BGC0001665 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001665 (Mycobacterium marinum M)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T3PKS,T1PKS	1	58,235	High	methylated alkyl-resorcinol/methylated acyl-phloroglucinol	PKS

BGC0001665 - Region 1 - T1PKS,T3PKS

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Location: 1 - 58,235 nt. (total: 58,235 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 58,236
Label		BGC0001665

Tailoring functions

Oxidoreductases: oxygenase

MMAR_2475: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Transferases: acylase

MMAR_2471: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

MMAR_2473: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Ligases: synthase

MMAR_2470: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

MMAR_2472: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

MMAR_2474: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001665.3	2.00	PKS	methylated alkyl-resorcinol, methylated acyl-phloroglucinol	Mycobacterium marinum M
BGC0001273.3	0.67	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.65	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0000041.3	0.61	PKS	oronofacic acid	Pseudomonas syringae
BGC0001254.3	0.61	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.61	PKS	FR901512	fungal sp. No.14919

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001665.3	1.00	PKS	methylated alkyl-resorcinol, methylated acyl-phloroglucinol	Mycobacterium marinum M
BGC0001273.3	0.67	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0000041.3	0.64	PKS	oronofacic acid	Pseudomonas syringae
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.64	PKS	FR901512	fungal sp. No.14919

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 58235:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (redmal) + (Me-redmal)
Non-colinear ordering:: MMAR_2473 + MMAR_2472 + MMAR_2471

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

MMAR_2471: mmal

PKS_AT (565..863): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 208.0
Ethylmalonyl-CoA: 200.0
Methoxymalonyl-CoA: 173.7
2-Methylbutyryl-CoA: 146.4
trans-1,2-CPDA: 125.2
Propionyl-CoA: 121.4
Malonyl-CoA: 110.7
CHC-CoA: 95.1
Isobutyryl-CoA: 92.6
Benzoyl-CoA: 78.5
Acetyl-CoA: 56.3
inactive: 47.5
3-Methylbutyryl-CoA: 46.4
fatty_acid: 40.7

MMAR_2472: mal

PKS_AT (560..846): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 187.0
inactive: 96.8
Methoxymalonyl-CoA: 84.2
Methylmalonyl-CoA: 70.8
Propionyl-CoA: 45.7
Ethylmalonyl-CoA: 38.5
Isobutyryl-CoA: 36.3
trans-1,2-CPDA: 33.2
fatty_acid: 32.5
Benzoyl-CoA: 28.8
2-Methylbutyryl-CoA: 27.9
Acetyl-CoA: 25.7
CHC-CoA: 25.4
3-Methylbutyryl-CoA: 0.0

MMAR_2473: mal

PKS_AT (520..796): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Methylmalonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 166.9
inactive: 81.4
Methoxymalonyl-CoA: 78.0
Methylmalonyl-CoA: 63.0
Propionyl-CoA: 39.7
Ethylmalonyl-CoA: 30.2
trans-1,2-CPDA: 28.0
Isobutyryl-CoA: 27.9
Benzoyl-CoA: 26.2
CHC-CoA: 24.6
fatty_acid: 21.1
2-Methylbutyryl-CoA: 19.2
Acetyl-CoA: 15.8
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor