca attactttgg ctggtggtat
      601 agttattaca gaccacagaa ggtaaaggga ttatgctcat catgcgacca aaagaagttc
      661 cagcaccgac agccagtacg atgtacagag atgaaagtag aggtttgctt tcccgtaaag
      721 tcgttattgt tctgggtttg cttagcgccg ttgctgcatt atccactgat atgtacttgc
      781 ctttatttcc agctatcgcc agtgatttgc atacgacgcc tgacaaagtt cagcttagta
      841 tcaccgcttt tatggtgggt ttagggattg ggcagttatt cattggccca ttgtccgatc
      901 attacggcag acgtaaatta ttgctaggcg ggatgactct attaaccatc gcttcattag
      961 ctggcgctat atctacgaac attcagctgc ttattgttac gcgattcttt cagggattgg
     1021 gaggcgcggc tggtatcgtt ctttcccggg caattatttc cgatctgtgc ccggggacta
     1081 aagccgctcg atattttaat ctggtgttag cgatacaggg gattgcccct gttattgcac
     1141 cattacttgg cggcgtggct gcatggttta tctggccggt ggtttttgtt tttatggctg
     1201 caatatcatt agtctccacc ttgctcagca gtcattttat tagcgaaacc ttaccccgcc
     1261 atcagcgatt acctttcaac ctcaacgagt ttatcagtca gtttatcgag ctgcttagtc
     1321 ataagaaata tattggttat actttaattt ttgcaatcca gttcggggcg ctatttgctt
     1381 atatatcagc atcgccgttt atctatcaat cggcgtttga tttatcctca ggggaattcg
     1441 ctgtaatatt ctctatcaac gccgcagtga tgatgtttgg tagtattgtc agcgctcgct
     1501 atgttacgaa atttggcgaa gataacctca taatagtggg ggtaataagc acgctggtga
     1561 tatctatatt actttgcatt gttaactata tttctcattt ccagtttgag attgcggcgg
     1621 tactactgtt aataatgatg tttactatgg ctttgacatt tggtaatgcc gcgagtatgg
     1681 ccatggcggc atcttcacat ttaaaaggaa cgggttctgc tattttaggt gtttttcagt
     1741 ttggtatcgc tgcgataacc ccattactgc ttggatttgg cgacccgttg tcattactgc
     1801 cgatgtcgct gattatagcg ggatgctgtt taatagccat catggcatta ttattgacag
     1861 gtaaaaaagg atagtgtgat gaatacacat gacgctataa aaattattgg cgcaagacaa
     1921 aataatctgc aggatattga tttagaggtg cctaaaaata aaataacagt tttcaccggt
     1981 gtttccgggt cgggaaaaag ttctttggta ttcggaacta tcgcggcaga atctcagcgt
     2041 cagctaaatg acacgtttcc tccttttatt cgacaccgtt taccgcatta tggtaatcct
     2101 gaagttgatg acattgaaaa cctgtcggtg gccattatta ttgaccaaaa acgtattggt
     2161 ggcaacgcac gttcaacggt gggcaccgca tcagatattt ataccctgct acggctactc
     2221 ttttctcgtg tcggcgaacc tttcgtaggt tattcgaatg ttttttcatt caatcatcct
     2281 gcggggatgt gtgcgacatg cgacgggttg gggattgcca gtaccattga tatcgaccaa
     2341 ctgattgatt caaatctgtc attaaatgca ggtgctattc gttatccttc ttttgcaccg
     2401 ggttcatggc gctggaaacg ttatgtttat tcagggcttt ttgatgctga taaaaaaatc
     2461 gcggattatt caaaagagga acgagagata ttactttatg cagataatct cactcctgaa
     2521 gcaccgttag ccggttggcc taagagtgca aagtttgaag gcgtcattac acgctttacg
     2581 cgaagttatt tgaaacaaga aactaaagat actaaaactg aggaatttca gcgagtcgtt
     2641 agtttgcagg tttgcccttc ttgtcagggc atgaggctca acgagaaaat actttcctgc
     2701 agaattagag ggaaaaatat tggcgaatgc gcaacgctgc ctgtcacaga gttaaagctg
     2761 tttgtagaaa agctcgatta tcctgaagtc aggccgctgc tcgaagcatt gctggaaagg
