BGC0001670 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001670 (Streptomyces virginiae)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	88,860	monensin	PKS	61%

BGC0001670 - Region 1 - T1PKS

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Location: 1 - 88,860 nt. (total: 88,860 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 88,861
Label		BGC0001670

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001670	1.00	Polyketide	monensin	Streptomyces cinnamonensis
BGC0000100	0.90	Polyketide	monensin	Streptomyces cinnamonensis
BGC0000084	0.43	Polyketide	laidlomycin	Streptomyces sp. CS684
BGC0000016	0.39	Other	amphotericin B	Streptomyces nodosus
BGC0001273	0.34	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001163	0.34	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001276	0.33	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244	0.33	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001275	0.33	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002729	0.31	Polyketide	sordarial	Neurospora crassa OR74A

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001670	1.00	Polyketide	monensin	Streptomyces cinnamonensis
BGC0000100	0.97	Polyketide	monensin	Streptomyces cinnamonensis
BGC0000084	0.74	Polyketide	laidlomycin	Streptomyces sp. CS684
BGC0000016	0.71	Other	amphotericin B	Streptomyces nodosus
BGC0001273	0.67	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001163	0.67	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001276	0.67	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244	0.66	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001275	0.66	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002729	0.65	Polyketide	sordarial	Neurospora crassa OR74A

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 88860:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-ccmal) + (Me-redmal) + (ccmal - Me-redmal) + (ccemal - redmal) + (Me-ccmal - redmal) + (ohmal) + (Me-ohmal) + (Me-ohmal - Me-ccmal)
Non-colinear ordering:: monAI + monAII + monAIII + monAIV + monAV + monAVI + monAVII + monAVIII

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

monAI

PKS_AT (553..877): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 91.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 187.6
inactive: 95.8
Methoxymalonyl-CoA: 64.0
Methylmalonyl-CoA: 50.6
Propionyl-CoA: 32.8
Acetyl-CoA: 31.1
Isobutyryl-CoA: 26.0
Ethylmalonyl-CoA: 21.0
Benzoyl-CoA: 10.2
3-Methylbutyryl-CoA: 10.0
trans-1,2-CPDA: 4.8
fatty_acid: 4.3
2-Methylbutyryl-CoA: 4.1
CHC-CoA: 0.1

PKS_AT (1616..1909): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 201.7
Ethylmalonyl-CoA: 193.1
Methoxymalonyl-CoA: 164.6
2-Methylbutyryl-CoA: 133.5
trans-1,2-CPDA: 122.6
Propionyl-CoA: 114.8
Malonyl-CoA: 99.2
CHC-CoA: 97.1
Isobutyryl-CoA: 70.9
Benzoyl-CoA: 59.3
Acetyl-CoA: 47.3
fatty_acid: 46.8
3-Methylbutyryl-CoA: 31.7
inactive: 26.3

monAII

PKS_AT (565..860): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 190.9
Ethylmalonyl-CoA: 188.6
Methoxymalonyl-CoA: 146.1
2-Methylbutyryl-CoA: 116.4
trans-1,2-CPDA: 112.5
Propionyl-CoA: 111.5
CHC-CoA: 110.3
Malonyl-CoA: 83.7
Isobutyryl-CoA: 66.0
fatty_acid: 42.6
Benzoyl-CoA: 41.7
Acetyl-CoA: 37.8
3-Methylbutyryl-CoA: 24.2
inactive: 18.7

monAIII

PKS_AT (609..912): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 227.9
inactive: 119.5
Methoxymalonyl-CoA: 64.9
Methylmalonyl-CoA: 58.8
Isobutyryl-CoA: 32.2
Propionyl-CoA: 30.0
Benzoyl-CoA: 21.5
Ethylmalonyl-CoA: 18.1
Acetyl-CoA: 18.1
2-Methylbutyryl-CoA: 15.9
CHC-CoA: 10.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2508..2803): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 191.0
Ethylmalonyl-CoA: 188.5
Methoxymalonyl-CoA: 145.6
2-Methylbutyryl-CoA: 116.8
trans-1,2-CPDA: 113.8
Propionyl-CoA: 111.9
CHC-CoA: 111.4
Malonyl-CoA: 81.9
Isobutyryl-CoA: 68.2
fatty_acid: 44.2
Benzoyl-CoA: 43.5
Acetyl-CoA: 39.6
3-Methylbutyryl-CoA: 25.5
inactive: 17.8

monAIV

PKS_AT (594..889): emal

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Methylmalonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 229.3
Methylmalonyl-CoA: 189.3
Methoxymalonyl-CoA: 157.9
2-Methylbutyryl-CoA: 118.8
trans-1,2-CPDA: 114.9
Malonyl-CoA: 112.8
Propionyl-CoA: 102.9
CHC-CoA: 96.8
Isobutyryl-CoA: 78.9
Benzoyl-CoA: 77.3
Acetyl-CoA: 57.1
fatty_acid: 40.3
inactive: 27.6
3-Methylbutyryl-CoA: 22.9

