BGC0001671 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001671 (Agrobacterium tumefaciens (Rhizobium radiobacter))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	hserlactone,NRPS	1	77,714	High	monobactam	NRPS:Type I

BGC0001671 - Region 1 - NRPS,hserlactone

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Location: 1 - 77,714 nt. (total: 77,714 nt) Show pHMM detection rules used

Region on contig edge.

hserlactone: Autoind_synth
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 77,715
Label		BGC0001671

Tailoring functions

Oxidoreductases: oxygenase

Rhz8: dioxygenase, TauD/TfdA

smcogs: SMCOG1121: dioxygenase, TauD/TfdA

Transferases: sulfotransferase

Rhz10: Sulfotransferase domain

extras: Sulfotransfer_3: Sulfotransferase domain

Hydrolases: back translocase deaminase hydrolase

Rhz11: GTP-binding protein LepA

smcogs: SMCOG1190: GTP-binding protein LepA

Rhz15: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Rhz5: ornithine cyclodeaminase

smcogs: SMCOG1158: ornithine cyclodeaminase

Ligases: ligase synthase

Rhz12: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

Rhz6: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001671.3	1.01	NRPS	monobactam	Agrobacterium tumefaciens
BGC0000342.4	0.36	NRPS	enniatin	Fusarium equiseti
BGC0002135.2	0.33	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.32	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001166.5	0.31	NRPS	HC-toxin	Alternaria jesenskae
BGC0001833.4	0.31	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.31	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.31	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000307.4	0.30	NRPS	AbT1	Aureobasidium pullulans
BGC0001128.4	0.30	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001671.3	0.98	NRPS	monobactam	Agrobacterium tumefaciens
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti
BGC0002135.2	0.66	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001166.5	0.65	NRPS	HC-toxin	Alternaria jesenskae
BGC0001833.4	0.65	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.65	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.64	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000307.4	0.64	NRPS	AbT1	Aureobasidium pullulans
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 2, location 25425 - 74014:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-X - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

Rhz6: X - X

AMP-binding (482..883): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAIIYGHILK
Nearest Stachelhaus code(s):: Ala DVFIYAAILK (56% 8Å match)
Stachelhaus code match:: 60% (weak)

AMP-binding (2020..2427): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DIWEITADDK
Nearest Stachelhaus code(s):: Dpr DIWEVTADDK (79% 8Å match); Dab DIWELTADDK (71% 8Å match)
Stachelhaus code match:: 90% (moderate)

Link to PARAS substrate predictor