LOCUS       BGC0001660              7887 bp    DNA     linear   BCT 13-JUN-2017
DEFINITION  Marinactinospora thermotolerans strain SCSIO 00652 mathermycin gene
            cluster, complete sequence.
ACCESSION   BGC0001660
VERSION     BGC0001660
KEYWORDS    .
SOURCE      Marinactinospora thermotolerans
  ORGANISM  Marinactinospora thermotolerans
            Bacteria; Actinobacteria; Streptosporangiales; Nocardiopsaceae;
            Marinactinospora.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 03:19:48
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 7887
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..765
                     /codon_start=1
                     /gene_functions="regulatory (smcogs)
                     SMCOG1041:transcriptional regulator, SARP family (Score:
                     249; E-value: 1.9e-75)"
                     /gene_kind="regulatory"
                     /note="MatR1"
                     /product="SARP"
                     /protein_id="ARW80048.1"
                     /transl_table=11
                     /translation="MAHRLEFRVLGPLDVTSQSGPVRIPAGKQRVLLSALLLAPNTVVS
                     LEELVGLLWDDVRPDSPRAALHTCLTRLRATLDSRGAGPSGLIRTTAAGYLIEVGPEEL
                     DLLRFRAHSGAAHAAAKRGDQAAERMALDRAVELWRGPMLPDVRSASLHRDVVPRITEE
                     WLRVRERRHEISMAGGCYDELVGELRELVRRYPFHERFWYQLIVCLCRCGRRVEALEAF
                     GEISGRLREEMGMDPGRQLRDLHLSILRGEPD"
     source          1..7887
                     /db_xref="taxon:531310"
                     /isolation_source="deep sea marine sedmient of South China
                     Sea"
                     /mol_type="genomic DNA"
                     /organism="Marinactinospora thermotolerans"
                     /strain="SCSIO 00652"
                     /type_material="type strain of Marinactinospora
                     thermotolerans"
     misc_feature    1..7887
                     /note="mathermycin gene cluster"
     protocluster    1..7887
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[1784:4994]"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1785..4994
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    1..7887
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..7887
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001660"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..7887
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             833..1006
                     /gene="allorf_0833_1006"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_0833_1006"
                     /protein_id="allorf_0833_1006"
                     /tool="antismash"
                     /transl_table=1
                     /translation="LKKFAHISYRFTGKCAAECKWRESPLKAWAAYIYFARCRGTVKSG
                     IFRNLCLVCPDQ"
     CDS_motif       833..940
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     LKKFAHISYRFTGKCAAECKWRESPLKAWAAYIYFA"
                     /locus_tag="allorf_0833_1006_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       941..1006
                     /prepeptide="core"
                     /locus_tag="allorf_0833_1006_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.20"
                     /molecular_weight="2329.8"
                     /monoisotopic_mass="2328.2"
