LOCUS       BGC0001677             23325 bp    DNA     linear   PLN 16-DEC-2016
DEFINITION  Penicillium roqueforti strain CBS221.30 mycophenolic acid
            biosynthesis gene cluster, partial sequence.
ACCESSION   BGC0001677
VERSION     BGC0001677
KEYWORDS    .
SOURCE      Penicillium roqueforti
  ORGANISM  Penicillium roqueforti
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Penicillium.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 03:30:18
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     mRNA            join(<1..192,445..>1479)
                     /gene="mpaH"
                     /product="putative hydrolase"
     gene            <1..>1479
                     /gene="mpaH"
     CDS             join(1..192,445..1479)
                     /codon_start=1
                     /gene="mpaH"
                     /product="putative hydrolase"
                     /protein_id="API82660.1"
                     /transl_table=1
                     /translation="MSSEKFTVTEHLVPGSYIREYPGSTVMQEDVLKIHVKQYTPKHEG
                     PVPADAITFIAAHGVGLPKMDHPRDLFLMINHFREQMPRPLVGVGHSFGGNIMFVTNNP
                     LNFENSKNEILISFSSTNLAYLHPRLFTTLLLIDPLIQLSPPSMGFGTDPPGPINYTLW
                     RNDVWPSREAAIRANRGLIHGWDPRCVDRMAKYFFRDLPTPLYPDVEAVKARFDAAADT
                     TATPVTLATPKYHELIAQIRQNFNARDPTTGRIEIPRATHADMDPLVASIPLYRPEPRS
                     TFRRLGTLRPSCLWIVGGATFLNVDEIHEGVKICGSGIGGSGGVSEGRVKEVILPGLGH
                     LMPFQEIGTVVGPCVAWLQQEMNRFRQMEREWEEERKGKSHLVLEENWYKVLKPMPSGR
                     GKGGRKEKL"
     source          1..23325
                     /db_xref="taxon:5082"
                     /mol_type="genomic DNA"
                     /organism="Penicillium roqueforti"
                     /strain="CBS221.30"
                     /type_material="culture from neotype of Penicillium
                     roqueforti"
     misc_feature    <1..>23325
                     /note="mycophenolic acid biosynthesis gene cluster"
     protocluster    1..23325
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[11694:19451]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      11695..19451
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     cand_cluster    1..23325
                     /SMILES="CC(=O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..23325
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001677"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..23325
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /subregion_numbers="1"
                     /tool="antismash"
     mRNA            join(<2509..2676,2772..>3758)
                     /gene="mpaG"
                     /product="putative O-methyltransferase"
     gene            <2509..>3758
                     /gene="mpaG"
     CDS             join(2509..2676,2772..3758)
                     /codon_start=1
                     /gene="mpaG"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 152.7; E-value:
                     2.5e-46)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative O-methyltransferase"
                     /protein_id="API82661.1"
                     /transl_table=1
                     /translation="MLTKSVTSILQGITLAAKEFENNEAGARESLIAHSRALISALEVP
                     SEFIQHTFWSQMFQHLKDAAGKGIDCEALSMKTGVDASLLSRLARHLVAMNVITFQNGA
                     FHGTDLSDSLAAENYQHSIRFCHDVSRPSFNEFPEFFKSNGYKTPTLSGTDGPFQAAHK
                     TELTFLQWLVNTPPYLQYFHSYMSVYRAGKPNWCDTGFYPVSERLLSGFDASVSDVVLV
                     DVGGGRGHDLETFASKFSPLPGRLVLQDREQTIASMPADESRQFEATAHNIFTPQPVKY
                     ARAYYMHSVPHGFGDEDAIKIMTNLVPALAKGYSRVLLNEIVVSEENPILAATNMDMIM
                     LAHLAVKERTEAEWRYIFTQAGLKVVNIYSYPGVAESLIEAELA"
     mRNA            join(<4345..4488,4622..4849,5018..>6052)
                     /gene="mpaF"
                     /product="putative inosine monophosphate dehydrogenase"
     gene            <4345..>6052
                     /gene="mpaF"
     CDS             join(4345..4488,4622..4849,5018..6052)
                     /codon_start=1
                     /gene="mpaF"
                     /product="putative inosine monophosphate dehydrogenase"
                     /protein_id="API82662.1"
                     /transl_table=1
                     /translation="MVEILDYTKALEVLKEYPGDGLHVDTLLDSDSHGALTYNDFLILP
                     GSIMDTVTEHSMAIHMALLGGLGVIHNNCPPDEQAEMVRKVKRYENGFIQDPIVLSPET
                     TVGEAKELKTKWGFGGFPVTMATDLVTAPAGTTLAEANEVLRSSKKGKLPIVDKDGSLI
                     SLLSRSDLMKNIHYPLASKLPSKQLLCAAAISTHDADKVRLQKLVDAGLDIVVVDSSQG
                     HSTFQIAMIKYIKQNFPDIDVIGGNIVTREQAAALIAAGADGLRIGMGSGSACITQEVM
                     AAGRPQAAAVRSVSAFAARFGVPTIADGGVQNLGHIVKGLALGASAVMMGSLLAGTTES
                     PGEYFMSSEGQLVKAFRGMGSIAVMEDKSKSGAGNNAGASRYFSENDKVKVAQGVAGSV
                     IDRGSITQYVPYLVAGVQHSLQDIGVQNLDALREGVNNGTVRFEMRSASAQTEGNVHGL
                     HTHEKKLYSS"
     mRNA            complement(join(<6293..7078,7694..8113,8209..8421,
                     8484..8804,8927..9304,9901..>10002))
                     /gene="mpaDE"
                     /product="putative P450 monooxygenase and putative
                     metallo-beta-lactamase superfamily II"
     gene            complement(<6293..>10002)
                     /gene="mpaDE"
     CDS             complement(join(6293..7078,7694..8113,8209..8421,
                     8484..8804,8927..9304,9901..10002))
                     /codon_start=1
                     /gene="mpaDE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 196.9; E-value: 1e-59)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative P450 monooxygenase and putative
                     metallo-beta-lactamase superfamily II"
                     /protein_id="API82663.1"
                     /sec_met_domain="p450 (E-value: 4.6e-35, bitscore: 110.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MRVEAGGDMRDKLMWIRLYILGNVGQTFGDMKRYRRLISILKVYF
                     IFILNPPAQVYVQDINLYTMDYLIIIRITAVAVVLYLTRYVCCLYLHLQDVPGPLFAKF
                     TNLQRVWWVKSGRAHEYHRRMHAVYGPAVRFGPNMVSISDPRTIPAIYPSRPGFPKMPA
                     VFNSQDEDLHKRLRSPIAPLYSMTNVVKLESFVDQTLAVLLEQLDGRFLGSNDVPFDLG
                     SWLQYFAFDSMGTLTFSRRYGFLEQGRDMNGILGEIWKFMKRVSVMGQIPWFDEFCNTN
                     PFIALFRSPTGFGVLKVVDKFILQRLAPREKDEVSDEKDMLSQFLNIQASNPDVMPWMA
                     GSDSTANVMRTIMYNLLVHRDTLSRLQDELLESESRNGLSRTCPSWEKVRDLPYLDACV
                     LEALRLHPPFCLPFERVVPGGGLTVCETYLPAGTIVGISPYMANRDKETFGNDADEWRP
                     ERWLGLSHEDRKRLENSLLTMIKSQTTIQNPRNISDILDSDASSLGIRSTDIEAIIWSH
                     AHFDHIGDPSTFPLSTELVVGPGIRDSHWPGFPTNPDAINLNSDIQGRKVREISFERTE
                     KEAIKIGSFDALDYFGDGSFYLLNAAGHSIGHIGALARVTTSPDSFVFMGGDSCHHAGV
                     LRPSKYLPCPSHSRHIPLSSESESVFTLSPVLPSDYDAALKTVDNIKELDAYDNVFLIL
                     AHDSTLKGNMDFYPLTINDWKAKGYGKQTKWLFYKDLEDAMEGTK"
     mRNA            join(<11695..12333,12568..13494,14020..18441,18522..>19451)
                     /gene="mpaC"
                     /product="putative polyketide synthase"
     gene            <11695..>19451
                     /gene="mpaC"
     CDS             join(11695..12333,12568..13494,14020..18441,18522..19451)
                     /NRPS_PKS="Domain: SAT (14-178). E-value: 1.8e-09. Score:
                     29.4. Matches aSDomain: nrpspksdomains_mpaC_SAT.1"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (347-637). E-value:
                     5.2e-55. Score: 178.8. Matches aSDomain:
                     nrpspksdomains_mpaC_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (747-1037). E-value: 1.5e-56.
