LOCUS       BGC0001659             16557 bp    DNA     linear   PLN 23-MAY-2018
DEFINITION  Fusarium equiseti strain CNC-477 mangicol biosynthesis gene cluster,
            partial sequence.
ACCESSION   BGC0001659
VERSION     BGC0001659
KEYWORDS    .
SOURCE      Fusarium equiseti (Gibberella intricans)
  ORGANISM  Fusarium equiseti
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Sordariomycetes; Hypocreomycetidae; Hypocreales; Nectriaceae;
            Fusarium; Fusarium incarnatum-equiseti species complex.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-08 03:19:34
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 89
            Orig. end    :: 16646
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     mRNA            complement(join(<1..731,781..978,1033..>1357))
                     /product="FmsA"
     CDS             complement(join(1..731,781..978,1033..1357))
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /note="epoxide hydrolase"
                     /product="FmsA"
                     /protein_id="APY21858.1"
                     /sec_met_domain="PF00561 (E-value: 3.2e-14, bitscore: 41.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MADNIKPYRINVPESDIQLLKNKLESARFPAEDEVSDDWTYGAGL
                     SDVKRLAAYWKDGFDWRTQEAKLNRHPQFTTNVAVDGFGDLEIHFLHQRSSKANSIPLL
                     FFHGWPGSFAEVLKLLPLLTEPNDGPSFHVVAPSLPNHCFSDGVSKRGFGIPRYGEAMH
                     KLMLKLGYDKYVTQGGDWGYIITRMIGAQYPEHCLASHMNMIPAVSPPNPLKTPWQFLR
                     FWLFPFTAQEKKGIEQMKNFFNEGLAYNLIMSTKPSTIGFGLADSPVALLAWIYEKLHD
                     WTDDYKWTDDEILTWVSLYQFSKAGPAASARIYYESRHADQELTKKVNDWIPCVQLGLS
                     YFPKDIVFVPKTWGRTLGPVVFEKIHTSGGHFASIEKPEELVEDVREMFGRSVGLQVLE
                     KLKESGAVHKGPAAENKS"
     misc_feature    <1..>16557
                     /note="mangicol biosynthesis gene cluster"
     subregion       1..16557
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="Terpene"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..16557
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     mRNA            join(<2860..3037,3183..3211,3259..3518,3566..4403,
                     4451..4605,4654..4817,4868..4969,5019..5164,5211..>5543)
                     /product="FmsB"
     CDS             join(2860..3037,3183..3211,3259..3518,3566..4403,
                     4451..4605,4654..4817,4868..4969,5019..5164,5211..5543)
                     /EC_number="4.2.3.145"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 249.9; E-value:
                     4.8e-76)"
                     /gene_kind="biosynthetic-additional"
                     /note="bifunctional sesterterpene synthase/cyclase"
                     /product="FmsB"
                     /protein_id="APY21859.1"
                     /transl_table=1
                     /translation="MDFTYRYSFEPTDYDTDGLCDGVPVRMHKGADLDEVAIFKAQYDW
                     EKHVGPKLPFRGALDITDVESAETVAAENDEFLDALQQGVREGDIESRASGKRHLQAWI
                     FKQMAAIDRERAIAAMNAWATFINTGAGCAHDTNFKSLDDYLHYRSTDVGYMFWHALII
                     FGCAITIPEHEVELCHRLALPAIMSVTLTNDIWSYGKEAQAAEKSGKPGEFVNALVVLM
                     REHNCSIEEAERLCRARNKIEVANCLQTTKETRERTDVSQDLKDYLYHMLFGVSGNAIW
                     STQCRRYHMDAPYNERQQARLNQKKNKLSSTYDPIQASKEALKESTRPEIHRLPTPDSP
                     AKESFAVRPLVNSSGEFDGNGYIDGHEANVRPKPVVNGHSDAEERPAFERKGSAKRATS
                     ANDIDWTAHKKVDHGNGHKKTLSDLMLQDLPPMEDDVVMEPYRYLCSLPSKGVRNKTID
                     ALNFWLKVPAERANTIKSITESLHGSSLMLDDIEDHSQLRRGKPSAHAVFGEAQTINSA
                     TFQYIQSVSLISKLQSPKALGIFVDEIRQLFIGQAYELQWTSNMICPSLEEYLQMVDGK
                     TGGLFRLLTRLMAAESTTQQDVDFSRLCQLFGRYFQIRDDYANLKLADYTQQKGFCEDL
                     DEGKFSLPLIIAFNEQNKAPKAVAQLRGLLMQRCVNGGLSFEQKVLALSLIDEAGGIEG
