BGC0001675 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001675 (Streptomyces griseoruber)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS	1	67,000	murayaquinone	PKS	100%

BGC0001675 - Region 1 - T2PKS

Download region GenBank file

Download region SVG

Location: 1 - 67,000 nt. (total: 67,000 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 67,001
Label		BGC0001675

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001675	0.97	Polyketide	murayaquinone	Streptomyces griseoruber
BGC0000231	0.35	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000234	0.34	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000922	0.33	Other	pseudomonas quinolone signal (PQS)	Pseudomonas aeruginosa PAO1
BGC0002069	0.33	Other (Aminocoumarin)	styrolide A, styrolide B	Pseudomonas fluorescens
BGC0000343	0.32	NRP	enterobactin	Pseudomonas sp. J465
BGC0001137	0.32	Alkaloid	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0002733	0.31	Other	sinapigladioside	Burkholderia gladioli
BGC0001444	0.31	Other (shikimate derived)	caboxamycin	Streptomyces sp. NTK 937
BGC0001903	0.31	Other	neocarazostatin A	Streptomyces sp. MA37

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001675	1.00	Polyketide	murayaquinone	Streptomyces griseoruber
BGC0000231	0.68	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0001928	0.67	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000234	0.67	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000922	0.67	Other	pseudomonas quinolone signal (PQS)	Pseudomonas aeruginosa PAO1
BGC0002069	0.66	Other (Aminocoumarin)	styrolide A, styrolide B	Pseudomonas fluorescens
BGC0000343	0.66	NRP	enterobactin	Pseudomonas sp. J465
BGC0001137	0.66	Alkaloid	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0002733	0.65	Other	sinapigladioside	Burkholderia gladioli
BGC0001444	0.64	Other (shikimate derived)	caboxamycin	Streptomyces sp. NTK 937

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

AQW35047.1

CAL_domain (40..482): pk

minowa: NH2

Prediction, score:

NH2: 111.0
Acetyl-CoA: 37.3
fatty_acid: 21.3
AHBA: 0.1
shikimic_acid: 0.0

AQW35054.1

AMP-binding (19..429): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: SRMEVSFPLK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Type II PKS gene cluster prediction details

Cluster section:: 9936 to 67000
Starter unit(s):: hexanoyl-CoA (Score: 345.0; E-value: 3.87e-122)
Malonyl elongations:: 8|9 (Score: 678.7; E-value: 5.3e-207)
Product molecular weight(s):: hexanoyl-CoA_8: 639 Da
hexanoyl-CoA_9: 681 Da

AQW35035.1: OXY (Score: 31.1; E-value: 2.9e-10)
AQW35041.1: GT (Score: 315.6; E-value: 1.5e-96)
AQW35046.1: KSIII (Score: 339.9; E-value: 3.5e-104); KSIII CAM58805.1_Benastatin_hexanoyl-CoA (Score: 345.0; E-value: 3.87e-122)
AQW35050.1: KR (Score: 172.6; E-value: 2.8e-53)
mrqA: KS (Score: 776.4; E-value: 1.4e-236)
mrqB: CLF 8|9 (Score: 678.7; E-value: 5.3e-207)
mrqC: ACP (Score: 98.3; E-value: 4.5e-31)
mrqD: CYC C5-C14 (Score: 436.8; E-value: 8.3e-134)
mrqE: CYC C7-C12 (Score: 480.0; E-value: 5.6e-147)
mrqF: KR C9 (Score: 455.2; E-value: 1.4e-139)
mrqH: KR (Score: 222.9; E-value: 1.3e-68)
mrqK: CYC C1-C18|C2-C19 (Score: 180.0; E-value: 4.8e-56)
mrqM: KR (Score: 192.5; E-value: 2.4e-59)
mrqO3: OXY (Score: 13.4; E-value: 6.7e-05)
mrqO6: OXY (Score: 206.6; E-value: 1.7e-63)
mrqO8: OXY (Score: 177.1; E-value: 1.5e-54)