                     Score: 183.8. Matches aSDomain:
                     nrpspksdomains_mpaC_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (1151-1249). E-value: 1.6e-13.
                     Score: 43.2. Matches aSDomain:
                     nrpspksdomains_mpaC_PKS_DH.1"
                     /NRPS_PKS="Domain: PP-binding (1472-1538). E-value:
                     4.7e-13. Score: 41.4. Matches aSDomain:
                     nrpspksdomains_mpaC_PP-binding.1"
                     /NRPS_PKS="Domain: cMT (1741-1932). E-value: 2.9e-64.
                     Score: 208.5. Matches aSDomain: nrpspksdomains_mpaC_cMT.1"
                     /codon_start=1
                     /gene="mpaC"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     hyb_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     mod_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     tra_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066:alpha/beta hydrolase domain-containing protein
                     (Score: 63.6; E-value: 2.7e-19)"
                     /gene_kind="biosynthetic"
                     /product="putative polyketide synthase"
                     /protein_id="API82664.1"
                     /sec_met_domain="PP-binding (E-value: 6e-14, bitscore:
                     41.4, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_KS (E-value: 6.6e-56, bitscore: 178.8,
                     seeds: 2284, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 1.9e-57, bitscore: 183.8,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="mod_KS (E-value: 6.2e-50, bitscore: 159.1,
                     seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="hyb_KS (E-value: 1.6e-50, bitscore: 161.0,
                     seeds: 33, tool: rule-based-clusters)"
                     /sec_met_domain="itr_KS (E-value: 1.3e-57, bitscore: 184.4,
                     seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="tra_KS (E-value: 8.1e-53, bitscore: 168.6,
                     seeds: 44, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S9 (E-value: 1e-10, bitscore:
                     30.3, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MSLNTEHSKGDLRLLFGPQCSEIEDSIAHIRDAVYKDSAGLGFLS
                     DILDELPSLWPVITSAWPALRKVQGEKQLAALGRRFENGSPDSEAEPSSLIMTPVTVMK
                     HLVDFWNLQNVATHPAFPSSPLSRTTAPRIIDSQGFCVGILAAIAVACSQDTREFQSLA
                     SNAIRLAVCIGALVDFDEIVSGKAKSIAVRWETPADHDYLEQTLTKSPNVMNLCVKDPR
                     FQLPHSNALILPLRSSHNGQVLINAAMLHTVALESILSVKADWWGTVSALLNSADMEVD
                     ESRLLSIGQEEFVPRSARGRLVARSNLDVYGAGVFANGNTSARSAVSLQNGTNTLNGSP
                     QAAEMPPIAITGMACRYSNADTTSELWDLLELGVCTVEKAPGNRFRMPDLQREPKGPFW
                     GHFLDRPDAFDHRFFNISAREAESMDPQQRVLLQVAYEAMESAGYCGWQHTELSDEIGC
                     YVGVGSEDYTENVASRNANAFSATGTLQSFIAGRISHHFGWSGPSITLDTACSSAAVAI
                     HMACKGTQVGDPIELESLRKTFGNPLRSQSLHVGSIKGNIGHTETSSGVAGLLKTILML
                     QKQRIPKQANFRQLNPKVMPPLENDRLVIPVESTKWASARRVAMVSNYGASGSNAALIV
                     RDHTPSLSGQGKAMAEYIRDMPILISARSEESIRAYCGALRTTLLRHPYSNTVVRELAY
                     NVAMKQNRTLPFTLTFSTSSDPTSLSTRLEAIAAGKSADIIQKRESNEPPIVLCFGGQN
                     GVTSSISQELYDSCVLLQTHLMACEQAGQKLGLPSLFPTIFTSDPIVNTVYLHFMLFSI
                     QYASARAWIDSGLRVDRIVGHSFGQLTALSVAGSLSVQEGIRLVTERARLIQSNWGPES
                     GVMLAVEGTQAEVQRVLEQTGHRAEIACYNGPQQQVLAGTGECIRAVEDALATNPLTSN
                     VRVRRLENSHAFHSRLVDSIVPGLTELAESFVYQAPAIPIEACSATGDWSIVTPAKIVE
                     HSRMPVHFQRAVERIAQKLQVPAVWLEAGSASPIIPMVRRVLEKSSATHTYHRVNLDGS
                     DGSGNLATVTSALWGQGVHVQFWPFHHSQRGTFGWMNLPPYQFAKNRHWVDFDPTAFSF
                     SGSSAEPQCGSQERAGLLRKLSDGPEEYLFAVNTQDVLYRSCTKGHAVLDQTLCPASMY
                     MEMVLRAATSVFTLGESSTLTMSHIEDLVISSPLVLDPQGSVFVRLIPEAVASSQTWSF
                     SVFNSSGTGNESSIHATGSVSLCNERSRALSHFQSMNRLMDPARARGIEDHLASNGLKG
                     STVYSALEQVTNYADYFRGVRQVFANGREAAGLVSMAPSATETTCNPILLDNFLQVAGI
                     HVNCLSGREAEEVFVCNAIGETYVSDSLFKKEDGAIPLSWKVYTNYVRPSKNEIVCDIY
                     VMNSQGDGLTAAIMGVRFMSVSIRSLTRALAKLNNNFPDVPQLPPTIQPAIVTADYDEA
                     SDNVNVDSDLVAVQEMLCELFGVSVEEVSPSVSLIDIGVDSLISTEVLSEIKRRFHKDI
                     SYSTLVDIPNIQGLTEHIFPGHSHLAPSQIVIKPVRQQTVIPQTVTFLPVPANAGPSLV
                     SVAHQCFYETHAAVSHTHNADWAGFFNAIYPQQMTLITAYILEAFRALGSPLESSQADE
                     VLPIISVLPRHEQLKKHLYTILESVNLVRQTPTGQLVRTATPISPLSSHALHAQIRDEH
                     PPYALEHDLLQITGSRLAECLTGQADGVSLIFQDSQTRRLVGDVYTDSPVFKSGNLYLA
                     QYLTDVIQTLGNGRQVKILEIGAGTGGTTKNLLEQLSALPGMATRMEYTFTDISPSLVA
                     AARKKFSKYDFVRYETINVESSPPSLLHGQYDIVLSTNCVHATRNLVESCSNIRKLLRP
                     DGILCLVELTRDIFWLDLVFGLLEGWWRFEDGRKHALATEDLWDQTLRQSGFEWVGWTN
                     NEAVESNALRVIVASPTKAPSALEICSKPANMETVVWGERNGLQLLADIFYPDVVDTTQ
                     KRRAMVHGGGHVMLSRKDIRPAQTQTLLDAGFLPISVDYRLCPEVSLSEGPMADVRDAL
                     GWVRRILPNIPLLRPDIRPDGNQVVAIGWSTGGHLAMTLAFTAPAVGIAAPEAILAFYC
                     PTDYEDPFWSRPNFPFGQTVASNDIEYDVWEGVQSAPIKGYNPAFKERPLGGWMSTSDP
                     RSRIALHMNWTGQTLPVLLGGMHKEFRIPDELPRPTDEEIQAVSPNYQIRIGRYRTPTF
                     MVHGTSDDLVPCAQTESTYNALTQNGIEADIRVVQGAVHLFDLYPSSHAGQNAKEAVAD
                     GYEFLKRHIHSKGYSDKD"
     aSDomain        11737..12228
                     /aSDomain="SAT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mpaC_SAT.1"
                     /evalue="1.80E-09"
                     /label="mpaC_SAT.1"
                     /locus_tag="mpaC"
                     /protein_end="178"
                     /protein_start="14"
                     /score="29.4"
                     /tool="antismash"
                     /translation="LFGPQCSEIEDSIAHIRDAVYKDSAGLGFLSDILDELPSLWPVIT
                     SAWPALRKVQGEKQLAALGRRFENGSPDSEAEPSSLIMTPVTVMKHLVDFWNLQNVATH
                     PAFPSSPLSRTTAPRIIDSQGFCVGILAAIAVACSQDTREFQSLASNAIRLAVCIGALV
                     D"
     aSDomain        join(12970..13494,14020..14364)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mpaC_PKS_KS.1"
