LOCUS       BGC0001674             11913 bp    DNA     linear   BCT 31-OCT-2016
DEFINITION  Streptomyces mirabilis strain OK461 genome assembly, contig:
            Ga0007938_103, whole genome shotgun sequence.
ACCESSION   BGC0001674
VERSION     BGC0001674
KEYWORDS    .
SOURCE      Streptomyces mirabilis
  ORGANISM  Streptomyces mirabilis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 16:03:27
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11913
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11913
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5190:7780]"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5191..7780
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     cand_cluster    1..11913
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..11913
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001674"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..11913
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1..675)
                     /locus_tag="SAMN02787118_103369"
     CDS             complement(1..675)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 190; E-value:
                     5.3e-58)"
                     /gene_kind="regulatory"
                     /locus_tag="SAMN02787118_103369"
                     /product="two component transcriptional regulator, LuxR
                     family"
                     /protein_id="SFF02396.1"
                     /transl_table=11
                     /translation="MAESVRVLIADDQALLRGSFRVLVDSTPGMKVVGEAGDGATAVRL
                     ARELAPDVVLMDLRMPVLDGIAATREICSDETLTGVRVLALTMFDMDEYVYPALQAGAS
                     GFMLKDASPSDLVDGIRVIATGEGVLAPTVTRRVIANFSRRGETPRPAPRLVGLTKREH
                     EVLVQIANGLSNAEISERLVISMPTVKTHVGSLLAKLHARDRAQLVIIAYESGLAERGM
                     PT"
     gene            complement(765..2087)
                     /locus_tag="SAMN02787118_103370"
     CDS             complement(765..2087)
                     /codon_start=1
                     /locus_tag="SAMN02787118_103370"
                     /product="poly-gamma-glutamate synthesis protein (capsule
                     biosynthesis protein)"
                     /protein_id="SFF02417.1"
                     /transl_table=11
                     /translation="MTRMTVALSGDCMATRGAVIASDPAAGRLHDLVHSADFAVTNLEV
                     VPSDGRGHPVHNAAGGGCLIADSGVLDEITAAGFSVLGCANNHAMDLGTEGVLGTVDLL
                     RSRRIPFAGIGADLTTARRPVYVDRPGGSLALLACTTTFLPGQEAADPSPELPGRPGLN
                     PLRHSATLRVTAPQMDVLRTIDAETGLRARRAEARTLLGVDPAILAPDRLTLFGTRFLT
                     ADEPGFTTECDPRDLDEISRWVGEARLRADLVVVSVHSHEPGPTPETPGEFLRAFAHRM
                     IDEGADVVVGHGPHFLRGVELYRNRPIFYSLGNIVSQIELTDRVSAEDYAKVTTDRPPT
                     PGRYYDRLGGHGTRLFAPHRRYWQSLLPVLTFDDGTLVRARLHPVDLGFALPVHRRGRP
                     RVADGAEAKEILTEVTRLSESYGTTVGAGVDGTAELLLDVA"
     gene            complement(2084..2815)
                     /locus_tag="SAMN02787118_103371"
     CDS             complement(2084..2815)
                     /codon_start=1
                     /locus_tag="SAMN02787118_103371"
                     /product="Protein-disulfide isomerase"
                     /protein_id="SFF02446.1"
                     /transl_table=11
                     /translation="MTSTQTTDATVREMVHQRHRRRRTMVVSLVAVLVVAAAALVGAGL
                     VRANNTAPGKAPSRVPAGIAADKSGVAASTGAVRVDVYLDYLCPECRRTERALTAALDD
                     LRSRGGVSVVYHPVAFLDGRSEPAGYSTQAASAAACAADAGRFEQYSTVLFAKQPAEQG
                     PGLSEAQLIAAGRDAGITDASFARCVEDAPYRPWVRYVSDIAASRKVALTPTVTVEGRR
                     VDVTGSDPGAALTRVVTEARR"
     gene            complement(2818..3342)
