BGC0001653 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001653 (Microbispora sp. GMKU363)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	66,233	linfuranone B/linfuranone C	PKS	100%

BGC0001653 - Region 1 - T1PKS

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Location: 1 - 66,233 nt. (total: 66,233 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 66,234
Label		BGC0001653

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001653	0.93	Polyketide	linfuranone B, linfuranone C	Microbispora sp. GMKU363
BGC0000041	0.34	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002631	0.33	RiPP	myxarylin	Pyxidicoccus fallax
BGC0001164	0.33	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001749	0.33	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0002099	0.32	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0001276	0.32	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0002084	0.32	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0001244	0.32	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001275	0.32	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001653	0.98	Polyketide	linfuranone B, linfuranone C	Microbispora sp. GMKU363
BGC0000041	0.67	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002631	0.66	RiPP	myxarylin	Pyxidicoccus fallax
BGC0001164	0.66	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001749	0.66	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0002099	0.66	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0001276	0.66	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0002084	0.66	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0001244	0.65	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001275	0.65	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 66233:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-ohmal) + (Me-ccmal - Me-ohmal) + (ccmal - ccmal) + (redmal - ccmal - Me-ohmal) + (Me-mal - redmal)
Non-colinear ordering:: AP234_RS38635 + AP234_RS38650 + AP234_RS14715 + AP234_RS38645 + AP234_RS14725

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AP234_RS38635

PKS_AT (40..334): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 79.2%; Malonyl-CoA: 70.8%; Ethylmalonyl-CoA: 70.8%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 165.0
Ethylmalonyl-CoA: 137.5
Methoxymalonyl-CoA: 133.3
Malonyl-CoA: 104.4
2-Methylbutyryl-CoA: 94.1
Propionyl-CoA: 85.0
Isobutyryl-CoA: 79.6
trans-1,2-CPDA: 78.5
CHC-CoA: 63.6
Benzoyl-CoA: 45.8
Acetyl-CoA: 38.6
inactive: 35.1
fatty_acid: 29.0
3-Methylbutyryl-CoA: 25.4

AP234_RS38645

PKS_AT (562..833): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 201.0
inactive: 84.5
Methoxymalonyl-CoA: 76.3
Methylmalonyl-CoA: 55.6
Propionyl-CoA: 39.1
Acetyl-CoA: 30.1
Isobutyryl-CoA: 28.9
fatty_acid: 16.9
CHC-CoA: 15.6
Ethylmalonyl-CoA: 15.2
Benzoyl-CoA: 14.9
2-Methylbutyryl-CoA: 11.9
trans-1,2-CPDA: 8.1
3-Methylbutyryl-CoA: 0.0

PKS_AT (2562..2832): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 193.7
inactive: 80.8
Methoxymalonyl-CoA: 74.4
Methylmalonyl-CoA: 54.1
Propionyl-CoA: 33.7
Isobutyryl-CoA: 25.8
Acetyl-CoA: 24.6
fatty_acid: 16.5
Ethylmalonyl-CoA: 14.8
CHC-CoA: 14.7
Benzoyl-CoA: 14.4
2-Methylbutyryl-CoA: 9.0
trans-1,2-CPDA: 4.1
3-Methylbutyryl-CoA: 0.0

PKS_AT (4285..4577): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 215.2
Ethylmalonyl-CoA: 199.2
Methoxymalonyl-CoA: 178.4
2-Methylbutyryl-CoA: 166.4
trans-1,2-CPDA: 126.9
Malonyl-CoA: 124.3
Propionyl-CoA: 119.4
CHC-CoA: 92.6
Isobutyryl-CoA: 82.1
Benzoyl-CoA: 68.2
Acetyl-CoA: 45.9
fatty_acid: 38.2
3-Methylbutyryl-CoA: 36.4
inactive: 36.2