                     /domain_subtype="Iterative-KS"
                     /evalue="5.20E-55"
                     /label="mpaC_PKS_KS.1"
                     /locus_tag="mpaC"
                     /protein_end="637"
                     /protein_start="347"
                     /score="178.8"
                     /tool="antismash"
                     /translation="IAITGMACRYSNADTTSELWDLLELGVCTVEKAPGNRFRMPDLQR
                     EPKGPFWGHFLDRPDAFDHRFFNISAREAESMDPQQRVLLQVAYEAMESAGYCGWQHTE
                     LSDEIGCYVGVGSEDYTENVASRNANAFSATGTLQSFIAGRISHHFGWSGPSITLDTAC
                     SSAAVAIHMACKGTQVGDPIELESLRKTFGNPLRSQSLHVGSIKGNIGHTETSSGVAGL
                     LKTILMLQKQRIPKQANFRQLNPKVMPPLENDRLVIPVESTKWASARRVAMVSNYGASG
                     SNAALIVRD"
     aSModule        12970..17067
                     /complete
                     /domains="nrpspksdomains_mpaC_PKS_KS.1"
                     /domains="nrpspksdomains_mpaC_PKS_AT.1"
                     /domains="nrpspksdomains_mpaC_PKS_DH.1"
                     /domains="nrpspksdomains_mpaC_PP-binding.1"
                     /iterative
                     /locus_tags="mpaC"
                     /monomer_pairings="mal -> mal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       13429..13476
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mpaC_0001"
                     /evalue="5.60E-05"
                     /label="PKSI-KS_m3"
                     /locus_tag="mpaC"
                     /protein_end="516"
                     /protein_start="500"
                     /score="15.4"
                     /tool="antismash"
                     /translation="GPSITLDTACSSAAVA"
     aSDomain        14695..15564
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mpaC_PKS_AT.1"
                     /evalue="1.50E-56"
                     /label="mpaC_PKS_AT.1"
                     /locus_tag="mpaC"
                     /protein_end="1037"
                     /protein_start="747"
                     /score="183.8"
                     /specificity="consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="CFGGQNGVTSSISQELYDSCVLLQTHLMACEQAGQKLGLPSLFPT
                     IFTSDPIVNTVYLHFMLFSIQYASARAWIDSGLRVDRIVGHSFGQLTALSVAGSLSVQE
                     GIRLVTERARLIQSNWGPESGVMLAVEGTQAEVQRVLEQTGHRAEIACYNGPQQQVLAG
                     TGECIRAVEDALATNPLTSNVRVRRLENSHAFHSRLVDSIVPGLTELAESFVYQAPAIP
                     IEACSATGDWSIVTPAKIVEHSRMPVHFQRAVERIAQKLQVPAVWLEAGSASPIIPMVR
                     RVLEKSSAT"
     CDS_motif       14941..15045
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mpaC_0002"
                     /evalue="5.70E-13"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="mpaC"
                     /protein_end="864"
                     /protein_start="829"
                     /score="40.9"
                     /tool="antismash"
                     /translation="IVGHSFGQLTALSVAGSLSVQEGIRLVTERARLIQ"
     aSDomain        15907..16200
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mpaC_PKS_DH.1"
                     /evalue="1.60E-13"
                     /label="mpaC_PKS_DH.1"
                     /locus_tag="mpaC"
                     /protein_end="1249"
                     /protein_start="1151"
                     /score="43.2"
                     /tool="antismash"
                     /translation="GHAVLDQTLCPASMYMEMVLRAATSVFTLGESSTLTMSHIEDLVI
                     SSPLVLDPQGSVFVRLIPEAVASSQTWSFSVFNSSGTGNESSIHATGSVSLCN"
     aSDomain        16870..17067
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mpaC_PP-binding.1"
                     /evalue="4.70E-13"
                     /label="mpaC_PP-binding.1"
                     /locus_tag="mpaC"
                     /protein_end="1538"
                     /protein_start="1472"
                     /score="41.4"
                     /tool="antismash"
                     /translation="AVQEMLCELFGVSVEEVSPSVSLIDIGVDSLISTEVLSEIKRRFH
                     KDISYSTLVDIPNIQGLTEHI"
     aSDomain        17677..18249
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mpaC_cMT.1"
                     /domain_subtype="cMT"
                     /evalue="2.90E-64"
                     /label="mpaC_cMT.1"
                     /locus_tag="mpaC"
                     /protein_end="1932"
                     /protein_start="1741"
                     /score="208.5"
                     /tool="antismash"
                     /translation="YTDSPVFKSGNLYLAQYLTDVIQTLGNGRQVKILEIGAGTGGTTK
                     NLLEQLSALPGMATRMEYTFTDISPSLVAAARKKFSKYDFVRYETINVESSPPSLLHGQ
                     YDIVLSTNCVHATRNLVESCSNIRKLLRPDGILCLVELTRDIFWLDLVFGLLEGWWRFE
                     DGRKHALATEDLWDQTLRQSGFEWVGWT"
     CDS_motif       18765..18806
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mpaC_0003"
                     /evalue="9.20E-03"
                     /label="NRPS-te1"
                     /locus_tag="mpaC"
                     /protein_end="2091"
                     /protein_start="2077"
                     /score="8.7"
                     /tool="antismash"
                     /translation="IGWSTGGHLAMTLA"
     mRNA            complement(join(<20210..20701,20862..>21158))
                     /gene="mpaB"
                     /product="putative dephospho-CoA kinase"
     gene            complement(<20210..>21158)
                     /gene="mpaB"
     CDS             complement(join(20210..20701,20862..21158))
                     /codon_start=1
                     /gene="mpaB"
                     /product="putative dephospho-CoA kinase"
                     /protein_id="API82665.1"
                     /transl_table=1
                     /translation="MDKGTSFFTTPSFSATTRAIFNTMPQWFSFAVGLLIAYPLLINSL
                     RYRRLKQLQKKFYFPTRESMAKMTDEEAFQIQKETAQLEFPFMFVKAGQFALFRMVENS
                     PTSQRAFLSVARTRFLHSGYQASGKILDTDLLYTLALFAVQPVNFIAAFEWRPLSDLER
                     CAIGTFWKSLGDALGISSDILPSGKTGFRDGIHWLEEVDTWSQEYEVKYMVPDAQNRES
                     ADQATAVLLYNLPKVFHPVGLQFTSFMMDDRLRKAMLYVE"
