LOCUS       BGC0001679             12482 bp    DNA     linear   PLN 27-FEB-2015
DEFINITION  TPA_asm: Aspergillus nidulans FGSC A4 chromosome III.
ACCESSION   BGC0001679
VERSION     BGC0001679
KEYWORDS    .
SOURCE      Aspergillus nidulans FGSC A4
  ORGANISM  Aspergillus nidulans FGSC A4
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus; Aspergillus subgen. Nidulantes.
COMMENT     Aspergillus nidulans FGSC A4 CADRE,
            updated by Eurofungbase with contributions from
            CADRE (http://www.cadre-genomes.org.uk),
            AspGD (http://www.aspergillusgenome.org) and
            Ensembl Genomes (http://www.ensemblgenomes.org).
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 16:03:52
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12482
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12482
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[2071:7247]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2072..7247
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..12482
                     /SMILES="NC(CC1=CNc2c1cccc2)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..12482
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001679"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..12482
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(2..1696)
                     /locus_tag="ANIA_10573"
                     /old_locus_tag="AN10573.4"
     mRNA            complement(join(2..783,840..1381,1464..1696))
                     /locus_tag="ANIA_10573"
                     /note="transcript_id=CADANIAT00005790"
                     /old_locus_tag="AN10573.4"
     CDS             complement(join(13..783,840..1381,1464..1689))
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CADANIAG00005790"
                     /db_xref="EnsemblGenomes-Tr:CADANIAT00005790"
                     /db_xref="GOA:C8V7P3"
                     /db_xref="InterPro:IPR001128"
                     /db_xref="InterPro:IPR002401"
                     /db_xref="InterPro:IPR017972"
                     /db_xref="UniProtKB/TrEMBL:C8V7P3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 282; E-value: 1.5e-85)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ANIA_10573"
                     /note="transcript_id=CADANIAT00005790"
                     /old_locus_tag="AN10573.4"
                     /product="cytochrome P450, putative (Eurofung)"
                     /protein_id="CBF77085.1"
                     /sec_met_domain="p450 (E-value: 4.7e-60, bitscore: 191.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSLDLVFSFPAWALLLVLTLLYTLYLATTRLLLSPIRHIPGPTL
                     AALSFWPEFYYDVVQRGQYFRQIDKMHQTYGPLVRINPFEIHIQDPSFYPVLYTGPTRR
                     RHKWLWAARMFGNNTSAFATVRHEHHRLRRSALNPLFSKSAIQRLTPHLQHTLARLCSR
                     LDGFAFTRQDVDLGIGLTAFAADVITEYCFGQSLELIGKDNFGKEWIDMVSAPSELGHL
                     VKQCPWILVVCKWAPKALVRALLPGVALLFQIQERMSAQIQPLVDRAAAVDKPADPLTV
                     FDFLLSSTLPQHEKTVDRLKGEGQTLIGAGTLTTGNALKTIIFHVLNDPDIFRKLRAEV
                     DGALENMDILSMSDTAYLERLPYLSACIKEGLRISYGVTHRLQLIAEEPLIYSGVTIPA
                     GTPVGMTSIFMHDNPVVFPQPREFRPERWFEADFETVQAMNRHFVPFSKGSRMCLGMNL
                     AYAEIYLVLAVLFRRYEISLSGVTREDIEMAHDFFDPAPKEGARGLIVQLQKRG"
     gene            complement(2072..7247)
                     /gene="ivoA"
                     /locus_tag="ANIA_10576"
                     /old_locus_tag="AN10576.4"
     mRNA            complement(join(2072..6745,6807..7247))
                     /gene="ivoA"
                     /locus_tag="ANIA_10576"
                     /note="transcript_id=CADANIAT00005791"
                     /old_locus_tag="AN10576.4"
     CDS             complement(join(2072..6745,6807..7247))
                     /NRPS_PKS="Domain: AMP-binding (233-621). E-value: 1.2e-83.
                     Score: 272.9. Matches aSDomain:
                     nrpspksdomains_ANIA_10576_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (757-818). E-value: 7.1e-10.