     2821 ttagatgcaa tgtgtgcagt aggcttggga tatctggatt tgaaccggac gacccctagc
     2881 ttatcgggcg gtgaatccca gcgattaaaa atggtccggc atctgggaag tagtctgacc
     2941 gggatcgttt atatcattga tgaacccagt accgggcttc atccagcaga tattgtgaaa
     3001 ctgaatgttt taattagcaa actacgtgac aaaggcaata ccattctgat ggtggagcac
     3061 gatcccgaca tgatagcgat agccgagcat gttattgatt tagggccggg agcgggtaag
     3121 caaggcggga atattgtctt tgagggcgac ctgtcggcac ttaagcagtc ccaaaccttg
     3181 acgggaagat atttctcttc acgggcagag ataaataaca gaccgagatg tgccaaaggt
     3241 tatatttcgg taagaaacgc cacattgcat aatctacata acttatcggt agacgtgcct
     3301 ttgagcgtta tggtcgctgt gacgggggtc gctgggtcgg gcaaaagttc attcgtcatg
     3361 ggagccctgg cgccacaatg tccggacgcg atcgttatcg atcaaaaacc gatacatact
     3421 tcgattcgat cgcatattgc ttcctggtgc ggtgcatttg atacgatccg tttactgttt
     3481 gccgaaaaaa accatgtgtc agcgtcgtgg ttcagcgcca atgccaaagg cgcctgtccg
     3541 gaatgtcatg ggctaggagt aatacaaacc gatctggcat ttatggatac ggttacgttg
     3601 ccctgtgagg cctgccaggg gcagcgctat agcccacagg cgctaaaata tcgttatcag
     3661 gggaaaaata ttgcggaggt attatccctg tcgattaacg atgctggcga ttttttcctg
     3721 aatgagccac agctcaggcc aatttttcgt agtctggtcg aagtcgggtt gggatatttg
     3781 cgcttggggg aatcgttaaa tcatctttca ggcggtgaat gccagcggct gaagttagcc
     3841 tcacaattaa atcatgatag tgacatgtat attttcgatg agccaaccac cggacttcat
     3901 cccagtgatg ttgcctcgct gctgaaactc tttaaccgac tggtagatcg cggaaacacc
     3961 gtcattatta ttgaacataa tatggagttg atcgctcagg ctgactggat tattgatatt
     4021 ggaccctatg ccgggcaaga agggggaaaa ttactgttta gcggtacacc tgaatcgatg
     4081 ctggcctgtc gccattcttt aaccgcggag tggttgcgca aacattgcca ggtggagtga
     4141 gaaagggtgg tcgggacagc cagaagagac tggcaataat gtgatgcata cccattatta
     4201 tacggatgta ttgtcccgat aatcttatta gtctacaggc cagtggtaat cgcgatccag
     4261 ccagccatcc aggtcataat ccatcataca ttgttcggca aaacctttat attcttgtac
     4321 ctgccccgac atctgtgcgg cgagcaacag ttcgatacga acattttcat gactgccggt
     4381 ataatttcgt tcatagagtt cgtgtctgct ggcgaattct gttcctaccg agtcccaaat
     4441 tagcttcatg agcttgaccc gttccacggc atccattccg ttggaaccgc gcatatattt
     4501 tttcagataa ggctccagtt ccggcgcggc aaaatctttg gcatgcgaat tgatataaat
     4561 aagcgcgctg ccaagatctt gctcaataat ttctctgatc cgtggatagc cgagactcat
     4621 aaaccaacgg taggctaaac cataatccag attaggcagg agggcgccgt tgtgccaggg
     4681 attcggcgat ttagccattg catcgcttat ggcccagaag aggttgcgcc aggccagcat
     4741 ttccccaacg cgggtctgta taccgcggaa atcggctacg ccggtggcct ccacgccttt
     4801 aatgaataaa ccacagataa aatcgatttt taccgccaga cgcgtcacac cgtggaacgt
     4861 agagcggtgc aggaagcctg aactgggtaa aaacgtggcc gctttagcgg tatcgccata
     4921 aataaaaatg ttttcccagg gaattttcac cttatccaga atgaagatca tgtcattctc
     4981 gtcgtagcgt gaggagagtg gatagtcaaa aggactgccg atcttttcgg cggctaagga
     5041 gtaagagggg cggcaaacca gcttcagccc tggggcattc atgggtaatg tgcataccag
     5101 ggcaaattct ctttttttga caggtaaacc gtaatgcgcg atgaaattgt aatgcgtcaa
     5161 ggcagagccg gtagcaacca ccttggcacc gctaacaatc acgccatcat cacactcttt
     5221 ttcgacatga atgcagatat cttcaatctg gtcgggcggg agattgcggt cgataggcgg
     5281 gttaatgatg gcatgattcc agtaaagtag ctcctcttgc gagcgtttgt accagtgtct
     5341 ggcgttatcc gcatattcgc cgtaggcctc gggattggcg ccgagagtcg taagaaacga
     5401 cgctttaaaa tcagggcttc ttcccaacca gccgtagcta agctttgccc actgggcgat
     5461 tgcgtcgcga tcgcgtatca ggtcgtcaac agaatgcgga acgcggaaga acggatgggt
     5521 gacaccaccg ctaccggtat cacacggcgt ggttaaaata gcctgatact tttcgtcatg
     5581 gagcgcgtcg tataatttag ctatcgacag tgctgaattg cgaaacgctg gatgtgtaat
     5641 aacattgtcg accttttcac cataagccca tatttctcgt ccatcattca gacccgccaa
     5701 aaagtcatta ccggtaggta acgatactga tttatttccc atgtcagctc tctccgaata
     5761 tcggttttca acgcttcctt ttaaacggcg tcttgttgac taagagttac cgttgttgtt
     5821 aaggcgttct gtatcagcca ttgataaata gaaaatgcgt cttgcgtcag gaatgactcg
     5881 ttatgaaatt gtatggaggc aacgttacct gacgataatg caacaatttc accggaaggg
     5941 agtcgctcca gctggactgt tttgtcatgc tccgggctgt accagcatgg ccgctgatgt
     6001 agcgcggaga aactgttata gaagccaacg gtatgagatt ttccctgaat ggatatctga
     6061 tgttggctac cctgacggtt attgatcagc cgctcgatcg gaatgcctaa ttcggcgcaa
     6121 attaactgat gtcccagaca agtcccgatt agcggacgct gctcccgcag ccgttgcgca
     6181 ataatttttc ggcccacgcg tattttttcg agttgtatat tggttggatc gccaggcccg
     6241 ggcccaatga atacgatgtc gcgatcggtg agctgcgtta gcttgctcag gcagtcatac
     6301 cagggaatga gggtaacggc gcaacctgcg ctgcgtaact gataggcaat catggcggtg
     6361 aagttgtcct ccatgtcgat cagtgtgatg gtatgacgag agagtaaagc gcacgggccc
     6421 aattgcgagt tatccagcca aaaggcggag gcgcatgcat tccgttttgc gagtatctgg
     6481 tcagcccgat ggcgaagttc tgcagacaat cctgttcggt ttggcgtccc ggcgcttgtg
     6541 tcagagaaga acgaatgcat tagcccttgt aatttggcgc gtgtttctcc ggcttcattt
     6601 tgcgcgatgg aacttctgac gatggttgaa cccgccgtaa gccgaaaatg tccctgagcg
     6661 gtaatatcgg ccgtgcggat cattatggcc gagtccagat aacgtttacc ttcttgcgca
     6721 cccgttatag caacgatgcc gctgtaatag ccgcgtccgc ggcgttctcg ccgggcgata
     6781 actttacagg cgctttctat tgggctgccg gtcactgttg gcgcaaagag cgattgcctg
     6841 atgatctctt tcagactgcg atctgagctg ccatggataa aatattcggt atgcgcgatg
     6901 tgcgacatag ctttgagctt cggcccggtt acctgaatat catgctgaca gatgctactc
     6961 atcattttga gttcttcatc caccaccata aatagttcgt cgcgctcttt tttatcctgc
     7021 agaaaatcat ccagcacgtg cgccatattc ccggagtcgg ggtattttaa cgtgccgctg
     7081 ataggattca tcgccacgtt ctgctcatca acctggatat gctgttcagg cgaactacct
     7141 atgaaatagc ggctgccggt gaagatcatc catgtccagt aagacccgca ttcagattgc
     7201 agtaaccgtt tgtacagcgt caacgcgtgg cggatgctga agtcggttat atcgccttcc
     7261 aggctgcgtg aaatcacaaa gttgctccct tctccggagc tgatttcctg atcaatgacg
