BGC0001661 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001661 (Streptomyces sp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	23,240	High	mayamycin	PKS

BGC0001661 - Region 1 - T2PKS

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Location: 1 - 23,240 nt. (total: 23,240 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 23,241
Label		BGC0001661

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

may11: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

may13: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

may8: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Transferases: PPTase aminotransferase glycosyltransferase methyltransferase transferase

may10: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

may21: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

may3: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

may6: methyltransferase

smcogs: SMCOG1248: methyltransferase

may7: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Lyases: cyclase dehydratase

may12: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

may17: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

may22: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

may9: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

may15: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

may16: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001661.5	1.00	PKS	mayamycin	Streptomyces sp.
BGC0000231.5	0.84	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.79	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.64	PKS	oviedomycin	Streptomyces antibioticus
BGC0002276.2	0.63	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000235.5	0.61	PKS	kiamycin	Streptomyces sp. W007
BGC0001904.2	0.60	PKS	fluostatin L, fluostatin D, difluostatin A, fluostatin C, fluostatin F, fluostatin G/H, fluostatin J, fluostatin K, rabelomycin	Micromonospora rosaria
BGC0002047.2	0.59	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0000236.5	0.59	PKS	kinamycin	Streptomyces murayamaensis
BGC0000253.4	0.58	PKS	oviedomycin	Streptomyces antibioticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001661.5	1.00	PKS	mayamycin	Streptomyces sp.
BGC0000231.5	0.84	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.79	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.64	PKS	oviedomycin	Streptomyces antibioticus
BGC0002276.2	0.63	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000235.5	0.61	PKS	kiamycin	Streptomyces sp. W007
BGC0001904.2	0.60	PKS	fluostatin L, fluostatin D, difluostatin A, fluostatin C, fluostatin F, fluostatin G/H, fluostatin J, fluostatin K, rabelomycin	Micromonospora rosaria
BGC0002047.2	0.59	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0000236.5	0.59	PKS	kinamycin	Streptomyces murayamaensis
BGC0000253.4	0.58	PKS	oviedomycin	Streptomyces antibioticus

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 23240
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 706.4; E-value: 2.1e-215)
Product class(es):: angucycline
Product molecular weight(s):: acetyl-CoA_8: 545 Da
acetyl-CoA_9: 587 Da

may11: OXY (Score: 532.2; E-value: 2.9e-162)
may12: CYC C7-C12 (Score: 484.8; E-value: 2e-148)
may13: KR C9 (Score: 481.4; E-value: 1.4e-147)
may14: ACP (Score: 130.6; E-value: 3.8e-41)
may15: CLF 8|9 (Score: 706.4; E-value: 2.1e-215)
may16: KS (Score: 789.9; E-value: 1.2e-240)
may17: CYC C4-C17/C2-C19 (Score: 195.6; E-value: 1.8e-60)
may21: GT (Score: 379.8; E-value: 4.4e-116)
may8: OXY (Score: 557.4; E-value: 6.6e-170)