                     Score: 31.2. Matches aSDomain:
                     nrpspksdomains_ANIA_10576_PP-binding.1"
                     /NRPS_PKS="Domain: Epimerization (936-1128). E-value:
                     2e-31. Score: 100.2. Matches aSDomain:
                     nrpspksdomains_ANIA_10576_Epimerization.1"
                     /NRPS_PKS="Domain: Condensation_DCL (1301-1566). E-value:
                     8.5e-16. Score: 49.8. Matches aSDomain:
                     nrpspksdomains_ANIA_10576_Condensation_DCL.1"
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CADANIAG00005791"
                     /db_xref="EnsemblGenomes-Tr:CADANIAT00005791"
                     /db_xref="GOA:C8V7P4"
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR001242"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="InterPro:IPR010071"
                     /db_xref="InterPro:IPR020845"
                     /db_xref="UniProtKB/TrEMBL:C8V7P4"
                     /gene="ivoA"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score: 281;
                     E-value: 2.4e-85)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ANIA_10576"
                     /note="transcript_id=CADANIAT00005791"
                     /old_locus_tag="AN10576.4"
                     /product="conserved hypothetical protein"
                     /protein_id="CBF77087.1"
                     /sec_met_domain="AMP-binding (E-value: 2.9e-92, bitscore:
                     297.0, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3.8e-11, bitscore:
                     31.2, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 9.4e-40, bitscore:
                     124.1, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASPIIQPAGAGIHDIFTQLELWESIDKGLSMITILRDNDVLWKP
                     FLQLTLFNQLNIVRKAWSATIQKASESDKVPTLKDVYTSESSFIAQALLDTKNLQITPP
                     ATPRTALSGALLAKTIVIFHHSERAQEELGTELPEEVRSLVNQNAICLKVLYNANQWHI
                     DLHYKRDSLSSAQAGEVAEIFEQYLEEALEAVASAIPPSPPVEDDNAGHGGLCKERTDC
                     PKVNRCIHDLIEEQAIARPDQEGICAYDGSLSYAGLSKLSSVLAEQLKTFGARPEQRVA
                     ILMNKSFWYPVVVLAVLKSGAAFVPLDPSHPKNRLKQLISEIEPCALITTSVLSELADD
                     LGCPSLAIDSDLTRSKEGSTTALLPNTSASPNNAAYIIFTSGSTGKPKGVVVEHSALST
                     SAITRGVVLGLGPDSRVLQYAPHTFDVSVDEILTTLIHGGCVCVPSEDDRFSIAHFMES
                     ARVTVALLTPTSARTLHPDEVPSLRILQTGGEVLTEDVNDKWSNRVTLFNVYGPTEASV
                     ACVISNRTGLKGAGHVLGQAVGGKLWIVDPDDIERHLPDNEVGELVISGAILARGYFRD
                     PSRTESSFVRMRNGERVYRTGDLASMDSAGTIIYHGRKDLEVKIRGQRINIAEIEIAIL
                     QCDLVHSVVVEYPRSGLFEKKLVAVLRFEDSSSDAEDGLFGGAKGLTEDIYCLLLSHVS
                     SVLTPAMIPSKWLSLPCVPQMPSGKADRKQVRGWLEDMDKRTYTRIFHPNGTDNLISDP
                     SDSMVAIWLKVLKLEPQSLRLDQSFIRNGGDSIMAMEARHQAHEAGINIDVRELLGSRA
                     LQEIGEMATKTSAVEEVSKIEDDRDEPFPLSPVQQMYFDKVSDPSLGLQQRVCVEIMTK
                     IQPDMLREALNHVIQKHRMLAARFTKHMGQWMQQVPFGKNLKHLSRCHIYSQAVGSLGD
                     FCSEPMALEDGTLLHAHLQSSGERQTLVLCVHHLVVDFVSWRVILQDLHDALAAAQNGL
                     PSGISRSTLTFQQWCREQTKYASTLIPEAVLPFAPGPVNLRFWQPSNVQAVSNTYSEIV
                     QHDFRLSSTQTTQMLEKFTTATVHPTDLMLATFALAFKRIFTERDTPTIFIEGHGREPW
                     HASLDVSQTVGWFTAAFPIHLPKDTLLNTTTAILGASERRRSVLANGHPYWACRYLSPN
                     GQKVFGDDPRHQEMEFVFNYAGSIVQRAPGQTLFAENVRIAEIGHPNCERFSLFDIGAA
                     IEMPSSELVVSFTFPKGIAHRERVAELVKTYQELLETAVERDLDLSAKLSSPLVCPADV
                     VRSLEVNGVCIERDVEIVYTPSSIQQHMLWRQSQEPWFYRVQGDWTIEKTTTQSEPVDI
                     DRLSHAWNQVVHRHTTLRTVFRYSSEEERFVAIVLHEVKPAISIIRKGIQTSGSLCRDD
                     DLSPPHRMVLREKDNGSVVCELEFSHTIIDAASRSIVVQDLLDAYDGKLAHRPLDFPPF
                     WEYIRLAQSSTPSARKEELHRAGRVVTLPFQPTHVLSKVPEACKKNEITISSFFMTAWS
                     IVLAKHFVAHNQRVDSTSSQAVAFDYVLSDRSANIPGIESAVGPYIRLPTLETHVKEGV
                     SLKNIARGLHAQCTFQSLSQSTQDGSSLELPSKATALQKYSTLVNIRNSGSDSLDLVSD
                     SGEWKWILQGFSDPWDYDLVFAVNVHAGKVTGWTVEYADGVVEHSAADEIAKDLNDVVE
                     RMVCEII"
     CDS_motif       complement(2489..2557)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ANIA_10576_0011"
                     /evalue="8.50E-04"
                     /label="C5_DCL_263-294"
                     /locus_tag="ANIA_10576"
                     /protein_end="1566"