                     /locus_tag="SAMN02787118_103372"
     CDS             complement(2818..3342)
                     /codon_start=1
                     /locus_tag="SAMN02787118_103372"
                     /product="Methylamine utilisation protein MauE"
                     /protein_id="SFF02470.1"
                     /transl_table=11
                     /translation="MDAGTADVTTTANTRATAGYWAGAARLTVRLLLAAVLAYAGLVKI
                     GDLTEAGRTVALYRIVPDDSAQLVGGVLPFVEVALALLLVAGLATRAAATGAAVLLVVY
                     GAAIASVWARGMSIDCGCFGSGGTLSGGAARGYALDIARDLLLLGAAALLIRNPRTPYA
                     LDSWVLDPKER"
     gene            complement(3363..4232)
                     /locus_tag="SAMN02787118_103373"
     CDS             complement(3363..4232)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065:ABC-2 type
                     transporter (Score: 125.6; E-value: 3e-38)"
                     /gene_kind="transport"
                     /locus_tag="SAMN02787118_103373"
                     /product="ABC-2 type transport system permease protein"
                     /protein_id="SFF02493.1"
                     /transl_table=11
                     /translation="MSRTDTAPAALGDITAAAPPTDRSRHPARPVLLLWRREMTRLRHN
                     PVRLAMGLVTPLLFLVVLGTGLDAASSSLGKAQLNDYRAYLFPGTLVMSVQAPAIAVGI
                     SLVWDRRLGVLRQMLVAPFPRASIVFGLALGGATTGAVYGLMVLSVGGIASIRYTPMLL
                     VVLLELLLVSLMFTSLGLLAAVTIRQVDTFQVVVNLSLMPLMFFSGAMFPPNGLPGWLD
                     TVVKLNPLTYGVDAVRRTLPGPSVLTSEQTRLMLGDWHPPVAAELGVLAALTAVALGLA
                     GYRFSRTS"
     gene            complement(4229..5194)
                     /locus_tag="SAMN02787118_103374"
     CDS             complement(4229..5194)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 206.6; E-value:
                     7.3e-63)"
                     /gene_kind="transport"
                     /locus_tag="SAMN02787118_103374"
                     /product="ABC-2 type transport system ATP-binding protein"
                     /protein_id="SFF02515.1"
                     /transl_table=11
                     /translation="MTAIRAEGLYAYYGTTPAVNGLDLTVPTGSMYGFLGPNGAGKTTT
                     INMLTTLLRPTAGRAEVAGFDVAARPAEVRRRIGIVFQESTLDLDLTAAENLRFQADLC
                     GLSRRASRDAIASMLDLMDLSERHRVPVRQFSTGLRRRLEIARGLLAEPSVLFLDEPTT
                     GLDAQTRAAVWEHLERLRRERGITVFVTTHQLDEAEHCDRIAIIDRGKVVTEGTPADLK
                     SVIGADLVVLRTEDDQRAAHALSDRFGLPAEPTPDGLLLRVERAAALVPRLCTELGVTV
                     HEVAIAPPTLDDVFLHHTGLAIRESTTGPRMLGNLGEGLR"
     gene            complement(5191..5682)
                     /locus_tag="SAMN02787118_103375"
     CDS             complement(5191..5682)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /locus_tag="SAMN02787118_103375"
                     /product="Transglutaminase-like superfamily protein"
                     /protein_id="SFF02531.1"
                     /sec_met_domain="PF13471 (E-value: 2.1e-27, bitscore: 85.5,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPAVAEEAPRLPWYRQLAPRCAAGAARLLVRLPPARLHRVLGV
                     VSKGSRPAGYAEVARARRSVVSVSTRCAGLGCLQRSVATVLLCRARGRWADWCTGFRTE
                     PFGAHAWVEADGRPVDEPGELSVFRTVLAVRRPDERTRPSDKNPHPTDVSPRPSEGSRS
                     "
     gene            complement(5679..5942)
                     /locus_tag="SAMN02787118_103376"
     CDS             complement(5679..5942)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SAMN02787118_103376"
                     /product="Coenzyme PQQ synthesis protein D (PqqD)"
                     /protein_id="SFF02555.1"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 5.6e-11,