     7321 gtatcaacaa tgtcgccata cgtttgatca tcaagatcga agtgcaggtt tcgcggcttg
     7381 atatcatagt cattaatggc tgcgataaac gaatctatag ggtaataatc ttgccgctca
     7441 atgtgcatga cgatcgtctg ttcaccatcg tcaatgcagg cataaccttt ttctttcagc
     7501 tgattaaatg gtaataaaat caatttgtta aatgagtttt ttcccttccc gtccagggga
     7561 ggatccagcg ctaattctga aagggattgg tttagctcaa tatccccttc aagaaataat
     7621 actgccttga taggttcgca ttgggggcgg taaatacagg caaagggtct atcaagattg
     7681 gccagatgag ccgaaagctc gtcgggcttt gctgtgcctt tagataacat catcatctcc
     7741 tggagtgccg tgaggatctt taatgttcca aagcgtcgat agcttgtcgg gttgacagca
     7801 cgactgagct ggtttccgca gctatctcaa gcgccagacg atgcttttct tcagagaaat
     7861 cggctagcgc atcggcaata aaaaatgtct cgatatcatt ggaataggcc tcttgcgctg
     7921 tgcataaaca accgatatgg gcgtaaacgc cgcagacgat cagctgatcg catttgagtt
     7981 cgtgcaacgt actcagaagg ggggagttaa agaaggcgct gtatcgccac ttcgttaata
     8041 cccactcatt ttccagaggc gtcaacggcg gaacaatctg tttatgttcc tggctgccgt
     8101 tcatgcctga accccataga ctgtgcagta agccgcgctg ttgtggcgtc atgtcgccgg
     8161 gttgggcagt ataaaatacg ggtacatgca gacgtcgggc gacgctaagc aagcggtaaa
     8221 tgttgtcgat aacctgcgct atcggcgggg cgtcagcagt gtaaaaatcg agaaaataac
     8281 gctgcatatc atgtatgagt agcgccgctc ttgaactgtt gggtcgccag tctgccattg
     8341 atttgggtaa ttgacgttct gtcggcaacg gatagggctg tatcttttcc atgttattct
     8401 ccttgtacgc ttagcagctg ccgagtgcgg cgccaccgtc gaccaataac gttgaaagcg
     8461 tggtttgccc tgattcttcg cacaggtaaa agcagaccgc ggcagcaatt tcttccgccg
     8521 tggcgacttt gttgagtggg ataccgatgc gaaattgttg tggattaccg ttaagcgtgt
     8581 tttgcctgtc actttcgcta tgccacatgc cgcgcagcat cggcgtatcg gttgagccgg
     8641 gagcgacaac attacaacgg atcccgtacg gagcgacctc cagccccaga gcataggtaa
     8701 atgcctgggc agcggctttt gaggcgcagt aggcggccat cgtcgcccgc ggcacgcgcg
     8761 ctgcgtttga ggcgatagtt acgatgctgc ctttacgctg agccatcatc agattggctg
     8821 catggcggct ggtgttaaat acgccagtcg cgttgacggc aaatgttttc gtccaatctt
     8881 gcggctgtgt ttcggccacg ctggcgtggc acagtacgcc ggcgccgttg accagataac
     8941 ccaccggacc cagttggcga ccgattgcgg taaaggcttc tgctacgctg cggtcgtcgg
     9001 caacgtccac attaaagcct gcaatgggct gcggatggtt attttgtagt gtggctacaa
     9061 gggttgccag ctgagaggcg ttattatcaa gaagcgctag tgaaacccct tctttcgcca
     9121 gcgcgtgggc aacggattcg ccaatgccac cgcaggcgcc ggtaataacg gcaatgtagt
     9181 ctttatcaaa ggtcattttg tctctctttc cagtgagtta ataacatctg cgtttgcgtt
     9241 acgttcaggc gcgggtcgca gagaatttgc ttaagttcat gttcttcagg gtgattattt
     9301 tcacagaagc attcgatgac cgggttcggc gtcgcttcca gatggagtcc agcggcgcag
     9361 gcgttatgtg ttttcacctg cctcaggaaa ccggagattt cagccatcat gtcgctaagc
     9421 tcgcggcgtt tattgcccgc ctgcgttttc ccggtattcc catgcattgg atcgcacatc
     9481 cataacaccg gcgtttcggt tgcctgtgcg gcctgaatca acgcgcccaa ccgatgaata
     9541 tgtgaacggc caaaacgcga aataaaagtc agacgtccag gaatacgttg aggattgagt
