LOCUS       BGC0001661             23240 bp    DNA     linear   BCT 21-MAR-2018
DEFINITION  Streptomyces sp. strain 120454 may gene cluster, complete sequence.
ACCESSION   BGC0001661
VERSION     BGC0001661
KEYWORDS    .
SOURCE      Streptomyces sp
  ORGANISM  Streptomyces sp.
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 03:20:03
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            1..1653
                     /gene="may1"
     CDS             1..1653
                     /codon_start=1
                     /gene="may1"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 355.3; E-value:
                     6.3e-108)"
                     /gene_kind="transport"
                     /note="transporter"
                     /product="May1"
                     /protein_id="AVO00800.1"
                     /transl_table=11
                     /translation="MTTESGTGEDANGALGTTGPEAVTAQAATAEGAAPPKAGRREWIG
                     LAVLALPTLLLSMDLSVLYLAVPHLSADLAPSGAQLLWIMDIYGFLMAGFLVMMGTLGD
                     RIGRRRLLLAGACAFGAASALAAFSTSPEMLIVTRALLGIAGATLAPSTLALLRTMFHD
                     PKQRTAAIGVWTVCFSAGSVLGPLAGGALLAHFWWGSVFLLGIPVMLLLLVAGPMLLPE
                     HRNPGAGRIDFVSAVMSVVAVLAVIYGMKDIATHGLGAASTLSIVGGLAVGAAFVVRQR
                     RLDDPLLDLGLFSTPRFGPALGIMGLAVLVMSGTLFFVAQYLQLVRGLSPLEAGLWMVP
                     MALGVVAGAITTGNIIKKVRPPVIMGSGLLVSCGAFALLSQMSVDSPIALFVAGVFCMS
                     FGVSPVMILGLELAVGSAPPERAGAASSVAETIQEFALGLGVAVIGSIGTAVYRSELKG
                     ELPADVPADAARAAEDTLGGAVHSAADLADGTGDTLLSLARSAFTEGLQTAATLCAVLV
                     VLGSLVAFTVLRGMGGPGGHQDQDGAEKAEAAP"
     source          1..23240
                     /db_xref="taxon:1931"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sp."
                     /strain="120454"
     misc_feature    1..23240
                     /note="may gene cluster"
     protocluster    1..23240
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[14828:17311]"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /t2pks_malonyl_elongations="8|9 (Score: 706.4; E-value:
                     2.1e-215)"
                     /t2pks_molecular_weights="acetyl-CoA_8 (Da): 545.511"
                     /t2pks_molecular_weights="acetyl-CoA_9 (Da): 587.547"
                     /t2pks_product_classes="angucycline"
                     /t2pks_starter_units="acetyl-CoA (Score: 0.0; E-value: 0)"
                     /tool="antismash"
     proto_core      14829..17311
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /t2pks_malonyl_elongations="8|9 (Score: 706.4; E-value:
                     2.1e-215)"
                     /t2pks_molecular_weights="acetyl-CoA_8 (Da): 545.511"
                     /t2pks_molecular_weights="acetyl-CoA_9 (Da): 587.547"
                     /t2pks_product_classes="angucycline"
                     /t2pks_starter_units="acetyl-CoA (Score: 0.0; E-value: 0)"
     cand_cluster    1..23240
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(t2ks and t2clf)"
                     /kind="single"
                     /product="T2PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..23240
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001661"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..23240
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T2PKS"
                     /region_number="1"
                     /rules="(t2ks and t2clf)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1748..2224)
                     /gene="may2"
     CDS             complement(1748..2224)
                     /codon_start=1
                     /gene="may2"
                     /product="May2"
                     /protein_id="AVO00801.1"
                     /transl_table=11
                     /translation="MTTTAPDLADLSRRLQALTDRVELTQVCDRFVRHLDQDRHSDHWL
                     DSVFVTDTHLTFPMGEFKGREGQVAFLETARKNFERTHHLSSNYDIRLDGDSARVTAHL
                     MAVHLPRSAEPDSHFSIGGHYEAEAVRTADGWRLRTLAFDLVWNAGDPPAGGKV"
     gene            complement(2221..3021)
                     /gene="may3"
     CDS             complement(2221..3021)
                     /codon_start=1
                     /gene="may3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012:4'-phosphopantetheinyl transferase (Score: 135.4;
                     E-value: 3e-41)"
                     /gene_kind="biosynthetic-additional"
                     /note="phosphopantetheinyl transferase-like protein"
                     /product="May3"
                     /protein_id="AVO00802.1"
                     /transl_table=11
                     /translation="MRDPRAPHGDAIRTAPPLMPGVVHLWVLHAEWPGVVEGLGCEGAL
                     GTEETARAAAYRSPRDRQTYVVAHLALRSLLSAYTGIAPDRLDLGRAPCPRCRGRHGPP
                     VLRSVPAHAPYFSLSHSHGLAVVALAASPVGVDVQRAVREESALRCLGALHPHERQQLT
                     ELNGHQLTLEFGELWVRKEAYLKGIGTGLCRGVAADFLGAPTPAAPPRPEGWSVHNVPL
                     PHAGHLAATALRSTAPHRTVIHREATRTHRPTRPAPCTPEGTRT"
     gene            complement(3018..3905)
                     /gene="may4"
     CDS             complement(3018..3905)
                     /codon_start=1
                     /gene="may4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /note="thioesterase"
                     /product="May4"
                     /protein_id="AVO00803.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.2e-14, bitscore:
                     45.1, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRATPAALDCGDGIVLSALVAEPEGPPRATIVALHGAGMRAGYFD
                     GRSHPDISLLALGARLGYTVVAVDRPGYGRSGKRLPNGQSLTDQRTTLHSGLTRLVAGR
                     DTGAGLFLLAHSFGGKLALACAAEPLPAPLLGLDVSGCGHRYAADPVGLGEDHPREWLR
                     HWGRLRFYPPGTFRDMTGLVTPPPALDLAEAARWPDAFDALAARVRVPVRLTFAEYEQW
                     WRHDPESLTDLASRFRAAPRVIVERLPDSGHNISLGLTARSYHLRALAFLEECLLAPAA
                     ESAGRPPRIGAAAP"
     gene            complement(3902..5314)
                     /gene="may5"
     CDS             complement(3902..5314)
                     /codon_start=1
                     /gene="may5"
                     /note="NDP-deoxyglucose-2,3-dehydratase"
                     /product="May5"
                     /protein_id="AVO00804.1"
                     /transl_table=11
                     /translation="MSTAALRPRADASLAGRLARSAAAVDGAWIATADVADWLDGRRRA
                     HRFSVERIGFAELDGWSFAEDTGNLVHRSGRFFSVEGLSVTMSEGPFRHWEQPIIRQPE
                     VGILGLLAQEIDGVLHFLLQAKMEPGNRNLLQLSPTVQATRSNYTKVHRGAGVKYLEYF
                     TDPDRGQVVFDVLQSEHGSWFYRKANRNMLVEALDEVPHDDDFCWLTLGQIGALLRRDN
                     VVNMDARTVVACFPMGAAEPDALLPDAAVRSWVTVERSRHDVVVDRVPLAGLAGWEHHP
                     DALRRPDGRFFQLVAVRVEAGSREVSAWSQPLLEPTGPAVAAFLVRRIAGVPHLLVAAR
                     AEAGFLDTIELGPTVQCDPGNWRGVTPPPFLDVVLAAGADRIVYAGLHSEEGGRFLNAE
                     IRYLFVEADEQQAPLNPPPGFQWLTPGQLGDLVQHAHYVNVQARTLLSCLHAGAATLDG
                     LRGDTSADRGGV"
     gene            complement(5311..6072)
                     /gene="may6"
     CDS             complement(5311..6072)
                     /codon_start=1
                     /gene="may6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248:methyltransferase (Score: 197.9; E-value:
                     3.3e-60)"
                     /gene_kind="biosynthetic-additional"
                     /note="N-methyl transferase"
                     /product="May6"
                     /protein_id="AVO00805.1"
                     /transl_table=11
                     /translation="MSDEESTGIYDAGDIYDAIYDGRGKDYRAESEAVTRHIRDRHPGA
                     ASLLDVGCGTGGHLRHFAEDFTHVEGVDLTEGMLAVARRALPHIPVHYGDMRSFERGRR
                     YDAVVSLFCAIGNMLGQDELDSAIAEFERHLEPGGVVVVEPWWFPENFTPDHVGSSLTT
                     GDGRTIARVSHSVRESESASRMDIHYLVAEPGKGVRHFSDTHVNSLYSYEQFDQAFSRA
                     GLSMEHVAGDYPGNGLFIGVKPRVAPAGERT"
     gene            complement(6155..7276)
                     /gene="may7"
     CDS             complement(6155..7276)
                     /NRPS_PKS="Domain: Aminotran_5 (41-167). E-value: 2.3e-07.