PKS_AT (2378..2672): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 195.3
inactive: 87.3
Methoxymalonyl-CoA: 83.8
Methylmalonyl-CoA: 74.0
Propionyl-CoA: 48.6
Isobutyryl-CoA: 44.7
Ethylmalonyl-CoA: 40.1
fatty_acid: 39.5
Acetyl-CoA: 30.4
trans-1,2-CPDA: 21.9
2-Methylbutyryl-CoA: 20.1
Benzoyl-CoA: 18.3
CHC-CoA: 15.4
3-Methylbutyryl-CoA: 0.0

monAV

PKS_AT (564..859): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 189.9
Ethylmalonyl-CoA: 189.6
Methoxymalonyl-CoA: 145.5
trans-1,2-CPDA: 113.7
2-Methylbutyryl-CoA: 111.5
Propionyl-CoA: 108.3
CHC-CoA: 105.4
Malonyl-CoA: 83.8
Isobutyryl-CoA: 63.7
Benzoyl-CoA: 45.8
fatty_acid: 39.5
Acetyl-CoA: 37.2
3-Methylbutyryl-CoA: 23.5
inactive: 18.2

PKS_AT (2399..2694): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.1
inactive: 97.7
Methoxymalonyl-CoA: 75.8
Methylmalonyl-CoA: 70.7
Propionyl-CoA: 44.8
Isobutyryl-CoA: 39.1
Ethylmalonyl-CoA: 36.7
Acetyl-CoA: 33.3
fatty_acid: 31.4
trans-1,2-CPDA: 20.5
Benzoyl-CoA: 17.2
CHC-CoA: 15.5
2-Methylbutyryl-CoA: 15.0
3-Methylbutyryl-CoA: 0.0

monAVI

PKS_AT (583..880): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 203.5
inactive: 99.1
Methoxymalonyl-CoA: 71.7
Methylmalonyl-CoA: 66.2
Propionyl-CoA: 45.3
Isobutyryl-CoA: 36.5
Ethylmalonyl-CoA: 33.8
Acetyl-CoA: 33.4
fatty_acid: 30.5
CHC-CoA: 18.4
trans-1,2-CPDA: 18.2
Benzoyl-CoA: 17.9
2-Methylbutyryl-CoA: 16.6
3-Methylbutyryl-CoA: 0.0

monAVIII

PKS_AT (564..862): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 192.4
Ethylmalonyl-CoA: 185.2
Methoxymalonyl-CoA: 152.8
2-Methylbutyryl-CoA: 124.3
Propionyl-CoA: 119.8
trans-1,2-CPDA: 119.0
CHC-CoA: 105.9
Malonyl-CoA: 89.5
Isobutyryl-CoA: 69.1
fatty_acid: 46.6
Benzoyl-CoA: 43.8
Acetyl-CoA: 38.5
3-Methylbutyryl-CoA: 26.4
inactive: 22.2

PKS_AT (2120..2415): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.7
Ethylmalonyl-CoA: 192.2
Methoxymalonyl-CoA: 150.6
2-Methylbutyryl-CoA: 125.9
CHC-CoA: 122.0
Propionyl-CoA: 118.6
trans-1,2-CPDA: 117.2
Malonyl-CoA: 93.2
Isobutyryl-CoA: 67.4
Benzoyl-CoA: 42.4
Acetyl-CoA: 41.7
fatty_acid: 40.2
3-Methylbutyryl-CoA: 34.1
inactive: 27.3

monAVII

PKS_AT (569..864): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 190.9
Ethylmalonyl-CoA: 188.6
Methoxymalonyl-CoA: 146.1
2-Methylbutyryl-CoA: 116.4
trans-1,2-CPDA: 112.5
Propionyl-CoA: 111.5
CHC-CoA: 110.3
Malonyl-CoA: 83.7
Isobutyryl-CoA: 66.0
fatty_acid: 42.6
Benzoyl-CoA: 41.7
Acetyl-CoA: 37.8
3-Methylbutyryl-CoA: 24.2
inactive: 18.7