     9601 tgtcggcaaa gtgtcgcgat gaacgacggc gttacggtgg cgtcaatctt gcaggcaaca
     9661 gggttggcga tattcgccag catggcgata tgtgggctgt caggcgcaag agtacgaatg
     9721 ccgatccagg gccaatgagt gctggctaaa taggattctc catggggatt agtgcggatt
     9781 tgagtggttt catagtccag caacagcgct tcatggctgg tccagatggg atgaacatcg
     9841 cgaggatatt cccgttcgta acgtttaatt tcggccagcg tttccgctgc agcatggtag
     9901 ctcagcagca tccgttgcgg atcgttacgc ctggcttctg gagtcgcttc gggcctgttg
     9961 acggaatcac cgcgccacac gggaagtacc ctgtcgccat cgacttcgtt gtgttgtgag
    10021 cgtggtttag catattgacc ggcaattcta ccgaccgtca atatcggcag tcccatcagg
    10081 gttgagagtt cgcgggacat ttgctccagg aaggtcaatt ttttccgtac atgtaacgcg
    10141 tcagattcgc aaattctttc agcgcagtcg ccagcctgaa atatcattgc cttccctgca
    10201 taaacggcgg ctaatgcttt attgaattcg cttatttctt caaaacttaa taactctgga
    10261 agagtgtcta attcacttat gaccagggca agcatgtcct tatcgctcca gaacggctgt
    10321 tgccagttgg acttattgcc aggaaatgat gtcatttcta atctctcact cgaaatttaa
    10381 caggttttcc atttgttttt taacaaaaaa gcgatgagaa agtactattc cttgtctgtt
    10441 taccggacat gaaagacgat acgttttgca caaagattgc acgccaatga gttccttatg
    10501 tcaatcaaaa aagttgattt tttattgttg tttttttaat tatttgaatt tattgattat
    10561 tatttttggt tgtttttgga ttttttctat atgatttttt tttggaaatc aaattgactg
    10621 agggtcaggt tcgaagatag actattgaaa acaacgcttg gttatgcttg tgttgcttat
    10681 atgttgcttt ccctgctgcg ctttttttga ggcgtctcac ggtaagctgg cggcatttct
    10741 ttagatcttt aatttcttct tcaagagaag attttatgcg tgtgaacgtt cctaattctc
    10801 caggagagag tgatgacgca ttcagcatat gtcaatcagc taaaggctgt tcctgatata
    10861 tttgatgaga tttcgcaacg ttttccggac agggttgcgt taattttcga tcaaagacaa
    10921 ataacctatc gagaacttgc tgagcaatgt tcagcgctgg ctgcagtatt gcaaaataat
    10981 tgcctgataa aaggcgatat cgttgcaata aaaatagaac gtagcccgga gttatatatt
    11041 tttatgctgg cgctcatgaa aataggcgct gttatggttc ccgtgaactc gaatagtcct
    11101 gagcgctata ttggtgaggt tttaagtgcg gcgggagcca gatacctgat tagcgatgat
    11161 gtaacaagcg tgcccggcgg gtcatggcag gtgttgtcga gcaggacgtt gatacaaaac
    11221 tgcgctcaac aaagaagcgg gaattatccg gtattaagcg ctgatgatcc ggcgctcatc
    11281 ttgatgacct ctggatcaac aggaaaaccg aagagcgtgc tgatcgctca tcgcgggatt
    11341 gccagactga gtttgccggt acccgcgttg gggaatagcg agcgggactg ctatttgcaa
    11401 attgcagatg tttctttcgc cgcctcagcg aatgaaatct ggatggcttt attgaccggc
    11461 gcgtgtctga cgattgcgcc gcctggcttg ccggatttga tggccctggt acggcagatc
    11521 gaatcggata acgtgacgat gctattcctc tctggcgggt tgttccggct atttgtcgag
    11581 gtttcgctcg aaacgctgca tatacctgct tgtgtggtgg tgtcgggcga ttttgtcaac
    11641 cctcgtctat ttagcgtggc ggcgcaggcc ggtaaagcaa aaatatttaa tggattagga
    11701 tgcacggaaa attcagcgat ctcgtctctc tatcatgttc agtcggaggg gcaattatcc
    11761 agtgattctc ctgtgcctgt tggtactgcg ctccctttgg ttgagatggt ggtgttcaat