                     Score: 21.9. Matches aSDomain:
                     nrpspksdomains_may7_Aminotran_5.1"
                     /codon_start=1
                     /gene="may7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     388.7; E-value: 4.8e-118)"
                     /gene_kind="biosynthetic-additional"
                     /note="NDP-deoxyhexose 3-aminotransferase"
                     /product="May7"
                     /protein_id="AVO00806.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 6.9e-122,
                     bitscore: 397.6, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTRVWDYLPEYEKEKADILDAVEQVFGSGQLILGGSVKGFEEEF
                     AAYHGAAHCTSVDNGTNALKLALEALGVGPGDEVITVSNTAAPTVVAILGTGAVPVFVD
                     VREEDFLIDTDLVEAAITERTKVLLPVHLYGQSVDFAPLRALADRYGLKILEDCAQSHG
                     ARHHGDLVGTLGDAAAFSFYPTKVLGAYGDGGAVITSDRATDQALRELRYYGMEKVYYV
                     IRTPGHNSRLDEVQAEILRRKLTRLDTYLEGRNAVARRYEAALGDLTGPGRLQLPGTNE
                     GNTHSYYVYVVRHPERDRIIEALKAHDIALNISYPWPCHTMSGFAHLGYAKGSLPVTER
                     LSQEIFSLPMYPSLPEAVQDQVIAALREVLASL"
     aSDomain        complement(6776..7153)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_may7_Aminotran_5.1"
                     /evalue="2.30E-07"
                     /label="may7_Aminotran_5.1"
                     /locus_tag="may7"
                     /protein_end="167"
                     /protein_start="41"
                     /score="21.9"
                     /tool="antismash"
                     /translation="EEEFAAYHGAAHCTSVDNGTNALKLALEALGVGPGDEVITVSNTA
                     APTVVAILGTGAVPVFVDVREEDFLIDTDLVEAAITERTKVLLPVHLYGQSVDFAPLRA
                     LADRYGLKILEDCAQSHGARHH"
     gene            complement(7338..8852)
                     /gene="may8"
     CDS             complement(7338..8852)
                     /codon_start=1
                     /gene="may8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 535.6; E-value:
                     2.2e-162)"
                     /gene_functions="biosynthetic-additional (t2pks) OXY
                     (Score: 557.4; E-value: 6.6e-170)"
                     /gene_kind="biosynthetic-additional"
                     /note="bifunctional monooxygenase-dehydratase"
                     /product="May8"
                     /protein_id="AVO00807.1"
                     /transl_table=11
                     /translation="MHSETDRDPLTADVIVVGAGPSGLMLAGELRLGGASVVVLEKLER
                     PTGQSRGLGFTARALESFAQRGLDTRFPGLETSPVGHFGGVQFDYTVLDGGHFGARGIP
                     QSQTEAVLEAWAVELGVDIRRGWEFTALDQAPDRVRVTARGAGGEQRLSSAYLVGADGG
                     NSPVRRAAGIGFPGAPATRGMYLADVRGCGLRPRFLGELLDGGMVMAAPLGEGVDRIIV
                     CEHGTLPAGRDQEVEFAEVAAAWQRLTGEDISGGQADWVSSFTDATRQAEVYRRGRVLV
                     VGDAAHVHLPAGGQGLSVGVQDAVNLGWKLAATVTGWAPAGLLDTYHGERHPVGERLLM
                     NTRAQGQIFLGGPEADPMRELFTELLAHDEVRRHLAGIVTGLDVRYDGMGDTPPAEAHP
                     LTGRRLPHRMLRTASGDRDTTGLLRAAQGVLLDLSGDAGLARTAAGHKDRVVTVTGAPA
                     TERDADTFADAGAVLVRPDGYVAWAGSDEAGLRSALGRWFGAPAAA"
     gene            complement(8900..9895)
                     /gene="may9"
     CDS             complement(8900..9895)
                     /NRPS_PKS="Domain: NAD_binding_4 (4-181). E-value: 1e-17.
                     Score: 55.9. Matches aSDomain:
                     nrpspksdomains_may9_NAD_binding_4.1"
                     /codon_start=1
                     /gene="may9"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 345;
                     E-value: 7e-105)"
                     /gene_kind="biosynthetic-additional"
                     /note="NDP-hexose 4,6-dehydratase"
                     /product="May9"
                     /protein_id="AVO00808.1"
                     /sec_met_domain="NAD_binding_4 (E-value: 4e-18, bitscore:
                     55.9, seeds: 102, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.5e-18,
                     bitscore: 57.4, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 4.9e-20, bitscore:
                     62.3, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRILVTGGAGFIGSHYVRSLLDGAYGVADDLRITVVDALTYAGNR
                     ENLPAAHPRLDFVRGDICDGPLLRELLPGHDAVVHFAAESHVDRSVAGGAAFVRTNVLG
                     TQTVLEAALHSGVERVLHVSTDEVYGSLAAGSWTEEEPLLPNSPYAASKAGSDLIARSY
                     WRTHGLDVSVTRCSNNYGPHQHPEKLIPRFVTNLLEGMPVPVYGDGRNRREWLHVDDHC
                     RALHLVLTRGGAGGIYNIGSGNELDNLSLTRRILELCGADDSMIRYVEDRKGHDLRYAL
                     DDRKIREELGYAPRIGFDAGLASTVDWYRSHPNRWKSAKDGSTAGTAGAL"
     aSDomain        complement(9353..9883)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_may9_NAD_binding_4.1"
                     /evalue="1.00E-17"
                     /label="may9_NAD_binding_4.1"
                     /locus_tag="may9"
                     /protein_end="181"
                     /protein_start="4"
                     /score="55.9"
                     /tool="antismash"
                     /translation="VTGGAGFIGSHYVRSLLDGAYGVADDLRITVVDALTYAGNRENLP
                     AAHPRLDFVRGDICDGPLLRELLPGHDAVVHFAAESHVDRSVAGGAAFVRTNVLGTQTV
                     LEAALHSGVERVLHVSTDEVYGSLAAGSWTEEEPLLPNSPYAASKAGSDLIARSYWRTH
                     GLDVSVTRCSNNYG"
     gene            complement(9964..10830)
                     /gene="may10"
     CDS             complement(9964..10830)
                     /codon_start=1
                     /gene="may10"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 276.6; E-value:
                     3.9e-84)"
                     /gene_kind="biosynthetic-additional"
                     /note="NDP-glucose phosphate nucleotidyltransferase"
                     /product="May10"
                     /protein_id="AVO00809.1"
                     /transl_table=11
                     /translation="MKGIILAGGLGTRLQPITFGVSKQLLPVYDKPMIYYPLSVLMLTG
                     VTDIQIISSPDDLGGFRKLLGDGSELGLNLTYAEQDKPRGIADAFLVGADHIGDDSVAL
                     VLGDNLFHGYGFGEVLQTNARDVEGCVLFGYPVRDPERYGVGVLDADGRLTSLEEKPTR
                     PRSNLAVTGLYFYDNSVIDIARGLEPSERGELEITDVNRTYLERGTARLVELGRGFVWL
                     DTGTHDALTEAGQYVQLLEHRQGVRIACIEEIAWRMGYIDRAACHRLGRNLASSPYGQY
                     VMEITAA"
     gene            complement(10937..12547)
                     /gene="may11"
     CDS             complement(10937..12547)
                     /codon_start=1
                     /gene="may11"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 519.3; E-value:
                     2e-157)"
                     /gene_functions="biosynthetic-additional (t2pks) OXY
                     (Score: 532.2; E-value: 2.9e-162)"
                     /gene_kind="biosynthetic-additional"
                     /note="bifunctional monooxygenase-dehydratase"
                     /product="May11"
                     /protein_id="AVO00810.1"
                     /transl_table=11
                     /translation="MTTGNGTQPGAATAPADPVVVVGAGPVGLLLAGELRLGGAGVVVV
                     DDRPGPTTESRASTLHARTMEILDSRGLLAELGLPANEPRGHYGGLPLDLTLPSSHPGQ
                     WKVSQTRTEELLQRWARALGADVRRGLRVRALAQDATGVSVEAEAADGSVVRLRGCLLV
                     GCDGELSTVRELVGAELAGREAGREMLRADVRGVRIENRRFQRLPGGLAVAATREGVTR
                     VMVHEFGSTVRPRSGPPGFEEVAAAWKRVTGDDISGGTPLWLNSFGDANRQLTRYRYGR
                     VLFAGDAAHQQMPVGGQALNLGLQDAFNLGWKLALEVGGRAPEGLLDSYHRERHETGRR
                     VLANIRAQSDLLLGGPEAEPLRALCAELLALAPVRENLAAAISGLDIRYADGAGEPSLL
                     GRRLPPSVLDTGAGEVWTPALLRSGRGLFLDLGPGPVTANAGAAAVVAGWTDRVVLARG
                     RPRPGGALSSATALLVRPDGHVAWVGGRTPADRWAGAHDALRRWFGPAGRRKAGAARGQ
                     EISAAIGARIDAGIDISLT"
     gene            complement(12544..13485)