                     /core_sequence="RCRGTVKSGIFRNLCLVCPDQ"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="LKKFAHISYRFTGKCAAECKWRESPLKAWAAYIYFA"
                     /leader_location="[832:940](+)"
     CDS             1019..1384
                     /codon_start=1
                     /note="MatN"
                     /product="hypothetical protein"
                     /protein_id="ARW80049.1"
                     /transl_table=11
                     /translation="MTVKPPTIYEGVHTIRQIQSLMILCSLLPPDGKLREALQIALALH
                     EEPLLAQITPISDLHPHTAKEWLETLWRRDDLSPQVKELVDWQSNSDNMSAAIQELRNV
                     EQQSGMKLVAVKPEQTT"
     CDS             1420..1659
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /note="MatA"
                     /product="structural protein"
                     /protein_id="ARW80050.1"
                     /transl_table=11
                     /translation="MSMTMTLQQAVVDDEFRSVLLADPAAFGLSVESLPGAVERQDHEA
                     IEAFTEAVVASEIYACASTCSFGPFTIACDGTTK"
     CDS_motif       1420..1530
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSMTMTLQQAVVDDEFRSVLLADPAAFGLSVESLPGA"
                     /locus_tag="ARW80050.1_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       1531..1659
                     /prepeptide="core"
                     /locus_tag="ARW80050.1_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.80"
                     /molecular_weight="4325.7"
                     /monoisotopic_mass="4323.0"
                     /core_sequence="VERQDHEAIEAFTEAVVASEIYACASTCSFGPFTIACDGTTK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSMTMTLQQAVVDDEFRSVLLADPAAFGLSVESLPGA"
                     /leader_location="[1419:1530](+)"
                     /alternative_weights="4343.8"
                     /alternative_weights="4361.8"
                     /alternative_weights="4379.8"
                     /alternative_weights="4397.8"
                     /alternative_weights="4415.8"
     CDS             1785..4994
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     668.5; E-value: 2.9e-202)"
                     /gene_kind="biosynthetic"
                     /note="MatM"
                     /product="class-II lanthipeptide synthetase"
                     /protein_id="ARW80051.1"
                     /sec_met_domain="LANC_like (E-value: 5.1e-64, bitscore:
                     205.1, seeds: 47, tool: rule-based-clusters)"
                     /sec_met_domain="DUF4135 (E-value: 9.1e-72, bitscore:
                     231.1, seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGNAHPVDIAARACNLAERMRVVESLGGPPPTAPTDLGPLDTWRI
                     GRIAGRLALKAAREVHHVPTPPRYDKDELVRVLTDYRRHELALDSSEDSAAKLRELLGD
                     IHGEWLPTYRSALEGFDAGEDPDAGWRDFDTYYGRLAKACEPFLLELGRRLRGPRRPDT
                     APAAPGVVEGFQRHLLDRFELALAWAVEADAKVHCAQAGIDPDRASRDDYLGYLDSTFG
                     DASSYHAFYLRFPVLGRWLAHVTRLLADYGRDLTAHLAADGPLLSRAFFDRPVTGVRAV
                     RLGRSDPHAGARSVAFVDVELADGGTGTVVYKPRCIAAESAMQELLSRITEDGALDFAT
                     RHVLPRDGYGYEALIPSGRNRVRTSEQVKRIYRQLGGYLGVFHALGGGDLHFENVIVAD
                     GNAYICDCETVLGVRPKGQGNKSGTLLDSVFSTGLLEWPDSQARGGPATMRISGYTGGT
                     SYEMPVAVPRIGDERLSFRAGVVHRTGVEVHPDAANRVFLGEQLVQPDEHADAIADGFA
                     RVYEWFRRPDAARHVTEVFTGVSVRFINRSTQVYAQALMSARHPKALSDPLEVDLLNSV