    11821 gaacggttgc aaccctgtgc ctgcggtgaa tatggggaat tgtttatcgc aggagctgga
    11881 gtggctctgg ggtattccga tccgcaactg acggcggaaa ggtttatctc cataccgtat
    11941 caaggcacag acgtgctttt ttatcgtacc gacgatcgcg caacgtgcga ccaggatagc
    12001 aatatcgtcc tggtcggaag aggcaaccat atttgtaaaa ttcgtggctt ccgcgtcaat
    12061 ctcgccggta ttgagcacct gttgcgctta catcacgctg tggaagatgt gctgattgtg
    12121 gtagaggaga cgccggatga accacgatta catgcttgtt atgtcacgca ggatgacgcg
    12181 ctatccgtag cggatttaaa gaatcacctc gctatgcatg ctcctgcctg gatgatacct
    12241 gaaaaattta gccgtctggc ggtactgcca atgaccgcta acggcaaaaa agatcgttta
    12301 cggttaaaaa atattttact ggagcaggtg taaatatgga caacgttgag caacagctac
    12361 tctcgatttg gcaggagatt attcattcag aggcgattaa cccgcaagat aattttttag
    12421 accagggtgg taactcatta catttcataa agttggcttc aatggtaagc aagacatttc
    12481 atttggctgt ctcgccggcg gacattttca ctgccggaac tattgccgcg ctggctcaga
    12541 ccattcggca acggcaacag ctctaatacc tggagctggg acagccggca aacaggaagg
    12601 gttttacagg gaattttaag agggggataa aatgccatca tttaatagcg gcgagtcaaa
    12661 taagggctgt ttgaacaagg cgtgtggaga aagtgcggta acgtatctgg cagcgacgcc
    12721 cggccagcag gcaatgtggt ggctggataa tacgctggat cagccccaat gctataacgt
    12781 gccggtgctg ctgaccgtta atgcgacact ggacgctgag attatgcagc gcgctgtggc
    12841 tgagctgacc ttgcgccatg aaatattcag aacgcgtttt gtttatcttg acggtaaatt
    12901 acaacagcgt atcggcgctg atggctatct ctctttttcc catcgacaac cagagcagac
    12961 ggaaacccct gaatcggtga ctgcacaact ggcggctagc cgtttatcat tagctgaggg
    13021 tccgttgagt atcattaata tgctcagttc agactcgggt acaacctggt tagcatgctg
    13081 tttccaccac atcattattg atgccccctc agtacgtatt gtcttgcatg atttgctgcg
    13141 catatattgt gcgcttgacg agaagcgcgc tctgccagcg tttaacgaca cgggaagcta
    13201 tcaggaattt actcgttggc aggccgcatc ccttgcggcg gcggagtgcg aagatatgcg
    13261 ggattactgg cggcaggcac tgcatccggc tccgccactg tcggacctcc cggtcgattt
    13321 tccccgtcgt cttcgggaag ataccaaagc cgcctatacc atgctggcgc tgaacgaaca
    13381 ggaagcggac tcactgcagc ggcacgcgag atcgttgtca atgactccat ttatgtatat
    13441 gtcgatgtgc tggcaatttt tcctcagccg catgagtggg cagaacgata ttaccgttgg
    13501 cgtacctttt actctgcggg atcgcagcga gtttgccgaa acgccgggat atatgatcaa
    13561 tactctgccg gttcgcgtgc aggtcaatga agatgacacg gtcaggacgc tggctgcaaa
    13621 ggtgcgtcaa tcttttattg gcgcgcattt caataagctg ctccctttca atgaaattgt
    13681 cgcactgtcg cgtgaaaacg cggggcagga cagtccacta ttcagaacgc tgttggttat
    13741 gcccgatacc cggggcgata ttttcaacga cttgcctttt aaagtcatgc tggatgacta
    13801 ttttagccag atggcaaaat acgatctgac gctgttcttt gaagcacaac cgcagtggaa
    13861 gctgacgctg gagtataaga cggcgttgta tcatccgcag accattgact actggttgaa
    13921 aatctttcgc catttattga gcgcgatggg cgaggacggc gaggtattac tgtcatccct
    13981 gaagctattg gatgcaccgt taagtcgtga actggttgtt cgatctagcc ttaagccgtg
    14041 cgcggaggcc tggcgatttg acgctctggc ggctttcaat cagcatgctg taaaccactc