                     bitscore: 32.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 3.5e-26,
                     bitscore: 81.1, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 6.4e-14, bitscore: 42.0,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLTLARDVTLTVVDSGAVLLDGRRGRYWQLNHSGAGVLRQLLDG
                     TAPDAAAAGLCAAAPVSDDQARQDVQALIDALSAAKLVEVAS"
     gene            complement(5939..7780)
                     /locus_tag="SAMN02787118_103377"
     CDS             complement(5939..7780)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177:asparagine synthase (glutamine-hydrolyzing)
                     (Score: 121.2; E-value: 8e-37)"
                     /gene_kind="biosynthetic"
                     /locus_tag="SAMN02787118_103377"
                     /product="asparagine synthase (glutamine-hydrolysing)"
                     /protein_id="SFF02575.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.8e-39, bitscore:
                     126.2, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFVVLPDCPAGAASAGRLRAARRVDHASGRPWIVGDWPEAEAVV
                     VEAGPRRMVVLGHTRLDETAAVAALGRLRSLHDVDSIASRLPGAVHLAVSLDGRTRVQG
                     SAVGARQIFSAVVGGVTVAASGVEPLLRLTGAGLDETVLAARLLAPGGPPWPLAQRPVR
                     RGIEALTTGHWLELATDGRARQTRWWELPEPSLTLAEGAAAVRSALDDAITTRVAAGGT
                     LSADLSGGLDSTSLCFLAHAAGADLVTYHVMPIDSANADTMWAHRAAECLPAARHHTLS
                     ADRAENLFDVGYTADLVGAAPEGPSTWASGLAHIQDLAKRATAEGATLHLTGFGGDELF
                     GRMPACAWSLARATPVGGLRLVNRYRLANRWPWRATVRSLLDRSTFTQNLGRVAARIDA
                     PPPPIDEPDFGWVFAPRMPAWATPDAVAAVRALLTDAATEGPGPLDTDRARHQALASLV
                     FEGTTVRQVNTALGDTGITWDAPFLDDRVVEAALATRIDQRLLGGRFKPLLTSAARGLV
                     PPDILGRRDKGEFSAEAFRGLARNRARILELSEDSHLARLGLIDPAAFRSAVLNPGPMS
                     HHLQPIDTTVACESWLRTHPETYPLPAARNTHTGELR"
     gene            complement(7853..8086)
                     /locus_tag="SAMN02787118_103378"
     CDS             complement(7853..8086)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (lassopeptides)
                     predicted lassopeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SAMN02787118_103378"
                     /product="hypothetical protein"
                     /protein_id="SFF02595.1"
                     /transl_table=11
                     /translation="MGQLPHAGGTVRPVTSVTDHRPNKVGLTDPKREDIMSAIYEPPML
                     QEVGDFEELTKCLGVGSCNDFAGCGYAIVCFW"
     CDS_motif       complement(7919..8086)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence:
                     MGQLPHAGGTVRPVTSVTDHRPNKVGLTDPKREDIMSAIYEPPMLQEVGDFEELTK"
                     /locus_tag="SAMN02787118_103378_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       complement(7853..7918)
                     /prepeptide="core"
                     /locus_tag="SAMN02787118_103378_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class I"
                     /score="12.20"
                     /molecular_weight="2171.5"
                     /monoisotopic_mass="2169.9"
                     /core_sequence="CLGVGSCNDFAGCGYAIVCFW"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MGQLPHAGGTVRPVTSVTDHRPNKVGLTDPKREDIMSAIYE
                     PPMLQEVGDFEELTK"
                     /leader_location="[7918:8086](-)"
     gene            complement(8097..8849)
                     /locus_tag="SAMN02787118_103379"
     CDS             complement(8097..8849)
                     /codon_start=1
                     /locus_tag="SAMN02787118_103379"
                     /product="ABC-2 family transporter protein"
                     /protein_id="SFF02612.1"
                     /transl_table=11
