BGC0001665 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001665 (Mycobacterium marinum M)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T3PKS,T1PKS	1	19,519	methylated alkyl-resorcinol/methylated acyl-phloroglucinol	PKS	100%

BGC0001665 - Region 1 - T1PKS,T3PKS

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Location: 1 - 19,519 nt. (total: 19,519 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 19,520
Label		BGC0001665

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001665	2.00	Polyketide	methylated alkyl-resorcinol, methylated acyl-phloroglucinol	Mycobacterium marinum M
BGC0000282	0.66	Polyketide	alkylresorcinol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000041	0.63	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001310	0.63	Polyketide	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0001962	0.53	Polyketide	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0002171	0.52	NRP, Polyketide	pyrophen, campyrone B	Aspergillus niger ATCC 1015
BGC0002275	0.52	NRP, Polyketide	pyrophen, campyrone B	Aspergillus niger CBS 101883
BGC0002227	0.52	NRP	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0002228	0.51	NRP	CIML B, CIML A, CIML D, CIML C	Colletotrichum incanum
BGC0001219	0.51	Polyketide	shanorellin	Chaetomium globosum CBS 148.51

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001665	1.00	Polyketide	methylated alkyl-resorcinol, methylated acyl-phloroglucinol	Mycobacterium marinum M
BGC0000282	0.66	Polyketide	alkylresorcinol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000041	0.65	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001310	0.65	Polyketide	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0001962	0.60	Polyketide	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0002171	0.60	NRP, Polyketide	pyrophen, campyrone B	Aspergillus niger ATCC 1015
BGC0002275	0.60	NRP, Polyketide	pyrophen, campyrone B	Aspergillus niger CBS 101883
BGC0002227	0.59	NRP	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0002228	0.59	NRP	CIML B, CIML A, CIML D, CIML C	Colletotrichum incanum
BGC0001219	0.59	Polyketide	shanorellin	Chaetomium globosum CBS 148.51

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 19519:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (redmal) + (Me-redmal)
Non-colinear ordering:: MMAR_2473 + MMAR_2472 + MMAR_2471

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

MMAR_2471

PKS_AT (565..863): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 208.0
Ethylmalonyl-CoA: 200.0
Methoxymalonyl-CoA: 173.7
2-Methylbutyryl-CoA: 146.4
trans-1,2-CPDA: 125.2
Propionyl-CoA: 121.4
Malonyl-CoA: 110.7
CHC-CoA: 95.1
Isobutyryl-CoA: 92.6
Benzoyl-CoA: 78.5
Acetyl-CoA: 56.3
inactive: 47.5
3-Methylbutyryl-CoA: 46.4
fatty_acid: 40.7

MMAR_2472

PKS_AT (560..846): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 187.0
inactive: 96.8
Methoxymalonyl-CoA: 84.2
Methylmalonyl-CoA: 70.8
Propionyl-CoA: 45.7
Ethylmalonyl-CoA: 38.5
Isobutyryl-CoA: 36.3
trans-1,2-CPDA: 33.2
fatty_acid: 32.5
Benzoyl-CoA: 28.8
2-Methylbutyryl-CoA: 27.9
Acetyl-CoA: 25.7
CHC-CoA: 25.4
3-Methylbutyryl-CoA: 0.0

MMAR_2473

PKS_AT (520..796): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Methylmalonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 166.9
inactive: 81.4
Methoxymalonyl-CoA: 78.0
Methylmalonyl-CoA: 63.0
Propionyl-CoA: 39.7
Ethylmalonyl-CoA: 30.2
trans-1,2-CPDA: 28.0
Isobutyryl-CoA: 27.9
Benzoyl-CoA: 26.2
CHC-CoA: 24.6
fatty_acid: 21.1
2-Methylbutyryl-CoA: 19.2
Acetyl-CoA: 15.8
3-Methylbutyryl-CoA: 0.0