BGC0001658: macrotermycins biosynthetic gene cluster from Amycolatopsis sp. M39
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Location: 155,192 - 208,720 nt. (total: 53,529 nt).
This entry is originally from NCBI GenBank LWSF01000005.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001658
Short description macrotermycins biosynthetic gene cluster from Amycolatopsis sp. M39
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
LWSF01000005.1
155192 - 208720
via
Compounds
  • macrotermycins
Species Amycolatopsis sp. M39 [taxonomy]
References
Chemical products information
macrotermycins Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • A4R44_03174
  • OAP25798.1
  • degU_13
 155192 - 155845 (-) Transcriptional regulatory protein DegU
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    • A4R44_03175
    • OAP25799.1
    • liaS_9
    		 155869 - 156984 (-) Sensor histidine kinase LiaS
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      • A4R44_03176
      • OAP25800.1
      • eryCIII_1
      		 156975 - 158237 (-) Desosaminyl transferase EryCIII precursor
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        • A4R44_03177
        • OAP25801.1
        • laaA
        		 158472 - 159404 (+) L-amino acid amidase
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          • A4R44_03178
          • OAP25802.1
          • fenF
          		 159397 - 160356 (+) Malonyl CoA-acyl carrier protein transacylase
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            • A4R44_03179
            • OAP25803.1
            • acpP_2
            		 160349 - 160594 (-) Acyl carrier protein
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              • A4R44_03180
              • OAP25804.1
              • srfAA
              		 160828 - 162327 (+) Surfactin synthase subunit 1
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                • A4R44_03181
                • OAP25805.1
                • lcfB_5
                		 162527 - 163987 (+) Long-chain-fatty-acid--CoA ligase
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                  • A4R44_03182
                  • OAP25806.1
                  • btrK_1
                  		 163984 - 165198 (+) L-glutamyl-[BtrI acyl-carrier protein] decarboxylase
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                    • A4R44_03183
                    • OAP25807.1
                    • mamA
                    		 165195 - 165671 (+) Methylaspartate mutase S chain
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                      • A4R44_03184
                      • OAP25808.1
                      • mutE
                      		 165668 - 166459 (+) Methylaspartate mutase E chain
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                        • A4R44_03185
                        • OAP25809.1
                        		 166401 - 166943 (+) Methylaspartate mutase E chain (MutE)
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                          • A4R44_03186
                          • OAP25810.1
                          		 166943 - 168139 (+) Cytochrome P450 107B1
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                            • A4R44_03187
                            • OAP25811.1
                            		 168293 - 170332 (+) Phenolphthiocerol synthesis polyketide synthase type I Pks15/1
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                              • A4R44_03188
                              • OAP25812.1
                              		 170341 - 173619 (+) Phenolphthiocerol synthesis polyketide synthase type I Pks15/1
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                                • A4R44_03189
                                • OAP25813.1
                                		 173685 - 173948 (-) hypothetical protein
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                                  • A4R44_03190
                                  • OAP25814.1
                                  • lgrE_2
                                  		 174055 - 174870 (-) Linear gramicidin dehydrogenase LgrE
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                                    • A4R44_03191
                                    • OAP25815.1
                                    		 175158 - 183599 (+) Phenolphthiocerol synthesis polyketide synthase type I Pks15/1
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                                      • A4R44_03192
                                      • OAP25816.1
                                      		 184098 - 184286 (-) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
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                                        • A4R44_03193
                                        • OAP25817.1
                                        		 184636 - 185052 (+) hypothetical protein
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                                          • A4R44_03194
                                          • OAP25818.1
                                          • eryCIII_2
                                          		 185273 - 186169 (+) Desosaminyl transferase EryCIII precursor
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                                            • A4R44_03195
                                            • OAP25819.1
                                            		 186428 - 191686 (+) Phenolphthiocerol synthesis polyketide synthase type I Pks15/1
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                                              • A4R44_03196
                                              • OAP25820.1
                                              • eryA_2
                                              		 191683 - 196446 (+) Erythronolide synthase, modules 1 and 2
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                                                • A4R44_03197
                                                • OAP25821.1
                                                		 196480 - 206856 (+) Phenolphthiocerol synthesis polyketide synthase type I Pks15/1
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                                                  • A4R44_03198
                                                  • OAP25822.1
                                                  • drrA_7
                                                  		 206970 - 207893 (+) Daunorubicin/doxorubicin resistance ATP-binding protein DrrA
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                                                    • A4R44_03199
                                                    • OAP25823.1
                                                    • drrB_3
                                                    		 207893 - 208720 (+) Daunorubicin/doxorubicin resistance ABC transporter permease protein DrrB
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                                                      Biosynthesis information
                                                      Annotation changelog

                                                      Entry version: 2

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2019-10-16
                                                      Migrated from v1.4
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 1

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2018-08-06
                                                      Submitted
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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