                     VRTFPRAWDDGGILVEHELGSLWRLDVPLFSVQATRRDLVHDHRGEIPGYLELSPLEHV
                     TERIGRLSDTDRGRQHHYITASLSTGEITSPSFVAACLDKAAQVGDRLCAALREPTASA
                     PWTSYDVSDGRTVKVDVEGDLYHGAAGIALFLAHLDSLVPRPEFRRAAERALAHAVTAC
                     DTDRIGAFQGMGGLIYLLTHLSRLWDDPALLERAVRLGRELPDRIDADRHLDLFGGAAG
                     LIPILLGLAAATDGNGLDTARQCADHLLRTAEADGEALTWPPFPPESNPVPLTGFAHGS
                     AGIGWSLITLGAFLDRGDYVEAGRRAFAYEARHFDSTEHDWYDLRTLGGGVARGGRHYA
                     NAWCNGAAGIGLSRITGWAALGRDDEGLLLEARQALAATMRNFPRLRNDTLCHGRSGNA
                     ELFLRFAELKDEPAFRMEANVQAQAQWRHLESGEGDSTRFFPGLMLGIAGTGMHMLRLA
                     APDRVPSVLLLDPPVSTTEKG"
     CDS             5003..5905
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03798"
                     /gene_kind="biosynthetic-additional"
                     /note="MatX"
                     /product="non-heme FeII-dependent hydroxylase"
                     /protein_id="ARW80052.1"
                     /sec_met_domain="TIGR03798 (E-value: 9.3e-08, bitscore:
                     21.2, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIESCTDFLRTAYASEELMRTLRAMTGPKEIIALGRRHGYDFHL
                     GDLATASMSFAPESAPGPRPAASPPPSESVFYHHEYDIADLPGFGDIIDLLPRLKVQPD
                     TVDLARFADRYREEDRASTDLSPVSQEFRRWQNRVEREESARGADPQQRGFHLVNLDEH
                     VDHSGYDSYLDAKSAAVGALERAFGTEVRFSGSMWYPPSSYRLWHTNETQPGWRMYLID
                     FDAPFTDPEHTTFFRYLHPRTGELVTLRERPRIARFFKIEQDPDRLFWHCIVNPTQRHR
                     WSFGFVVPDDWRERLGLPA"
     CDS             5966..7012
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 219.2; E-value:
                     9.8e-67)"
                     /gene_kind="transport"
                     /note="MatT"
                     /product="putative ABC transporter"
                     /protein_id="ARW80053.1"
                     /transl_table=11
                     /translation="MFRIRRFGGRTPAPAGPLPETPDGHAVPAIRAVGVRKNYPGVEAV
                     RGLDLTVAQGEMFGFLGPNGCGKTTTIAMMCTLARPTAGRIEIAGHDTCTAPGRVRRRL
                     GLVFQETTLDLELTAEENLRFHADLYALPRATLAGRIEEMLSLAGLTDRRDRPVRTFSG
                     GMRRRLEIARGLLHRPSVLFLDEPTLGLDPQARADIWEHLREVRRREDTTLFLTTHYLD
                     EAEQCDRIAIIDHGRIVTQGSPEELKSVVGADLVELRTGDDAAAARDLRDRFGLDPAVG
                     AGGVAVRAPDGARLVPRLCAGLDVPVYAVTVTRPTLDDVFLHHTGHRIREEPTPASATL
                     TELAGDRS"
     CDS             7009..7887
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065:ABC-2 type
                     transporter (Score: 147.2; E-value: 7.9e-45)"
                     /gene_kind="transport"
                     /note="MatH"
                     /product="putative ABC-2 type transporter"
                     /protein_id="ARW80054.1"
                     /transl_table=11
                     /translation="MTSIVAPSDRGAVGDERDRSSTFGAELRAGRMVWWREMLHFLRDP
                     ARTAVSLFQPLIFLFILGVGLSRLYAQAGADPGAGADYLVFLFPGVLVMAAQVPAVSVG
                     ASIVWDRQSGFLREMLVAPVRRSTLLIGKCLGGATVATCTGTVVLLCCGLVGVPYRFGL
                     SLLLLAELGLASLVMTALGALVAVTIRRIQTFNIVLGVLMTPLLFLSGAVFPVAAMPTW
                     MVPVALVNPLTYTIDAMRRTIAHYTEDGVALADPVAWGTWHPPVLLELGLAVGFSVVLL
                     ALAARRFARID"
ORIGIN
        1 atggcccacc ggctggaatt tcgcgttctc ggccctcttg acgtcacctc gcagagcgga