    14101 tgcggatact gcgttaatta ccgctaatgg cacgcgatcg tatggttggt tagcggaacg
    14161 atcggggcag attgccgctt acctgcagca gcagtttaat atcgctcctg gcaaacgtgt
    14221 tgcgttatta ctggaaagga atgccgaggc gattgccact ctgtttggcg tattaaaaac
    14281 cggcgcggcc tacattccgg tcgatccgca atacccgcaa gagcgtatcg gttacatgtt
    14341 acaggacgcc aaggtggatt gcatcgccac gacgcgatcg ctggtagcga gatttccagt
    14401 gtctgcctcc gtacctctgt tattaatcga tgatattccc ccggagtacc ctggggaatg
    14461 gtcttatatc aaaagaatgc ccgacgatga gctgtatatc atttatacat ccggttcaac
    14521 cgggcagccc aagggagtac ggttattaaa taaaacgctc aataacctga ttaagtggca
    14581 acaagatgta tctgagtgcg gtcagggaga ttgtactttg cattttatgt cactttcttt
    14641 tgatgtatcg gttcaggaga tcttcggcac gttagcctgc ggtgggcgct tatatatcgc
    14701 cagtgaagaa gagcggagag acctggatca tctgcaagag gttatccagg agcagggaat
    14761 taatcggctc tatttcccct atgttgcttt gcaacagttc gcgcatttga gcgcattggc
    14821 caacaggcaa ttcccgagtt taaaagaggt ctactccact ggggaacagc tcgtactcac
    14881 tgcggatatt aaacattttt tcaggcaacc cgttcgcctg attaatctct atggtccctc
    14941 agaaagccac gtctgttccg catatgtgct gccgccggag agcgataaat ggggagatgc
    15001 agcgtccatt ggttaccctc tacccggatt cactctgctg gtggtggatg agcatctgca
    15061 gctggttccc gccggcgtcg ccggtgaact gcttatcgtt agcgattctc tctctcccgg
    15121 ctatcacaat aaaagtgaag aaagcgctcg acgttttatc tctgctgagg gctttgccgc
    15181 acaaagttgc cacgcgtatc gtaccggtga tctggtgagg ctggagcatg acgatcggtt
    15241 cagctatctt ggcaggatag acaatcagtt aaaaatacgc ggttttagga tcgaaccgtc
    15301 tgaagtcgag gcggccatca atgccctgga gggcgtgcag gtttcagcgg tagttggcag
    15361 ggcagataat tcaggaagca agcagctcat cgcctttatt gctggcttat tggatgataa
    15421 aggcaatcaa aaggataaga tcaaacgcgg ccttcgcctg gtgctgccgg agtatatggt
    15481 tcccacagag ttggtctttg tggataagct gccgaccacg cctagcggga aaatcgatcg
    15541 taaggcattg cttaaggtgg atattattgt tgaatcatcc acgcagatgc cggagcggcc
    15601 tctgaccaaa acgcaggagc aggtcaaggc gctatgggaa acgctatttc cgggacgtca
    15661 catcgcactg cacgatgatt ttttcgccat tggtggacat tctttgttgg ccacacagct
    15721 ggtttttctg ctgcgtaagg cgttcgattg cgatattcct ctacgtttgt tatttaatca
    15781 tccgaccttg tcggctatgg ctgagtccat cgacggctat attgccagtg aaaaggggcc
    15841 cgtcgatgcc gttgatcgtt cctttgttca ggacggatac gaacgcatac attggcaggg
    15901 gggagtgcgt tcaacccctg ggctgacgct gctcaccggg gcgacaggat ttttgggcat
    15961 ctacctgctg cgttcattgc tattggccgg gacccaatcc gtgctctgta tggtaagagc
    16021 caggacagat gagcaagcgt tggctcgttt gcgtgaaaat gcgatgcgtt acggaatcgc
    16081 cgatgagatt gatttttccc gggttgaagt ttgcctcggc gatattggtc agcgcaattt
    16141 agggttaagc tctgaagcgt atagccgttt ggcagagcga gtagacacgg tattccatgc
    16201 ggccgcacag attaattttt tgctctctta ttcttcggta aaacagtcaa atgtgcaggg
    16261 tacgctgaat attttagctt tctgcggttg tggcggacga aaaacgctgc actatttatc