                     /translation="MSETLAAVRAETTKLRGIRGTQISLLLFAAVSVLIAALDGWSAKN
                     ALESDNPSLRSDFTPEQAGLDGILYGQLALIVFGVLIVTSEYTSGMIRVSLLAVPRRGR
                     LYLAKMSVTAVAAVAVSLPVTVLGYLVTQAALGSHGSSLGASGVPRALAGAVVYLTLMC
                     LFAAGIAAIARNAVVPLAVLLPMVLAGTHILSLIGATKEMARYFPDQAGNELLTVRSPH
                     TAFGFTVLLAWTVAALGWGWVRQRRWDS"
     gene            complement(8842..9789)
                     /locus_tag="SAMN02787118_103380"
     CDS             complement(8842..9789)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 164.4; E-value:
                     5.6e-50)"
                     /gene_kind="transport"
                     /locus_tag="SAMN02787118_103380"
                     /product="ABC-2 type transport system ATP-binding protein"
                     /protein_id="SFF02632.1"
                     /transl_table=11
                     /translation="MIDVQNLTKRYGPTTVVDGLTFTVRPGAVTGFLGPNGAGKSTTLR
                     MTLGLTRPDTGTARIDGHAYGDLAYPLRHIGALLETSAPHRGLTARDHLLWLAQSNRIA
                     RGRVSEVLEAVGLADAARRRTGTFSLGMGQRLGLAAALLGDPPVLVLDEPVNGLDTEGI
                     RWLRDLLRSMAAEGRTVLISSHLMTEMALVADHLVVISRGRLLADTGMSDFIERHGRSY
                     VRVRTPEPDRLGRGLEGRGATVTRIPGGGLDVVGMAAADVSRIAAAGGFPLDELSTHTG
                     SLEETFLDVIGEGGTRAGADGARVLGEEGRNTHV"
     gene            complement(9936..11069)
                     /locus_tag="SAMN02787118_103381"
     CDS             complement(9936..11069)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048:sensor
                     histidine kinase (Score: 211.6; E-value: 3.4e-64)"
                     /gene_kind="regulatory"
                     /locus_tag="SAMN02787118_103381"
                     /product="Signal transduction histidine kinase"
                     /protein_id="SFF02653.1"
                     /transl_table=11
                     /translation="MGDVSRRRLVLLDGAAALGFALLPQLTLVRPDDGGAPGGLTVSLL
                     SLATALPLAVRRLWPVPVFAIVLTASCAALAAGLGPAVFLAAAYALYLVATTRRRQLGR
                     SAVIVGGASTAGAALLTVTGGQHYTGGTLAVQLLFGLLVLGATWAAGTAVRERRESLRR
                     TIVQAAEQAKVEERMRIARDIHDVVTHSVGLIAIKAGVANHVIATHPEEAREALTVIED
                     ISRGALRDMRATLKVLRREHVDQQQDLQPVRGLSDLPSLVHTAEAAGVSVDLRSDCAEE
                     PPDGVALTAFRIVQEALTNVVKHAAPTRCLVSVTAQDGVLTIDVTDDGPGPGHRPNVPG
                     GSMGLVGMKERAVAHGGTLTAGPRSGAGFRILATLPY"
     gene            11221..11913
                     /locus_tag="SAMN02787118_103382"
     CDS             11221..11913
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 110; E-value:
                     1.5e-33)"
                     /gene_kind="regulatory"
                     /locus_tag="SAMN02787118_103382"
                     /product="DNA-binding response regulator, NarL/FixJ family,
                     contains REC and HTH domains"
                     /protein_id="SFF02673.1"
                     /transl_table=11
                     /translation="MRINLFILSEDPVSLAGLEAIVEQDDSVNLIGTAVDESHGLRCLE
                     NNPLRPDVVIIGEPPSKRAICRNVEWIVSMYRQEKSRPQIVVVSQNDYDDVIVSALRLG
                     VNGYLARIASPEELFQSLHIVARGGAAFSPTIAARFSRFFATMQRLPEPPEFSQLTSRE
                     TEILELLADGMNNRQIARRLFLAEKTVRNYVSRIFTKLEVHDRAAAVLRARDAGFGDQP
                     DTVLPQHA"
ORIGIN
        1 tcacgtcggc attccccgct cggccaggcc gctctcgtac gcgatgatga ccagctgtgc
       61 gcggtcccgg gcgtgcagct tggccaggag gctgccgacg tgagtcttca cggtcggcat
      121 gctgatgacc aggcgttcgg agatctccgc gttggacagg ccgttggcga tctggacgag
      181 gacttcgtgt tcccgcttgg tgagaccgac gagtcgtgga gcggggcggg gcgtctcgcc
      241 gcgccgggag aagttggcga tgacgcgccg ggtgaccgtc ggggccagta cgccctcgcc