                     TEKVLHSLYGEMEAELERLAGIFGEENCQLELILEMLRID"
     mRNA            join(<7313..7592,7637..7771,7818..8088,8143..8208,
                     8255..8330,8378..8742,8803..8887,8976..9136,9189..>9354)
                     /product="FmsC"
     CDS             join(7313..7592,7637..7771,7818..8088,8143..8208,
                     8255..8330,8378..8742,8803..8887,8976..9136,9189..9354)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 271.4; E-value: 2.5e-82)"
                     /gene_kind="biosynthetic-additional"
                     /note="cytochrome p450 monooxygenase"
                     /product="FmsC"
                     /protein_id="APY21860.1"
                     /sec_met_domain="p450 (E-value: 4.6e-56, bitscore: 179.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MERLKMDSLNININDWFERDLPKTPDWKLFALASLAFVALRFTCT
                     VIYRLYLSPLSKFPGPKIAAATHLYESYYDFWKKGQYYKVIQRMHEVYGPIVRVTPDEL
                     SINDPDFYDTVYVNGNVRRTESFGHSFGGGLGIEDTFFASQDHDLHRKRRKPIEPYFSR
                     NGVLKLEQLINERVEKLFNKFHELSGTGVVARLDYAFEAFTGDVMQHICIEKPESLLNS
                     DDFSSEWFEMLRNVSLSVPLMGMIPWLVHILKFIPERLIIWLAPEAAHFQNFRIQAGRQ
                     IEQAKQEKFDNDRKGVATVGGKPTLFRFLVHESGLAPEDLSTERLQKEAMVLLGGGTTT
                     TARTATMTCFWMLSMPEKGQRLREELKDIMAEYPKKKPSLTELEKLPYLGAVIQESLRM
                     AYGSMRRLPRTSPDQALQFKEWVIPPGTPVGMNAYYLHTDPNAFPEPMEYKPERWLGEV
                     TPAMKRSFVPFSRGSRRCPGSSLALADLHFVLAALFGPTGPKFELFESDRSDVDAIHDY
                     LMPLPRLDSKGVRVTVR"
     mRNA            complement(join(<9982..10332,10383..11495,11545..>11619))
                     /product="FmsD"
     CDS             complement(join(9982..10332,10383..11495,11545..11619))
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 314.9; E-value: 1.6e-95)"
                     /gene_kind="biosynthetic-additional"
                     /note="cytochrome p450 monooxygenase"
                     /product="FmsD"
                     /protein_id="APY21861.1"
                     /sec_met_domain="p450 (E-value: 8e-71, bitscore: 227.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MELPSFALKLEHDKLVALAIVSLATLVTSLAAIAIYRVWFHPLSI
                     FPGPKWLAATNIPERWMSNISGTWIWRVSPLHRKYGPIVRIGPNRLAVDGSIGWFQVYA
                     MRGKDDEFPKYPEYIFPGDGLSILGANQTNHRRHRRQFWSAFNDQALVEQEIVIQPYTD
                     MLLQRLSERAKVGDPINIVDWINFLLFDIAGELVFSQPFDCLDKQEYHPWVSNFFWAVK
                     GNAMNRFVKHYPVIEPLMNFFFTGKEQIKRETDQRNMTFHHAMQRMKLGEQPTPGRRDF
                     MSFLMRRNRDGGGLTDPEILVDCPVLIGASSETTTTALSGFFFYLGTSPQAYQRLVEEV
                     RSSFKSESEINMKTTKQLEYLNATVDEALRVYPPAAESPPRISPGAEIEGKYLPKGVIV
                     SIYQWGTFHNPDNFADPDDYVPERWLQPSHPLHNPKYANDNRSVFRPFGFGMRDCLGKN
                     LAHAEIRVVVSRILYRFDFELGPNQEDWHSSQKCFLAWDKKPLILTLKPRDFAP"
     mRNA            complement(join(<12969..13906,13961..14216,14267..14746,
                     14797..>14961))
                     /product="FmsE"
     CDS             complement(join(12969..13906,13961..14216,14267..14746,
                     14797..14961))
                     /EC_number="1.14.13.8"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1092:hypothetical
                     protein (Score: 145.6; E-value: 4.3e-44)"
                     /gene_kind="other"
                     /note="flavin containing monooxygenase"
                     /product="FmsE"
                     /protein_id="APY21862.1"
                     /transl_table=1
                     /translation="MRVAVVGAGPGGLTTLKYLKEATKFFDIDPIEARLFEREDAVGGT
                     FTKRTYEDAELVSSKYLTCFSDWRADLEDPDFLSAERFIRYLKEYADHFNLWPEISLST
                     SVTSIRRGQAGGHVIHYRGPDGVDMTWECDAVAVCTGLHVTPNIPDVQGTDKVKIVKHS