     mRNA            join(<22200..22304,22557..22667,22759..>23325)
                     /gene="mpaA"
                     /product="putative prenyl transferase"
     gene            <22200..>23325
                     /gene="mpaA"
     CDS             join(22200..22304,22557..22667,22759..23325)
                     /codon_start=1
                     /gene="mpaA"
                     /product="putative prenyl transferase"
                     /protein_id="API82666.1"
                     /transl_table=1
                     /translation="MVGSMENPGSWDLACLLISTSRFNRYMPYYTMMAAMRPLASGKVS
                     TVEALVWMVGQYFLSVKMLDLILDNRSMLPLTASIMLYPYLKRPVFSRVFIYPQYILGL
                     AVAYPSITGWASINGQEQSMSEIFTHCTPICLLIFFWCLYFNTAYSHQDSVDDRKMNIN
                     SAYVVAGQRIRLFLAFLGALPLAVIPYVVLKINSPWLWFSWMAVWTVSIVMQIVRFDSK
                     KLESGGRIHWDNFLLGLWTTVACIVEVGLQKVEFWNLI"
ORIGIN
        1 atgtcaagcg agaagttcac cgttactgag catcttgtcc cgggcagtta tattagagaa
       61 tacccaggga gcaccgtcat gcaggaagat gtactgaaaa ttcatgtcaa acaatatacc
      121 cccaaacacg aaggtcccgt cccagctgat gcaattactt tcattgccgc tcatggagtc
      181 ggtctcccga aggtgaccct gtctttaacc tgataattcg tctcatgtgc tcaacattgg
      241 acacaggaac tgtacgagcc gctgtgggac gagctgctgg aacgaactaa tggcttccac
      301 attcatggca tctgggtggc cgacgtcgcc agtatgaacc agagcgggat ccagaatgag
      361 gataagctca gtatggattg tatgtgcttc ccattcgatt cttgatacat ctccccccat
      421 attaacaatt tcctaggttc ttggatggat cacccgcgag acctcttctt gatgatcaac
      481 cattttcgtg agcagatgcc acgtcctctc gtcggagttg gccacagttt tggcgggaat
      541 atcatgtttg tgacgaataa ccctctcaat tttgagaatt caaagaatga gatactgatt
      601 tctttttcca gcacaaatct tgcctatcta catccacgcc tgtttacaac cctcctcctt
      661 atcgaccccc tcattcagct aagccctccc tcgatgggct tcggcaccga ccctccaggc
      721 ccgatcaact acactctctg gcgaaatgac gtctggccca gtcgcgaggc agccatacgt
      781 gccaaccgtg gcctcatcca tggctgggat cctcggtgcg tagatcgtat ggcgaaatac
      841 ttctttcgcg atctaccgac accgctgtat ccggatgtcg aggccgtgaa ggcgcgcttt
      901 gatgcagccg ctgatactac tgccactccg gtcaccctag cgacgccgaa gtaccacgag
      961 cttatagcgc aaatacggca gaacttcaat gcccgggacc cgaccacggg ccggatcgaa
     1021 atcccacgag ccacccatgc cgatatggac ccattggtgg catctattcc cttataccga
     1081 ccagaacctc gaagtacgtt ccgccgctta gggacactcc ggccttcatg cctgtggatt
     1141 gtgggcgggg cgacgttttt gaatgtcgat gagattcatg aaggtgtcaa gatatgcggg
     1201 tcaggcatcg gcgggagtgg aggtgtgtct gagggaagag tgaaagaggt tatcttacct
     1261 ggattggggc atttgatgcc atttcaggag attgggactg ttgtagggcc atgtgtggcc
     1321 tggttacagc aggagatgaa tcgattccgg cagatggaga gggagtggga agaagaaagg
     1381 aaaggcaaga gtcatctagt gctagaggag aactggtata aagtcttaaa accaatgcct
     1441 agtggacgtg gtaagggtgg gagaaaggaa aagttgtaga tactagatgg ccaaatgtct
     1501 actttttcaa ttttatgtta tcgaggtatc ctcgtgaatc ccaacaaccc ttgattatcc
     1561 gtctgcatct ccacagatcg cctaacatta gcaatcaagt gaggtctagt gcacacgatt
     1621 gatatgtcgc tggatgtatg ccaaggccag ggtggtcctg gagaaaccca gcagacgaca
     1681 tggcgagatc gacatcctta caataacccc gcttcccaca ccgtttgaat tatatctctc
     1741 attctaacca gaagtttcac atcagctctt tcatataccg tccgtttacc gtatgtaact
     1801 ttatatgtat gttgtagatc ccaaacaaaa cgtacatttt cattggtccg tagcaagggt
     1861 accgaaatgg gggaggttac ccgacatatg catgcaggtg acgttttgat tctaaaacat
     1921 ttgtaatatt gaatagttga ataatagttg aataatagtt ggataatagt tttatatcct
     1981 ttacatgtat ttttacccaa agatacctcg gatcggattt caacgttccg tccgacccaa
     2041 attcgacgga aatttactag gacaggattg gggcgggtga cctagcacca gtcacccgcc
     2101 ttacaccgta ttaccgcccc aatatttaca tgtacataca acatacatgg cccactacat
     2161 ggcccacttg gatggaaatt tcatacatac acgctaaaaa gagcagagat aaaaatcttt
     2221 taatttaaac cccggtcgta ttgtcaaaac tagagaaact tgaaaagtac taggcatcat
     2281 ggcagtaaca acgaggcaga ccaaaaacat ccatggacag cccccaggtt ccacctagcg
     2341 tcgactatac atcgaaagac cccgatttcc gtttaggacg gcatgtgaga ggctttggtg
     2401 tcgccagcca cggctacaaa tataataggt catcttccaa ttttaacatg atattgtgta
     2461 cacctttctc ccatattctc tgagttgaaa tcgttcatca aaagcaccat gctcaccaag
     2521 tctgtgacct ccatcctcca agggattacc ttggcagcca aagaatttga gaacaatgaa
     2581 gctggtgcaa gagaatccct cattgctcat agtagagctc tgatatccgc tcttgaagtt
     2641 ccgagcgagt ttattcaaca cactttctgg tctcaggtaa gcctgatttg gcggggtaag
     2701 actcgaaact attgctgatg ttcatatagc cagcactgtc tgctattatc aggcttgctg
     2761 ctgatgtcaa tatgtttcaa cacttgaaag atgccgcggg taaggggata gattgtgaag
     2821 ctctgtctat gaagacgggc gttgatgcca gccttctatc gcgcttggcc agacacctcg
     2881 tggctatgaa tgtgattacg tttcaaaatg gagcattcca tggcacagac ctgagcgata
     2941 gccttgccgc cgagaactat caacactcca tccgcttttg tcatgatgtg tccaggccct
     3001 cgttcaatga attcccggaa ttcttcaaga gcaatgggta caagaccccg acgctgagtg
     3061 gaactgatgg tccattccaa gctgctcata agactgagct cacctttctg caatggcttg
     3121 tcaacacacc cccctatctg cagtattttc actcttacat gagtgtttac cgtgctggaa
     3181 aaccaaactg gtgcgacacc ggtttctacc ctgtctcaga gcgtctcctt tccgggttcg
     3241 atgcctctgt cagcgatgtt gtgctggtcg atgtgggcgg tggtcggggg cacgacctcg
     3301 agacttttgc ctctaaattc agtcctcttc caggaaggct cgtgcttcag gatcgagaac
     3361 aaaccattgc tagcatgccg gccgatgaat cccgccaatt tgaagcgacg gctcataaca
     3421 tcttcacacc gcagccggtc aaatacgctc gggcgtacta catgcactct gttccccatg
     3481 gcttcggaga cgaggatgca atcaagataa tgacaaacct agtgcctgcg ctggcgaagg
     3541 gatactcccg agttcttttg aatgagattg tcgttagcga ggagaacccc attctagcgg
     3601 caactaatat ggatatgatt atgctggccc acttggcagt gaaggagaga acagaagctg
     3661 aatggagata tatcttcacc caggcgggat taaaggtggt caatatatat tcgtatccag
     3721 gcgtggcgga gagcttgatt gaagcagagc tcgcctaaac gtcaccaatt tctataggtt
     3781 ggctacatat cgaggaaatc agaatcagac tcggaaacaa tataggaaat aaaaacccga
     3841 atcccgaatc ggcaaatcta ggcttcagcc tcggaaggtt agcgcattta aattttcggt
     3901 tctgtggggc cggcggccgc agccctactc cctacggtat cccaagttta agcctgtaac
     3961 aaaaacgcgt tgtttacgga gaagtccgaa ctccgtaggt aaaaatcctt ctgagggatt
     4021 aaaccggtca ttgtgggggt gtagatcatc aaaagaaaga aaacgaaagg cttttcgcta
