BGC0001667: microcystin-LR biosynthetic gene cluster from Fischerella sp. CENA161
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Location: 1 - 55,137 nt. (total: 55,137 nt).
This entry is originally from NCBI GenBank KX891213.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001667
Short description microcystin-LR biosynthetic gene cluster from Fischerella sp. CENA161
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
KX891213.1
via
Compounds
  • microcystin-LR
  • microcystin-FR
  • microcystin-LA
  • microcystin-LAba
  • microcystin-LM
  • microcystin-LV
  • microcystin-LL
Species Fischerella sp. CENA161 [taxonomy]
References
Chemical products information
microcystin-LR Evidence:
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C49H74N10O12
microcystin-FR Evidence:
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C52H72N10O12
Chemical database entries
NPAtlas
microcystin-LA Evidence:
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C46H67N7O12
microcystin-LAba Evidence:
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C47H69N7O12
microcystin-LM Evidence:
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C48H72N7O12S1
microcystin-LV Evidence:
(no structure information available)
microcystin-LL Evidence:
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C49H73N7O12
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AQH32478.1
  • mcyH
 1 - 1773 (-) ABC transporter
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    • AQH32479.1
    • mcyI
    		 1795 - 2823 (-) phosphoglycerate dehydrogenase
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      • AQH32480.1
      • mcyF
      		 2849 - 3637 (-) amino acid racemase
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        • AQH32481.1
        • mcyE
        		 3685 - 14220 (-) hybrid polyketide synthase/peptide synthetase
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          • AQH32482.1
          • mcyD
          		 14372 - 25990 (-) type 1 polyketide synthase
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            • AQH32483.1
            • mcyG
            		 26148 - 34067 (-) hybrid peptide synthetase/polyketide synthase
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              • AQH32484.1
              • mcyA
              		 35371 - 43734 (+) peptide synthetase
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                • AQH32485.1
                • mcyB
                		 43752 - 50162 (+) peptide synthetase
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                  • AQH32486.1
                  • mcyC
                  		 50165 - 54016 (+) peptide synthetase
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                    • AQH32487.1
                    • mcyJ
                    		 54075 - 55016 (+) O-methyl transferase
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                      Biosynthesis information

                      Biosynthetic modules

                      Name
                      Unk01
                      Type
                      nrps-type1
                      Genes
                      mcyE
                      Substrates
                      glutamic acid (evidence: Structure-based inference, Sequence-based prediction, Mass spectrometry)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk02
                      Type
                      nrps-type1
                      Genes
                      mcyA
                      Substrates
                      serine (evidence: Structure-based inference, Sequence-based prediction, Mass spectrometry)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk03
                      Type
                      nrps-type1
                      Genes
                      mcyA
                      Substrates
                      alanine (evidence: Structure-based inference, Sequence-based prediction, Mass spectrometry)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk04
                      Type
                      nrps-type1
                      Genes
                      mcyB
                      Substrates
                      leucine (evidence: Structure-based inference, Sequence-based prediction, Mass spectrometry)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk05
                      Type
                      nrps-type1
                      Genes
                      mcyB
                      Substrates
                      tyrosine (evidence: Structure-based inference, Sequence-based prediction, Mass spectrometry)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk06
                      Type
                      nrps-type1
                      Genes
                      mcyC
                      Substrates
                      serine (evidence: Structure-based inference, Sequence-based prediction, Mass spectrometry)
                      Integrated Monomers
                      Domains
                      adenylation
                      Annotation changelog

                      Entry version: 3

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-09-15
                      Added NRP substrate specificities
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2019-10-16
                      Migrated from v1.4
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2019-10-16
                      Updated compound(s) information (NPAtlas curation)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2018-08-06
                      Submitted
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      Detailed domain annotation
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