       61 ccggtccgca ttcccgccgg taaacagcgg gtactgctgt ccgcgctcct gctcgcgccc
      121 aacaccgtgg tgtcgctgga ggaactggtc ggcctcctgt gggacgacgt gcggccggac
      181 agcccccgcg ctgccctgca cacctgtctc accaggttgc gcgcgaccct cgactcccgt
      241 ggagcgggcc cctccggcct catccgcacc accgccgccg gctatctcat cgaggtggga
      301 cccgaggaac tggatctcct gcgctttcgc gcccacagcg gcgcggcgca cgccgcggcg
      361 aagcggggcg accaggcggc ggagcgtatg gccctggacc gcgcggtgga actgtggcgc
      421 ggcccgatgc tgccggacgt ccgctccgcc tccctccacc gcgacgtcgt tccccggatc
      481 accgaggagt ggctgcgggt gcgcgagcgc cggcatgaga tcagcatggc gggagggtgc
      541 tacgacgagc tcgtcggtga actgcgggag ctcgtccgcc gctacccctt ccatgagcgg
      601 ttctggtatc agctcatcgt ctgtctgtgc cgttgcgggc gccgtgtcga ggcgcttgag
      661 gcgttcggtg agatcagtgg gcgcttgcgc gaggagatgg ggatggaccc cggccggcag
      721 ctgcgtgacc tgcacctgtc cattcttcgg ggcgaaccgg actgaacgcc aatatggcga
      781 cgatagtttc ctagttctct aaaattgaca tccggccgtt ttttctcgaa gcttgaaaaa
      841 gttcgctcat atttcctatc gatttactgg gaaatgtgct gccgagtgta agtggagaga
      901 aagtccactg aaagcctggg ctgcttatat ttactttgcg cgatgtaggg gaacggtgaa
      961 aagcgggatt ttccggaacc tttgtttggt ctgtcctgac cagtgaggaa ggtggctgat
     1021 gacggtaaag cctcccacca tatatgaagg cgtccacact attcgtcaga ttcagagtct
     1081 gatgattctg tgctcgcttc tcccacctga cggaaagctt cgcgaggccc tccagatcgc
     1141 gctcgcgctg cacgaggagc ctctgctcgc ccagatcacg cccatatcag acctccaccc
     1201 gcacaccgcc aaggagtggc tcgaaaccct ctggaggcgc gacgacctgt caccccaggt
     1261 gaaggagttg gtcgactggc agagcaatag cgacaacatg agtgccgcca tccaagaact
     1321 cagaaacgtc gagcagcaga gcggtatgaa gctggtcgcc gtgaagcccg agcagaccac
     1381 ctgaccaacg gtcaggtcac accacgagaa ggagtctcca tgtccatgac catgaccctc
     1441 cagcaggccg tcgtcgacga cgagttccgc agcgtcctgc tcgccgaccc cgcggccttc
     1501 ggcctctcgg tcgagtcgct gcccggcgcg gtcgagcggc aggaccacga ggcgatcgag
     1561 gccttcaccg aggccgttgt cgccagcgag atctacgcct gcgccagcac ctgcagcttc
     1621 ggccccttca ccatcgcctg cgacggcacc acgaagtagc cggagagccg gcgcggggtg
     1681 accccgcgcc ggcggggtgg cgggccggtg gtgccggatc gccacccctc ggagtccgtt
     1741 ccgcgtgttt ccgccgtttc gtcgtccacc gaggagcccc cagtatggga aacgcccacc
     1801 cagtcgatat cgcggcccgc gcctgcaacc tggcggagcg catgcgtgtc gtcgaatccc
     1861 ttggtgggcc tcccccgacg gcccccaccg acctcggccc tctcgacacc tggcggatcg
     1921 gccgcatcgc gggccggctc gccctcaagg ccgcccgcga ggtccaccac gtaccgaccc
     1981 cgccccgcta cgacaaggac gagctggtcc gcgtcctgac cgactaccgg cggcacgaac
     2041 tcgccctcga ctcctcggag gactccgccg cgaagctacg cgagctcctc ggcgacatcc
     2101 acggcgaatg gctgcccacc taccggtcgg cccttgaggg gttcgacgcg ggcgaggacc
     2161 ccgacgcagg gtggcgcgac ttcgacacct actacggacg gttggccaag gcctgcgaac
     2221 cgttcctcct cgaactcggc cgccggttgc gcgggccgcg caggcccgac accgctcccg
     2281 ccgcccccgg cgtcgtcgag ggcttccaac gccacctgct cgaccggttc gaactcgcgt
     2341 tggcctgggc cgtcgaggcc gacgccaagg tccactgcgc ccaggccggg atcgatcccg
     2401 accgggcctc ccgtgacgac tacctcggct acctcgactc caccttcggc gacgcctcct
     2461 cctaccacgc cttctacctc cgcttcccgg tactgggacg atggttggcc cacgtcaccc
     2521 ggcttctcgc cgattacggc cgggacctca ccgctcacct cgcagccgac ggcccccttc
     2581 tctcccgggc cttcttcgac cggcccgtca cgggcgtgcg cgccgtgcgc ctcggacgct