                     SQFKKREEFPHGSQVVVLGTGETGMDIAHLAVTSPTKRVVLCHRQGFLGAPKKIPNPIL
                     FPCLGNKPNPNAQELPIDVSWQAPLLDSYLPPFLRDRLFTWRFQDFNIKVANWLCSGTT
                     DGVDQWVGGLDKERFHTSQSFFNKAVWRCLHYISEPYRPTNPGIIERIRRALVTVPVKK
                     VPGGKYIDLAPWPSHIDEKGIMHFKENGRPEAERMKTLGPVKPDMVVYATGYRQEFAFF
                     DEANKNGENYPTCADADVRCIWRRNDPTVGFIGFVRPGYGAIPPLAELQAQLWLMTLIN
                     PEMAKSLSSREDYHFKLRGHKRIDYGVHHESYAYQLALDMDAVPSFWDGVRAGWNAGAK
                     HPGLWWRLPVLWLTGAQFNTKFRVVGPYQWDGAVDVLGGELWETITRREGAFGAFFMTV
                     VPMTMVGTSSIIMWFVELFATLINAIGRFLKVNRVV"
     mRNA            join(<15521..15937,15985..>16557)
                     /product="FmsF"
     CDS             join(15521..15937,15985..16557)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039:aldo/keto reductase family oxidoreductase (Score:
                     175; E-value: 3.3e-53)"
                     /gene_kind="biosynthetic-additional"
                     /note="aldo-keto reductase"
                     /product="FmsF"
                     /protein_id="APY21863.1"
                     /transl_table=1
                     /translation="MSQKGPQIIFGTASIGYGSLAEEDAVKQFLKVASDNGVKQLDTAA
                     SYPTEETTGQTEVLLGKVKSGNEDWVIDTRVAISRNLQGALAPDAIERSLSTSLEKLHQ
                     RSVNILSAHMPDPATSLEDQARGFDEQFRQGKFKKLGLCNWPLSMIEKYIEICDAKGYV
                     KPSVAQYMYNYIWRGTESTILPFLRKHNISLHAYSPLAGGFLTGKPTSGDTAGTRYGEP
                     THPLTIYKFIYDKEPFHQAVKDLYSLIKDGQVESTSDVAIRWLYYHSKLEPQDAIILGG
                     SKIEHFEKNVAAVKKGPLPEAVLKALEGLGVSDAGMGDGNVFGSVFEQ"
ORIGIN
        1 tcagcttttg ttctctgctg ccggtccttt atgaacagcg ccactttcct ttagcttctc
       61 caatacctgc aggccaacag acctcccaaa catctctctt acatcctcaa caagctcttc
      121 gggcttctca atcgacgcaa agtgtccacc actagtatgg atcttttcaa atacaacagg
      181 acctagtgtc ctgccccaag tcttgggaac aaacacaata tccttgggaa agtatgaaag
      241 acccagttga acacaaggaa tccagtcatt aaccttcttt gtcagctcct ggtccgcatg
      301 tcggctctcg tagtagatcc tcgcactagc tgctggaccc gctttggaga actggtacaa
      361 tgagacccac gtgagaatct catcatcagt ccatttgtag tcgtctgtcc agtcatgcag
      421 cttctcgtag atccaggcta ggagtgccac tggagagtcg gctaggccaa agcctatggt
      481 ggacggcttg gtgctcatga tcaagttgta agcaaggcct tcgttgaaga agttcttcat
      541 ctgctcaata cctttcttct cttgtgctgt aaaggggaag agccagaagc ggaggaactg
      601 ccaaggcgtc ttcaacgggt tgggagggct aacggctggg atcatgttca tgtgagaggc
      661 tagacagtgt tcgggatact gagctccgat cattcgcgtg attatataac cccaatcgcc
      721 tccttgtgtg acttgaaaat tgttagtttt gtgttattgg aggggtattt actatcttac
      781 cgtatttgtc gtaacccaac ttcaacatta gcttgtgcat ggcctcgcca taacgcggga
      841 ttccaaagcc acgcttcgat accccgtcag agaagcaatg atttggcaag gatggtgcaa
      901 ctacatggaa ggaaggtcca tcattgggct cagtcaacag aggaagcaac ttgagaactt
      961 ctgcaaagct tccaggccct atattagatg taagcgtcat gttcagtcac aaaactgctg
     1021 atgtctactc acaaccatgg aagaatagta gaggaatact attagccttg ctactcctct
     1081 gatgcaagaa gtgaatctca agatccccaa atccgtccac agcaacgttg gttgtgaact
     1141 ggggatgacg attcaacttg gcttcttggg tccgccagtc gaatccatcc ttccagtatg
     1201 cagcaagacg cttcacgtca ctgagacctg cgccataggt ccagtcatca gagacttcgt
     1261 cttctgcggg gaacctggca ctttcgagtt tgtttttcaa aagctgaatg tccgattctg
     1321 gaacattgat tcggtatggt ttgatattat cagccatagt ggataggcgg aatatgataa
     1381 ggctaacaaa cgacaggtat cggtgaagct accagtctcg caggcgattt taagtatctt
     1441 ggttgatcga agaatctcct aaactgtcgt cattcacgca aagactgtca tagtactcta
     1501 ttgacgtcgt caatttcact acccctgcct tcttcctatt ctaagcgggc acctcaatcc
     1561 ctcaaccaaa gtcaaagcga ccgaatcctt caacaatttc agtctccagc ggcggacatc
     1621 cgccgaaacc ctgtatcaga agccgggaac agagcgatat gaaggatctg agcgttgcct