                     /gene="may12"
     CDS             complement(12544..13485)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (4-146). E-value:
                     4.7e-12. Score: 38.3. Matches aSDomain:
                     nrpspksdomains_may12_Polyketide_cyc2.1"
                     /codon_start=1
                     /gene="may12"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1128:cyclase/dehydrase (Score: 448.8; E-value:
                     1.6e-136)"
                     /gene_functions="biosynthetic-additional (t2pks) CYC C7-C12
                     (Score: 484.8; E-value: 2e-148)"
                     /gene_kind="biosynthetic-additional"
                     /note="bifunctional cyclase/dehydrase"
                     /product="May12"
                     /protein_id="AVO00811.1"
                     /transl_table=11
                     /translation="MTTREVEHEITVLAAAADVYRLIAEVENWPRIFPPTIYVDHVERG
                     RREERIQIWATANGTAKHWVSHRTLDPGALRITFRQEVTSPPVAAMGGTWIIEPLSERE
                     SRVRLLHDYRAIDDDPESLAWIDEAVDRNSRSELAALKKNVEFAQAAEEITFSFEDTVR
                     VDGAAKDLYDFINEGDRWEERLPHVASVRLEEVSPGLQILEMDTRAKDGSTHTTKSYRV
                     CLPASTIAYKQVTLPALMTLHTGVWTFSQEGDTVAATSQHTVVLNTDNIARVLGDDATV
                     ADAKAYVQGALSTNSRATLGHAKDYAEQKRRV"
     aSDomain        complement(13048..13473)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_may12_Polyketide_cyc2.1"
                     /domain_subtype="Polyketide_cyc2"
                     /evalue="4.70E-12"
                     /label="may12_Polyketide_cyc2.1"
                     /locus_tag="may12"
                     /protein_end="146"
                     /protein_start="4"
                     /score="38.3"
                     /tool="antismash"
                     /translation="EVEHEITVLAAAADVYRLIAEVENWPRIFPPTIYVDHVERGRREE
                     RIQIWATANGTAKHWVSHRTLDPGALRITFRQEVTSPPVAAMGGTWIIEPLSERESRVR
                     LLHDYRAIDDDPESLAWIDEAVDRNSRSELAALKKNVE"
     gene            complement(13532..14320)
                     /gene="may13"
     CDS             complement(13532..14320)
                     /NRPS_PKS="Domain: PKS_KR (8-161). E-value: 4.2e-12. Score:
                     38.1. Matches aSDomain: nrpspksdomains_may13_PKS_KR.1"
                     /codon_start=1
                     /gene="may13"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     265; E-value: 1.1e-80)"
                     /gene_functions="biosynthetic-additional (t2pks) KR C9
                     (Score: 481.4; E-value: 1.4e-147)"
                     /gene_kind="biosynthetic-additional"
                     /note="ketoreductase"
                     /product="May13"
                     /protein_id="AVO00812.1"
                     /sec_met_domain="adh_short (E-value: 5.6e-39, bitscore:
                     124.5, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTMSQYQPVALITGATSGIGLAVARLLASQGHRVYIGARNEENVA
                     STVKQLREEGHQAAGTTLDVRSDEDVKAFVRAAVAEFGGVDVLVNNAGRSGGGVTADIS
                     DELWHDVIDTNLNSVFRLTREVLTTGGLREKSRGRIINIASTAGKQGVVLGAPYSASKH
                     GVVGFTKALGNELAPTGITVNAVCPGYVETPMAQRVRAGYAAAYDTTEEAILDKFQAKI
                     PLGRYSTPEEVAGLVGYLASDTAASITAQALNVCGGLGNF"
     aSDomain        complement(13838..14296)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_may13_PKS_KR.1"
                     /evalue="4.20E-12"
                     /label="may13_PKS_KR.1"
                     /locus_tag="may13"
                     /protein_end="161"
                     /protein_start="8"
                     /score="38.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VALITGATSGIGLAVARLLASQGHRVYIGARNEENVASTVKQLRE
                     EGHQAAGTTLDVRSDEDVKAFVRAAVAEFGGVDVLVNNAGRSGGGVTADISDELWHDVI
                     DTNLNSVFRLTREVLTTGGLREKSRGRIINIASTAGKQGVVLGAPYSAS"
     CDS_motif       complement(14222..14290)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_may13_0001"
                     /evalue="2.00E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="may13"
                     /protein_end="33"
                     /protein_start="10"
                     /score="23.7"
                     /tool="antismash"
                     /translation="LITGATSGIGLAVARLLASQGHR"
     gene            complement(14479..14832)
                     /gene="may14"
     CDS             complement(14479..14832)
                     /NRPS_PKS="Domain: ACP (42-112). E-value: 1.8e-14. Score:
                     45.7. Matches aSDomain: nrpspksdomains_may14_ACP.1"
                     /codon_start=1
                     /gene="may14"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1129:acyl carrier protein (Score: 114.3; E-value:
                     3.5e-35)"
                     /gene_functions="biosynthetic-additional (t2pks) ACP
                     (Score: 130.6; E-value: 3.8e-41)"
                     /gene_kind="biosynthetic-additional"
                     /note="acyl carrier protein"
                     /product="May14"
                     /protein_id="AVO00813.1"
                     /sec_met_domain="PP-binding (E-value: 7.4e-12, bitscore:
                     36.3, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGGRAIRPRQSTTVQHPKNSSDEKLREQTMATTGFTLDALRRIL
                     REGAGADESVDLDGDILDVDFEALGYESLALLETGSRIEREYGITLDEDALATASTPRA
                     LIEAVNAQTGIAA"
     aSDomain        complement(14497..14706)
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_may14_ACP.1"
                     /evalue="1.80E-14"
                     /label="may14_ACP.1"
                     /locus_tag="may14"
                     /protein_end="112"
                     /protein_start="42"
                     /score="45.7"
                     /tool="antismash"
                     /translation="RILREGAGADESVDLDGDILDVDFEALGYESLALLETGSRIEREY
                     GITLDEDALATASTPRALIEAVNAQ"
     gene            complement(14829..16043)
                     /gene="may15"
     CDS             complement(14829..16043)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (68-403). E-value:
                     2.4e-27. Score: 87.7. Matches aSDomain:
                     nrpspksdomains_may15_PKS_KS.1"
                     /codon_start=1
                     /gene="may15"
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2clf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 673.9; E-value:
                     1.1e-204)"
                     /gene_functions="biosynthetic-additional (t2pks) CLF 8|9
                     (Score: 706.4; E-value: 2.1e-215)"
                     /gene_kind="biosynthetic"
                     /note="chain length factor"
                     /product="May15"
                     /protein_id="AVO00814.1"
                     /sec_met_domain="t2clf (E-value: 7.2e-212, bitscore: 693.8,
                     seeds: 26, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAPVVVTGLGVAAPNGLGVEDFWAATRSGKSGIARLTRFDVSGY
                     PAQLGGEVPGFVAEDLLPGRLLPQTDRMTRMALAATDWALADAGVTPGERDSFDMGVVT
                     ASSSGGFEFGQGELQKLWSQGSQYVSAYQSFAWFYAVNSGQISIRNGMKGPCGVVVSDQ
                     AGGLDAVAQARRQIRKGTPLIVSGAVDASLCPWGWVAQLTSGRLSTRSEPARAYLPFDA
                     DASGHVAGEGGAILIMESAAAARARGAKVYGEIAGYGATTDPAPGSGRPPGLRKAVELA
                     LADAGTGPDEVDVVFADAAAVPELDRVEAEALTAVFGTRGVPVTAPKTMTGRLYSGAAP
                     LDLAAALLAMEEGLIPPTVNVEPVASLGLDLVVGQSRTAEVRTALVLARGHGGFNSAVV
                     VRAAA"
     aSDomain        complement(14835..15839)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_may15_PKS_KS.1"
                     /domain_subtype="Iterative-KS"
                     /evalue="2.40E-27"