     4081 aaattcccct gccggagtcc tctttgattg gactacagtg tagtgctgcg atgaaagagg
     4141 gagagagttg tatttccagt tcttgtattt cctgaagttg gtgcctgccg caccggactg
     4201 atggtcaggt gaccatcaca tccaacaatc ttaaaaggcc gtccctcccc tgcccctctg
     4261 acttcctttg ggaatcaccc ccccattccc attacctatt agtttttttt ttttctattt
     4321 tttttttttt tttaaatcag catcatggtc gaaattctgg attataccaa ggctttagaa
     4381 gtactcaagg agtatcctgg agatggcctc cacgtcgata ctctcctcga ttcggatagt
     4441 catggagctt tgacttacaa tgacttcctg attttgcccg gttctatcag taaggcaatg
     4501 aacattatct cataggtcgt tctctctaat cgtacgaaca gccttcccgg catcggatgt
     4561 ttcgttggaa accagagtaa cccggcggtt caccatcaag gcccctctac tgtcttctcc
     4621 catggacact gtgaccgaac acagcatggc catccatatg gctctcctgg ggggtctggg
     4681 tgttatccac aataactgcc cacctgacga gcaggctgag atggtgagga aggtgaaacg
     4741 ctatgagaat ggcttcatcc aggaccctat cgttctgtct ccggagacga cagttggaga
     4801 agcaaaggaa ttgaagacta aatggggatt cggcgggttc ccagtgactg gttagttgga
     4861 tttctccttg gtggctcttt ttctttttgt ttcgtttggt gatccttacc ttgtttcgtt
     4921 catagaaaag ggaaccctcc actcgaagct tctcggaatc gtcaccagcc gagatatcca
     4981 gttccacaag aaccacgagg atccagtcac ggctgtcatg gcgacagacc tcgtcaccgc
     5041 accggcaggc actactctcg ccgaagccaa cgaagtcctc cggagttcga agaagggtaa
     5101 actgccaatt gtggataagg atggatccct gatctccctg ctctcccgga gtgacttgat
     5161 gaagaacatt cattaccctc ttgcatcaaa gcttccatcc aagcagctgc tctgcgccgc
     5221 ggccattagc acccacgacg cggataaggt tcgtctccag aagctcgtcg atgccggtct
     5281 ggacattgtc gtcgtggata gtagccaggg ccacagcact ttccaaattg ctatgatcaa
     5341 atatatcaag cagaacttcc ccgacattga cgttatcggc ggtaatattg ttacccgtga
     5401 gcaagccgcg gcattgatcg ctgctggtgc agacggtctt cgtatcggca tgggcagtgg
     5461 ctctgcgtgt atcacgcagg aagtcatggc cgctggtcgt cctcaggctg cagccgtacg
     5521 cagtgtatct gccttcgccg cgcgtttcgg tgttcccact attgctgacg gtggtgtcca
     5581 gaacctgggc cacatcgtca agggacttgc cttgggtgcc tcggcagtta tgatgggaag
     5641 tctgcttgct ggcactaccg aatctcctgg tgagtacttt atgagcagtg aaggccagtt
     5701 ggtcaaggct ttccgtggta tgggcagtat tgcggtcatg gaggacaaaa gcaagagcgg
     5761 cgctgggaac aacgccggtg cttctcggta cttctctgag aatgataagg tcaaggttgc
     5821 gcagggtgtt gcgggctccg ttattgatcg tggctctatc acccagtatg tcccttacct
     5881 tgttgctggt gtgcagcatt ctctccagga tattggtgtc cagaaccttg atgccttgcg
     5941 tgaaggggtg aacaatggaa cagttcgctt tgagatgaga agcgctagcg cgcagaccga
     6001 gggtaatgtc cacggcttgc acacccacga gaagaagttg tactcttctt gaaatgcggc
     6061 gtctctgttt tcgtcgactg ttgtctagag ttccttccat ctagtacacc agaccaaaag
     6121 ttagtcaata cactcttttt gataatctgc cataagcaaa ttgttgtcaa gcattttgaa
     6181 aagcctggaa tagaaatcta gtgattatac aagatttaag gggtacagag agctcttgaa
     6241 gcatatgttt tcaaagagta aggtttatga aattcaaaat tcaaacacat ctctacttgg
     6301 tcccttccat agcgtcttca agatctttgt aaaacagcca cttcgtctgc ttgccgtacc
     6361 cttttgcctt ccaatcattg atagtcaaag gataaaagtc catattccct ttcaaggtac
     6421 tatcatgagc aagaatcaga aatacattgt cgtatgcatc gagctctttg atattgtcga
     6481 ctgtcttcag cgccgcgtcg taatcagaag gaagcacagg cgacaaggtg aaaacagatt
     6541 ctgattcaga cgaaagcgga atgtgacgag agtgagatgg acaaggaaga tatttggaag
     6601 gccgaagaac accggcatgg tggcaggaat ctccacccat gaatacgaat gagtccggcg
     6661 aggtggtaac ccgcgcgagg gcgcctatat gaccaatgga atggcctgcg gcatttagaa
     6721 gatagaagga tccgtcaccg aaatagtcca gcgcgtcgaa cgagcctatc ttgatggctt
     6781 ccttttctgt cctttcgaag gagatttccc gcactttccg accttggatg tccgaattga
     6841 gattgatcgc gtccgggtta gttgggaacc cgggccagtg gctgtcccgg atgccaggac
     6901 cgacgacgag ctcggtagac agtgggaaag tggacgggtc gccgatatgg tcaaaatggg
     6961 catgcgacca gataatggct tcgatgtctg tgctgcggat gcctagggac gatgcgtcag
     7021 agtccagaat atccgagatg ttgcgcgggt tctggatggt tgtctgtgat ttgatcatgg
     7081 ctacaacgga tggcggaagt ctttcccagt cctgtcgaac tcccaagtca aatagaacat
     7141 ggcgagtgcc gactgagatt aagaagcagt aagttggcgc tgtcaccttt ctaaggcctg
     7201 gcagttcggg ttgccagaat agatcaggtc gtaggtcaag gagtgttcct ctgcgattat
     7261 taggtcaatt ggttcccatg gatacgacga ggtagggcct tacgggtcga tcactcgcac
     7321 atcgacggtc gatgatgaag gaggaatatt caagacaggt ggaagagtgg gcttgtcttt
     7381 gttactggaa cctctctcca ttttcgcccg cttgcgaatc actgcttgta gtcccgtctg
     7441 cttgaagaac caagcattct cggttttgta gttctccggg ttgacgattt gtatctggca
     7501 cggaacaaat taggaagagc acatacctga attgaagcaa agtactcaca tcgtagttca
     7561 aaagcagtac cggaattaat ttcttgatct caaggatggc gatattcttc cccagacaag
     7621 tacgacggcc cgctccaaac taaatctcaa gattagtaag agtatgtctg acgtagacga
     7681 agtctagacc cacagtcaac aagctattct ccagcctctt acggtcttca tggctcaggc
     7741 ctagccatct ctcgggtctc cattcgtccg catcattacc aaaggtttct ttatcccggt
     7801 tggccatata tgggctgatt ccgacaatgg tccctgctgg aagatatgtc tcgcaaacag
     7861 tcaaaccacc gccaggaaca actcgctcaa aaggtagaca aaatggagga tgcagccgta
     7921 aagcctccag aacgcacgcg tcgaggtacg gcaaatctct cactttctcc cacgagggac
     7981 atgtacgaga aagaccattt ctgctctcag attccaggag ctcatcttgc agacggctca
     8041 gcgtgtcccg atgaactaag agattataca taattgtacg catgacattt gcagtcgagt
     8101 ctgagccagc catgatatta gagaaagtcc aggctcttgg ggccctggat atgagttagc
     8161 cggatataag gcaagagata gaaatcgatc agcgggaaga tttctttacc aaggcataac
     8221 atcagggttt gaggcctgta tattgagaaa ctgggagagc atatccttct cgtctgaaac
     8281 ctcgtctttt tcacgaggcg ccaagcgctg caatataaac ttgtcgacta cctttaacac
     8341 cccaaaccct gtcggtgacc tgaacaatgc tataaacggg ttcgtattac agaactcgtc
     8401 aaaccacgga atttggccca tctgagaaag tcatacgcat tagaaaccaa cggtagcacg
     8461 acgtgcacag agctagaacc caccacagaa actctcttca taaacttcca aatctcgccc
     8521 aagattccat tcatatcgcg gccttgttcg aggaatccat atcgtcgaga gaacgtcaat
     8581 gtccccatcg aatcaaacgc aaaatactgg agccagctcc ccagatcaaa cggaacatcg
     8641 ttgctgccta ggaaccgacc atcgagctgt tccaacagta ccgcgagggt ttgatcgaca
     8701 aatgactcga gcttcaccac atttgtcatg gaatatagag gagcaattgg gcttcgaagc
     8761 cttttatgaa ggtcctcgtc ttgggaattg aacaccgccg gcatggcgcc cttgtttggc
     8821 gtgtagggct tctgtgtgcg ataaaagtcg ctctgggggt agcgatgtta gcgattgaaa