     1681 atcctgacag cacacgagtt agccaggacc gaaagccgta aggctaaccg atgcacatgt
     1741 atggtaggta gcattgtagc gagggattca aattttccct caactggaga agcaatcgcc
     1801 aaaaaagcct cttcagttac gtaggttgtg caaggggata acctttgtat cagaatcctt
     1861 ccatgaagat gaaagggcct actcacgtca tgatagaaag accccaagac cttgtagccc
     1921 ggttgagaaa cccatatgtc tgtatgggct gattttattc ctttgcagat caatccttat
     1981 cagggcccag tctttggcca agattatctc tgtccactga aaatcggtag gattatgaga
     2041 taattgggtc aggtttcagg acagaactac tgagccacaa gcctgctcag ccttgccaca
     2101 gggaaaggaa ggacttgggg ctgtcaggga aggggattga cttgaccgtt ggggtgacat
     2161 ccatccatcc gcagatcaac tgaagtccca caagcaggaa taagaaatat gatggacttt
     2221 cgagtcagag gtggtgctga gacatggcaa tggcgattgg ataattcagg gtatggataa
     2281 tggaggtgga ctgggtagta cggaaggatc agacacaagg tttcggcatt tcacgatgtt
     2341 ccccataggg cgaatttccc gcaaggtcgc cgatcataag cggcgaatat tgccctgtcc
     2401 tttggttaac ttctccaccg gggcatgagt cctatcatga catggatcca gcgcctctga
     2461 gatgcagaat ccttacggct gtccccgcgg aagacatacc tctctatcga cacggcacca
     2521 cctcctcaag gtgacagttt tccttggtca agacaaaaaa gcttggcctc gttacattgt
     2581 cttcctggtg gatacagacc tgcctgccgc gtggggttga ggatgacaat ccttgccggc
     2641 ggttagaccc ctgttagctt ctcacccccc atggactcac accctctgac ggaatgctga
     2701 gtatcagatc tctgggcgta agaacgactt gtattacggg atacgtagaa ggcaaagaga
     2761 agactcaggg ttcaagacat aaaagcagca aaaacgtacg acaagaagcg caaatactcg
     2821 tcgtcacact atccacttca atttgtttac cccagcacaa tggactttac ataccgctac
     2881 tcatttgagc ctacagacta cgacactgac ggtctgtgtg atggtgttcc agtacgtatg
     2941 cacaagggtg cagacctgga tgaagttgcc atcttcaaag cccagtatga ctgggagaag
     3001 catgttggtc caaagttgcc ctttcgaggt gctctaggtc ctagacacaa ctttatctgt
     3061 ctgacgctac ctgagtgtct gcctgagagg ttagagattg tgtcttatgc taatgagttt
     3121 gctttccttc acgatggtga gtggtgccta ccttatttct tgatgagggc tgacgaagat
     3181 agatatcact gatgttgagt cggctgaaac agtaagaggc attttgtatt tccaagtagt
     3241 caatgctgac tttggcaggt tgctgctgag aatgatgagt ttcttgatgc ccttcagcaa
     3301 ggtgttcgag aaggcgacat cgagagtcgt gcttctggaa agcgccatct ccaagcctgg
     3361 atcttcaagc agatggctgc cattgatcgt gagcgagcca tagcagccat gaacgcttgg
     3421 gccactttca tcaacacagg tgccggatgt gcccacgaca caaacttcaa gtcacttgat
     3481 gactatcttc actacaggtc cactgatgtt ggatacatgt aagtaatccg gcccaagaat
     3541 gtcaatgcct actaacaagt cacaggttct ggcatgctct catcatattt ggttgtgcca
     3601 tcactatacc cgagcatgag gtcgagctat gccacagact tgctctcccg gccatcatgt
     3661 cagtaactct gacaaatgac atctggtcat acggcaagga agctcaagca gctgaaaagt
     3721 ccggcaagcc tggcgaattt gtcaacgctc ttgtcgtctt gatgagagag cacaactgct
     3781 ccatcgagga ggccgagcgc ctttgcagag cacgaaacaa gatcgaagta gcaaattgtc
     3841 tccagaccac aaaagagaca cgtgagcgaa ccgatgtttc tcaagatctc aaggattatc
     3901 tgtatcacat gttgtttggt gtcagtggga acgctatttg gagcactcag tgccggagat
     3961 atcacatgga tgcaccatac aacgagaggc agcaagctag actcaaccag aagaaaaata
     4021 agctttcttc cacttatgat cctatccagg cttctaagga ggcgctgaag gagtctactc
     4081 gtcctgagat tcataggcta cctactcccg acagtcctgc caaggagagt tttgctgttc
     4141 ggcctctggt caatagtagt ggggagtttg atggtaacgg ctacatcgat ggtcacgagg
     4201 ccaacgtacg tcccaagcct gttgtcaatg gacactctga tgctgaggag cgtcccgcct
     4261 ttgagaggaa gggctctgct aagcgcgcta cctcagcgaa tgacattgat tggacggcac
     4321 acaagaaggt ggaccatgga aatggtcaca aaaagactct gtcagatctc atgctgcaag
     4381 acctgcctcc catggaagat gatgtaagtt gataccgcct gtgcttccgc acattgctaa
     4441 ccatattcag gttgttatgg aaccataccg atatctctgc tcccttccct caaaaggagt
     4501 tagaaacaag actattgatg ctcttaactt ctggctcaag gtccctgccg aaagagcaaa
     4561 caccatcaag tctatcacag agagtcttca tggctcatca cttatgtagg tcatctgcct
     4621 tactgaacca cctttcctta ctgacattcc caggctcgat gatatcgagg accactctca