                     /label="may15_PKS_KS.1"
                     /locus_tag="may15"
                     /protein_end="403"
                     /protein_start="68"
                     /score="87.7"
                     /tool="antismash"
                     /translation="QTDRMTRMALAATDWALADAGVTPGERDSFDMGVVTASSSGGFEF
                     GQGELQKLWSQGSQYVSAYQSFAWFYAVNSGQISIRNGMKGPCGVVVSDQAGGLDAVAQ
                     ARRQIRKGTPLIVSGAVDASLCPWGWVAQLTSGRLSTRSEPARAYLPFDADASGHVAGE
                     GGAILIMESAAAARARGAKVYGEIAGYGATTDPAPGSGRPPGLRKAVELALADAGTGPD
                     EVDVVFADAAAVPELDRVEAEALTAVFGTRGVPVTAPKTMTGRLYSGAAPLDLAAALLA
                     MEEGLIPPTVNVEPVASLGLDLVVGQSRTAEVRTALVLARGHGGFNSAVVVRAA"
     CDS_motif       complement(15348..15386)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_may15_0001"
                     /evalue="5.50E-03"
                     /label="PKSI-KS_m4"
                     /locus_tag="may15"
                     /protein_end="232"
                     /protein_start="219"
                     /score="10.1"
                     /tool="antismash"
                     /translation="FDADASGHVAGEG"
     gene            complement(16040..17311)
                     /gene="may16"
     CDS             complement(16040..17311)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (6-397). E-value:
                     2.8e-56. Score: 183.0. Matches aSDomain:
                     nrpspksdomains_may16_PKS_KS.1"
                     /codon_start=1
                     /gene="may16"
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2ks"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 495; E-value:
                     3.1e-150)"
                     /gene_functions="biosynthetic-additional (t2pks) KS (Score:
                     789.9; E-value: 1.2e-240)"
                     /gene_kind="biosynthetic"
                     /note="ketosynthase alpha"
                     /product="May16"
                     /protein_id="AVO00815.1"
                     /sec_met_domain="t2ks (E-value: 3.2e-251, bitscore: 823.9,
                     seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTARRVVITGIEVLAPGGVGTRDFWELLSDGRTATRGITFFDPSP
                     FRSRVAAEIDFDPRRHGLSAQEIRRMDRAAQFAVVAARGAVADSGIGLADLDPHRVGVT
                     VGSAVGATMGLDEEYNVVSDGGKLHLVDHAYAVPHLYNYLVPSSFAVEVAHAVGAEGPS
                     TVVSTGCTSGIDSVGYAVELIREGSADVMVAGSSDAPISPITMACFDAIKATTPRHDDP
                     ERASRPFDGTRNGFVLGEGAAVFVLEELESARKRGAHIYAEIAGYATRSNAYHMTGLRP
                     DGAEMAEAIRLALDEARMNPTEIDYVNAHGSGTKQNDRHETAAFKRTLGDHAYRTPVSS
                     IKSMVGHSLGAIGSIEIAASALAMEHHVVPPTANLHTPDPECDLDYVPLEAREQLTDAV
                     LTVGSGFGGFQSAMVLARPERSAA"
     aSDomain        complement(16121..17293)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_may16_PKS_KS.1"
                     /domain_subtype="Iterative-KS"
                     /evalue="2.80E-56"
                     /label="may16_PKS_KS.1"
                     /locus_tag="may16"
                     /protein_end="397"
                     /protein_start="6"
                     /score="183.0"
                     /tool="antismash"
                     /translation="VITGIEVLAPGGVGTRDFWELLSDGRTATRGITFFDPSPFRSRVA
                     AEIDFDPRRHGLSAQEIRRMDRAAQFAVVAARGAVADSGIGLADLDPHRVGVTVGSAVG
                     ATMGLDEEYNVVSDGGKLHLVDHAYAVPHLYNYLVPSSFAVEVAHAVGAEGPSTVVSTG
                     CTSGIDSVGYAVELIREGSADVMVAGSSDAPISPITMACFDAIKATTPRHDDPERASRP
                     FDGTRNGFVLGEGAAVFVLEELESARKRGAHIYAEIAGYATRSNAYHMTGLRPDGAEMA
                     EAIRLALDEARMNPTEIDYVNAHGSGTKQNDRHETAAFKRTLGDHAYRTPVSSIKSMVG
                     HSLGAIGSIEIAASALAMEHHVVPPTANLHTPDPECDLDYVPLEAREQLTD"
     gene            complement(17308..17637)
                     /gene="may17"
     CDS             complement(17308..17637)
                     /codon_start=1
                     /gene="may17"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1225:Polyketide synthesis cyclase (Score: 155.9;
                     E-value: 4.9e-48)"
                     /gene_functions="biosynthetic-additional (t2pks) CYC
                     C4-C17/C2-C19 (Score: 195.6; E-value: 1.8e-60)"
                     /gene_kind="biosynthetic-additional"
                     /note="polyketide synthase cyclase"
                     /product="May17"
                     /protein_id="AVO00816.1"
                     /transl_table=11
                     /translation="MHSTLIVARMDPDSSIDVAGRFAEFDRTDMPHRMGTRRRQLFAYR
                     GLYFHLQDFDGDNGGDLIEEAKTDPRFVRISEELKPFIQAYDPATWRSPADAMAGRFYH
                     WEASA"
     gene            complement(18052..18726)
                     /gene="may18"
     CDS             complement(18052..18726)
                     /codon_start=1
                     /gene="may18"
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 184.9; E-value: 2.7e-56)"
                     /gene_kind="regulatory"
                     /note="DNA-binding response regulator"
                     /product="May18"
                     /protein_id="AVO00817.1"
                     /transl_table=11
                     /translation="MVENDTKEAECLTRGLRRHGHEAVSVATGDAALRAYEDADLILLD
                     LDLPDLDGLEVCRTVRAACDVPIIAVTARGTELDRVLGLQAGADDYLTKPYGFQELMAR
                     MDAVMRRARPRRRARAAPAPVAEPPPATIRHGALVIDTGSREVTLDGRRITLTRKEFDL
                     LHLLAANPDSVIPRKHVMQQVWGDSWSRRTVDTHVSTLRNKLGASTWVITVRGVGFRLG
                     HA"
     misc_feature    complement(18565..18567)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(19587..20294)
                     /gene="may19"
     CDS             complement(19587..20294)
                     /codon_start=1
                     /gene="may19"
                     /note="monooxygenase"
                     /product="May19"
                     /protein_id="AVO00818.1"
                     /transl_table=11
                     /translation="MRAPRVPLPDMARADAGVSVLYRWVTAPKDQLTLADSSLETWANT
                     PWPAGLIAVHVLVSTNGDTVLTYEQWAGARELTTFQDHDRDTVTKEITTSVPAVEEFDP
                     LVCTPHRRTAAHPVSARAECLVISTYGFESLGAARAWSRVRASAEERRAGPTPGLLARH
                     FLIGSGAGGGGVRLLDYAEWTGAHAHAEFLENGYERRCGTPRAGIIPGPARRCRPYGVL
                     TAPLPGRTRARTW"
     gene            complement(20443..20922)
                     /gene="may20"
     CDS             complement(20443..20922)
                     /codon_start=1
                     /gene="may20"
                     /note="hypothetical protein"
                     /product="May20"
                     /protein_id="AVO00819.1"
                     /transl_table=11
                     /translation="MHPRTRLAGTVLAGALLTASLATAPTALATSPAPAPAAFLSPAGC
                     WNAQAAEGDMPPADVKLEFRTDRSVKLIGPPDENGTPYFVGHGTWTPGWSGSFRFTVEH
                     PLPGGPPGEARSALNGKLSSSKAFAAKGETHYFYDDGTTGGPSSITITGTRAACS"
     gene            complement(20963..22102)
                     /gene="may21"
     CDS             complement(20963..22102)
                     /codon_start=1
                     /gene="may21"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062:glycosyltransferase, MGT family (Score: 270.3;
                     E-value: 5.5e-82)"
                     /gene_functions="biosynthetic-additional (t2pks) GT (Score:
                     379.8; E-value: 4.4e-116)"
                     /gene_kind="biosynthetic-additional"
                     /note="C-glycosyltransferase"
                     /product="May21"
                     /protein_id="AVO00820.1"
                     /sec_met_domain="MGT (E-value: 1.6e-93, bitscore: 304.4,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKILFLAAGSAATVYGMTPLATAARSAGHQVIMAAPRNVLPDIAA
