BGC0001663 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001663 (Nostoc sp. UIC 10110)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS,T3PKS	1	22,989	High	merocyclophane C/merocyclophane D	PKS

BGC0001663 - Region 1 - T1PKS,T3PKS

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Location: 1 - 22,989 nt. (total: 22,989 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 22,990
Label		BGC0001663

Tailoring functions

Oxidoreductases: oxygenase

merG: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Transferases: methyltransferase

merF: isoprenylcysteine carboxyl methyltransferase

smcogs: SMCOG1150: isoprenylcysteine carboxyl methyltransferase

Ligases: ligase synthase

merC: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

merD: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

merE: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

merI: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001663.3	1.96	PKS	merocyclophane C, merocyclophane D	Nostoc sp. UIC 10110
BGC0001164.3	0.72	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.70	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0000282.3	0.69	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000107.3	0.67	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001284.4	0.67	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001276.3	0.67	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001273.3	0.67	PKS	asperlactone	Aspergillus ochraceus
BGC0002154.2	0.67	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001663.3	0.99	PKS	merocyclophane C, merocyclophane D	Nostoc sp. UIC 10110
BGC0001164.3	0.69	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.68	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0000282.3	0.67	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000107.3	0.67	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001284.4	0.67	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001276.3	0.67	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001273.3	0.67	PKS	asperlactone	Aspergillus ochraceus
BGC0002154.2	0.67	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 22989:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal) + (mal)
Non-colinear ordering:: merC + merD

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

merC: mal

PKS_AT (531..825): mal

ATSignature: Malonyl-CoA, inactive

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 95.8%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.6
inactive: 188.1
Methoxymalonyl-CoA: 63.5
Methylmalonyl-CoA: 57.9
Isobutyryl-CoA: 36.2
Propionyl-CoA: 36.1
Acetyl-CoA: 25.2
Benzoyl-CoA: 20.8
trans-1,2-CPDA: 19.0
Ethylmalonyl-CoA: 11.6
2-Methylbutyryl-CoA: 11.1
CHC-CoA: 10.1
3-Methylbutyryl-CoA: 5.4
fatty_acid: 0.0

merD: mal

PKS_AT (575..869): mal

ATSignature: Malonyl-CoA, inactive

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 95.8%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.6
inactive: 188.1
Methoxymalonyl-CoA: 63.5
Methylmalonyl-CoA: 57.9
Isobutyryl-CoA: 36.2
Propionyl-CoA: 36.1
Acetyl-CoA: 25.2
Benzoyl-CoA: 20.8
trans-1,2-CPDA: 19.0
Ethylmalonyl-CoA: 11.6
2-Methylbutyryl-CoA: 11.1
CHC-CoA: 10.1
3-Methylbutyryl-CoA: 5.4
fatty_acid: 0.0

merI: NH2

CAL_domain (48..492): NH2

minowa: NH2

Prediction, score:

NH2: 23.9
AHBA: 21.2
fatty_acid: 12.9
shikimic_acid: 11.6
Acetyl-CoA: -1.2

Link to PARAS substrate predictor