     8881 tccaatcatg actgcacgca ataactctgg tactaccatc actgaccttg ggaaacccag
     8941 gcctactagg gtagatagcc gggatggtgc gaggatccga gatagagacc atgtttggac
     9001 cgaatcgaac ggcaggccca tacacagcat gcatccgacg gtggtattca tgagctcgtc
     9061 cggactttac ccaccacacg cgttgcaggt ttgtgaactt tgcaaacaac ggacctggta
     9121 catcttgcag atgcaagtat agacaacaaa cgtagcgggt gagatatagc acaacagcaa
     9181 cagctgtgat acgtattatg atcagatagt ccatagtata taagtttatg tcttgtacgt
     9241 atacttgtgc tggaggattg agaatgaaaa tgaaatagac tttcaagatt gagatcaatc
     9301 gtctagtatc tattaaccga atcatattgc tattgataga acaacaagct attggcctaa
     9361 agggacagag tacatttgca cacacctcgc ctctttacac agctggattg agttcgtatc
     9421 aatacagttt atggaaatta gatatttcgt aatctatagg cagttgccta atttgtgcct
     9481 tagtgcatct ccacctccaa atctagaatg ctcccacata tagccccgcg ctactgcgta
     9541 cacctcacgc gaatcgggtc tatacataat aacactccac aaaaagtgaa gcggactacc
     9601 ccgcgtataa tataacatgt gcgtgacatt caagcctttg catatcttac tgcattgtat
     9661 acctgctcca ctcgaattcg atatcgattg ttcgggcgat cgtaatagga tgacggctgg
     9721 ctgcccggtg taggcatctt agtctacacc tgcatatggg ttcaagtcga taagactcaa
     9781 taggtagccc gacggggtta cgtacgcttt gtgctgatcg ggaataacat accactccac
     9841 atcccactcc gcaaattatc cataggtgaa ataagtactt gagcggcata cttcttccat
     9901 gtaacgcttc atatcgccaa aagtctggcc tacattgcca agaatataca atcggatcca
     9961 cattaactta tcgcgcatat cgcccccggc ctcaacgcgc attatacgag aagcattcgt
    10021 ggcagtgtta gaaagcagat aggatctccc agaattaaca gaatgaattg atttgcaatc
    10081 gctcttctac ctttacgaaa gtatcctaga taaaaaacac gaaatatatg cggtgtatac
    10141 gggatcctac cagtgaacaa gtaaagggca gtatatatta agaatggcgc ccatagagcg
    10201 tttttggttc gtatttccgc actattgaca atccgaaagg gacacctggc gccgacaggg
    10261 gaggccgaat agagcaaatt caaggaagtg gcgaaggaag gactttttgc gacattacat
    10321 caactctaca aggtttattc caaggttgct accgcgtcag atgcgctcga aaagtatgat
    10381 ctacttttcg ggggccaatc ctagtatgta agctacaaac tataaatgta atgcaaaacg
    10441 ctccttccag aactgagaca tcaccccacc tctacgcaac ctccaaaatt tggaatggat
    10501 gtcagcttcg ttaaagtacg ccgatcggca ggagatggtt gatgcgcgga acatcccttg
    10561 cgggccgcat aaccgtaatc gtgcccaagc cggagacggg ccgggcccgg gcatccccca
    10621 cggggaaaaa cgtaccgcca ataccgcctt actgaacgcg aattatagaa cctttctaga
    10681 acggtacaca agctgtacgc aagccgtttg tttcgtgaaa aatagcattc ttattttctt
    10741 ataaatttct aaacctattg cttattttct tatgccatta aacagagata attataatgc
    10801 attcagtgat tctgctggca aaatatcatg taatctatgc ggtgtgggga cacggagcaa
    10861 atacatatgt ccgctgcctg caggtatgtg caaacgagtt cagaaaatgg catagaacta
    10921 gataatgaga cccccacttt cagttcagtg agataagaga agatcatcaa agcgggaaaa
    10981 caaggctcgg gagatggatc aatggcgcgg gaggggtcta ggcgccacga ggtctcatgc
    11041 atcaaaatgc ccaaagattc cgggatttag accattctat agtccgctct gtactagcat
    11101 tacatgatgg ttattttcgt ctcaccttct gtattgagat tccaactccg gagggtagta
    11161 tgtatgtatg agcatgactt cccaaatcat gtagtaaggc tagatttgaa ggccagcaca
    11221 ccactatata gctctagcaa gggtttgtgg tcagcagagt tgtctactta gaacatggga
    11281 gataaagtaa gtttctaggt tattgctaaa tagtttgaac aacacagccg aagcatctca
    11341 cgacctaaat ttcggacaat ctatcagttt gtaatgtaac aaaattctga tttttaatat
    11401 cttcaacctc agaggtttgc agcccatgaa aattgtgtgc ttcgttgtat taattcagta
    11461 atttactttc ggctgcctgc agaggctcta gctggccccc ctccgtaaat aagagatgga
    11521 tagttttgta gcggactagc cctctcgttt tttgccttat atcaatcaga cttatatctt
    11581 ctcccgaacc aagtttctta tagatctgta aatatacgat atcctgtacg tgaagggcgt
    11641 accaggaact tattacattc ttacctctat cgtttcttca tcgagtttca tatcatgtca
    11701 ttgaatacag agcattcaaa aggagacctt cgtcttctct tcggaccaca atgctctgaa
    11761 attgaagact ccatcgccca catccgggat gccgtataca aagattcagc cggtctgggg
    11821 ttcttatctg atattcttga cgagcttccc tccttatggc ccgtcataac ttctgcctgg
    11881 ccagccctac ggaaggtgca gggggagaag caactagctg cactggggcg gcgttttgag
    11941 aatggatctc cagatagtga agcagaaccc tcaagtctca tcatgactcc agtcacggtg
    12001 atgaaacatc tagttgactt ttggaatctc caaaacgttg cgacacatcc ggcgtttcca
    12061 tcctcgccat tatcacggac cacagcccca aggataatcg actcacaggg gttctgtgtg
    12121 ggtattctgg cggcaattgc tgtggcctgc tcccaggata cacgggaatt ccagtctttg
    12181 gcttcgaacg ccatacggct cgctgtctgt attggggcgt tggtggactt cgatgagatc
    12241 gtgtcgggta aggctaagtc aattgcagtg cggtgggaga ccccagcgga ccatgactat
    12301 cttgaacaga ccttgacaaa aagtcccaat gttagtttct cctcatggaa agaaaaggaa
    12361 acaaaagcaa agagctgata gacattcaag gtttatatct cctgctatac agacgttaac
    12421 agcgtcacta tcactatccc cggtgacact gcacaacggg tcaaattcaa acaggagctt
    12481 agcggccgtg gtcttcacac aaagccgatc cccctccaag gccgcttcca ccaccagcaa
    12541 acacaccgcg aaggcatcca gcacataatg aatctatgtg tgaaggatcc tcgctttcaa
    12601 ctccctcaca gcaacgcgtt gatattaccc cttcgatcaa gtcacaatgg gcaggtgctc
    12661 ataaatgcag ccatgttgca cactgttgcc ttggaatcaa tcctctctgt caaggcagac
    12721 tggtggggaa cagtctccgc attactaaac agcgccgata tggaagttga cgagtcccgt
    12781 cttctatcca tcggccagga agagttcgtc ccacgatcag ctagaggccg tctggtagcc
    12841 aggagcaacc ttgatgtcta cggggcagga gtgtttgcta acggtaacac gtcggctcgc
    12901 tccgcagtgt cgctgcagaa cggcacgaac accctcaatg gtagtccaca ggcagctgag
    12961 atgccaccta ttgccattac tggcatggct tgtagatatt ctaacgcaga caccacgagc
    13021 gagctatggg atttgctgga gctgggggta tgtacagtgg agaaggcccc tgggaatcgg
    13081 ttccggatgc cagacttgca gcgggagccc aagggcccat tttggggtca cttcctcgac
    13141 cggccagatg cattcgacca tcgttttttt aacatctcag cgcgagaggc cgagtccatg
    13201 gatccacaac aacgcgtgtt gctgcaagta gcatatgaag ccatggagtc tgccggatac
    13261 tgcggatggc agcacactga gctatcggac gaaattggct gctatgtggg agtgggatct
    13321 gaggactata ctgagaatgt ggcatcgcgg aatgcgaatg ccttctcagc cacaggaacc
    13381 ctgcagtcat ttatagctgg ccgtatcagc catcatttcg gctggtcggg cccatcgatt
    13441 acgctagata cagcgtgttc atccgcagca gtggctatcc atatggcatg caaggtacga
    13501 tatgagactc ccattgacct atctgaaagt gcaatggctg actgatgtat aaatgatagg
    13561 ccctgcaaac aaaggagtgc tcgattgccg tggctggcgg tgtgaatatt ctgacaaacc
    13621 ccagggtgta ccagaacctg gctgctgctt ctttcctgtc atctacggga gcatgtaagt
    13681 cgtttgatgc ctctgcggat ggatactgcc gcggagaggg cgctggactc gttgtccttc