     4681 gcttcgacgc ggtaagcctt cagcgcatgc cgtctttggc gaggctcaaa ccatcaactc
     4741 cgccacattc cagtatatcc aatctgtaag cttgatcagc aagcttcaaa gccccaaggc
     4801 tttaggtatc ttcgttggta agtcattagt gaaccatggt gtactgccga agctaacgac
     4861 tgcatagatg agattcgaca actcttcatt ggacaggctt acgagcttca gtggacctct
     4921 aacatgattt gtccatctct ggaggagtat ctgcaaatgg tagacggaag taagtgatat
     4981 tcgtacttac tttgcagtga gtgtactaac tctggtagaa actggtggtc tattccgcct
     5041 gctcacacgc ctcatggccg ctgagtccac aacccagcaa gacgtcgact tcagccgtct
     5101 ttgtcagctc tttggccgct acttccaaat ccgcgatgac tacgccaatc tcaaactcgc
     5161 agacgtaatt ctaccttcca ttaccttctg atctctacta acaagcatag tacacccaac
     5221 agaaaggctt ctgcgaagac ctggacgagg gcaaattctc acttcctctc atcatcgcct
     5281 tcaatgagca gaacaaagct ccaaaggcag ttgctcaact ccgcggtctc ttgatgcagc
     5341 gctgtgtgaa cgggggtctg agctttgagc agaaggtcct ggcactgagt cttatcgatg
     5401 aggctggtgg tattgaaggt accgagaagg ttttgcattc tctttatggt gagatggagg
     5461 ctgagttgga gagattagct ggaatctttg gcgaggagaa ttgtcagctt gaacttattc
     5521 ttgagatgct acgaatagat tagttagttg agatatgata tacgggaaat tgaaattgga
     5581 tcttgtttac aatcaactac tacttacttc attggttagg ggtgaaaaaa aactaagata
     5641 gagagcagga atgtaagctc tactgcgatg aatcactaac ctgttcagtt agaaacaaat
     5701 gatgctgctg ttaggatgaa aagtgttgca tctacatgtg ctgtcctaag ctgaaagtct
     5761 cgttcaagaa aaaagctatt tggaggaagc agagtacaaa agttaaacac gtccagtatc
     5821 gttttcggcc atggtataat tctgttaaag atgattgtgg gactcaccac aatcaatcac
     5881 atatagagta aaactttact tattaaaact gattctacaa gctaggaggt ttatggaaaa
     5941 cctattgtca acgtacaatt tgaacttgcc cgatatttac tgattgagat agttatgttg
     6001 gttcagataa agccaagatt gattttccta acctatagcc cttttttttc atggcattcg
     6061 tttgtcgctc ccggctccgg cacaaaggtg aacacagaac gaggaatcga gcacttattt
     6121 tccccacaat cttatgtcag actagctaat ctacgcgcgt tgagttgcta ttcctttgaa
     6181 tcctcgccat ctcaaagttc ctgtctctca ccgcgggcca atagcgtttg attctatccg
     6241 aggctcagtc acgcaagatg ccaagctgcc agtaatccat aaatcaagaa ttgctatcgt
     6301 ctgtcgtgga gaaatggaga tcatacgaat tacctatagt ggtagagtgg tatcgtatgg
     6361 ttgcccttgc atgctgacaa gggggggtgt gaaggtcgat gcaaacctgc aagcttatct
     6421 tagacatcca cttcccctgc tacggcacgg tccgcggacg cggtcagctt agcaaactaa
     6481 ctccgcatcg ttttttgtaa ctcgtaaagg gtgtcatgga gcgacgggat atccacacga
     6541 agatcttagt atcagcttac ggtcatcatg gaaatctcgg cactgggcat tgccagtaga
     6601 cggctcgtaa agccatgtac ttgtcgtcta tttcccaacc cctccttcat gaccaaacaa
     6661 catccgattt ctgtctccac taaaggattt ggatgtactt cacctgccag ggtaaggatt
     6721 gtcgtttctc cgcccacaac ccgccttgta attatgcagt caatcctttc tgacaagcat
     6781 gtacttcgca aggtcccccc acgtgcttac tcttgtgtca ccgttaagat gcatcttgga
     6841 caccatcctt cagagaaacc ttccgaagtg aaggtgtgct gccaaggtag ttgacgaacc
     6901 aggggtacaa tccttacagg aaccctccga cagttaccca cacttcacgc taagtgagag
     6961 aaaccttccg ctccggcatt tgcgcctcta tcacgatgat tctatatgcc ccatcctggc
     7021 attgatggag tgagatttat gatgagaaac ttcaacagac gcacgcgtag gaacaatgac
     7081 gaaatgagga ttcgacaaag aggaggtggc gttttaggtc tgttccttct cggcatatca
     7141 tggaggcaga taatctgtaa tcccgctgac atggcttcgt aatagtatcc aagatcaaaa
     7201 gtgacgtacc aaaaggcttc ataggactcc ttcctatacc ccgagattcc tcaagacaaa
     7261 ctcactttac cttctttccc ttactcaacc gatatcctat cttgtagaga aaatggagag
     7321 actcaagatg gacagtctca atatcaacat caacgattgg ttcgagcgag atcttcccaa
     7381 gacaccagac tggaagctct tcgctctcgc cagtcttgcc tttgttgctc tacgctttac
     7441 ctgcactgtt atctaccgtc tctacctttc tcctctttcc aagttccctg gacccaagat
     7501 tgctgctgct actcatctct acgagtccta ttatgacttc tggaagaagg gacagtatta
     7561 caaggtgatc cagcgcatgc atgaagtata tggtatgttg gccttgagga cttctcgaat