      301 cgtggcgatg acccggatgc cgtcgaccag gtcggacggc gaggcgtcct tcagcatgaa
      361 gccgctggcg cccgcctgga gggccgggta gacgtactcg tccatgtcga acatggtcag
      421 ggccagcacc cggacaccgg tcagcgtctc gtcggagcag atctcccggg tggctgcgat
      481 gccgtcgaga accggcatcc ggaggtccat caggacgacg tccggggcga gttcccgggc
      541 gagccggacc gccgtggcgc cgtcgcccgc ctcgccgacg accttcatgc cgggtgtgga
      601 gtcgacgagg acccggaagc ttccgcgcag cagtgcctgg tcgtccgcga tcagtacccg
      661 gaccgactcg gccatgcgtg ttccccggtt cctcgtccgc tcgtaggtga catatgacat
      721 tttagcaagg ctctatcgtc aactcgcccg ccacgtgcgg cccttcacgc cacgtccaga
      781 agcagttccg ccgtgccgtc gacccccgcc ccgaccgtcg taccgtacga ctccgacagc
      841 cgggttacct cggtgaggat ctccttggcc tcggctccgt cggccacgcg ggggcggccc
      901 ctgcggtgca ccggcagggc gaagccgagg tcgaccgggt ggaggcgggc cctcacgagg
      961 gtgccgtcgt cgaaggtgag gaccggcagg agcgactgcc agtagcggcg gtgcggggcg
     1021 aacaaccggg tgccgtggcc gcccagtcgg tcgtagtagc ggcccggcgt gggcggccgg
     1081 tcggtggtga ccttggcgta gtcctcggcg gagacgcggt cggtcagttc gatctggctg
     1141 acgatgttgc cgaggctgta gaagatcggc ctgttccggt acagctcgac accgcgaagg
     1201 aaatgcgggc cgtgcccgac cacgacgtcc gcgccctcgt cgatcatccg gtgggcgaag
     1261 gcacgcagga actcgcccgg tgtctcgggc gtcgggccgg gctcgtggga gtgcacgctc
     1321 accacgacga ggtccgcgcg gaggcgggcc tcaccgaccc agcgggagat ctcgtcgagg
     1381 tcgcgcggat cgcactcggt cgtgaagccc ggttcgtccg ccgtcaggaa gcgggtgccg
     1441 aagagggtga gccggtcggg cgcgaggatg gcggggtcga ccccgagcag ggtgcgggcc
     1501 tcggcccggc gggcgcgcag gcccgtctcg gcgtcgatcg tccgcagcac gtccatctga
     1561 ggggccgtca cccgcagggt cgcggagtgg cgcagcgggt tgaggcccgg tcggccgggc
     1621 agttccggcg acggatcggc cgcttcctgg ccgggcagga acgtcgtggt gcaggcgagc
     1681 agcgccaggc tgccgcccgg ccggtcgacg tagacgggtc ggcgcgccgt ggtgaggtcg
     1741 gcgccgatcc cggcgaacgg gatccgcctc gaccgcagca ggtccacggt gccgagcacg
     1801 ccctccgtgc ccaggtccat ggcgtggttg ttggcgcagc ccagcacgga gaacccggcc
     1861 gccgtgatct cgtccagtac accggagtcc gcgatcagac agccgccgcc ggccgcgttg
     1921 tgcaccggat gtccgcgtcc gtcgctgggg accacctcca ggttggtgac ggcgaagtcg
     1981 gcgctgtgga cgaggtcgtg gagccgtccg gcggccgggt cggaggcgat caccgctccc
     2041 cgggtcgcca tgcagtcgcc ggagagggcc acggtcatcc gggtcaccgc cgggcctccg
     2101 tgaccacgcg ggtcagcgcg gcgcccggat cggagccggt gacgtcgacg cggcggccct
     2161 ccactgtgac ggtcggtgtc agcgccacct tgcgggaggc ggcgatgtcg gagacgtacc
     2221 gtacccaggg ccggtacggg gcgtcctcga cgcagcgtgc gaaggacgcg tcggtgatgc
     2281 cggcgtcccg gcccgccgcg atcagctggg cctcgctgag cccagggccc tgttcggcgg
     2341 gctgcttcgc gaacaggacc gtggagtact gctcgaacct ccccgcgtcc gccgcgcagg
     2401 ccgctgcgga ggccgcctgt gtcgagtagc ccgcgggttc gctgcggccg tcgaggaagg
     2461 cgaccgggtg gtagacgacg ctcaccccac cgcgcgacct cagatcgtcc agggcggcgg
     2521 tcagagcccg ttcggtacga cggcattcgg ggcagaggta gtcgaggtac acgtcgacgc
     2581 gtacggcgcc ggtggaggcg gccacgcccg acttgtcggc ggcgatcccg gccggtacgc
     2641 ggctcggtgc cttgccgggg gccgtgttgt tcgcccggac caggcccgcg ccgaccagcg
     2701 cggcggcggc gaccaccagg acggccacca gcgacaccac catcgtgcgc cgtcgccggt
     2761 gccgttggtg caccatctcg cgcaccgtgg cgtccgttgt ctgtgtgctc gtcatgctca
     2821 tcgctccttc gggtccagga cccagctgtc gagcgcgtac ggggtgcgcg gattccggat
     2881 caggagggcg gccgcgccga gcagcaacag gtcgcgcgcg atgtcgagcg cgtagccgcg
     2941 tgcggcgcca ccgctgagcg tgcctccact gccgaaacag ccgcagtcga tggacattcc
     3001 ccgtgcccac accgaggcga tggccgcccc atacacgacc agcagtacgg ccgcgcccgt
     3061 cgctgccgcc ctggtggcca gcccggccac gagcagcagc gcgagcgcca cctcgacgaa
     3121 cggcaggacg ccacccacga gttgcgcgga gtcgtcgggc acgatgcggt agagcgcgac