    13741 ggccattgca ggatgcgatt gacaacggcg accctatcct cggcgtgatc gctggctcag
    13801 tcgtcaacca gagttcgaac aggtcaccca tcaccgtccc cgatgcagag tctcaacgat
    13861 cgctgtatag caaagctttg tcactcgctg gggttgcccc gggtgaggtc acctatgtgg
    13921 aggcccatgg cactggtatg tatcctgctt tctttttacc cttggtctcc tctattctgc
    13981 cctcttctat ttcgcctgca gtttagtaac aatgtcaaag gcacacaagt tggagatccg
    14041 attgaactgg aaagccttcg caagacattt ggaaacccgc tccgaagtca gagtctccat
    14101 gttgggtcca tcaagggtaa catcggacac actgaaacct cctcgggggt cgccgggctg
    14161 ttgaagacga tcctcatgct tcagaagcaa cgaataccga aacaggcaaa cttcaggcag
    14221 ttgaatccca aggtcatgcc tccactcgag aacgaccgat tggtgattcc cgtagagtca
    14281 accaaatggg catcagcgag acgggttgct atggtcagca attacggggc atcggggagc
    14341 aacgccgcgc ttatagtgag agaccacact cctagcctat cgggacaggg gaaggcaatg
    14401 gcggaataca ttcgagatat gcctatcttg atttctgcac ggtctgaaga atctattcgg
    14461 gcctattgcg gtgcccttcg caccaccctt ttgaggcatc cgtattccaa taccgtcgtc
    14521 cgggaattgg cgtacaacgt cgcaatgaag cagaatcgaa cactgccgtt tactcttacc
    14581 ttttcaacct cttctgatcc gacatcactg agcacccgct tggaggctat cgccgcaggc
    14641 aagtctgccg atattatcca gaagcgggaa tccaacgagc ccccaatagt tttgtgtttc
    14701 ggcggtcaga atggagttac ttcgagcatt tcacaagaac tttacgacag ctgtgtcctt
    14761 ttacagacgc acctcatggc gtgcgagcaa gcaggccaga agctcggcct tcccagtctt
    14821 ttcccaacta tcttcacatc agaccccatc gtgaataccg tttacctgca cttcatgctc
    14881 ttctctatac agtacgcatc tgccagagcc tggatcgact caggactgcg cgtagaccgc
    14941 atagtgggcc atagctttgg tcagctcact gcgctatccg tggctggcag tttgagtgtt
    15001 caagaaggca tccgcctggt tactgagcgt gcacgcctga tccagtccaa ctggggcccg
    15061 gagtcagggg tgatgctcgc tgtggagggt acgcaggccg aggtccagcg tgtgctagag
    15121 cagacaggcc accgtgctga aattgcctgc tataatggac cacagcagca agtgcttgcc
    15181 ggcacggggg aatgcatccg agcggttgaa gacgctctcg ctacaaaccc attgacaagc
    15241 aacgtcaggg tcagacgttt ggagaactcg catgccttcc actctagact tgttgatagc
    15301 attgtgcccg gcctcacaga gctcgcagag tcctttgtct accaagcacc agctatcccc
    15361 atcgaagcct gttcggcgac tggcgactgg tcgattgtca ccccggcaaa gatcgtcgag
    15421 cacagtcgca tgcccgtgca cttccaacgc gctgtcgaaa gaatagctca aaaactacaa
    15481 gttcccgctg tctggctcga agccggctca gcctcgccta tcatccccat ggtgcgtcga
    15541 gtgctggaga aatcgtccgc aactcacaca taccataggg ttaacctcga tgggtcggac
    15601 ggaagcggga atttggcaac tgtcaccagc gccctctggg gtcagggcgt ccatgtccag
    15661 ttctggccct tccatcactc gcagcgtggg accttcggct ggatgaacct tccgccgtat
    15721 cagttcgcga agaacagaca ctgggttgac tttgacccta ctgctttctc gttttccgga
    15781 tcctccgccg aaccgcaatg tggcagtcag gagcgggctg gcctgttgcg caagttgagc
    15841 gacggcccag aggagtatct atttgccgtt aacacccaag atgtattgta taggtcatgc
    15901 acgaaggggc acgcggtatt ggaccaaaca ttgtgtcccg catccatgta tatggagatg
    15961 gtcctgcggg cagcaacttc cgtattcacc ttgggtgaat cctcaacgct gactatgtct
    16021 catatcgagg acctggtgat atcatccccc ttagtattag atccgcaagg aagtgtgttc
    16081 gtacgactga tcccagaggc agtggcttct tcccagacgt ggtcattctc ggtctttaac
    16141 agtagcggga cgggtaatga gtcgtcgatt catgctacag gcagtgtatc cttatgcaat
    16201 gaaaggtcca gggctctgtc acactttcag tctatgaatc ggttgatgga cccggcacgg
    16261 gcaagaggaa ttgaggatca tctggcatca aacggactga aaggatcgac ggtttactct
    16321 gccctcgaac aggttaccaa ttatgcagac tacttccgcg gagtgaggca ggtgtttgca
    16381 aatggccgtg aggctgcggg gctggtcagt atggcaccgt cagccactga gaccacgtgc
    16441 aaccccatcc tcctggacaa ctttctgcaa gttgcgggaa ttcacgtcaa ctgcctctct
    16501 ggccgtgaag cagaggaagt attcgtgtgc aatgctatcg gggaaacgta tgttagcgat
    16561 tcgttgttca aaaaggaaga cggagctatt ccgttatcat ggaaggtata taccaactac
    16621 gtccggccgt ccaagaatga gatcgtgtgc gatatctacg tgatgaactc tcaaggagac
    16681 ggtcttaccg ccgcaattat gggcgttcgg ttcatgagtg tctccatccg ctctctcact
    16741 cgcgcactgg ctaagctgaa caacaatttc cctgacgtcc cacaactccc gcccacgatc
    16801 cagccagcaa ttgtgacagc cgattatgat gaagccagtg acaatgtaaa tgtggatagc
    16861 gaccttgttg cagtccaaga gatgctttgc gagctgtttg gagttagtgt cgaagaggta
    16921 tctccatcag tctcgctgat agatatcgga gtggactcgc tcataagcac agaagtgctc
    16981 tccgagatca agaggagatt ccataaggat atttcctatt ccaccttggt ggatattccc
    17041 aacatccagg gtttgacaga gcatatcttc ccgggacatt ctcacctagc tccttcccag
    17101 attgtgatca aaccagtacg gcagcagaca gtgataccgc aaactgtaac ttttctgcct
    17161 gtgccagcta acgccggacc gtcgctagtc tcagtagcac accaatgctt ctatgagact
    17221 cacgccgcgg tatcccacac acacaatgcc gactgggccg gcttcttcaa tgccatctat
    17281 ccgcaacaaa tgacactcat cacggcgtac atcctggaag cattccgcgc cttgggctcc
    17341 ccgctagagt ccagtcaggc agatgaggtc cttcctatta tttccgtcct acctcgtcac
    17401 gagcagttga agaagcacct gtatacaatt ttggaatccg tcaacctcgt gcgccaaact
    17461 ccaactggtc aactcgtgcg cacagcgaca cccatctcgc cgctctcatc acacgccttg
    17521 catgcccaga tccgggatga acaccctcca tatgcactgg agcacgatct tctacagatc
    17581 acaggctcgc ggttggctga gtgtctgacc gggcaagcgg acggggtatc gctaattttc
    17641 caggattccc agactcggcg cctggtagga gatgtctata cggactcccc ggtgttcaag
    17701 tcgggtaacc tctacctcgc acagtatctc acggatgtca ttcaaactct cggaaacggt
    17761 cggcaggtta aaatcctcga gatcggggcc ggcacaggag gcactaccaa gaatctcctc
    17821 gagcagctct cggccctccc cggaatggcg acacgcatgg agtatacatt cacggatatc
    17881 tcgccatcgc ttgttgcagc cgcgcggaag aagttttcca agtatgattt cgtacggtac
    17941 gaaactatta acgtggagag tagccctccc tcgctcttgc acggccaata cgacattgtg
    18001 ttgtcgacca actgcgtcca tgctacccga aatctcgtcg agtcctgctc aaatatccgc
    18061 aagctcctcc ggcctgatgg gatcttgtgt ctcgttgagc tgacgcgtga catattctgg
    18121 ttggatcttg tgttcggact cctggagggc tggtggcggt ttgaggacgg tcggaagcac
    18181 gcgctggcca ctgaagatct ttgggatcag acgcttcgcc aatctggctt cgagtgggtg
    18241 ggctggacga ataatgaggc tgtagagtca aatgctctgc gcgttattgt cgcatcgccg
    18301 acgaaggccc cttctgctct ggagatttgc tccaagccgg caaacatgga aactgttgtt
    18361 tggggcgaaa gaaatggtct gcagctgctg gctgatatat tttatcccga cgtggttgac
    18421 accacgcaga aacgacgagc atgtggtaag ttcaaattca tcttttgtcc cttgtaataa
    18481 ctccatttca tactttcatt tgctaaccct cttcagctct gatggttcat ggaggtggcc