     7621 aaagctaacg tgacaggtcc aattgttcgc gtcactcctg atgaactctc catcaatgac
     7681 ccagactttt atgatactgt ctatgtcaat ggtaacgttc gccgtacaga gtcctttggc
     7741 cactctttcg gtggtggact tggtatcgag ggtgagctcc tcctcccaac accctcagac
     7801 ctcctctaac ttgatagata ccttctttgc ctctcaagac catgacctcc accgcaagcg
     7861 aagaaagcca attgagcctt acttctctcg caatggtgtc ctgaaacttg agcagctcat
     7921 caatgagcga gtcgagaagc tgttcaataa gtttcatgag ctttctggta ccggtgtcgt
     7981 tgctcgtctt gactatgctt ttgaggcttt cacgggtgat gttatgcagc acatttgcat
     8041 tgagaaacct gagtcgctcc tcaacagtga tgatttttct tctgagtggt atgaggcgtc
     8101 cgtaaatgtg cttgagaatg acatatgctg atctgttttc aggtttgaga tgcttcgaaa
     8161 tgtttctcta tcggtaccgc ttatgggcat gatcccatgg cttgttcagt aagttgaatc
     8221 gccttcgatc catacagtca ccaaccattc gcagcatcct caagttcatc cccgagcgtc
     8281 tcattatctg gctcgcccca gaagctgctc acttccaaaa tttccgaatc gtaagtgttc
     8341 attcctgtcc attcctccag gcactaacca tctacagcaa gctggtcgtc aaattgagca
     8401 agccaaacag gagaaatttg ataatgatcg taagggtgtc gctactgtcg gtggtaaacc
     8461 cactctcttc cgctttctcg ttcacgagag cggtcttgca cctgaagatc tcagcactga
     8521 aagacttcag aaggaagcaa tggttcttct tggcggtggt acaaccacta ctgcgcgcac
     8581 ggctaccatg acttgcttct ggatgctcag catgcctgag aagggtcagc gtcttcggga
     8641 agagcttaag gatatcatgg cagagtatcc caagaaaaag ccttctttaa ctgaacttga
     8701 aaaacttcct tatctgggag ctgtcatcca ggagagtttg aggtacgccc accccacaga
     8761 cagggttacc cctgcttagt ttgctgacat ttcctctttc agaatggctt atggatccat
     8821 gcgacgtctt cctcgcacct cgcccgatca agctctgcag ttcaaagaat gggtgatccc
     8881 tcctggggta agtgacacat tgaaatgggg gccgaaccaa caagttcagc ctcaagattg
     8941 ataagctcac gcactaatgc ttgttccaac tacagactcc cgttggcatg aacgcttatt
     9001 atctgcacac tgatcccaat gctttccctg agccaatgga gtataaacct gagcgatggc
     9061 ttggcgaggt tacgcctgcc atgaagcgca gtttcgtgcc tttctcccga ggctcgcgac
     9121 gctgccctgg ctccaggtat gtctcaccac cattttccgt atgcgaatga atactaattc
     9181 gtgcacagct tggctctggc cgaccttcat tttgtccttg cggcattgtt tggaccaact
     9241 ggtcccaagt ttgaactttt tgagtcggat aggtctgacg tggatgctat tcacgactat
     9301 ttgatgccgc ttcctcggct ggactctaag ggcgtccggg tcaccgttcg atagatagga
     9361 aatgactaaa ttcatatttc gtgaaagaag gttgagattc aagagaagaa tgatgctccc
     9421 aacgtagtgg ttgagcaatg agaacttcgt ggttagatat tttctgtagt ctctcattta
     9481 ggcagaaata ttacgttcct taaaaagaac acattcaacc caagttttcc ataagacttt
     9541 acatgacagg tctagaggtg aaggtgaaat taattcccgg tacacctcat cgtatcgcca
     9601 gagatgggta aagatttaat atcaaatttt ggatcacggg aattctacga aactagccag
     9661 tcaataacgc tgtaagctcc atgggcctcg tgatagatta cacagatgag agtcattctg
     9721 ttccatatca gactttcatc actgtaggca gtgttgtcgc tgcaaacatt gtgaagtcct
     9781 tcgtatacat gtttgactct tcagaagaat ggacccaata attaaacctt ccaggaactg
     9841 tgacgagaat gattaagttc tcagcatgaa gtatccaagc agtactgggc ataatttcat
     9901 gagaagtcgt tttttattga gaacaatttg tattcaatat gtgatctaaa cgaatgacct
     9961 aatccgttgt cgttcccttc ttcaaggtgc aaagtctctc ggcttcaaag tcaagataag
    10021 cggcttcttg tcccaagcaa gaaagcactt ctgagaagaa tgccaatcct cttggttggg
    10081 gcccaactca aagtcaaacc ggtacaagat tcgactaacg acaacacgaa tctcggcgtg
    10141 agcaagattc ttaccaagac agtccctcat accgaatcca aaaggccgga acactgagcg
    10201 gttgtcattg gcatacttgg ggttgtgcag cgggtgagac ggctggagcc accgctcagg
    10261 gacgtaatca tccgggtcag caaagttatc agggttgtgg aatgtacccc actggtagat
    10321 ggacacgatg acctgtgatt gttagcaaga atgtcatggt ttgggtaggt ggaaggcctc
    10381 actcctttgg gaaggtattt gccttcgatc tcggcgcctg ggctgattct tggtggcgac
    10441 tcggcggcag ggggataaac tctcaatgcc tcatcaacag tggcgttgag gtactcgagc
    10501 tgtttggtgg tcttcatgtt tatctcgctc tcactcttga aagaagatcg gacctcctcc
    10561 accaatcgtt gataggcctg gggggaagta ccaaggtaga agaagaatcc tgataatgca