     3181 cgtccgtccg gcctccgtga ggtcccctat cttcaccaga ccggcgtagg ccaggaccgc
     3241 cgccaggagc agccggaccg tgagccgcgc cgcgcccgcc cagtagccgg ccgtggcccg
     3301 ggtgttcgcc gtcgtcgtga catccgctgt gcccgcgtcc accgtgccct gtcctccccg
     3361 gttcatgacg tacgggagaa ccgatagccc gcgaggccca gcgcgaccgc ggtgagggcg
     3421 gccagcacac ccagttcggc ggccacgggt gggtgccagt cgccgagcat cagccgggtc
     3481 tgctccgagg tgagcacgct cggtcctggc agggtccggc ggaccgcgtc gacgccgtac
     3541 gtcagcgggt tgagcttgac gacggtgtcg agccagccgg gcaggccgtt gggcgggaac
     3601 atcgcgccgg agaagaacat cagcggcatc aggctcaggt tcaccacgac ctggaaggtg
     3661 tcgacctgcc ggatggtgac ggcggcgagc agcccgagcg aggtgaacat gagtgagacc
     3721 agcaggagtt cgagcaggac gaccagcagc atcggcgtgt agcggatgct cgcgatcccg
     3781 ccgacggaca gcaccatgag gccgtagacc gctcccgtgg tggcgccgcc gagggccagt
     3841 ccgaacacga tggacgcgcg cgggaacggc gccacgagca tctggcgcag cacccccagc
     3901 ctgcggtccc acaccagcga gatgcccacc gcgatggccg gggcctgcac ggacatgacg
     3961 agcgtgccgg ggaacaagta ggcccggtag tcgttcagtt gggctttgcc gaggctggac
     4021 gacgccgcgt cgaggccggt gccgaggacg acgaggaaca gcaggggtgt cacgagtccc
     4081 atggccaggc gcacggggtt gtgccgcagt cgggtcatct cccgccgcca gagcagcagg
     4141 acagggcgag ccgggtgacg ggaccggtcg gtcggtggtg ccgcggcggt gatgtcgccg
     4201 agtgcggcgg gtgcggtgtc ggtccggctc atcgcagtcc ttccccgagg ttgccgagca
     4261 tgcgcgggcc ggtcgtgctc tcccggatgg cgagaccggt gtggtgcagg aagacgtcgt
     4321 cgagtgtggg tggggcgatg gcgacctcgt gtacggtcac gccgagttcg gtgcacaggc
     4381 ggggcaccag ggctgccgcg cgctcgaccc ggagcagcag accgtccgga gtgggctccg
     4441 ccgggaggcc gaaccggtcg ctgagggcgt gggctgcgcg ctggtcgtcc tcggtgcgca
     4501 ggacgacgag gtcggccccg atgacggact tgaggtccgc gggtgtgccc tccgtgacca
     4561 ccttgccccg gtcgatgatc gcgatccggt cgcagtgctc ggcctcgtcc agttgatggg
     4621 tggtgacgaa gaccgtgatg cccctctccc gccgcagccg ttccaggtgc tcccagacgg
     4681 cggcgcgggt ctgggcgtcc agtccggtcg tcggctcgtc gaggaacagc acgctgggct
     4741 cggcgagcag gccacgggcg atctcgaggc ggcggcgcag tccggtggag aactgccgta
     4801 cgggcaccct gtggcgctcg gaaaggtcca tcaggtcgag catcgaggcg atcgcgtcgc
     4861 gggacgcgcg gcgggacagg ccgcacaggt cggcctggaa gcggaggttc tcggcggcgg
     4921 tgaggtccag gtcgagggtc gactcctgga acacgatgcc gatacggcgg cggacctcgg
     4981 cgggccgggc ggcgacgtcg aagccggcca cctccgcacg gcccgcggtg ggccgcagca
     5041 gggtggtcag catgttgatg gtggtggtct tgcccgcgcc gttcggtccg agaaagccgt
     5101 acatgctgcc cgtgggcacg gtcaggtcga gcccgttcac ggccggtgtg gtgccgtagt
     5161 acgcgtagag gccctcggcc cggatcgctg tcatgagcgg ctcccttcgg aggggcgggg
     5221 gctgacgtcg gtggggtgcg ggttcttgtc ggaagggcgc gtgcgctcgt ccgggcgacg
     5281 gaccgccagg accgtgcgga acacgctgag ttcgccgggc tcgtccaccg gccgcccgtc
     5341 ggcctccacc caggcgtgcg cgccgaacgg ttcggttctg aatcccgtgc accagtcggc
     5401 ccacctgccg cgtgcccggc acagcaggac ggtggccacg gaacgctgga ggcaaccgag
     5461 gcccgcgcag cgggtactga ccgagacgac agaccggcgg gcccgcgcca cctcggcgta
     5521 tccggcgggg cgggacccct tgctgaccac gcccagcacg cggtgcagtc gggctggggg
     5581 caaccggacc agcagacgtg ccgccccggc ggcgcaccgg ggggcgagct gccggtacca
     5641 gggcagccgc ggggcctctt cggccacggc gggggtggtc acgaggccac ctccacgagt
     5701 ttggccgcgc tgagcgcgtc gatgagggcc tggacgtcct gccgagcctg gtcgtcgctg
     5761 accggggccg cggcgcacag gccggcggcg gccgcgtcgg gtgccgttcc gtcgagcaac
     5821 tggcgcagga cgcccgcgcc ggagtggttc agctgccagt agcggccgcg gcgcccgtcg
     5881 agcagcacgg ccccggagtc gacgacagtg agggtgacgt cgcgggcgag ggtcagcttc
     5941 atcggagttc tcccgtgtgc gtgttccggg cggctggcag ggggtacgtc tccggatgcg
     6001 tccgcagcca gctctcgcac gccaccgtgg tgtcgatcgg ctggagatga tgggacatcg
     6061 gccccgggtt cagcaccgcg gaccggaagg ccgccgggtc gatgaggccg agccgggcga