     2641 ccgacccgca cgccggcgcg cgcagcgtcg cgttcgtcga cgtcgaactc gccgacgggg
     2701 ggaccggaac cgtcgtctac aaaccgcgct gcatcgccgc cgagtcggcc atgcaggagc
     2761 tgctgtcccg catcaccgag gacggcgccc tcgacttcgc cactcgccat gtgctgcccc
     2821 gggacggcta cggttacgaa gcgctcatcc cctccgggcg caatcgggtc cgtacctcgg
     2881 aacaggtcaa gcgcatctac cgccaactcg gcggttatct cggcgtcttc cacgccctgg
     2941 gaggcggcga cctccacttc gagaacgtca tcgtcgcgga cgggaacgcc tacatctgcg
     3001 actgcgagac cgtgctcggg gtgcgtccca agggacaggg gaacaagtcc ggcaccctgc
     3061 tcgactccgt cttcagcacg ggactgctcg aatggcccga ttcccaggcg cgcggagggc
     3121 ccgccaccat gcgcatcagc ggttacaccg gcggcacctc gtatgagatg ccggtggccg
     3181 tcccgcgcat cggcgacgag cggctcagct tccgcgccgg cgtcgtccac cgcaccggtg
     3241 tcgaggtcca ccccgacgcg gccaaccgtg tcttcctcgg tgagcagctg gtccagccgg
     3301 atgagcacgc cgacgccatc gccgacgggt tcgcccgcgt ctacgagtgg ttccgccgtc
     3361 ccgacgccgc ccgccacgtc accgaggtct tcaccggtgt ctccgtccgc ttcatcaacc
     3421 gcagcaccca ggtgtacgcc caggcgctca tgtcggcccg ccaccccaag gccctgagcg
     3481 acccgctcga ggtggacctc ctcaacagcg tcgtccggac cttcccccgc gcctgggacg
     3541 acggagggat cctcgtcgag cacgaactcg gctccctgtg gcggctggac gtccccctgt
     3601 tctccgtgca ggccacgcgc cgcgacctcg tccacgacca ccgcggcgag atccccggct
     3661 acctcgaact ctccccgctc gaacacgtca ccgagcgcat cggccggttg tccgacaccg
     3721 accgcggccg gcaacaccac tacatcaccg cgagcctgtc caccggcgag atcaccagcc
     3781 cctcctttgt cgcggcctgc ctggacaagg ccgcccaggt cggcgaccgc ctctgcgcgg
     3841 ccctgcgcga acccaccgcc tccgccccgt ggacctccta cgacgtcagc gacggacgca
     3901 ccgtcaaggt cgacgtcgag ggcgatctct accacggggc ggcgggtatc gccctgttcc
     3961 tcgcccacct cgactccctc gtcccgcggc ccgagttccg acgggcggcc gaacgcgcgc
     4021 tggcccacgc cgtcacggcc tgcgacaccg acaggatcgg tgccttccag gggatgggcg
     4081 ggctcatcta cctgctcacc cacctctcgc gcctgtggga cgatccggct ctgctcgaac
     4141 gagccgtccg gctcggccgt gagctgcccg accgcatcga cgccgaccgc cacctcgacc
     4201 tcttcggagg agcggccggg ctcatcccga tcctgctcgg cctggcggcg gccaccgacg
     4261 gcaacggtct cgacaccgcc cggcaatgcg ccgaccacct gttgcgcacc gccgaggccg
     4321 atggcgaggc gctgacctgg cctcccttcc cgcccgagag caacccggtc ccgctcaccg
     4381 gattcgccca cggcagcgcc ggcatcggat ggtcgctgat cacgctgggg gccttcctcg
     4441 accgtggcga ctacgtcgag gcgggccgac gggccttcgc ctacgaggcc cgccacttcg
     4501 attccaccga gcacgactgg tacgacctgc gcaccctcgg cggaggggtg gcgcgcggcg
     4561 gccggcacta cgccaacgcc tggtgcaacg gcgccgccgg catcgggctg agccgcatca
     4621 ccggctgggc ggcgctcggc cgcgatgacg agggcctgct gctcgaggca cgccaggcgc
     4681 tggccgcgac catgcggaac ttccctcggc tccgcaacga caccctgtgc cacggtcggt
     4741 cgggcaacgc cgaactcttc ctgcgtttcg ccgagctcaa ggacgagccc gcgttccgga
     4801 tggaggccaa cgtccaggcc caggcccagt ggcgccacct cgaatccggc gagggcgact
     4861 ccactcgctt cttcccgggg ctcatgctcg gcatcgccgg taccggcatg cacatgctgc
     4921 gtctggcagc acccgaccgt gtgccttccg tactgctgct cgacccgccc gtgtccacca
     4981 ccgagaaggg ctgacccgac cgatgtcgat cgaatcctgc accgatttcc tgcgcaccgc
     5041 gtacgcctcg gaggagctca tgcggaccct tcgggccatg accgggccga aggagatcat
     5101 cgcgctcggc cgccggcacg gttacgactt ccacctgggt gacctcgcga cggcctccat
     5161 gtccttcgcc cccgagtccg cgccgggacc gcgccccgcg gcgtcgccgc ctccctccga
     5221 atcagtcttc taccaccacg aatacgacat cgccgatctc cccggattcg gcgacatcat