                     /protein_start="1543"
                     /score="11.9"
                     /tool="antismash"
                     /translation="FDYVLSDRSANIPGIESAVGPYI"
     aSDomain        complement(2489..3283)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ANIA_10576_Condensation_DCL.1"
                     /domain_subtypes="Condensation_DCL"
                     /evalue="8.50E-16"
                     /label="ANIA_10576_Condensation_DCL.1"
                     /locus_tag="ANIA_10576"
                     /protein_end="1566"
                     /protein_start="1301"
                     /score="49.8"
                     /tool="antismash"
                     /translation="VYTPSSIQQHMLWRQSQEPWFYRVQGDWTIEKTTTQSEPVDIDRL
                     SHAWNQVVHRHTTLRTVFRYSSEEERFVAIVLHEVKPAISIIRKGIQTSGSLCRDDDLS
                     PPHRMVLREKDNGSVVCELEFSHTIIDAASRSIVVQDLLDAYDGKLAHRPLDFPPFWEY
                     IRLAQSSTPSARKEELHRAGRVVTLPFQPTHVLSKVPEACKKNEITISSFFMTAWSIVL
                     AKHFVAHNQRVDSTSSQAVAFDYVLSDRSANIPGIESAVGPYI"
     CDS_motif       complement(2846..2905)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ANIA_10576_0010"
                     /evalue="5.00E-04"
                     /label="C3_DCL_135-156"
                     /locus_tag="ANIA_10576"
                     /protein_end="1447"
                     /protein_start="1427"
                     /score="12.8"
                     /tool="antismash"
                     /translation="HTIIDAASRSIVVQDLLDAY"
     CDS_motif       complement(3089..3172)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ANIA_10576_0009"
                     /evalue="3.70E-11"
                     /label="C2_DCL_024-062"
                     /locus_tag="ANIA_10576"
                     /protein_end="1366"
                     /protein_start="1338"
                     /score="35.3"
                     /tool="antismash"
                     /translation="EPVDIDRLSHAWNQVVHRHTTLRTVFRY"
     CDS_motif       complement(3803..3853)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ANIA_10576_0008"
                     /evalue="3.90E-07"
                     /label="NRPS-E5"
                     /locus_tag="ANIA_10576"
                     /protein_end="1128"
                     /protein_start="1111"
                     /score="22.3"
                     /tool="antismash"
                     /translation="DVSQTVGWFTAAFPIHL"
     aSDomain        complement(3803..4378)
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ANIA_10576_Epimerization.1"
                     /evalue="2.00E-31"
                     /label="ANIA_10576_Epimerization.1"
                     /locus_tag="ANIA_10576"
                     /protein_end="1128"
                     /protein_start="936"
                     /score="100.2"
                     /tool="antismash"
                     /translation="ALEDGTLLHAHLQSSGERQTLVLCVHHLVVDFVSWRVILQDLHDA
                     LAAAQNGLPSGISRSTLTFQQWCREQTKYASTLIPEAVLPFAPGPVNLRFWQPSNVQAV
                     SNTYSEIVQHDFRLSSTQTTQMLEKFTTATVHPTDLMLATFALAFKRIFTERDTPTIFI
                     EGHGREPWHASLDVSQTVGWFTAAFPIHL"
     aSModule        complement(3803..6487)
                     /complete
                     /domains="nrpspksdomains_ANIA_10576_AMP-binding.1"
                     /domains="nrpspksdomains_ANIA_10576_PP-binding.1"
                     /domains="nrpspksdomains_ANIA_10576_Epimerization.1"
                     /locus_tags="ANIA_10576"
                     /monomer_pairings="Trp -> D-Trp"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(4253..4318)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ANIA_10576_0007"
                     /evalue="8.40E-10"
                     /label="NRPS-E2"
                     /locus_tag="ANIA_10576"
                     /protein_end="978"
                     /protein_start="956"
                     /score="30.9"
                     /tool="antismash"
                     /translation="LVLCVHHLVVDFVSWRVILQDL"
     CDS_motif       complement(4502..4594)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ANIA_10576_0006"
                     /evalue="4.00E-04"
                     /label="C2_DCL_024-062"
                     /locus_tag="ANIA_10576"
                     /protein_end="895"