     6121 ggtgggagtc ctcgctcagc tccaggatcc gggcccggtt gcgggccagg ccccggaacg
     6181 cctccgcgct gaactcgccc ttgtcacggc ggcccaggat gtccgggggg acgagacccc
     6241 gtgcggccga ggtgagcagc ggcttgaacc gcccgccgag caggcgctgg tcgatccggg
     6301 tggccagggc cgcctccacc acccggtcgt cgaggaaggg cgcgtcccag gtgatgccgg
     6361 tgtccccgag ggcggtgttg acctggcgga cggtggttcc ctcgaagacg agtgaggcga
     6421 gcgcctggtg ccgggcccgg tcggtgtcca ggggcccggg tccctcggtg gcggcgtcgg
     6481 tgagcagggc gcggaccgcg gccacggcgt cgggggtcgc ccaggccggc atgcggggcg
     6541 cgaacaccca gccgaagtcg ggctcgtcga tcggcggggg cggggcgtcg atgcgggcgg
     6601 cgacccgacc gaggttctgc gtgaacgtcg accggtcaag cagtgagcgt acggtcgccc
     6661 gccacggcca gcgattggcc agccggtagc ggttgaccag ccgcagcccg ccgaccggtg
     6721 tggcccgggc cagggaccag gcgcaggcgg gcatccggcc gaacagctcg tcaccgccga
     6781 agccggtcag gtgcagcgtg gcgccctccg ccgtggcccg cttggccagg tcctggatgt
     6841 gggcgagtcc ggaggcccag gtcgaggggc cttccggggc cgcgcccacg aggtcggcgg
     6901 tgtagccgac gtcgaacagg ttctcggcgc ggtcggcgga cagcgtgtgg tgccgggccg
     6961 ccggcaggca ctccgcggcc ctgtgggccc acatcgtgtc cgcgttggcg ctgtcgatcg
     7021 gcatcacgtg gtaggtgacc aggtcggccc cggccgcgtg ggcgaggaag cacagtgagg
     7081 tggagtccag gccgccggac aggtcggcgc tgagggtgcc gcccgcggcg acccgggtgg
     7141 tgatcgcgtc gtccagcgcc gaacggacgg cggccgcgcc ctccgcgagc gtgagggacg
     7201 gctccgggag ttcccaccag cgggtctgcc gggcccggcc gtccgtggcc agttccagcc
     7261 agtggccggt ggtgagcgcc tcgatgcccc ggcggacggg gcgctgggcg agcggccagg
     7321 gtggtccgcc cggcgccagc aggcgggcgg cgagcacggt ctcgtcgagg ccggcaccgg
     7381 tcagccgcag caggggttcc accccgctcg cggcgacagt caccccgccg acgacggcgc
     7441 tgaagatctg tcgtgcgccg acggccgaac cctgcaccct ggtcctgccg tccagtgaca
     7501 ccgccaggtg gacggctccc ggcagccggg acgcgatcga gtccacgtcg tgcagcgagc
     7561 gcagccggcc gagcgcggcc accgcggcgg tctcgtcgag ccgggtgtgt cccagcacga
     7621 ccatccgccg tgggccggcc tcgacgacga cggcctcggc ctcgggccag tcgccgacga
     7681 tccagggccg tcccgacgca tggtcgacgc gccgtgccgc ccgcagccgg ccggccgatg
     7741 cggcaccggc cgggcagtcc ggaagaacca cgaattccat gtcgcctcgt tccccgtctc
     7801 ctcgttcccc gggtggtgcc ggtgcgcgtg aacgcaccgg caccggacgt gatcaccaga
     7861 agcagacgat cgcgtaaccg cagccggcga agtcgttgca gcttccgacg ccgaggcact
     7921 tcgtgagctc ctcgaagtcg ccgacttcct ggagcatggg gggctcgtag atcgcggaca
     7981 tgatgtcctc ccgtttcgga tcggtcaggc cgaccttgtt cggcctgtga tctgtcacgg
     8041 aagttacggg gcggactgtc ccaccggcat ggggcagttg tcccatgccg gtcctgtcag
     8101 ctgtcccaac ggcgctggcg cacccagccc caaccgaggg cggcgacggt ccaggcgagc
     8161 agcaccgtga agccgaaggc cgtgtgcggg gagcggacgg tgagcagttc gtttcccgcc
     8221 tggtcgggga agtaccgtgc catctccttg gtcgccccga tgagggacag gatgtgcgtc
     8281 ccggcgagca ccatcggcag cagaacggcc agcggtacga cggcgttgcg ggcgatcgcc
     8341 gcgataccgg ccgcgaacag gcacatcagg gtcagataga cgaccgcccc ggccagggcg
     8401 cgcgggacac cgctcgcgcc gagcgaggaa ccgtgggacc cgagagccgc ctgcgtgacc
     8461 aggtagccga ggacggtgac cgggagggag acggccaccg ccgcgacggc ggtgacgctc
     8521 atcttcgcca ggtagagccg cccgcgccgg ggtacggcga gcagcgagac acggatcatg
     8581 ccggacgtgt actcgctggt gacgatgagc acgccgaaca cgatcagcgc caactggccg
     8641 tagaggatgc cgtcgagacc ggcctgctcc ggggtgaagt cggaacgcag gctcgggttg
     8701 tcggactcca gcgcgttctt cgcggaccag ccgtcgaggg cggcgatgag gacgctgacc
     8761 gcggcgaaca gcagcagcga gatctgggtg ccgcgaatgc cacgcagctt ggtggtctcg
     8821 gcgcggacgg ccgcgagggt ctcagacatg ggtgttcctg ccttcctcac cgaggacgcg
     8881 cgcgccgtcg gctcccgcgc gggtgcctcc ttctccgatg acgtcgagga aggtctcctc
     8941 caacgacccg gtgtgggtgc tgagttcgtc gagcgggaag ccgcccgccg cggcgatccg