    16321 cactatcgcg gtcttttctc cacgctatcc gcaatcgcct atcgtggaac attgtgtgcc
    16381 ggggcatccg gaagcactgt cgataggtta cacgcaaagt aagtgggtgg ctgaacgcta
    16441 tgttatacag gccagagaac agggacttga tgctaacgta tttcgcatag gacgtattgg
    16501 cggagacagc agaagtgggg cctgccagag cgatgatttt ttatggcgac agataaaaag
    16561 ttttatccag atgggattgg cacccgatcc gtctgcacta tcaacggacc tgttacctgt
    16621 cgactttgtc gctgaagcga tagttgcatt agcgcgttca gaagctacgc gacaggaaaa
    16681 cttccatatt ttccatccgc agagcactcg atttgacccg gtgtatcggg cgattcgttc
    16741 tctgggctat ccgttggaaa cgacttctga cggcgagtgg ttgcaacaac ttgagctgtg
    16801 tgtcacccag gggcgcgagg ttgcgctggg gccggtcatt catctcttta aagagaattt
    16861 gttggatact ggcgataacg tctacggtaa tccagagacg actaagcgta ttgcacaact
    16921 gggtttgcgc tttcctgaac tgtcggagga gacgttcaaa cgtatgattg tttatttcca
    16981 gcggcagaac gaaattgtct aacaagattt ttatcaattt catcaagagg ataataaaat
    17041 ggttccggcg ttatttgata aatatatttc ggcagtgatg gagaagtcat cggataagct
    17101 ggcgtccctt ttctctgtta acgggcgttt gtcgttgcct tttcgtcgca acagggaggt
    17161 gattgttgga cgtgagaata ttcgcttaca ctatgctaat ggctttggcg ttgcgccctt
    17221 acgctttacc tctatagagg atgaacgatt tcattatacg aataatcccg atgtcgtcat
    17281 tgttgaatat aaactacatg ggaatactct gccggatgga aaacacttct ctttgttata
    17341 tgttaatgtg attgaaataa ataatggtga gataattgag ttaatagatt atgaggatgt
    17401 tttgaacaga gaatatatct ttcaggatta gcaggacagt tcttatgttg ttaatggggg
    17461 caaaaggtat gatgactttt ccttccttga agggatgtgg taaaatagta agcttaactt
    17521 attgtaagcg gcatcaggag aatgtatgga aatgaataaa aaagtggcta gtggttctga
    17581 acgcgaaata tcattgaatc gtcaatttga agatgcttta ggaaatttgc aatgcgtact
    17641 tgttgctcgt cgctcgttga ttaatcctga tggtattaac tggccacaat acgatacgtt
    17701 gtatatttta cgccagttcc agcccatgac tccaagcgca attggtgaaa agctcggttt
    17761 tgcgcgtagt aaaatgtcca agatcctgcg gatgttgaaa gataagcact ttgttgaaca
    17821 ggaatcggca gaaagcgaca aacgagaaat gctgacgcgg attacggaaa aaggtattga
    17881 gttcctgcat tctgcagaat ccagcaggcg cataatggct gagcaggtgg catcgtgcat
    17941 gtcgcagggt gaaattgcta ttttcgctga gctttgtaca agggctgcaa atatattaca
    18001 tgagaatatt aaaggtaaac tcgaagacac cagcgaaaat taataaggtt tatggtgata
    18061 aaacgctaaa ctggtcgctg gcgtggagtt ctctttgccc aatgtccaac ccaatatatg
    18121 gcataaggat tgtgctaaaa cattactatg ggatgatgtt ggacgccaac tatatatatc
    18181 aaaaatggga aggtttttac cgcaggacat aaataaagtt agactagact ggtatagtta
    18241 gtgtgttatt cgccaaacgt tgcatcatcg tattgagatt ttacttattt ttgattaagc
    18301 gtcataacaa cctgtgctga taaacgcgtc gtcaaataac tgtaccggct ttggcgtcag
    18361 agacttgtcg cgaagaactt ttatgcaaag cgcgacacgc ccggcgaagg gtatatcaat
    18421 gattgcgttt tcaacgcgtt ttatctagaa tcctcgcttt cggagataga aaatgtccgt
    18481 cgcagattcc cttcttgctt attcctttgc cgcgctgctg ctcacgctga ccccgggtct
    18541 tgataccgcg ctcattttgc gcacctctac cgttgaagg
//