                     MGLTPFSVTSTPIPHFRTKDRAGNPVTVPDNPVEGRLFTGGWFGRLAAASMDPLLGLAE
                     DWRPDLVVGGTLTYAAPLLAHRLGVPYVRQTWDGKDFDGIDPGATAELRPELAHLGLDA
                     LPEPQLLVDVTPPSLRHTHALPAQPMRWTPVNQQREPEPWMLRRGERRRVVVTGGSRGL
                     NLEFLRDVVGKVGALGVEVVVAAPEELAAKLRAEADGIRAGWIPLDVVAPTSDLIVHHS
                     GGVTSLTALHFGVPQLSVMENRDNASHGAALDRIADFGAGLSLQPHERTAERIGAACEQ
                     LLGDPSSTARAQAIAAEMATMPPPSTVLGLLEELAARTA"
     gene            complement(22314..23240)
                     /gene="may22"
     CDS             complement(22314..23240)
                     /codon_start=1
                     /gene="may22"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     133.6; E-value: 1.6e-40)"
                     /gene_kind="biosynthetic-additional"
                     /note="NDP-4-keto-6-deoxyhexose reductase"
                     /product="May22"
                     /protein_id="AVO00821.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2e-07, bitscore:
                     20.8, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSRPASPPTLLVLGATGFVGRHVCAASAAAGHQVLAVARSPLPG
                     LAAHRFLSFDLARTPADEVARVLREERVDVVVNSIGSIWGAPPEEMTERCTAPTLRLLE
                     ALRLLDEPPRLVQLGSVLEYGDPPATAYGRAKLAAARAVLEADARGEVRALVLRIANAA
                     GPGTPDISLLGQVAARLREAAAEGREAVVELNALLAHRDYVDVRDVADAVVAAATSSAR
                     GQIVGIGRGEAVPVRSLVTELIRVSGVPARVVEREAPTTAPGTDDWIQVDTGPARGLLG
                     WRAGRSLESALRAFWTDAQRSPLPAGP"
ORIGIN
        1 atgacgaccg aaagcggcac gggcgaggac gcgaacggcg ccctcggcac cacaggcccg
       61 gaagcggtca ccgcgcaagc ggcgaccgcc gaaggcgccg cacccccgaa ggccgggcgg
      121 cgcgaatgga tcggcctcgc cgtcctcgcc ctgcccaccc tcctgctctc catggacctg
      181 agcgttctct acctcgccgt cccccatctg agcgctgatc tggcgcccag tggggcccag
      241 ctcctgtgga tcatggacat ctacgggttc ctgatggccg gattcctggt catgatgggc
      301 accctcggcg accgcatcgg tcgcaggcgg ctcctgctgg cgggcgcctg cgccttcggt
      361 gcggcctcgg cgctcgccgc gttctccacc agcccggaga tgctcatcgt gacccgggcc
      421 ctgctgggca tcgccggggc gaccctcgcg cccagcaccc tggccctgct gcggaccatg
      481 ttccacgacc cgaagcagcg cacggctgcg atcggtgtgt ggaccgtctg cttctccgcg
      541 ggcagtgtgc tcggcccgct cgccggaggc gcgctcctcg cccacttctg gtggggctcg
      601 gtcttcctgc tcggcatccc ggtcatgctg ctcctgctcg tcgcgggccc gatgctgctg
      661 cccgagcacc gcaacccggg cgcggggcgc atcgacttcg tcagcgccgt gatgtcggtc
      721 gtcgcggtcc tcgcggtgat ctacgggatg aaggacatcg ccacccacgg gctcggcgcg
      781 gccagcaccc tgtcgatcgt cggcggactc gcggtcggcg cggccttcgt ggtgcgccag
      841 cgcaggctgg acgaccccct gctggacctc ggcctcttct ccacgccgcg cttcggaccg
      901 gcgctcggca tcatgggcct ggccgtgctg gtgatgtcgg gcacgctgtt cttcgtcgcc
      961 cagtatctcc aactggtccg cggactcagc ccgttggaag cagggctgtg gatggtgccg
     1021 atggcgctcg gcgtggtcgc cggtgccatc accaccggca acatcatcaa gaaggtccgg
     1081 ccgccggtca tcatgggatc cggcctgctg gtgtcctgcg gggcgttcgc cctgctctcc
     1141 cagatgagcg tcgactcgcc gatcgccctg ttcgtcgccg gcgtcttctg catgtccttc
     1201 ggggtgtccc cggtgatgat cctcggcctc gaactggccg tcggatccgc accgccggaa
     1261 cgggccggcg ccgcctccag cgtcgccgag acgatccagg agttcgcgct ggggctgggc
     1321 gtcgccgtga tcggcagcat cgggaccgcc gtctaccgga gcgaactgaa aggcgaactc
     1381 cccgcggacg tgcccgccga cgcggcgcgt gccgccgagg acacgctggg cggcgccgtc
     1441 cacagcgcgg ccgacctcgc ggacggcacc ggcgacaccc tgctctccct ggcccgctcc
     1501 gccttcaccg aagggctcca gaccgccgcg acgctgtgcg cggtcctggt ggtgctcggt
     1561 tccctcgtcg ccttcacggt gctgcggggc atgggcgggc cgggcggcca ccaggaccag
     1621 gacggtgcgg agaaggcgga ggccgccccg tagggccgaa ggcgctcgta cgacggtgac
     1681 ggccgcacgg ccgaaggccg cgcccctcgt tcgggagggg cgcggccgtc tgcggctcct
     1741 ggaggtccta gaccttcccg cccgccggcg ggtcgcccgc gttccagacg aggtcgaagg
     1801 ccagggtgcg caggcgccag ccgtcggcgg tgcggaccgc ctccgcctcg tagtggccac
     1861 cgatgctgaa gtggctgtcc ggctccgcac tgcgggggag gtgcacggcc atcaggtgcg
     1921 cggtgacacg ggcgctgtcg ccgtcgaggc gtatgtcgta gttggagctg aggtggtgcg
     1981 tgcgctcgaa gttcttccga gctgtctcca ggaaggcgac ctgcccttcc cttcccttga
     2041 actctcccat ggggaaggtg agatgagtgt ccgtgacgaa gaccgaatcc agccagtggt
     2101 cgctgtgccg gtcctggtcg aggtggcgga cgaagcggtc gcacacctgc gtcagctcga
     2161 cgcggtcggt cagcgcctgg aggcggcggg agaggtccgc gaggtcgggt gcggtggtgg
     2221 tcatgtacgt gtcccttctg gcgtgcacgg cgccggccgg gtcggccggt gggttcgggt
     2281 ggcttctcgg tggatgacgg tgcggtgcgg tgcggtcgag cggagcgccg ttgcggcgag
     2341 atgcccggca tgcggcagcg gaacgttgtg gacgctccag ccctccggac ggggcggagc
     2401 ggccggtgtg ggagccccga ggaaatcggc ggccacgccg cggcagagcc cggttccgat
     2461 ccccttcaga tacgcctcct tcctgaccca caactcgccg aattctagcg tcagttgatg
     2521 gccattcagc tcggtcagct gttgtcgctc gtgggggtgc agcgcgccca ggcaccgcag
     2581 cgccgactcc tcgcgcaccg cccgctggac gtccactccg accggcgagg cggcgagggc
     2641 caccacggcg aggccgtgac tgtgcgacag ggagaagtac ggcgcgtgcg cgggcacgct
     2701 ccgcagcacg ggtggcccgt gccggccgcg gcagcgtgga cagggggcgc ggcccaggtc
     2761 cagccggtcc ggggcgatgc cggtgtacgc ggacagcagg gaccgcaggg cgagatgggc
     2821 gacgacgtag gtctgccggt cgcgggggct gcggtacgcg gcggcccggg cggtctcctc
     2881 cgtccccagc gcgccttcgc accccagccc ttccacgacg ccgggccatt ccgcgtgcag
     2941 cacccacaga tgcacgacgc cgggcatgag cggcggtgcc gtccggatgg cgtccccgtg
     3001 aggcgcgcgg gggtccctca tggcgccgcg gccccgatcc ggggagggcg ccccgccgac
     3061 tccgccgcgg gcgcgagcag gcactcctcc aggaaggcca gcgcccgcag gtggtagctg
     3121 cgggcggtca ggcccaggct gatgttgtgg cccgaatccg gcagcctttc cacgatcacg
     3181 cggggcgccg cccggaaacg ggaggcgagg tcggtgaggc tctccgggtc gtgccgccac
     3241 cactgctcgt actcggcgaa cgtcagccgg accggcaccc gcacccgggc ggccagcgcg
     3301 tcgaacgcgt ccggccaccg cgcggcctcg gccaggtcga gggcgggcgg gggcgtgacg
     3361 agtccggtca tgtcccggaa cgtgccgggc gggtagaagc gcaggcggcc ccagtggcgc
     3421 agccattccc gggggtggtc ctccccgagc cccacggggt cggccgcgta ccggtggccg
     3481 cagcccgaca cgtccagccc gagcaggggc gcgggcagcg gttcggcggc gcaggccagg
     3541 gcgagcttgc cgccgaagga gtgggcgagg aggaacaggc ccgccccggt gtccctgccc
     3601 gccaccaggc gggtgagccc ggagtgcagc gtcgtgcgct ggtcggtgag gctctggccg
     3661 ttcggcaggc gcttcccgga gcggccgtag ccggggcggt cgacggcgac gacggtgtag
     3721 ccgagccggg ccccgagggc gagcagggag atgtccggat gggaacggcc gtcgaagtag
     3781 cccgcccgca tgcccgcccc gtgcagggcc acgatcgtgg cccgcggggg accctccggc
     3841 tcggcgacga gcgccgacag gacgatgccg tccccgcagt ccagggcggc gggtgtggct
     3901 ctcacacacc gcccctgtcc gcggaggtgt ccccgcgcag cccgtccagc gtcgccgccc
     3961 ccgcatgcag gcaggacagc agggtgcggg cctgcacgtt gacgtagtgg gcgtgctgca
     4021 ccaggtcgcc cagctgtccg ggcgtgagcc actggaagcc cggcggcggg ttcagagggg
     4081 cctgctgttc gtcggcctcg acgaacaggt agcggatctc cgcgttcagg aagcggccgc
     4141 cctcctcgga gtgcaggccc gcgtagacga tccggtccgc tcccgccgcc agcaccacgt
     4201 cgaggaacgg gggaggcgtc accccgcgcc agttccccgg atcgcactgc acggtcggcc
     4261 ccagctcgat cgtgtccagg aaccccgcct ccgcccgggc cgcgaccagc aggtgcggca
     4321 ccccggcgat ccggcgcacc aggaacgccg cgacggccgg tccggtcggc tccagcagcg
     4381 gctgggacca ggcggacacc tcccggctgc ccgcctcgac gcgtaccgcc accagctgga
     4441 agaaccggcc gtccggccgc ctcagcgcgt ccggatggtg ctcccagccc gccagacccg
     4501 ccagcggcac ccggtccacc acgacatcgt gccgcgaccg ctcgacggtc acccaggacc
     4561 gtacggccgc gtccggcagc agcgcgtccg gctccgctgc gcccatcggg aagcaggcga
     4621 cgacggtccg ggcgtccatg ttcaccacgt tgtcgcggcg gagcagcgca ccgatctggc
     4681 cgagggtgag ccagcagaaa tcgtcgtcgt gcggcacctc gtcgagcgcc tcgacgagca
     4741 tgttccggtt ggccttgcgg tagaaccagg aaccgtgctc ggactggagc acgtcgaaca
     4801 ccacctgccc ccggtccggg tcggtgaagt actccagata cttcacgccg gcgccccggt
     4861 ggaccttggt gtagttgctg cgggtggcct gcaccgtcgg cgacagctgg agcagattgc