    10621 gtagtggtgg tttcactgga ggcaccaatc aagacaggac aatcgacaag gatctccggg
    10681 tcagtgagac cgccaccatc acggttacga cgcatcaaga agctcataaa gtctcgacgg
    10741 ccaggggtgg gttgctctcc aagcttcata cgctgcatgg cgtgatggaa cgtcatgttc
    10801 cgctggtccg tctcacgctt aatttgctcc tttccggtga agaagaagtt catgagaggc
    10861 tcgatgacag ggtagtgctt aacaaagcgg ttcatagcat tacccttgac ggcccagaag
    10921 aagttggaca cccaagggtg gtactcctgc ttatccagac aatcaaaggg ctgagagaat
    10981 accagctccc ctgcaatgtc gaagagaaga aagttgatcc aatcaacgat gttgataggg
    11041 tcgccgacct tggctcgctc actcagacgc tggagaagca tatccgtgta aggctggata
    11101 acgatttcct gctcaacaag ggcttgatcg ttgaaagcag accagaactg tcgacgatga
    11161 cgacgatgat ttgtctgatt ggcgccaaga atactgagtc catcaccagg gaagatgtac
    11221 tcaggatact tggggaactc gtcatctttg cctctcatgg cgtacacctg gaaccagcca
    11281 atactgccat cgacggcaag gcggttagga ccaatgcgca cgatgggacc gtacttgcgg
    11341 tgcaagggcg agactctcca gatccaggtt cctgagatgt tgctcatcca gcgttcagga
    11401 atgttggtag ctgcgagcca ttttggacca gggaagatgg agaggggatg gaaccagacg
    11461 cggtagatag cgatggctgc caaagaggtg accagctttg gtactgtcag ttacttcaaa
    11521 gttggtaaca aaagtcgaac gtacagtggc caagctaacg atggcaaggg ccacgagctt
    11581 gtcatgttcg agcttcagag cgaaactcgg aagttccatg ttgcgatagg agattgtcat
    11641 tgctttagac tgtgatgttc tgagcaagtg ccactcttcc ctctcttttc gtctgtattt
    11701 atgtccgttt gatcccgagc aaaagagaaa acatcatctc actggcagta actttcgtaa
    11761 tccgacaggt ttattgtccc tcttccctga tgtcagttct tgttgctgat tctcttctca
    11821 cgcaagggct aaatcctttg caaatctgac agggtggttg tgcagcttac atacaccccc
    11881 ggtagtagga tctgaaccct ggtattcggg ccgcagtatc tagacagggt ttgaaccagg
    11941 gcggagaaga catccggctg gcaaagtgca agggtagggt gtatgaatca gtcagccaca
    12001 agtattttaa ccctccaaga gttggtgatc tgttctcagg agaatgtggg ttgaaaggaa
    12061 gcggggaaga ggggcagtca gatcctatgc agggatccat cgttcgatat tcatgttatt
    12121 tctccaagtc ctattctggg ctagatggaa gaggattatt gtagcgttgc ttacgctgtg
    12181 cctcacacac tgatagctcg gcatcgaaac atacgcggat ccttccagaa atcttccgaa
    12241 ggtacgtcat cagcagagcg attttgcgat cagataacaa agcccgctta ctgcagatcc
    12301 tgtaagacaa actgaactgt cgttacggcg acatgggccg ctactagtag gtaatcttcc
    12361 tatctgtcct ttgattctgc cgtggggtgg ctttgatgta gttctgaggt aagcagcaaa
    12421 agcatgatat gatagtaaga atcagcccca tcttggccag ctggaaagat actttatgtt
    12481 ccgccacaac atcggaaact cagcaatctt attggctaag atatgattgg gataggtatc
    12541 attttgtctt gaatcaagtg cttggggcat aggctatagg gcatcagaaa catcggctag
    12601 acgaaacagt ttggtcattt gtgacgagat agtttggact gacacttacg ctgctctaac
    12661 tcgttggtcc aggtcttaca ggatgaatgt tctgttacct tccaggcgag acattatttt
    12721 tccagaatcc tgaaatccac agtattttgt gagagtttct tgtgattgac tgaggcttca
    12781 acaagtcagg gctaagaatc agccaaagct aactgtaact tcaaactggt aaaagcacag
    12841 tgaaagacat caatgctcat ggatgactcc agatcatgat attaactgga agtacatgtc
    12901 tacaggagcg tttggcaaac atagtaaatc aaacaacaca agtatcattg aactattctg
    12961 cggacaggct aaacgacccg gttgactttc aagaaccttc caatagcgtt gatcaaagtc
    13021 gcaaagagtt cgacaaacca cataataatg ctgcttgttc caaccatggt catcgggaca
    13081 actgtcatga agaaggcacc gaaagcaccc tcgcggcggg tgatagtctc ccaaagctca
    13141 ccaccaagaa catccacagc accatcccac tggtacggtc caacaacgcg gaacttggtg
    13201 ttgaactgag ctcccgtcaa ccataaaacg ggtaaacgcc accagaggcc aggatgctta
    13261 gcaccagcgt tccacccagc gcgaacaccg tcccagaagc tgggaacagc atccatgtcg
    13321 agagcaagct ggtaagcgta agattcatga tgaacgccgt agtcgatacg cttgtgacca
    13381 cgaagcttga aatggtagtc ttctctggag ctaagtgatt tggccatctc agggttgatg
    13441 agagtcatga gccaaagctg ggcttgaagc tctgcaaggg gaggtattgc gccgtagcca
    13501 ggacgtacga atccaatgaa accaacggta gggtcattgc gacgccagat gcaacgaaca