                     /protein_start="864"
                     /score="12.7"
                     /tool="antismash"
                     /translation="CVEIMTKIQPDMLREALNHVIQKHRMLAARF"
     aSDomain        complement(4733..4915)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ANIA_10576_PP-binding.1"
                     /evalue="7.10E-10"
                     /label="ANIA_10576_PP-binding.1"
                     /locus_tag="ANIA_10576"
                     /protein_end="818"
                     /protein_start="757"
                     /score="31.2"
                     /tool="antismash"
                     /translation="VAIWLKVLKLEPQSLRLDQSFIRNGGDSIMAMEARHQAHEAGINI
                     DVRELLGSRALQEIGE"
     CDS_motif       complement(5294..5359)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ANIA_10576_0005"
                     /evalue="8.60E-08"
                     /label="NRPS-A_a8"
                     /locus_tag="ANIA_10576"
                     /protein_end="631"
                     /protein_start="609"
                     /score="24.6"
                     /tool="antismash"
                     /translation="YHGRKDLEVKIRGQRINIAEIE"
     aSDomain        complement(5324..6487)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ANIA_10576_AMP-binding.1"
                     /evalue="1.20E-83"
                     /label="ANIA_10576_AMP-binding.1"
                     /locus_tag="ANIA_10576"
                     /protein_end="621"
                     /protein_start="233"
                     /score="272.9"
                     /specificity="substrate consensus: Trp"
                     /tool="antismash"
                     /translation="EEQAIARPDQEGICAYDGSLSYAGLSKLSSVLAEQLKTFGARPEQ
                     RVAILMNKSFWYPVVVLAVLKSGAAFVPLDPSHPKNRLKQLISEIEPCALITTSVLSEL
                     ADDLGCPSLAIDSDLTRSKEGSTTALLPNTSASPNNAAYIIFTSGSTGKPKGVVVEHSA
                     LSTSAITRGVVLGLGPDSRVLQYAPHTFDVSVDEILTTLIHGGCVCVPSEDDRFSIAHF
                     MESARVTVALLTPTSARTLHPDEVPSLRILQTGGEVLTEDVNDKWSNRVTLFNVYGPTE
                     ASVACVISNRTGLKGAGHVLGQAVGGKLWIVDPDDIERHLPDNEVGELVISGAILARGY
                     FRDPSRTESSFVRMRNGERVYRTGDLASMDSAGTIIYHGRKDLEVKIR"
     CDS_motif       complement(5435..5524)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ANIA_10576_0004"
                     /evalue="3.30E-11"
                     /label="NRPS-A_a6"
                     /locus_tag="ANIA_10576"
                     /protein_end="584"
                     /protein_start="554"
                     /score="35.4"
                     /tool="antismash"
                     /translation="PDNEVGELVISGAILARGYFRDPSRTESSF"
     CDS_motif       complement(5582..5635)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ANIA_10576_0003"
                     /evalue="1.50E+00"
                     /label="C5_DCL_263-294"
                     /locus_tag="ANIA_10576"
                     /protein_end="535"
                     /protein_start="517"
                     /score="1.4"
                     /tool="antismash"
                     /translation="ACVISNRTGLKGAGHVLG"
     CDS_motif       complement(6005..6064)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ANIA_10576_0002"
                     /evalue="5.00E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="ANIA_10576"
                     /protein_end="394"
                     /protein_start="374"
                     /score="34.3"
                     /tool="antismash"
                     /translation="AYIIFTSGSTGKPKGVVVEH"
     CDS_motif       complement(6263..6304)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ANIA_10576_0001"
                     /evalue="2.70E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="ANIA_10576"
                     /protein_end="308"
                     /protein_start="294"
                     /score="17.3"
                     /tool="antismash"
                     /translation="LAVLKSGAAFVPLD"
     gene            complement(10867..12481)
                     /locus_tag="ANIA_04640"
                     /old_locus_tag="AN4640.4"
     mRNA            complement(join(10867..11183,11233..11271,11355..11697,
                     11836..12053,12109..12220,12269..12481))
                     /locus_tag="ANIA_04640"
                     /note="transcript_id=CADANIAT00005792"