     9001 gctgacgtcc gcagccgcca tgcccaccac gtccaggccg ccgccgggga tacgggtcac
     9061 ggtggcgccg cgaccttcca ggccccggcc gagccggtcg ggttcagggg tgcggacgcg
     9121 gacgtaggac cgtccgtggc gctcgatgaa gtccgacatt ccggtgtccg cgaggagccg
     9181 gccccggctg atgacgacca ggtggtcggc gaccagggcc atctcggtca tcagatggct
     9241 ggagatgagg acggtacggc cctcggcggc catcgagcgc agcaggtcgc gcagccagcg
     9301 gatgccctcg gtgtccaggc cgttgaccgg ttcgtcgagc accagcacgg gagggtcgcc
     9361 gaggagcgcg gcggccaggc ccagccgctg gcccatgccg agggagaagg tgccggtccg
     9421 gcgccgggcc gcgtccgcga gcccgaccgc ctccaggacc tcggagaccc ggccgcgggc
     9481 gatccggttg ctctgggcga gccagagcag atggtcgcgc gcggtcaggc cgcggtgcgg
     9541 ggccgaggtc tccagcaggg cgccgatgtg gcggaggggg taggccaggt cgccgtaggc
     9601 gtggccgtcg atccgcgcgg ttccggtgtc ggggcgggtc aggcccagcg tcatccgcag
     9661 ggtggtcgac ttcccggcgc cgttggggcc gaggaagccg gtgacggctc cgggccgcac
     9721 cgtgaaggtc aggccgtcca cgacggtggt cggcccgtac cgcttggtca ggttctggac
     9781 gtcaatcacg cgacgagtct ggccgcggcg gccgcaccac acatcggacc ggggtcggga
     9841 cggcgcgggc cggttccgcg gaccggaccc atacccgggt atgagaccgt ttcagccata
     9901 tgcggtgggc gggacgtatg gcggctggcg cggcactagt acggcagtgt cgcgaggatc
     9961 cggaagcccg cgccggagcg ggggcccgcg gtgagggtcc cgccgtgcgc gacggcccgt
    10021 tccttcatcc cgacgagccc catgctgccg ccgggcacgt tcggccggtg ccctggtccg
    10081 gggccgtcgt cggtgacgtc gatcgtcagc acgccgtcct gcgcggtgac gctgaccagg
    10141 cagcgggtcg gggcagcgtg tttgacgacg ttggtcagcg cctcctggac gatccggaac
    10201 gcggtcagcg cgaccccgtc cggtggttcc tccgcgcaat cggagcgcag gtcgacgctg
    10261 acgcccgccg cctcggccgt gtggaccagg gaaggcaggt ccgacagtcc gcggaccggc
    10321 tggaggtcct gctgctggtc gacgtgttcc cgacgcagca ccttgagggt ggcccgcatg
    10381 tcgcgcagcg ccccgcggct gatgtcctcg atgacggtga gggcttctct ggcctcctcg
    10441 gggtgggtgg cgatgacgtg gttggcgacc ccggccttga tcgcgatcag gcccacgctg
    10501 tgggtgacga cgtcgtggat gtcccgggcg atcctcatgc gttcttcgac cttggcctgc
    10561 tcggccgcct gcacgatggt ccgccgcagg ctctcgcgtc gctcccgtac ggccgtcccc
    10621 gcggcccacg tcgcccccag caccaacagc ccgaacagca gttgcaccgc cagggtgccg
    10681 cctgtgtagt gctgcccgcc cgtcaccgtc agcagggccg cgcccgccgt gctcgccccg
    10741 ccgacgatca cggccgaccg ccccagctgc cgtcgccgtg tcgtcgcgac caggtacagg
    10801 gcgtaggcgg cggcgaggaa gacggcaggg ccgagaccgg cggccagcgc cgcgcaggac
    10861 gcggtgagga cgatcgcgaa caccgggacg ggccacagcc gccgtacggc gagcggcagc
    10921 gcggtggcga gcgagagcag cgacacggtg agcccaccgg gcgcgccgcc gtcgtcgggc
    10981 cgtaccagcg tcagttgcgg aagcagggcg aacccgaggg ccgccgcccc gtcgaggagg
    11041 accaggcgtc ggcgcgagac atctcccatg tcccaaacct aggtgtctga tcagccggac
    11101 gtccaacgcg gccggaacag gaccatgacc gcctaagtcg gtgtagaccg tccgtttcgt
    11161 ctgcttaggc tggcaccgtc tttgcaggcg tacagacgct taccacgggg gtgcaaagct
    11221 atgcggatca acctgttcat tctcagtgag gacccggtgt ccctggccgg acttgaggcg
    11281 atcgtcgaac aggacgacag cgtcaacctc atcggcacgg cggtggacga gtcccacggc
    11341 cttcgatgtc tggagaacaa cccgctccgg ccggacgtgg tgatcatcgg tgagccaccg
    11401 tcaaaacgcg ccatctgcag gaacgttgag tggatcgtct ccatgtaccg ccaggagaag
    11461 tcacggccac agatcgtcgt ggtgtcgcag aacgactacg acgacgtgat cgtctccgcc
    11521 ctccgcctcg gcgtgaacgg gtatctcgcg cggatcgcgt ccccggagga actgtttcag
    11581 tccctgcaca tcgtggcacg cgggggtgcc gcgttcagcc cgacgatcgc ggctcgcttc
    11641 agcaggttct tcgccaccat gcaaagactt cccgagccgc ccgagttctc ccaactgacc
    11701 agcagggaaa cagagatact ggaactgctc gcggacggca tgaacaaccg tcagatcgcc
    11761 cggcgcctct ttctcgcgga gaagaccgta cgcaactacg tctcccgcat cttcaccaaa
    11821 ctggaggtgc acgaccgggc cgccgccgta ctgcgcgcac gcgatgccgg tttcggcgac
    11881 cagcccgaca ccgtactgcc ccaacacgcc tga
//