     5281 cgatctgctc ccccggctca aggtgcaacc ggacacggtc gacctcgccc gtttcgccga
     5341 ccgctaccgt gaggaggacc gcgcctccac cgacctctcc ccggtgagcc aggagttccg
     5401 gcgctggcag aaccgggtcg agcgggagga gagcgccagg ggagccgacc cccaacagcg
     5461 gggtttccac ctcgtcaacc tcgacgagca cgtcgaccac tccgggtacg actcctatct
     5521 cgacgccaag agcgccgccg tcggagcgct cgaaagggcc ttcggcaccg aggtccgttt
     5581 ctcggggtcc atgtggtatc cgccgtccag ctaccggctg tggcacacca acgagaccca
     5641 accgggctgg cgcatgtacc tcatcgactt cgacgccccc ttcaccgatc ccgagcacac
     5701 caccttcttc cgctacctgc atccgcggac gggtgagctc gtcaccttgc gcgagcgtcc
     5761 gcgcatcgcc cggttcttca agatcgagca ggatcccgac cggctcttct ggcactgcat
     5821 cgtcaacccc acccaacgcc accggtggag cttcgggttc gtggtccccg acgactggcg
     5881 cgaacgtctg gggctgcccg cctgatccgg ccccgtgcca cggcgaccgc gaccgcggtc
     5941 gccccaccag cgaagggaga ccccgttgtt ccgaatccgg cgtttcggtg gacgcacgcc
     6001 cgctcctgcc ggcccgctcc ccgaaacgcc ggacggtcac gccgttccgg cgatccgggc
     6061 cgtcggagtg cgcaagaact atcccggtgt cgaggcggtc cgcggcctcg acctcaccgt
     6121 cgcccagggc gagatgttcg gcttcctcgg ccccaacggg tgcggcaaga cgaccaccat
     6181 cgccatgatg tgcacgctgg cccgccccac cgcgggccgc atcgagatcg ccggacacga
     6241 cacctgcacg gcccccggcc gggtccgccg ccggctcggc ctggtcttcc aggagaccac
     6301 cctcgatctc gaactcaccg ccgaggagaa cctgcgcttc cacgccgacc tgtacgcgct
     6361 gccgcgcgcc acactggccg ggcgcatcga ggagatgctg tccctcgccg ggctcaccga
     6421 ccgccgcgac cgaccggtgc gcacgttctc cggggggatg cgccggcgtc tggagatcgc
     6481 ccgagggttg ctccaccggc ccagcgtgct gttcttggac gagcccaccc tgggactcga
     6541 cccgcaggcc cgcgccgaca tctgggagca tctgcgcgag gtccgtcggc gtgaggacac
     6601 caccctcttc ctcaccacgc actacctgga cgaggccgag cagtgcgacc ggatcgccat
     6661 catcgaccac ggccgcatcg tcacccaggg ctcccctgaa gagctcaaat cggtggtcgg
     6721 cgccgacctg gtggaactgc gcaccggcga cgacgcggcg gcggcccgcg acctgcggga
     6781 ccgtttcggc ctggacccgg cggtgggggc cggcggcgtc gcggtccgcg ctcccgacgg
     6841 cgcccgcctc gtcccccggc tctgcgcggg actggatgtg cccgtctacg cggtcaccgt
     6901 cacccgcccc accctcgacg acgtcttcct ccaccacacc gggcaccgga tccgcgagga
     6961 gccgacgccc gccagcgcca cgctcaccga actcgccgga gaccgctcat gacctcgatc
     7021 gtggccccct ccgaccgggg cgctgtcggt gacgagaggg accgttcctc cacattcggc
     7081 gccgagctgc gcgccggccg catggtgtgg tggcgcgaga tgctgcactt cctgcgcgat
     7141 cccgcgcgca ccgctgtgtc gctcttccag ccgctgatct tcctgttcat cctcggggtg
     7201 gggctctccc ggctctacgc ccaggccggc gccgacccgg gcgcgggcgc cgactacctg
     7261 gtcttcctgt tccccggcgt gctcgtcatg gccgcccagg tgcccgcggt ctcggtgggg
     7321 gcgtccatcg tctgggatcg gcagagcggg ttcctgcgcg agatgctcgt cgctccggtg
     7381 cgtcgttcga ccctgctcat cggcaagtgc ctgggcgggg ccacggtcgc cacctgtacc
     7441 ggaaccgtcg tcctcctctg ctgtgggctg gtcggcgtcc cctaccgttt cggtctgtcg
     7501 ttgctgctgc tcgccgaatt ggggttggcc tcgctcgtca tgaccgcgct cggtgcgctg
     7561 gtggccgtga ccatccggcg catccagacg ttcaacatcg tcctcggtgt gctgatgacc
     7621 ccgttgctct tcctgtcggg cgcggtgttc ccggtcgcgg ccatgccgac ctggatggtg
     7681 ccggtcgccc tggtgaaccc gctgacctac acgatcgacg cgatgcgccg gaccatcgcc
     7741 cactacaccg aggacggtgt cgcgctcgcc gacccggtgg catggggaac ctggcatcca
     7801 ccggtgcttc tcgagctggg tctggcggtc ggcttcagcg tggtgctgtt ggcgttggcg
     7861 gcccgcaggt tcgcccgcat cgactga
//