                     /old_locus_tag="AN4640.4"
     CDS             complement(join(10867..11183,11233..11271,11355..11697,
                     11836..12053,12109..12220,12269..12481))
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CADANIAG00005792"
                     /db_xref="EnsemblGenomes-Tr:CADANIAT00005792"
                     /db_xref="GOA:Q5B490"
                     /db_xref="InterPro:IPR011701"
                     /db_xref="InterPro:IPR016196"
                     /db_xref="UniProtKB/TrEMBL:Q5B490"
                     /locus_tag="ANIA_04640"
                     /note="transcript_id=CADANIAT00005792"
                     /old_locus_tag="AN4640.4"
                     /product="MFS transporter, putative (AFU_orthologue;
                     AFUA_4G00260)"
                     /protein_id="CBF77088.1"
                     /transl_table=11
                     /translation="MNAEKPPCKTEEPVVSPSQDTDSGPDASTIDGKGPPPLLAKLFAV
                     LFISCISFGSHWSSGVTGAMESTIKKQMQVSNTQFSLLEASEDFMATVLLLISGIVTDR
                     IGGAEMIVYGNIVNTVGSILVAAATTVRSLNFMIGGRVILALGDIATQVAQYKMFSSWF
                     PPSNGFASTLGFELAIGKNTGNFAWVFWTSVFMDLFTDAVTAIFYLFTRYCNKHYTGRQ
                     DSALKEVLTEKNKKFEFQKIFQLPWMFWAVMAFSLFQTSTALVFSQNATELAEKRFDVD
                     SITVGWYSSLSQYAGVFIDFLGNRASVLCVCGLGIFLSMVLVNFANTKAGTAASFGIYA
                     IAVSLGPTSIIDSIRTTLWHQSVFGSAYALKVTMNNAYAIPPSFSFPLRPTVTDEAEQH
                     EHNHTHYNQRSPRR"
ORIGIN
        1 tttactctga tctcaccccc tcttctgcag ttgaacgatc aatcctcttg ccccctcctt
       61 tggcgcagga tcgaaaaaat catgtgccat ctcaatatcc tccctcgtca ccccgctcag
      121 agaaatctca taccgtcgaa aaagtactgc cagcaccaag taaatctccg catacgccag
      181 gttcattccc agacacatgc ggctgccctt gctgaagggg acgaagtggc gattcattgc
      241 ctgcacagtc tcaaaatctg cctcgaacca gcgctctgga cggaattccc gcggctgagg
      301 gaatactact ggattgtcgt gcatgaagat cgatgtcatt ccaactggtg ttcctgctgg
      361 gatggtcact cctgagtata ttaggggctc ttcggcgatc agttggagtc tatgcgtgac
      421 gccgtaggaa atccgtagac cttcctttat gcacgctgac aggtacggga ggcgttcgag
      481 gtaggccgta tcagacatgg acagaatatc catattttct agagcaccgt cgacctctgc
      541 tcgaagtttc cgaaagatgt cgggatcatt gaggacgtgg aagattatcg tcttcaatgc
      601 attcccggtc gttaatgtcc ccgcgccgat gagcgtctgc ccttcgccct tgagtcggtc
      661 cactgtcttt tcgtgctgtg ggagggtact cgagaggagg aagtcgaaga cggtcaaagg
      721 gtcagctggc ttgtcaacgg cggcggctcg atcaacaagc ggttgaatct gggcgctcat
      781 tctctatcca tcgttagcat caatctcctc ttaattttac tgttaagggg aaaaggtacc
      841 tcttgtattt gaaacaacaa cgcaaccccc ggcagcaaag ccctaacaag agctttcggc
      901 gcccatttac aaaccaccaa gatccacgga cactgcttta ccagatggcc gagctctgac
      961 ggagcgctta ccatatcaat ccactccttt ccaaagttat ctttcccaat caactccagt
     1021 gactgtccga aacagtactc tgtgatgacg tcggccgcga acgctgtaag tccgatcccc
     1081 aagtccacat cctgtcttgt aaaagcgaac ccatcgagcc gactacatag ccgcgctagg
     1141 gtatgttgca ggtgcggtgt tagccgctgg atagcgctct ttgagaagag agggttcaat
     1201 gcactccttc ttagtctgtg gtgttcgtgc cggacggttg caaaggcaga ggtgttgttc
     1261 ccgaacattc gtgcagccca gagccattta tgtcgtcgac gagttgggcc tgtgtacagc
     1321 acgggataga aggaggggtc ttggatgtgg atttcgaatg ggttaatgcg gactagcggg
     1381 cctatatata cgttctttgt tagcggcggt gagaatccag gtggctctga actgtttgag
     1441 acggtaaaag aagggaggca aaccgtatgt ctgatgcatc ttgtcaattt gtcgaaaata
     1501 ctgtccccgc tggacgacgt cgtagtagaa ttcaggccaa aacgacagtg cggctagagt
     1561 tgggccggga atatggcgaa tggggctcag gaggaggcgc gttgtggcta ggtatagtgt
     1621 atacaagagg gttaggacta ggaggagcgc ccatgctggg aaagagaata ctaggtcgag
     1681 actcagcatg ttgctgttct tgttcttggg agtctgccat gccgctggta aagcctggct
     1741 cagcttatat gcttacatct ggttaaccgg ggggatgtgg tgaagtatgt aagacgcagt
     1801 ctcaaagacg gtgaggatat cgtattggat ctagtggcag gtttctattc tgcaaggagc
     1861 tattgaagtt tctgcgtctc attgcatcag gttcacagcg aatgcaaaat gtaaggagac
     1921 aaccccaaag cctgtctagg taagacatga agggtgtaca tacatggcat gacacaatca
     1981 atgcatccaa catcgtctaa taccaatatt catcgatgta catggcgaga ttaaaccaaa
     2041 ttccaacata accaattcct tccaggtcag atcaaatgat ttcacacacc atgcgctcaa
     2101 caacatcatt caggtccttc gcgatttcat cggcagcaga atgctcgaca acaccgtcag
     2161 catactcaac tgtccaaccc gtgacctttc cggcatgcac attcaccgca aaaacgagat
