BGC0001650 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001650 (Lysobacter enzymogenes)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	26,129	Le-pyrrolopyrazines	NRPS:Type I	100%

BGC0001650 - Region 1 - NRPS

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Location: 1 - 26,129 nt. (total: 26,129 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 26,130
Label		BGC0001650

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001650	1.00	NRP	Le-pyrrolopyrazines	Lysobacter enzymogenes
BGC0001050	0.39	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001434	0.38	NRP	nematophin	Xenorhabdus budapestensis
BGC0002071	0.36	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0000438	0.34	NRP	syringopeptin 25A	Pseudomonas syringae pv. syringae
BGC0001132	0.33	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002706	0.33	NRP	saframycin Mx1	Myxococcus xanthus
BGC0000465	0.33	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0001249	0.32	NRP	dimethylcoprogen	Alternaria alternata
BGC0001135	0.32	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001650	1.00	NRP	Le-pyrrolopyrazines	Lysobacter enzymogenes
BGC0001050	0.71	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001434	0.70	NRP	nematophin	Xenorhabdus budapestensis
BGC0002071	0.69	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0000438	0.67	NRP	syringopeptin 25A	Pseudomonas syringae pv. syringae
BGC0001132	0.67	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002706	0.66	NRP	saframycin Mx1	Myxococcus xanthus
BGC0000465	0.66	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0001249	0.66	NRP	dimethylcoprogen	Alternaria alternata
BGC0001135	0.65	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 26129:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Pro) + (Pro - X) + (X - Pro - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ATD51278.1

Search NORINE for peptide: strict or relaxed

AMP-binding (167..575): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DALLMGAVCK
Nearest Stachelhaus code(s):: Leu DAWLLGAVCK (76% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (1238..1661): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVQHVAHVAK
Nearest Stachelhaus code(s):: Pro DVQHAAHVAK (88% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (2342..2762): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAFTLGAVCK
Nearest Stachelhaus code(s):: Leu DAFILGAVCK (62% 8Å match)
Stachelhaus code match:: 90% (moderate)

ATD51279.1

Search NORINE for peptide: strict or relaxed

AMP-binding (30..454): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVQHIAHVVK
Nearest Stachelhaus code(s):: Pro DVQHIAHVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1123..1524): X

nrpys: Leu, Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAIYLGVVLK
Nearest Stachelhaus code(s):: Leu or Ile DAIYLGVVLK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ATD51280.1

Search NORINE for peptide: strict or relaxed

AMP-binding (545..962): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVQHAAHVAK
Nearest Stachelhaus code(s):: Pro DVQHAAHVAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)