    13561 tccgcgtctg cgcaggttgg atagttttca ccgttcttgt tggcttcgtc gaagaatgca
    13621 aattcctgac gatagccagt ggcatagacc accatgtctg gttttacagg gcccagcgtc
    13681 ttcatacgtt ctgcctcggg acggccattc tccttgaagt gcatgatgcc cttttcatcg
    13741 atgtgactgg gccaaggagc aaggtcgatg tatttacctc ccggaacctt cttgactggg
    13801 actgtgacga gggcgcggcg aatacgctct ataataccag ggttggtagg gcgataaggc
    13861 tcactgatgt agtgaaggca cctccagaca gccttgttga agaagcctgt gaactgttag
    13921 taacttcaca ttgtagttgt taaataccaa gataacttac tttgagatgt gtggaaacgc
    13981 tctttgtcga gacctccaac ccactgatca acaccgtcgg tggtaccaga gcaaagccag
    14041 ttggcaacct tgatgttgaa atcttggaat ctccaagtga agagacgatc tctcaagaat
    14101 gggggcaagt acgaatcaag cagaggagct tgccagctga cgtcaatggg cagttcctga
    14161 gcgttggggt tgggcttatt ccccagacaa gggaacaaaa tggggttcgg gattttctat
    14221 aaactcagtc agttttggtt tttgatatgc tacgggatga ttttaccttt ggagctccga
    14281 gaaatccttg tctgtgacaa agaacgacgc gcttggtagg tgaagtaaca gcaagatgag
    14341 caatatccat acccgtctca ccagtaccta gaactacaac ctggctacca tgagggaact
    14401 cttctctctt cttgaactga gaagagtgct tgacaatctt gaccttgtca gtaccctgaa
    14461 catcgggaat gttaggtgtg acgtgaagac cagtgcagac agcgacagca tcgcattccc
    14521 aggtcatgtc aacgccatca ggaccacggt agtgaatgac atgaccacca gcctgacctc
    14581 ttctaattga agtcacagaa gttgaaagag aaatctcagg ccaaagattg aagtggtctg
    14641 cgtactcttt caagtaccgg atgaaccttt ccgcactgag aaagtctggg tcttcaagat
    14701 ctgcgcgcca gtcggagaag cacgtcagat acttggagga gacaagctag ttgactatca
    14761 gtataggtat ctttcagacg ctgttgagag ccttacttct gcatcctcgt aagtacgctt
    14821 tgtaaaagta ccaccgaccg catcctcacg ctcaaagagt cgagcttcga tggggtcaat
    14881 gtcaaagaac ttggtagctt ctttaagata cttcaacgta gtaagaccac caggaccagc
    14941 accaacgaca gcgacacgca tattggagaa gatagatgag agatcaggaa agggttgaga
    15001 atgaggttgg ctggtgctga gtcaaagggg agagacttga cagataatag ctacatatcg
    15061 caacatatac gcgggcggca tctataccct actctgtaat atcaagcttc attgtggcaa
    15121 ggaaaattac aatatccatg caagtcgaag gcgttatcgg atccttcagt tcaaaggatc
    15181 tgtttactag aaaaactccc ctcgggggtg ggtacgtaag attccccacg acatccttgt
    15241 cagttgcctc acggatatca cacacttcga aaataacgac agaacaagaa tgagacaata
    15301 ttcgtaatcc ttcggggata ttgatgacga aggtggtaag cgggatccac ctccagcctt
    15361 cgcgagtgtg agagcgccaa tttgggcaat tcgagtttag attcttggga gtacctggta
    15421 taaatggtga gaaggcaaag tgccacatac ccagctccag atattctgaa cacctttgaa
    15481 cccatctctc actctaccaa cccatcttca tttcctcatc atgtcccaaa aaggccctca
    15541 gatcatcttc ggcacagcat ccatcggcta tggctctctt gccgaggaag atgctgtcaa
    15601 acaattcctc aaggtagctt ctgacaatgg tgttaagcaa cttgacaccg ctgcgagcta
    15661 tcctaccgag gaaactactg gccagactga ggttctcctc ggaaaggtca agtccggcaa
    15721 tgaggactgg gttattgaca ctcgagttgc catcagccgt aacctccaag gcgctttggc
    15781 acctgacgct attgaaagga gcttgagcac cagtctggag aagcttcatc agcgttctgt
    15841 gaatattctc tcggctcata tgcctgatcc tgctacttca cttgaagatc aggcgagagg
    15901 tttcgatgaa cagttccgtc agggcaagtt caagaaggta aggcatgtct tataccgatg
    15961 ttgcctctgg ctaacttgca tcagctgggt ctttgcaact ggcctctcag catgattgag
    16021 aaatacatcg aaatctgcga cgccaaaggc tacgtcaaac catctgtcgc ccagtacatg
    16081 tacaactaca tctggcgcgg cacagagtca actattctcc ctttcctccg caagcacaac
    16141 atatctctcc acgcctacag tcccctagca ggtggcttcc ttacaggcaa gcccacaagc
    16201 ggtgacacag cgggcacacg ttacggcgag cccactcatc ctctgaccat ttacaagttc
    16261 atctacgaca aggagccatt ccaccaggct gtcaaggacc tgtacagttt aatcaaggat
    16321 ggtcaagttg aaagcacctc tgatgttgcg attcgatggc tgtactacca ttctaagctt
    16381 gagcctcagg atgcgattat cctgggtgga tccaagattg agcactttga gaagaatgtt
    16441 gctgctgtca agaaggggcc tctgcctgag gctgtgttga aggctcttga ggggctgggg
    16501 gtcagtgatg ctggtatggg tgatggaaat gtgtttggtt cggtctttga acagtag
//