     2221 catagtccca tggatcacta aacccttgca ggatccactt ccactcacca gagtccgaga
     2281 ccaagtccag actgtcggag ccactgttgc ggatgttcac cagcgtggag tacttttgca
     2341 gtgcagtagc cttgctcgga agctcaagac ttgacccgtc ttgagtcgac tgggacagag
     2401 actggaacgt gcactgcgcg tgcaagcccc gggcaatgtt tttgagcgat acgccctcct
     2461 tcacatgggt ttcaagagtt gggagacgga tgtaggggcc aacagcactt tcaatacccg
     2521 gaatgttggc ggagcggtcg gagagcacat agtcaaacgc tacggcttgg ctcgaagtgc
     2581 tgtcgaccct ctggttgtgg gcgacaaagt gtttagctag cacgatgctc caagcggtca
     2641 tgaagaaact tgagatggta atttcgttct tcttgcacgc ttcggggact ttcgaaagaa
     2701 catgggttgg ttgaaaagga agggtgacaa cgcggccagc acgatgtagc tcttccttcc
     2761 tggctgaagg ggtagaggac tgggccagac ggatgtattc ccagaaggga ggaaagtcca
     2821 ggggacgatg ggccagcttt ccatcgtacg catcgagaag gtcttgcacg acgattgagc
     2881 gagacgcagc gtctataatg gtatgactaa attccaattc gcatacgact gacccattgt
     2941 ctttttcacg gagaaccatg cgatggggag gggaaagatc atcgtcacgg cagagggagc
     3001 cgctggtctg aatgcctttg cggatgatag aaatggctgg cttaacctca tgcaagacaa
     3061 tggcgacaaa ccgttcctcc tcactgctgt acctgaacac agttcgtaga gtagtgtggc
     3121 ggtgaacaac ctggttccat gcgtgggaca gacggtctat atcgacaggt tctgactgag
     3181 tagtggtctt ctcgatggtc caatctccct gcacgcggta gaaccatggt tcctgggact
     3241 gacgccagag catatgctgc tgaatcgatg aaggggtgta aacgatctcg acatcgcgct
     3301 caatgcaaac accatttacc tcgagcgaac gaacaacgtc tgcgggacag acaagcggcg
     3361 acgataactt cgcgctgaga tctaagtccc gctcaacagc tgtttcgagc aactcctggt
     3421 aagttttcac cagttccgca acacgctcac ggtgcgcaat acccttggga aaagtgaaag
     3481 agacaacaag ctcagagctc ggcatctcaa tagcagcacc aatatcgaac agcgaaaagc
     3541 gttcgcagtt tggatggccg atctcagcga tacgcacatt ctccgcaaac aacgtttgac
     3601 cgggtgcgcg ctgcacaatg ctacctgcat aattgaagac aaactccatt tcctgatggc
     3661 ggggatcatc tccgaacact ttctgcccgt tgggtgagag atatcgacag gcccagtatg
     3721 gatgaccatt agcaagaaca gatcggcggc gctcggatgc tccaagtatg gcagtggtgg
     3781 tgttcaaaag agtgtccttc ggaagatgaa tagggaatgc agccgtaaac cagccaaccg
     3841 tctgcgagac atctaaagag gcatgccaag gctcgcgacc gtgtccttct atgaatattg
     3901 taggggtgtc gcgctcggta aatattcgtt taaaggcgag agcaaatgtt gctagcatga
     3961 ggtctgtggg atgaacagtg gcggtggtga acttctccaa catttgggta gtttgtgttg
     4021 aggaaaggcg aaagtcatgc tgaacaatct cgctatacgt gtttgagact gcctgcacgt
     4081 tcgacggctg ccagaaacga agattgactg ggcccggcgc gaagggaaga acggcctcgg
     4141 gaatcagagt agaagcgtat tttgtctgct cacggcacca ctgctggaat gtgagtgtcg
     4201 agcgagaaat gccagaagga agaccattct gtgctgcggc aagggcgtca tggagatcct
     4261 gcagaatgac tcgccatgag acgaagtcga cgaccaagtg gtgaacacag agcacgagtg
     4321 tctgcctctc accactcgac tgcaaatgcg cgtgaagtag cgtcccatcc tcaagggcca
     4381 tgggctcact gcagaagtcg ccaagggacc ccacagcctg actgtagata tgacagcgag
     4441 acaggtgttt gagattcttt ccaaacggaa cctgctgcat ccattgtccc atgtgcttcg
     4501 taaatcgagc ggccaacatt cggtgtttct gaataacgtg gttcaatgcc tcgcgcagca
     4561 tatcaggctg tatcttcgtc ataatttcca cgcaaacacg ttgctgaaga ccaagactgg
     4621 gatcagatac cttatcgaag tacatctgct gaacaggcga caggggaaaa ggttcgtccc
     4681 tatcatcctc tatctttgag acctcttcta cggctgaagt tttggttgcc atttcgccaa
     4741 tctcttgaag tgcacggcta cccaggagct cccgaacgtc gatgttgatt ccagcttcgt
     4801 gcgcctggtg ccgggcctcc atggccatta ttgagtcacc gccgttacgg atgaaagatt
     4861 gatcaaggcg gagactctgc ggctctaatt tgaggacttt gagccaaatc gctaccatgc
     4921 tgtctgatgg atctgagatc agattatcag tgccattggg gtggaaaatg cgagtataag
     4981 ttcttttgtc catatcttca agccaaccac gaacttgttt gcgatcggcc tttccggatg
     5041 gcatctgtgg tacgcaggga agcgacaacc atttcgatgg gatcatcgct ggagtaagaa
     5101 cactcgagac atggcttaaa agcaggcaat aaatgtcttc agttaatccc ttggccccgc
     5161 caaataatcc atcttcagcg tcggacgaag agtcctcgaa gcgtagaaca gcgacgagtt
     5221 tcttctcaaa cagtccagag cgagggtact cgacgacaac actatgaact aaatcgcatt
     5281 gcaagatagc gatctcaatc tccgcgatat tgattcgctg accgcggatc ttgacttcca
     5341 gatccttgcg gccgtggtat atgatggtcc cagcgctatc catactcgcc aggtcaccgg
     5401 tccggtaaac ccgttcaccg tttcgcattc taacaaaaga gctttctgtg cggctcggat
     5461 cgcgaaaata tccacgggct aatattgctc ctgagataac caattcgcca acttcattgt
     5521 ccggaagatg gcgctcaata tcgtcgggat caacgatcca gagcttccct ccgaccgcct
     5581 gtccaagaac atgaccagcc cctttcaggc cagtgcggtt gctgataaca caagcaacgc