AP234_RS14715

PKS_AT (566..837): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 203.2
inactive: 85.0
Methoxymalonyl-CoA: 77.0
Methylmalonyl-CoA: 55.9
Propionyl-CoA: 39.7
Acetyl-CoA: 30.2
Isobutyryl-CoA: 29.0
Ethylmalonyl-CoA: 17.5
fatty_acid: 16.9
CHC-CoA: 16.0
Benzoyl-CoA: 14.9
2-Methylbutyryl-CoA: 10.6
trans-1,2-CPDA: 8.6
3-Methylbutyryl-CoA: 0.0

PKS_AT (2278..2549): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 202.0
inactive: 90.5
Methoxymalonyl-CoA: 77.3
Methylmalonyl-CoA: 57.7
Propionyl-CoA: 38.7
Isobutyryl-CoA: 30.3
Acetyl-CoA: 25.3
fatty_acid: 20.0
Ethylmalonyl-CoA: 17.8
Benzoyl-CoA: 14.0
CHC-CoA: 13.8
2-Methylbutyryl-CoA: 9.3
trans-1,2-CPDA: 6.5
3-Methylbutyryl-CoA: 0.0

AP234_RS38650

PKS_AT (858..1143): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 91.7%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.3
Ethylmalonyl-CoA: 173.9
Methoxymalonyl-CoA: 160.5
2-Methylbutyryl-CoA: 132.9
trans-1,2-CPDA: 132.7
Propionyl-CoA: 106.6
Malonyl-CoA: 102.5
CHC-CoA: 90.0
Isobutyryl-CoA: 62.8
Acetyl-CoA: 43.0
3-Methylbutyryl-CoA: 32.7
inactive: 31.7
fatty_acid: 28.5
Benzoyl-CoA: 26.4

PKS_AT (2557..2842): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 91.7%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 197.0
Ethylmalonyl-CoA: 181.2
Methoxymalonyl-CoA: 162.0
trans-1,2-CPDA: 134.5
2-Methylbutyryl-CoA: 133.9
Propionyl-CoA: 109.3
Malonyl-CoA: 108.3
CHC-CoA: 92.6
Isobutyryl-CoA: 69.8
Acetyl-CoA: 43.4
3-Methylbutyryl-CoA: 36.1
inactive: 32.8
fatty_acid: 27.9
Benzoyl-CoA: 27.1

AP234_RS37235

PKS_AT (526..811): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 91.7%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.3
Ethylmalonyl-CoA: 173.9
Methoxymalonyl-CoA: 160.5
2-Methylbutyryl-CoA: 132.9
trans-1,2-CPDA: 132.7
Propionyl-CoA: 106.6
Malonyl-CoA: 102.5
CHC-CoA: 90.0
Isobutyryl-CoA: 62.8
Acetyl-CoA: 43.0
3-Methylbutyryl-CoA: 32.7
inactive: 31.7
fatty_acid: 28.5
Benzoyl-CoA: 26.4

AP234_RS14725

PKS_AT (539..825): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Malonyl-CoA: 83.3%; Methoxymalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 186.1
Ethylmalonyl-CoA: 181.6
Methoxymalonyl-CoA: 151.4
2-Methylbutyryl-CoA: 140.2
trans-1,2-CPDA: 108.5
Propionyl-CoA: 106.9
Malonyl-CoA: 94.3
CHC-CoA: 91.3
Isobutyryl-CoA: 78.4
Benzoyl-CoA: 73.2
inactive: 40.5
Acetyl-CoA: 35.6
3-Methylbutyryl-CoA: 31.1
fatty_acid: 16.7

PKS_AT (1530..1820): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 220.2
inactive: 102.0
Methoxymalonyl-CoA: 81.3
Methylmalonyl-CoA: 70.1
Isobutyryl-CoA: 40.7
Propionyl-CoA: 37.7
Ethylmalonyl-CoA: 32.3
Acetyl-CoA: 22.5
2-Methylbutyryl-CoA: 20.5
Benzoyl-CoA: 18.6
fatty_acid: 15.8
CHC-CoA: 15.5
trans-1,2-CPDA: 8.1
3-Methylbutyryl-CoA: 0.0