     4921 ggttgcccgg ctccatcttg gcctgcagca gaaagtgcag gacaccgtcg atctcctggg
     4981 ccagcaggcc caggatgccg acctcgggct gtcggatgat cggctgctcc cagtgccgga
     5041 acgggccttc ggacatcgtc acggacaggc cctcgacgct gaagaaccgg cccgagcggt
     5101 gcaccagatt gccggtgtcc tcggcgaagg accagccgtc gagctccgcg aagccgatgc
     5161 gctcgaccga gaagcggtgg gcgcgccggc ggccgtcgag ccagtccgcg acgtcggcgg
     5221 tggcgatcca cgccccgtcg acggccgcgg cggacctggc cagccgcccc gccagcgacg
     5281 cgtccgcgcg cggccgcagg gccgccgtgc tcatgtccgc tccccggccg gcgcgacacg
     5341 gggcttgacg ccgatgaaca gcccgttgcc ggggtagtcg cccgcgacgt gctccatcga
     5401 aaggccggct ctgctgaagg cctggtcgaa ctgctcgtag ctgtacagcg aattcacatg
     5461 ggtgtcggag aagtgccgca cgcccttgcc cggttcggcc accaggtagt ggatgtccat
     5521 gcggctggca ctctcgctct cgcgaacgga gtgcgacacc cgcgcgatcg tccggccgtc
     5581 ccccgtggtc agggaactgc ccacgtggtc gggggtgaag ttctccggga accaccacgg
     5641 ttccacgacc acgaccccgc ccggttccag atggcgctcg aactccgcta tggcggagtc
     5701 gagttcgtcc tgccccagca tattgccgat cgcgcagaac agggagacca cggcgtcgta
     5761 cctgcggccc cgctcgaagg agcgcatgtc gccgtagtgc accgggatgt gcggcagggc
     5821 gcgccgggcc accgcgagca tgccctccgt gaggtccacc ccttcgacgt gggtgaagtc
     5881 ctcggcgaag tggcgcagat gacctccggt gccgcatccc acgtccagga gggaggccgc
     5941 accggggtga cggtcgcgga tatggcgggt caccgcctcg gactcggccc ggtagtcctt
     6001 gccccgtccg tcgtagatgg cgtcatagat gtcaccggcg tcgtagatcc cggtgctctc
     6061 ctcgtcggac atcaggctgc ctttctggcg gaacgcggtg tcgtcgcggt ctcgtcgggg
     6121 atgggggcgc cgagcgggtg gtcccggcac ggggtcacag cgaggccagc acctctcgca
     6181 gcgcggcgat cacctggtcc tgcaccgctt ccgggagcga ggggtacatc ggcagtgaga
     6241 agatctcctg ggacagccgc tcggtgaccg gcagcgagcc cttcgcgtat ccgaggtgcg
     6301 cgaagccgga catggtgtgg cagggccacg ggtagctgat gttcagcgcg atgtcgtgcg
     6361 ccttcagcgc ctcgatgatc cggtcccgct cggggtggcg gacgacgtag acgtagtagg
     6421 agtgcgtgtt gccctcgttg gtacccggca gctggagccg gccggggccg gtcagatcgc
     6481 cgagcgcggc ctcgtaccgc cgggccacgg cgttgcggcc ctccagatag gtgtcgagac
     6541 gggtcagctt gcggcgcagg atctccgcct gcacctcgtc cagacgggag ttgtgccccg
     6601 gagtgcggat gacgtagtag accttctcca tgccgtagta gcgcagctcg cgcagggcct
     6661 ggtccgtcgc ccggtccgag gtgatcaccg cgccgccgtc gccgtacgcg ccgagcacct
     6721 tggtcgggta gaaggagaac gcggccgcgt cgcccagggt gcccacgagg tcgccgtggt
     6781 ggcgggcgcc gtgcgactgc gcgcagtcct ccaggatctt cagcccgtac cggtcggcga
     6841 gcgcccgcag cggggcgaag tccacgctct gcccgtacag gtgcaccggc agcagcacct
     6901 tggtgcgctc ggtgatcgcc gcctccacga ggtccgtgtc gatgaggaag tcctcctcgc
     6961 gtacgtccac gaagaccggg accgcgccag tgccgaggat ggccacgacg gtgggagccg
     7021 ccgtgttcga cacggtgatg acctcgtcgc cggggcccac gcccagggcc tccagggcca
     7081 gcttcagtgc gttggtgccg ttgtcgacgc tcgtgcagtg cgccgcgccg tgatacgcgg
     7141 cgaactcctc ctcgaacccc ttgacgctcc cgccgaggat cagctgaccg gagccgaaga
     7201 cctgctccac ggcgtccagg atgtcggcct tctccttctc gtactccggc aggtagtccc
     7261 acacacgcgt tgtcactgtc gtacctccag gtactggtcg ttcacgaggg aaaggggagc
     7321 ggttcgccgg acacgcccta ggccgccgcc ggggcgccga accagcggcc cagagcggac
     7381 cggagacccg cttcgtcgga cccggcccac gccacgtagc cgtcgggccg caccagtacg
     7441 gccccggcgt cggcgaacgt gtccgcgtcc ctctccgtcg cgggcgcccc ggtcacggtg
     7501 accacccggt ccttgtggcc ggcggccgtc ctggcgagcc cggcgtcgcc ggacagatcc
     7561 agcagcacac cctgggccgc gcgcagcagg cccgtggtgt cccggtcgcc cgaggcggtg
     7621 cgcagcatgc ggtgcggcag gcggcggccc gtgagggggt gggcctcggc gggcggtgtg
     7681 tcgcccatgc cgtcgtagcg cacgtcgagg ccggtgacga tacccgccag atgccgcctc
     7741 acctcgtcgt gggcgagcag ctcggtgaag agctcccgca tcgggtcggc ctcggggccg
     7801 ccgaggaaga tctgtccctg ggcgcgggtg ttcatcagca accgctcgcc caccgggtgg
     7861 cgttcgccgt ggtaggtgtc cagcagcccg gccggcgccc agcccgtcac ggtcgccgcg
     7921 agcttccacc cgagattcac cgcgtcctgg acaccgacgc tcaacccctg tccgcccgcg
     7981 ggcagatgga cgtgcgcggc gtcccccacg accagcaccc ggccgcgccg gtacacctcg
     8041 gcctgtcgtg tggcgtcggt gaacgagctg acccagtccg cctgtccacc ggagatgtcc
     8101 tcaccggtca gccgctgcca ggcggcagcc acctcggcga actccacctc ctggtcgcgc
     8161 ccggcgggca gggtgccgtg ctcgcacacg atgatgcggt ccacaccctc gccgagcggg
     8221 gcggccatca ccatgcctcc gtccagcagt tcgcccagga agcgggggcg cagcccacag
     8281 ccgcgcacat cggcgaggta catgccccgg gtggcggggg cgccggggaa gccgatgccg
     8341 gccgcccggc gcaccgggct gttcccgccg tccgcgccca ccaggtaggc ggagctcagc
     8401 cgctgttccc cgccggcccc ccgggcggtg acccggaccc ggtccggggc ctggtcgagc
     8461 gcggtgaact cccagccgcg ccggatgtcg acgccgagct ccaccgccca cgcctccagc
     8521 accgcttccg tctgcgactg cggtatgccg cgcgccccga agtggccgcc gtccaggacg
     8581 gtgtagtcga actgcacccc gccgaagtgg cccacggggc tggtctccag gccggggaag
     8641 cgggtgtcca ggccgcgctg ggcgaacgac tccagcgcgc gtgcggtgaa ccccagcccg
     8701 cgcgactgcc cggtgggccg ctccagcttc tccagtacga cgacggaggc gccgccgagg
     8761 cgcagctcgc cggcgagcat cagcccgctg ggtcctgcgc cgacgacgat cacgtccgcg
     8821 gtgagcgggt ctcggtccgt ctcgctgtgc acggctgctc cctcgatggg tggggcggtc
     8881 ggtagtctgt cgggtgccgt cacagggcac cggctgtccc ggcggtgctg ccgtccttcg
     8941 cggacttcca ccggttcgga tgggagcggt accagtcgac ggtcgacgcg agcccggcgt
     9001 cgaaaccgat gcgcggggcg tagcccagct cctcgcggat cttgcggtcg tccagggcgt
     9061 agcgcagatc gtgccccttg cggtcctcga cgtaccggat catcgagtcg tcggctccgc
     9121 agagctccag gatccgacgg gtcagggaga ggttgtcgag ctcgttgccg ctgccgatgt
     9181 tgtagatccc gccggccccg ccgcgggtga ggaccaggtg cagtgcccgg cagtggtcgt
     9241 cgacgtgcag ccactcgcgc cggttgcggc cgtctccgta gaccgggacg ggcatgcctt
     9301 ccagcaggtt ggtgacgaag cgggggatca gcttctcggg gtgctggtgg gggccgtagt
     9361 tgttggagca gcgggtgacg gagacgtcca ggccgtgggt gcgccagtag gaccgggcga
     9421 tgaggtcgga gcccgctttg gacgccgcgt agggggagtt gggcagcagc ggctcctcct
     9481 ccgtccagga tccggccgcc agggagccgt acacctcgtc ggtggagacg tgcaggacgc
     9541 gttccacgcc gctgtgcagt gcggcctcca gcaccgtctg ggtgccgagg acgttcgtac
     9601 ggacgaacgc ggcgccgccc gccaccgacc ggtcgacgtg ggactcggcg gcgaagtgca
     9661 ccaccgcgtc gtggccgggc agcagctcgc ggagcagagg gccgtcgcag atgtcgcccc
     9721 ggacgaaatc caggcggggg tgcgcggcgg gaagattttc ccggttgccg gcgtacgtca
     9781 gagcgtcgac gacggtgata cgcaggtcgt ccgcgacacc gtaggcgccg tcgagcaggg
     9841 agcgcacata atgggagccg atgaatccgg ccccgccggt caccagaatt ctcatgccaa
     9901 ttcccggttc tctgtggacg tgctcgaagt ttttccgtgc atgcggcgga ggcttctccc
     9961 gggtcaggcg gcggtgatct ccatgacgta ctggccgtac ggggagctgg ccaggttgcg
    10021 gccgagccgg tggcaggcgg cccggtcgat gtaccccatc cgccaggcga tctcctcgat
    10081 gcaggcgatg cgcacgccct gacggtgctc caggagctgc acgtactggc ccgcctcggt
    10141 gagggcgtcg tgggtgccgg tgtccagcca gacgaagccc cgtccgagct ccaccagccg
    10201 ggccgtaccg cgttccaggt acgtccggtt gacatcggtg atctccagct cgccacgctc
    10261 ggagggttcg agaccgcgcg cgatgtcgat cacgctgttg tcgtagaagt acagaccggt
    10321 gacggccagg tttgagcggg gccgggtggg cttctcctcc agtgaggtga gcctgccgtc
    10381 ggcgtcgagc acgcccacgc cgtagcgctc cgggtcgcgc acggggtagc cgaacagcac
    10441 gcagccctcc acgtcgcggg cgttggtctg gagcacctcg ccgaagccgt agccgtggaa
    10501 caggttgtcg ccgagcacca gggccacgga gtcgtcaccg atgtggtcgg ccccgaccag
    10561 gaaggcgtcg gcgatcccgc gcggcttgtc ctgttcggcg tacgtgaggt tcagacccag
    10621 ctccgagccg tccccgagga gcttgcggaa gccgcccagg tcgtcgggcg aggaaatgat
    10681 ctggatgtcg gtgacgcccg tcagcatcag cacggacaac gggtagtaga tcatcggctt
    10741 gtcgtagacc gggagcagtt gtttcgagac gccgaaggtg atcggctgca gcctggtgcc
    10801 caggccgccg gccaggataa ttcccttcac tactctgtct ccattcagtt cgcgcgattt
    10861 cccggtgcgc attcccgtgc aagtgaaagg aaaccgacta caggatcttg ggggcgccgg
    10921 agaatggcaa ggtaattcag gtcagggaaa tgtcaattcc cgcgtcaatt cgcgcgccga
    10981 tcgccgcgga gatctcctgg ccccgcgcgg cgcccgcctt ccggcggccc gcgggcccga