     5641 tagcctcagt aggtccataa acgttaaaaa gcgtcacacg atttgaccat ttgtcgttca
     5701 catcctcggt aagaacctct ccgccagttt ggaggattcg aagagagggt acttcgtcgg
     5761 gatggagagt tcgagcagaa gtcggagtca acagggcaac cgtaacacgg gcagattcca
     5821 taaagtgagc gatcgaaaac ctgtcatcct cggaaggaac gcagacacat ccgccatgga
     5881 tcagagtcgt aagaatctca tcaacgctga cgtcgaaggt atgtggggcg tactggagga
     5941 cacgggagtc cggaccgagc cctagaacga cgccacgagt gattgcgctg gtggagagag
     6001 cagaatgctc aacgaccact cctttcggtt tcccagtact gccggaggta aagataatat
     6061 aggcagcatt gttaggactt gcgcttgtat ttggaagtaa tgctgtagtc gagccttctt
     6121 tactgcgagt gagatcggag tcgatcgcga gagaagggca gcccaagtcg tctgccaatt
     6181 cggaaagaac cgaagtcgta attagagcgc agggctctat ctcgctaatg agctgcttca
     6241 acctattttt agggtggctg ggatcgagtg gaacgaatgc agccccggat ttcagcactg
     6301 caaggacgac gactgggtac caaaatgatt tgttcattaa gatagcgacc cgctgctcag
     6361 ggcgcgctcc gaaagtcttt agttgttcag ccaacaccga agagagtttc gacagccctg
     6421 catatgaaag cgaaccatca taagcgcaga taccctcctg gtcgggtcgc gcgatggcct
     6481 gttcctcgat caaatcatga atgcatcgat taactttagg gcaatcggtt cgttccttgc
     6541 atagtccacc atggcccgca ttgtcatctt caacgggcgg cgaaggtggg atagccgacg
     6601 caactgcttc caaagcctct tccagatatt gttcgaagat ctcggcaacc tctccagcct
     6661 gagcggaaga gagcgaatcg cgcttgtaat gaaggtcaat atgccattga ttggcattgt
     6721 agagtacttt gagacaaatg gcattctatt gtacctatcg cattagtcct gcaatcaaat
     6781 gaaccggttt gaagaagctc acttacctgg ttgaccagag atcggacttc ctctggcagt
     6841 tcagtgccca attcttcctg cgctctttct gaatgatgaa atataacgat agtctttgcc
     6901 aacaaagctc ccgagagggc tgttcggggt gttgcgggtg gagtaatctg caagttcttg
     6961 gtgtctaaca gtgcttgagc aataaaagaa gattcactcg tgtaaacatc tttgagagta
     7021 ggaaccttgt cagattcaga agccttttga atagttgcac tccatgcttt cctgacaatg
     7081 ttgagttggt tgaacagggt aagctggaga aacggtttcc acaggacatc gttatcacgt
     7141 aaaatagtaa tcatgctgag tcccttgtct attgactccc agagctcaag ctgagtaaag
     7201 atgtcatgta ttccagcacc agctggctgg atgatgggtg aggccatcac agtggtattt
     7261 taaggacgat gtacaaaggc acgaataaaa gacaacagat tttatatcta gacaaaccat
     7321 aacatagata aagataggct aactgtaaga gatggtgaaa gggagagtaa gaaaagttta
     7381 caactaagaa tgtgacgggg cttaagtaga gagaaggtgg ctgttctctc ctgcatgggg
     7441 tacttcagat gtgttactct ccattcacta caaaaatttt ctccctctga atgacttcat
     7501 gatcagacta ctagcctttc acttattcat ttacccattg atggctattc tctggcaatc
     7561 acctgaaagc tgtttgattg aacctgattg atttggatcc aatactgcag aagctccttg
     7621 aaattgactt ctacaaccgc ctttctcttt acagatcaag tataaaggct caaacggaat
     7681 gtcagccaga ggccttcaag tgagttcagc gctgtctagt catgcctgga acatttgggc
     7741 catctaatca tgcccgagtc acaagattag gctgtatcca agcctgcttt tctggagaca
     7801 actgcgacat cgacgtcaat ttcttgcatc tacagggtca aaccttgcat tgttcgcagt
     7861 cagtcaaaga ccggccagct gccagccttc tttccctatt tggcgaagag gtccaagaca
     7921 cgtgcatgca aggggtcttc gagatcattt ggcgatcaga gtctggcaac gtgagctcgt
     7981 gtaatcatgc tgacattgag cttccccaga atcgtgctca tctaaacctg aatggtgaac
     8041 ctgcacttca aacttttccc tgcgatgtgc ctagacaagt gaaacgaact gctcttctcg
     8101 actgcagact tcaagccgta tcctacgccc ccgggtcttg ggtactcctt accggtggat
     8161 gaatctaaat atccagcgat tttaatacac tcaggctcct tggcgcttgt actatgctcc
     8221 ccgctgcggc tccaaacaac tattgctggt ttggcctacc gacggtgaca tcaacatatc
     8281 tacccacaag atattgctat cgaccagtga attatcgtga gcagaagatc taagacaacc
     8341 cgcccgaaat ggcttagcgg ccatttgaga aacgcgatct agactgaaac aagagtgact
     8401 cttgctgctg aaactccact gcagcttgtg cccaaatatg catgcttctg gatccagcca
     8461 agaacaaaag gaatctgttc ctaccgccaa ctaggcggtc tgtcctgtct caaacggcgc
     8521 gagaaaccag atcaatagtt ctctgcgtgc tgcgagggct gtgaccgggg gccttaaaca
     8581 cacagttgag ccaccaagtg ccaaagacta cactaccaaa gacctccatc gagtcgctac
     8641 aagaccgagg ctgttcattt cggatgaaac gcaaaggcac agctgcactt accccgcagg
     8701 gaggtattga gaatgacaat actggaggaa ggagcggtgg ggagcttgaa ctagcctgaa
     8761 aggaaagggc ggcccccaag tctaccttca gccgtaccat ccttgcagac tttgctgaag
     8821 cggatgaata ggatacccgg aacaggatag gactgtgatc gttggcttga gcaagacagg
     8881 ctcggctaaa ccttagcctt cggaatgtgc catttcgcta gttgtaaact agggaagccc
     8941 tggcagggaa taagactgat tctcacccta tggaacacca ctttgtagtt acacggaagc
     9001 ttcatccgca attctactaa gaatatgctt atgtaactac tcgctctcct taacaagatg
