BGC0001667: microcystin-LR biosynthetic gene cluster from Fischerella sp. CENA161
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Location: 1 - 55,137 nt. (total: 55,137 nt).
This entry is originally from NCBI GenBank KX891213.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001667
Short description microcystin-LR biosynthetic gene cluster from Fischerella sp. CENA161
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: KX891213.1
Compounds
  • microcystin-LR
  • microcystin-FR
  • microcystin-LA
  • microcystin-LAba
  • microcystin-LM
  • microcystin-LV
  • microcystin-LL
Species Fischerella sp. CENA161 [taxonomy]
References
Chemical products information
microcystin-LR
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C49H74N10O12
microcystin-FR
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C52H72N10O12
Chemical database entries
NPAtlas
microcystin-LA
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C46H67N7O12
microcystin-LAba
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C47H69N7O12
microcystin-LM
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C48H72N7O12S1
microcystin-LV
(no structure information available)
microcystin-LL
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C49H73N7O12
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AQH32478.1
  • mcyH
 1 - 1773 (-) ABC transporter
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  • AQH32479.1
  • mcyI
 1795 - 2823 (-) phosphoglycerate dehydrogenase
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  • AQH32480.1
  • mcyF
 2849 - 3637 (-) amino acid racemase
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  • AQH32481.1
  • mcyE
 3685 - 14220 (-) hybrid polyketide synthase/peptide synthetase
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  • AQH32482.1
  • mcyD
 14372 - 25990 (-) type 1 polyketide synthase
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  • AQH32483.1
  • mcyG
 26148 - 34067 (-) hybrid peptide synthetase/polyketide synthase
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  • AQH32484.1
  • mcyA
 35371 - 43734 (+) peptide synthetase
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  • AQH32485.1
  • mcyB
 43752 - 50162 (+) peptide synthetase
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  • AQH32486.1
  • mcyC
 50165 - 54016 (+) peptide synthetase
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  • AQH32487.1
  • mcyJ
 54075 - 55016 (+) O-methyl transferase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
mcyE
Module ?
Specificity: glutamic acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
  • Mass spectrometry
mcyA
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
  • Mass spectrometry
Module ?
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
  • Mass spectrometry
mcyB
Module ?
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
  • Mass spectrometry
Module ?
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
  • Mass spectrometry
mcyC
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
  • Mass spectrometry
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added NRP substrate specificities
Detailed domain annotation
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