    11041 accagcggcg cagcgcgtcg tgcgcgcccg cccagcggtc ggccggggtc cggcccccca
    11101 cccaggcgac gtggccgtcc ggccgaacca gcagggccgt ggccgacgac agggcgccgc
    11161 cgggccgggg ccggccgcgg gcgaggacga cccggtccgt ccagcccgcc accacggccg
    11221 ccgcaccggc gttcgccgtg acggggccgg gccccaggtc gaggaacagc ccgcgtccgg
    11281 accgcaggag cgcaggtgtc cacacctctc cggcgccggt gtccagcacc gagggaggca
    11341 gccgccgccc gagcagcgac ggctcaccgg ctccgtccgc gtaccgtatg tccagaccgg
    11401 agatcgccgc ggccaggttc tcccgtacgg gcgcgagcgc cagcagttcg gcgcacagag
    11461 cccggagcgg ctcggcctcc ggaccgccga gcagcaggtc ggactgggcc cggatgttcg
    11521 ccagcacccg ccgcccggtc tcgtgacgct cccggtgata gctgtccagc agcccctcgg
    11581 gcgcccgccc gccgacttcg agcgccagct tccagcccag gttgaaggcg tcctggagtc
    11641 cgaggttgag ggcctggccc cccaccggca tctgctgatg ggcggcgtcg cccgcgaaca
    11701 ggacccggcc gtaccgatac cgcgtgagct gccggttcgc gtcgccgaag gagttcagcc
    11761 acagcggtgt gccgccgctg atgtcgtccc cggtgacccg cttccaggcg gcggcgacct
    11821 cctcgaagcc gggcgggccc gaacgggggc ggaccgtgct gccgaactcg tggaccatca
    11881 cccgcgtcac cccctcccgg gtggcggcga cggcgagtcc gccgggcagc cgctggaaac
    11941 gccggttctc gatccggacg ccccgcacat cggcgcgcag catctcgcgc cccgcctccc
    12001 gcccggcgag ttcggcgccc accagctccc gtacggtgct gagttcgccg tcgcagccca
    12061 ccagcaggca gccgcgcagc cgcaccacgg acccgtcggc ggcttcggcc tccacgctca
    12121 cgccggtggc gtcctgggcc agggcgcgga cgcgcagacc gcgccgcacg tcggccccga
    12181 gcgcgcgtgc ccaccgttgg agaagctcct cggtacgggt ctgcgacacc ttccactggc
    12241 ccggatggct gctgggcagg gtcaggtcca ggggcagccc gccgtagtgc ccgcggggct
    12301 cgttcgcggg gagacccaac tccgccagga gccctcggga gtcgaggatc tccatggtgc
    12361 gcgcgtgcag ggtggaggcc ctcgactcgg tggtgggccc cggccggtcg tccacgacca
    12421 ccacaccggc cccgccgagc cgcagttcgc cggcgagcag cagtccgacg ggccccgcgc
    12481 cgacgacgac gaccggatcg gcgggggccg tggccgcccc cggctgcgta ccgttgcccg
    12541 tcgtcatacc cggcgcttct gctccgcgta gtccttggca tggcccagcg tcgcccggct
    12601 gttggtgctc agggcgccct ggacgtacgc cttggcgtcg gcgaccgtgg cgtcgtcgcc
    12661 gagcacacgc gcgatgttgt cggtgttcag caccacggtg tgctgcgagg tcgccgcgac
    12721 cgtgtcgccc tcctgggaga acgtccacac ccccgtgtgc agggtcatca gagccggcag
    12781 cgtgacctgc ttgtacgcga tggtgctcgc cgggaggcac acccggtacg acttcgtcgt
    12841 gtgtgtggag ccgtccttgg cccgggtgtc catctccagg atctgcagcc ccggcgacac
    12901 ctcctccagc cggacgctcg ccacatgtgg caggcgctcc tcccagcggt cgccctcgtt
    12961 gatgaagtcg tagaggtcct tggccgcgcc gtcgacgcgc accgtgtcct cgaaggagaa
    13021 ggtgatctcc tcagcggcct gtgcgaactc cacgttcttc ttcaacgcgg caagttccga
    13081 acgggagttg cgatccacgg cctcgtcgat ccaggccagc gactcgggat cgtcgtcgat
    13141 cgcacggtag tcgtgcagca gccggacgcg cgactcccgc tccgacagcg gctcgatgat
    13201 ccacgtgccg cccatggccg ccaccggggg gctcgtcacc tcctggcgga aggtgatgcg
    13261 cagggccccg ggatccaggg tgcggtggga gacccagtgc ttggcggtgc cgttggccgt
    13321 cgcccagatc tggatacgct cctcacgccg accgcgctcg acgtgatcga cgtagatggt
    13381 cggcgggaag atccggggcc agttctctac ctcggcgatc agccggtaga cgtcggcggc
    13441 cgcggcgagc acggtgatct cgtgctcgac ctctcgggtg gtcatcgtcg gctctccaag
    13501 tcggttgtcc ggaacggtcg atggggtgtc atcagaagtt gccgaggccg ccgcagacgt
    13561 tcagggcctg cgcggtgatc gaagcggccg tgtccgaggc caggtagccg acgaggccgg
    13621 cgacctcctc gggggtggag tagcggccga gcgggatctt cgcctggaac ttgtcgagga
    13681 tggcttcctc ggtggtgtcg tacgcggcgg cgtagcccgc ccgcacccgc tgtgccatcg
    13741 gggtctcgac gtaaccgggg cacaccgcgt tgacggtgat gccggtgggc gcgagctcgt
    13801 tgccgagagc cttggtgaat ccgaccacgc cgtgcttgga ggcggagtac ggggcgccga
    13861 gcaccacacc ctgcttgccc gccgtggagg cgatgttgat gatccggccc cggctcttct
    13921 cccgcaggcc gccggtggtg aggacctcgc gggtgagccg gaagacgctg ttgaggttgg
    13981 tgtcgatgac gtcgtgccac agctcgtcgc tgatgtcggc ggtgactccg ccgccggagc
    14041 ggcccgcgtt gttcaccagg acgtccacac cgccgaactc cgcgaccgca gcccgcacga
    14101 acgccttcac gtcctcgtcg gagcggacgt cgagcgtggt gcccgcggcc tggtggcctt
    14161 cctcgcgcag ctgcttgacg gtggacgcga cgttctcttc gttgcgggcg ccgatgtaga
    14221 cgcgatgccc ctgggaggcc aggagacggg cgacagccag accgattccg ctggtggctc
    14281 cggtgatcag ggcgacgggc tggtactgcg acatggtcac ttctttcctg cggagggtag
    14341 ggggcgttgc tgcggagggg gctttcccgc ggagggggtc tttcctgctg agggaggcgg
    14401 gggaggcggg aggcggggga ggggctgagt gcccggtggg tccctgcgct gccgcccccg
    14461 tgccgccgta cgtgaacctc aggcggcgat gccggtctgc gcgttgaccg cctcgatcag
    14521 tgcccgtggt gtgctcgccg tggcgagggc gtcctcgtcg agcgtgatgc cgtactcgcg
    14581 ctcgatccgg ctgccggtct ccagaagggc gagggactcg tagcccagcg cctcgaagtc
    14641 gacgtcgagg atgtcgccgt cgaggtccac gctctcgtcg gcgcccgcgc cctcacggag
    14701 gatgcggcgc agcgcgtcga gggtgaatcc ggtggttgcc atggtctgct cccttagctt
    14761 ctcgtccgaa ctgttcttgg ggtgctgcac cgtggtgctc tgccgcgggc ggatcgcccg
    14821 tccgccggtc atgccgccgc gcggaccacc accgcggagt tgaacccgcc gtggccgcgc
    14881 gccaggacca gcgccgtcct cacctcggcg gtgcgggact gcccgaccac caggtccagg
    14941 cccaaggagg cgacgggctc gacgttgacc gtcggcggga tcagcccctc ctccatggcg
    15001 agcagcgccg ccgccagatc cagcggcgcg gcccccgagt acaggcggcc ggtcatggtc
    15061 ttgggcgcgg tgacgggcac accccgcgtg ccgaacacgg cggtcagtgc ctccgcctcg
    15121 acacggtcga gttcgggtac ggccgccgcg tccgcgaaga ccacgtccac ctcgtccggt
    15181 ccggtgcccg cgtccgccag cgccagctcc acggccttcc gcagccccgg cgggcgaccg
    15241 ctgccgggcg cggggtccgt ggtggccccg tacccggcga tctcgccgta caccttcgcc
    15301 ccgcgagccc gggccgccgc cgccgactcc atgatcagga tggcgccgcc ttcgcccgcc
    15361 acatggcccg aggcgtccgc gtcgaacggc agataggcgc gcgcgggctc gctgcgcgtg
    15421 ctcaggcggc cgctggtgag ctgggcgacc cagccccacg ggcagagcga cgcgtcgacg
    15481 gcgccggaga cgatcagcgg ggttcccttg cggatctgcc ggcgcgcctg cgccactgcg
    15541 tccaaaccgc ccgcctggtc gctgacgacg accccgcagg gccccttcat gccgttgcgg
    15601 atggagatct ggccgctgtt gaccgcgtag aaccaggcga aggactgata ggcgctgacg
    15661 tactggctgc cctggctcca cagcttctgc aactcaccct ggccgaactc gaatccgccc
    15721 gacgagctgg ccgtgaccac gcccatgtcg aaggagtccc gctccccggg ggtcacaccc
    15781 gcgtcggcga gcgcccagtc ggtggccgcc agcgccatcc gggtcatccg gtcggtctgc
    15841 gggagcagcc ggcccggcag caggtcctcg gcgacgaatc cgggtacctc gccgcccagt
    15901 tgggcgggat agccggagac gtcgaagcgc gtcagccggg cgatgccgct cttgccgctg
    15961 cgggtcgccg cccagaagtc ctcgacgccg agtccgttgg gggcggcgac gccgagcccc
    16021 gtcaccacta cgggtgcgtt catgccgcgc tcctctccgg gcgggccagg accatggcgc
    16081 tctggaagcc gccgaacccg ctgcccaccg tcaggaccgc gtcggtgagc tgctcgcgcg
    16141 cctccagcgg cacgtagtcg aggtcgcact cggggtcagg ggtgtgcagg ttcgccgtgg
    16201 gcggcaccac gtggtgctcc atagcgagcg cggacgcggc gatctcgatg gacccgatcg
    16261 cgcccagcga gtggcccacc atcgacttga tggaactcac cggcgtccgg taggcgtggt
    16321 cacccagcgt ccgcttgaac gcggcggtct cgtggcggtc gttctgcttg gtgcccgaac
    16381 cgtgcgcgtt gacgtagtcg atctcggtgg ggttcatccg tgcctcgtcc agcgcgagcc
    16441 ggatggcctc cgccatctcc gccccgtccg gccgcagccc ggtcatgtgg tacgcgttgg
    16501 agcgcgtcgc gtatccggcg atctccgcgt agatgtgcgc cccgcgcttc ctcgcactct
    16561 ccagctcctc cagtacgaag acagcggccc cttcaccgag gacgaatccg ttgcgggtgc
    16621 cgtcgaaggg gcgggaagcg cgctccgggt cgtcgtgccg cggcgtggtg gccttgatcg
    16681 cgtcgaagca ggccatggtg atcggcgaga tgggggcgtc ggacgacccg gcgaccatca
    16741 catcggcgga gccctcacgg atcagttcca cggcgtaccc gacggagtcg atgccggagg
    16801 tgcagccggt ggagaccacg gtgctcggcc cctcggcgcc gaccgcgtgg gcgacttcga
    16861 ccgcgaacga gctgggcacc aggtagttgt agaggtgcgg gacggcgtat gcgtggtcga
    16921 ccagatgcag cttcccgccg tcactgacga cgttgtactc ctcgtccagg cccatcgtgg
    16981 ctcccacggc gctgccgacc gtcaccccga cccggtgcgg atccaggtcc gcgaggccga
    17041 tgccgctgtc ggcgaccgcc cccctggcgg cgaccaccgc gaactgcgcg gcccggtcca
    17101 tgcggcggat ctcctgggcg ctcagaccgt gccgacgcgg atcgaagtcg atctccgcgg
    17161 ccacccggga gcggaacggc gacgggtcga agaaggtgat ccccctggtg gcggtacggc
    17221 cgtcgctcag gagctcccag aagtcgcgcg tgccgacgcc tcccggagcc agcacctcga
    17281 ttccggtgat gaccacgcgt cgggcggtca tgcggaggcc tcccagtggt agaaacgccc
    17341 cgccatcgcg tcggccggcg agcgccaggt ggcggggtcg taggcctgga tgaacggctt
    17401 cagctcctcg ctgatccgca cgaagcgggg gtcggtcttg gcttcctcga tcaggtcgcc
    17461 gccgttgtcg ccgtcgaagt cctggaggtg gaagtagagg ccgcggtagg cgaaaagctg
    17521 ccgcctgcgg gtgcccatcc ggtgcggcat gtccgtgcgg tcgaactcgg cgaagcgccc
    17581 ggcgacgtcg atgctggagt cggggtccat ccgggcgact atcagagtgc tgtgcatggg
    17641 gcggtctctc ctagagcaaa gtgacaggaa agcgaagaat cacttgcgaa caagtgttcg
    17701 atcacgtgcg cggaggcggc gccggcccga gcggtgcccg ggaggatgaa gtgcggcagg
    17761 acgccgtcgg agcggggtgc gccggggcgg aacggccggg tccggagtag ccgggcaggg
    17821 cccgtggaag ctccggggcg acgtcctcaa ccctgtccga cggcccgccc cccgggcaag
    17881 gaaagcctgt tcaggagttg gtcaggtttc acaagtgctg ctgcgcggtg gcgcgccggg
    17941 tcaagccggc gtcaagtttg tgtccaccat cggcagagcc ccttgggatc ccgttgacat
    18001 ggatcccaag gggctcgggg atgggccgga gtgttctgcg ctccggccgg atcaggcgtg
    18061 gccgaggcgg aagccgacgc cgcgcacggt gatcacccag gtgctggccc cgagcttgtt
    18121 gcgcagggtg ctgacgtggg tgtcgacggt ccgccgggac caggagtcgc cccacacctg
    18181 ctgcatcacg tgcttgcggg gaatgacgct gtcggggttc gcggcgagga ggtgcaggag
    18241 gtcgaactcc ttgcgtgtga gggtgatgcg ccggccgtcc agggtcactt cgcgcgaacc
    18301 ggtgtcgatg acgagcgccc cgtgccggat ggtggcggga ggcggttccg cgacgggcgc
    18361 cggcgccgcc cgggctcgcc gccgggggcg ggccctccgc atcaccgcgt ccatccgggc
    18421 catcagttcc tggaacccgt acggcttggt caagtagtcg tcggccccgg cctgaagccc
    18481 cagcacccgg tccagctcgg tgccgcgcgc ggtgaccgcg atgatcggga cgtcgcacgc
    18541 cgcgcggacg gtgcggcaga cctctaagcc gtccagatcg ggcaggtcga ggtccagcag
    18601 gatcaggtcg gcgtcctcgt acgcccggag agcggcgtcg cccgtggcga cgctgaccgc
    18661 ttcgtggccg tgtctgcgca gcccccgagt gaggcactcc gcttccttcg tatcgttctc
    18721 caccaccagt aggcgccagg aatctgacgc ggtttgcccc ccgtgtacgg cacggccgtc
    18781 acccggttcc tgcggatgag atcccccgga accgtgagga gcaggtacga aagacgccag
    18841 catattgctg gaacgctggt tcattttctc ccctagctcg tcagctgagt accactccag
    18901 cgttcgaact tacaaaccac tccttcggtt tgtcaaagat ttacttgagg ggaggcgggt
    18961 gagtagaata tcgaaagaga tgtcaaggaa cggggggtta agcatgcgtc caggagtgcc
    19021 tggagcctgc gctggagaag cgacattaca gcccaatcca caagactctg caccctccgg
    19081 atgagtggaa ttcggtattc cgattgctgg ggagagtcgc tttctctttc gttcccgcaa
    19141 gaccccggtc cggcggacgg ggcacgggtc ggcgtgaagt ggctgaatcg tgagggtgtg
    19201 gacgatcgaa cgtcctgctg tgcgccgctc tgtgctgccg ctcttgggtg atttaacccg
    19261 acctgctagg aatgagggcg aacgttttcg gtcattctgg gggcggggtg tgcggccgga
    19321 ttcccgcttc tgtggatagc agagtgttgt ccctcacttt cttcggtgcc ggcgaccggg
    19381 ctatcgctcc gggtgtgaga atagtggtcg gcgcctccgg tggtggtgtt gcgggccgga
    19441 ttttcggccg ggaaagtgaa ggtcgataat ttttgtttat gctctgcatt attcggcccc
    19501 cggtgcaggg taaggcgttt tgtgtaatgc gagcactttt tccaggtgtg ttcgagcccc
    19561 gtggacaaat gagccgcgat ggtccttcac caggtgcgcg cccgggtccg gcccgggagg
    19621 ggggctgtca gtaccccgta cgggcggcaa cggcgggcgg ggccggggat gatcccggcc
    19681 ctgggtgtgc cgcaccggcg ttcgtatccg ttctccagga attccgcgtg agcgtgagcg
    19741 cctgtccatt ccgcgtagtc caggagccgg acgccgccgc ccccggcgcc gctgccgatc
    19801 aggaaatgcc gggcgagcag ccccggggtg gggccggctc tgcgctcctc ggccgacgcg
    19861 cggacccggg accaggcgcg ggcggccccc aggctttcga agccgtacgt actgatcacc
    19921 aggcactccg cccgtgcgga caccgggtgg gccgcggttc tgcggtgcgg ggtgcacacc
    19981 agcggatcga actcctcgac ggccgggacc gaggtcgtga tctccttggt gacggtgtcc
    20041 cggtcgtggt cctggaaggt ggtcagctcc ctggcgcccg cccactgctc gtacgtgagc
    20101 acggtgtcgc cgttcgtgct gacgaggacg tgtaccgcga tgagtcccgc aggccagggg
    20161 gtgttcgccc acgtctccaa cgaggagtcg gccagggtca gttgatcttt cggtgcggtc
    20221 acccatcggt acaacacgga gacaccggca tcggcgcggg ccatgtcggg cagcggaaca
    20281 cgcggggcgc gcatcggacg aatcctccgg aaggtcggtt gccggatcgt gcggggagcc
    20341 cgaagaggcc ggcgacgggg cgatcccccc gaagccggcc cctccggtcc gccgcgtggc
    20401 ggcgcccgcg cgggcgccgc cacgagtccg cggggaagtg ggtcaggaac aggccgcgcg
    20461 cgtaccggtg atggtgatgg agctcgggcc gccggtcgtg ccgtcgtcgt agaagtagtg
    20521 cgtctccccc ttcgcggcga acgccttcga cgaggacagc ttgccgttca gcgcggaacg
    20581 ggcctcgccg ggcggaccgc ccggcagcgg gtgctcgacg gtgaagcgga aggatccgga
    20641 ccagccgggc gtccaggtgc cgtgcccgac gaagtacggg gtgccgttct cgtccggcgg
    20701 cccgatcagc ttgacgctcc ggtcggtgcg gaactccagc ttcacgtccg ccggcggcat
    20761 gtcgccctcc gccgcctggg cgttccagca gccggcgggc gagaggaagg ccgccggggc
    20821 cggtgcgggc gacgtggcga gggcggtcgg cgcggtcgcc agggaggcgg tgagcagggc
    20881 gcctgcgagg acggttccgg cgagccgtgt gcgggggtgc atgaaaggtc tccttcggtg
    20941 ggaggggcgg cacatgaggt ggtcaggcgg tgcgggctgc cagctcctcc aggaggccga
    21001 gcaccgtgga gggcggcggc atcgtcgcca tctccgcggc gatggcctgc gcccgcgcgg
    21061 tggaggacgg gtcgcccagc aactgctcgc aggcggcgcc gatccgctcg gcggtccgct
    21121 cgtgcggctg gagggacagc ccggcgccga agtcggcgat ccggtccagg gcggcgccgt
    21181 gcgaggcgtt gtcccggttc tccatgacgg acagctgcgg caccccgaag tgcagggcgg
    21241 tcaggctcgt caccccgccg gagtggtgga cgatcaggtc actcgtgggg gccaccacgt
    21301 cgagcgggat ccagccggcg cggatgccgt cggcctcggc gcgcagcttc gcggccagct
    21361 cctccggcgc ggccaccacg acctcgacgc ccagcgcgcc gaccttgccg acgacatccc
    21421 gcaggaactc caggttcagc ccgcggctgc cgcccgtgac gaccacccgg cggcgctcgc
    21481 cgcgccggag catccacggc tcgggctcgc gctgctggtt gaccggggtc caccgcatcg
    21541 gctgggcggg cagcgcgtgg gtgtggcgga ggctcggcgg ggtgacgtcg accaggagct
    21601 gcggctccgg cagtgcgtcc aggcccaggt gcgcgagctc gggacggagt tcggcggtgg
    21661 caccggggtc gatgccgtcg aagtccttgc cgtcccaggt ctggcgcacg tacgggacgc
    21721 ccagccggtg ggcgaggagg ggggcggcat acgtgagggt gccgccgacg accaggtcgg
    21781 ggcgccagtc ctcggccagc ccgagcagcg gatccatgct ggcggcggcg agcctgccga
    21841 accagccacc ggtgaagagc cgtccctcga cggggttgtc cggcacggtg acgggattgc
    21901 ccgcgcggtc cttggtgcgg aagtggggga tgggggtgga ggtcaccgag aacggggtca
    21961 ggcccatggc ggcgatgtcc ggcagcacat tgcggggcgc ggccatgatg acctggtgtc
    22021 ccgcactgcg ggcggcggtg gccagggggg tcatgccgta gacggtggcg gcactgcctg
    22081 cggcgagaaa gaggatcttc atgggtgcct ttcggggcgg attcggttgg gtgcgggccc
    22141 cgggcgggtg cccggggcga accaggggcg tgcggcccgt tgaggcgcgg gaccgtgccg
    22201 gatccgcggg ccggagaacg ggcgagcagg ccacgggcca cccgctccga acgcccgcgg
    22261 gatccccggg ccttgccacg gggacgggcc gcgggcagga ggaggggacg gagtcagggc
    22321 cccgcaggca gcggagagcg ctgggcgtcg gtccagaagg cccggagcgc cgactccagg
    22381 gaacgccctg cccgccatcc cagaagtccc cgcgccggac cggtgtccac ctggatccag
    22441 tcgtccgtcc cgggggccgt cgtcggcgcc tcccgttcca cgacccgcgc cgggaccccg
    22501 ctgacccgga tcaactcggt caccagggac cgcaccggca cggcctcgcc ccgtccgatg
    22561 ccgacgatct gcccccgcgc cgacgacgtc gcggcggcga cgaccgcgtc cgccacgtcc
    22621 cgtacgtcga cgtaatcccg gtgtgcgagc agggcgttca gctccacgac cgcctccctg
    22681 ccctcggcgg cggcctcccg gagccgggcg gcgacctgtc cgagcaggct gatgtcgggg
    22741 gtcccgggac cggccgcgtt cgcgatgcgc agcaccaggg cccgcacctc gccgcgggcg
    22801 tccgcctcca gcaccgcccg ggcggcggcg agcttggccc gtccgtacgc ggtggcgggc
    22861 ggatccccgt actccagcac ggaaccgagc tggacgagcc gcggcggctc gtccagcagt
    22921 cgcagggcct ccaggagcct gagcgtgggg gccgtgcagc gctccgtcat ctcctcgggc
    22981 ggtgcgcccc agatactgcc gatggagttc acgacgacgt cgacccgctc ctcgcgcagc
    23041 acccgggcaa cctcgtcggc gggggtgcgc gccaggtcga atgagaggaa ccggtgcgcg
    23101 gccaggcccg gcagcggact ccgggccacc gcgagaacct gatggcctgc ggctgccgac
    23161 gccgcgcaca catgtcgtcc cacgaagccg gtggctccca ggacgagaag ggtgggcggg
    23221 ctcgcgggcc gagagggcat
//