     9061 gatcgcactg cagatgttct ccttcgtctg ggtgctacct tggagccgtc cttccgcgca
     9121 ggcgctatgg cctttatctt tcccattccg gatgaattac tccaaatcgc tatccaaaac
     9181 gaagggagac tctatactga ttggcatcag cgatggcaca acacgttgtt atttcatcta
     9241 cccagagcct acatatatta ctaaacagct aggcgggagg ccagcctaat attaatcaaa
     9301 tggagggccc tagccgcaca gtacatagat ccaaggagag gagcaacgaa gatttgacta
     9361 taagaggtag cttcactttc atgatttgga gttcctggtc gtgcaaactc cagttgtgga
     9421 gattgaaccg gtctcctaag caatgcatct ataattgtgc acttgtccaa gccccgttca
     9481 tctgtaggcc tcagtgcgct ctctatgcca ggatccgatc tcttgcccta atcaaacaac
     9541 atctaaaaca tgtcactgta cagatgctaa gttcccaacg agaacgggca gtatctaaac
     9601 cgctgataaa gaaaacataa agagctcaca actcagcaaa ttgagctgtc cactacaacc
     9661 gaacgaaagg aaacataggc attgtcacca atgtcgacag tactggggtt tgctcagaga
     9721 gctttgcaga acaaatcctt tatgaagcta cgactaataa cggcgcactt gttagatctg
     9781 tcaataaaag atgctccgcc aatctacctt ctccggtccc ttttatccaa tttttccttt
     9841 gttcgaagag cttatatata ctcttcggga atccccctac ttcttgacaa ccaccttctt
     9901 ccacaatcgc attcgaatag ggtccagttc tcatcatata cgccttcgaa ctcatctctt
     9961 agccgatctc ttgcacgttg ccggaattgc tgactttcgc catgatgtcg cgctcgctca
    10021 tctcccaggt tcccctttgg gcagccagcg cgttagcaca tctacgtcta ctcctgattc
    10081 gatcatcgat gcggtaggaa gccctatatc cggttagtaa aaacgtatac gtcgctggtt
    10141 tgccctgaag ctatcaaggt accggtgcaa ccccaccaag aaacttggaa aatagcaagc
    10201 gcctttggga tcttctcaac ttcctctctg aagcccatgg cctgctctgt attgtctccc
    10261 ctgcaggtcc ctctcgccca gtttcttagg taatcttctt acatttccta cctggtttgt
    10321 cctgtacctc cgtgtttgct tccgtgtctg cattcgatgt acttgcaaaa ctacccatat
    10381 tttgaccctg atttgtattt tctcgcaact gcaccctctt atcgtctacg ttttcccgtt
    10441 aattcgattt catttgtatt tcaagttggt ttagggctgt ccaggttccg ttcggctgag
    10501 aagcagctga gttactactg tggttagttg gcagcaattg tttcgaaaat gcgaattaag
    10561 tcatcctata gagttatttt gtttccacat ttagtatgct gctaatgtag agacgtgacg
    10621 tctataaaat aggctatatc gcttccgggg aacatagcgc ctatcaatag ctgtttagga
    10681 tgatctaaat gctaaagatc agtttggcta gtgtcaatat acttcagtat tgggtactat
    10741 accatctaat gtagcgacag agcttgctag ccttttgata ttgccattgt atcttcaatc
    10801 taatgtggcc ataattccta cctcttaata tcaagcgggt tcagacgtat aaccatatct
    10861 acctcgtcag cgtcttggag agcgctggtt ataatgcgta tgattatgtt catgctgttc
    10921 tgcttcgtca gtgactgttg gtcgcaaagg gaaagagaaa gaaggaggga tagcgtacgc
    10981 attattcata gtgactttca aagcatatgc agagccgaat acagactgat gccaaagtgt
    11041 tgttcggata ctgtcaatta tggaggtcgg tccgagcgag acagcgattg catagatgcc
    11101 gaaggaagcg gcagtgccag cttttgtgtt ggcaaaattg acgagaacca tgctaaggaa
    11161 tattccgagg ccgcagacgc atactgaaaa gattagtggg cacttctagt tggaagtaga
    11221 tgcataacat acagacgctc gctcgattcc caagaaaatc gatgaagaca cctagacatg
    11281 gaagaaggaa gaagccttct cctgtaagca ggaatcttgt ccccaggctc ttgtagcctt
    11341 attcaaagac ataccagcat actgtgacaa cgaactgtac catcccaccg tgatactgtc
    11401 gacatcaaac ctcttctccg cgagctccgt agcattctga ctaaagacca gcgcggtgct
    11461 cgtctggaag agcgagaatg ccatgacggc ccaaaacatc cagggcagtt gaaatatctt
    11521 ttggaactcg aacttcttgt tcttctctgt tagcacttcc ttcaatgcac tgtcttggcg
    11581 cccggtatag tgcttgttgc agtaccgcgt gaagagatag aagatggctg tcacggcgtc
    11641 ggtgaagagg tccatgaaaa cagaggtcca gaagacccag gcgaaattgc cggtgttctg
    11701 gccagccata ttggtcattg ccccggggat attgagtgtg atttactttg gcaataacat
    11761 tcgctgtgga ttaccgacga agccaccgac ctacattgcc aggaaccatt tcttcaaatt
    11821 aatgatggca agtaccttcc cgatcgccaa ctcaaacccc agcgtagacg caaacccatt
    11881 gctaggagga aaccacgagg aaaacatctt atactgcgca acttgcgtag cgatatcccc
    11941 cagtgcaaga atgacccggc cgccgatcat aaagtttaaa gagcgtacag tcgtcgcggc
    12001 tgcgacaagg atggatccga ctgtgttgac gatgtttccg tagacgatca tttctttagg
    12061 aacatagaag ttaggattag ttgtagtaag taatcgaggg tgatgtaccc gcgcctccaa
    12121 ttcgatccgt cacgatcccg ctaatcaata agagtacagt ggccataaag tcctcacttg
    12181 cttctagaag cgagaattgc gtgttagaga cttgcatttg ctgattgctt tcagctatgc
    12241 gcgtgattat tgaagtacga taacgtacct ttttgatagt actctccatg gcgccggtta
    12301 cgccagagct ccagtgcgag ccgaaactaa tgcacgagat gaacaaaacg gcaaagagct
    12361 tggccagcaa agggggcggg ccttttccgt cgatagtaga ggcatccggg ccagagtctg
    12421 tatcctgtga cggggagacg accggctcct cagtcttgca aggtggtttt tcggcgttca
    12481 tg
//