    18541 acgtcatgct atctcgtaaa gacatccgtc ctgcccagac acagaccctt ctcgatgccg
    18601 gattcctgcc catcagtgtt gactaccgcc tgtgccctga ggttagcctt tcagaaggcc
    18661 ctatggccga cgtgcgcgac gccctaggtt gggtgcgccg catcctccca aatatcccct
    18721 tgctacgtcc agatatccga ccggacggca accaggttgt ggctatcggg tggtccactg
    18781 gtggtcatct cgcaatgacg ctggctttta ctgctcccgc tgtgggtatc gccgctccag
    18841 aggccatatt ggctttctac tgtccaaccg attatgaaga tccattttgg tcgaggccaa
    18901 acttcccctt tggacagact gtcgcgtcaa atgatataga gtacgatgtc tgggaaggcg
    18961 tgcagagcgc cccgatcaaa ggctataatc cagcgttcaa ggaacggcca ctagggggct
    19021 ggatgtcaac cagcgacccg cgtagtcgga ttgcattgca catgaattgg acgggacaaa
    19081 ccctccctgt gctgttggga ggcatgcaca aagagtttcg catacctgat gaactacctc
    19141 gtccgacaga cgaagagatt caggcagtta gtccaaacta tcagatccgc atcgggcggt
    19201 accgaacacc tacgtttatg gttcatggaa caagcgatga ccttgtcccg tgcgcgcaga
    19261 ccgagtcaac atataacgcg ttgacccaaa acggcattga ggcagatatc agggtggtgc
    19321 agggagcggt gcatctattt gatctttatc cgagctctca tgctggccag aatgcgaagg
    19381 aagcagtggc tgatgggtat gaatttttga aaagacacat tcactctaag ggttatagcg
    19441 acaaggatta gatttagatt caaattttgc ttccgcattg aatattacaa tttgaagatt
    19501 atattgaggt cttgctatat ctacaacatc cagaacgggc gagaaaatgg atatgttcgg
    19561 gttcactaac gctggagatt tgacaagttg gaacacgacg gtgtgccaat aagcggccct
    19621 ggccgcaaca aggaggaaga aaacgaagtt actctgtctt tcagtttaca atctaagagt
    19681 ttagtaggct gtacagatct gcttttcttc caagtatccc atgcggtctg aacttcacta
    19741 aatcataaga cttgctttaa actaatgaaa aggacacttt cccgtcctag aaatcttcag
    19801 ttccttcatc atctcctcaa ttgccttctg cccctttcct tcaaaatact tcggcccgat
    19861 atcgtgaata tgatacccct tcggatagta cttctcaccc tggtcgcccg ggacaggatg
    19921 accgagcgcc caggaaaccc acgccattgg accccatcta ttccaaaatg ttggtttcac
    19981 gtagtaggga agtgcgtccc aagatttgcg gtaatagcgg ttgtttggat cgggttgctt
    20041 ggctgtattt gacaccgcga agatcaaagg tcgtgggggt gttaggtagc ggagaatgaa
    20101 tgtgcgggtt attaggaggg cagagaagac ttttgtccag aatggcgttg gtggttcgta
    20161 tctagttgat gttagcgctc gatatttcgt tttataagat cagatcttac tattccacat
    20221 acaacatagc cttcctcagc cggtcatcca tcatgaacga agtgaactgc aatcccaccg
    20281 gatggaatac cttcggcaaa ttataaagca gcacagctgt tgcctgatcc gctgattccc
    20341 gattctgagc atctggaacc atatacttga cctcatactc ctgactccaa gtatccacct
    20401 cctcgagcca atgtattcca tccctaaacc ccgtcttacc tgacgggaga atgtcagaac
    20461 taatacctag cgcgtcacct agactcttcc aaaacgttcc aatagcacag cgttccaaat
    20521 cacttagcgg ccgccactcg aatgccgcga tgaaatttac aggctggacg gcaaagagcg
    20581 caagtgtgta gagcaaatct gtatcaagga tcttgcctga agcttggtag ccgctgtgta
    20641 ggaaacgcgt gcgggctaca gagagaaaag cccgttgcga ggtagggcta ttttctacca
    20701 tttcgccgat aagggcggct gtgtctgtat agcgcttgaa ggaggtttct ggtttagaaa
    20761 attgccctgt ctttatgaga aggtgggaga ttgttggaat gccgtaagtc tagaggaggt
    20821 tagaataaga aaaatataga ttggtgtata tatttgcgta cccgaaataa agcaaactgc
    20881 cctgctttca caaacatgaa tgggaattct agctgcgccg tttctttttg aatctggaat
    20941 gcttcttcgt ctgtcatctt agccatagac tcgcgtgtcg ggaagtagaa ctttttttgt
    21001 agctgtttaa gtcgtctata gcgcagcgaa ttgataagaa gggggtacgc aatcaacaag
    21061 cccactgcaa atgaaaacca ttgcggcatg gtattgaaaa tagctctggt ggttgcagag
    21121 aacgagggag ttgtaaagaa agatgtgcct ttatccataa tgtggatatt gtagttttga
    21181 agggtatctc aatcccatat agaaagctct gatatttaaa tgattactgg ccccaaggcc
    21241 catagaaagg ggctatttat gtgacgccat ttacatgtaa ctagctggtc ataatacaag
    21301 tactgtagaa catcgaaatt caggcgggct tgaagcaaag cccgaattat tcttgatcat
    21361 taggtcattg tatactatcc gtctctcctt gcacccaatt atacgcaaga taaactgaaa
    21421 aaaagacacg aggcaactat tctatttcaa ccgtagaccc aggtatcaca tgtaccgtgg
    21481 acgtctaaaa caaagatgat attacattta tcttattcga gattttccgt aactgtttta
    21541 catctttgta ttattgccct tccatatgta tgcacatcta tggatctagt aagcattctg
    21601 caaaggatgg agtcccgcgg ggttgtatcg tggggctaat cttataccca ttgagtctct
    21661 tgcatgggcc tggctggccc cctattatta tttattcaga tatactccgt actatacagt
    21721 gcttctccaa aagtacatac atgtacggta aatactgccc gcatattacc tagtactttg
    21781 gtgtagatgc attggtgtag atgcattatg gtataggaag cagctcggtc acgataggct
    21841 ccacggtagc tctcgctgcg gtaagacgga gcattcctcg tcactcatgc acccgttcca
    21901 ccgtctatgt tattctcatg catggtcatt agaaattcat ttttctgata gtcaccataa
    21961 cgtggatacg gcaacgtggg ggcagaaaac tgcaggatga tgcggcaatg tggaaaaacc
    22021 gggtctctta tagtacagga tgtctcccct agaagtgctt tgtgctgcga taccgggtat
    22081 aacttttgat agttctcaag gacagcccga ttttctagct catctgcaaa gtttttgagt
    22141 ttccgtcttt aaaggatatt tgccaatctc taacacttta ttgcattgca ttcaccaaca
    22201 tggttggttc aatggagaac cctggttcat gggaccttgc ctgtcttctg atcagcacct
    22261 cgcggttcaa ccgatatatg ccctactaca cgatgatggc cgctggtaag gagagcacca
    22321 ttccaagctc tctcatgaat aaagtattaa cttgaaatct ccgtgacaaa acagtatggt
    22381 ctaccttgat tgctggcgct ttaaagttgc aagaggatcc cgccagtctc tctgtcgagt
    22441 acatcctctt caaagccggc ctgtgctttg ttcactgctt gttactatgc ggtgctggga
    22501 acacatggaa cgacctgata gaccgtgata ttgacgccag ggtggaaagg acaaaaatgc
    22561 ggccgttggc atctggaaaa gtctcaaccg tcgaggccct ggtatggatg gtcggtcagt
    22621 attttctgtc ggtgaaaatg ctggacttaa tattggataa cagaagcatg taagtctgac
    22681 attcagtgtg ataaaactcc ggccgcatgg aagagcacaa cttgattaac cccgtccatc
    22741 cctcttagat ggggcttaat gctgcctttg acagccagta tcatgctgta tccctacttg
    22801 aaacgacccg tattcagcag agtcttcatc tacccccagt atatccttgg cttggccgtc
    22861 gcctatccat cgataacagg ctgggcctca atcaacgggc aagagcagtc catgtctgag
    22921 atcttcacac attgcacccc gatctgcctt cttatcttct tctggtgcct ctatttcaac
    22981 accgcctaca gtcaccagga cagcgtcgac gaccggaaga tgaatatcaa ttctgcctat
    23041 gtggtcgcgg ggcaacgcat ccggttattc ctcgccttcc tgggtgctct accactcgcg
    23101 gtgattccgt atgttgtgtt gaaaatcaac tctccctggc tgtggttctc ttggatggcg
    23161 gtttggaccg tttctattgt gatgcagatt gttcggttcg attcgaagaa gcttgaaagt
    23221 ggcgggcgta ttcattggga caactttctg ttgggactgt ggactaccgt tgcttgtata
    23281 gtcgaggtcg gtctgcagaa agtagagttc tggaacctaa tctag
//
