BGC0001663 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001663 (Nostoc sp. UIC 10110)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T3PKS,T1PKS	1	22,989	cylindrocyclophane	Polyketide	50%

BGC0001663 - Region 1 - T1PKS,T3PKS

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Location: 1 - 22,989 nt. (total: 22,989 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 22,990
Label		BGC0001663

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001663.1	1.34	Polyketide	merocyclophane C, merocyclophane D	Nostoc sp. UIC 10110
BGC0000282.1	0.68	Polyketide	alkylresorcinol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001962.1	0.63	Polyketide	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0001068.1	0.58	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000041.1	0.58	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001858.1	0.57	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001831.1	0.53	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001162.1	0.52	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001161.1	0.52	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0001163.1	0.52	Polyketide	1-heptadecene	Moorea producens 3L

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001663.1	0.87	Polyketide	merocyclophane C, merocyclophane D	Nostoc sp. UIC 10110
BGC0000282.1	0.67	Polyketide	alkylresorcinol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001962.1	0.65	Polyketide	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0001068.1	0.63	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000041.1	0.62	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001858.1	0.62	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001831.1	0.60	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001162.1	0.60	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001161.1	0.60	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0001163.1	0.60	Polyketide	1-heptadecene	Moorea producens 3L

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 22989:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal) + (mal)
Non-colinear ordering:: merC + merD

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

merC

PKS_AT (531..825): mal

ATSignature: Malonyl-CoA, inactive

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 95.8%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.6
inactive: 188.1
Methoxymalonyl-CoA: 63.5
Methylmalonyl-CoA: 57.9
Isobutyryl-CoA: 36.2
Propionyl-CoA: 36.1
Acetyl-CoA: 25.2
Benzoyl-CoA: 20.8
trans-1,2-CPDA: 19.0
Ethylmalonyl-CoA: 11.6
2-Methylbutyryl-CoA: 11.1
CHC-CoA: 10.1
3-Methylbutyryl-CoA: 5.4
fatty_acid: 0.0

merD

PKS_AT (575..869): mal

ATSignature: Malonyl-CoA, inactive

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 95.8%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.6
inactive: 188.1
Methoxymalonyl-CoA: 63.5
Methylmalonyl-CoA: 57.9
Isobutyryl-CoA: 36.2
Propionyl-CoA: 36.1
Acetyl-CoA: 25.2
Benzoyl-CoA: 20.8
trans-1,2-CPDA: 19.0
Ethylmalonyl-CoA: 11.6
2-Methylbutyryl-CoA: 11.1
CHC-CoA: 10.1
3-Methylbutyryl-CoA: 5.4
fatty_acid: 0.0

merI

CAL_domain (48..492): pk

minowa: NH2

Prediction, score:

NH2: 23.9
AHBA: 21.2
fatty_acid: 12.9
shikimic_acid: 11.6
Acetyl-CoA: -1.2