BGC0001692 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001692 (Xenorhabdus nematophila ATCC 19061)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	32,914	nematophin	NRPS:Type I	100%

BGC0001692 - Region 1 - NRPS

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Location: 1 - 32,914 nt. (total: 32,914 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 32,915
Label		BGC0001692

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001692	1.00	NRP	nematophin	Xenorhabdus nematophila ATCC 19061
BGC0000416	1.00	NRP	rhabdopeptide 1, rhabdopeptide 2, rhabdopeptide 3, rhabdopeptide 4	Xenorhabdus nematophila ATCC 19061
BGC0001434	0.45	NRP	nematophin	Xenorhabdus budapestensis
BGC0000465	0.38	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0000375	0.34	NRP	indigoidine	Streptomyces chromofuscus
BGC0001133	0.34	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0001249	0.33	NRP	dimethylcoprogen	Alternaria alternata
BGC0000427	0.28	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000979	0.27	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980	0.27	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001692	1.00	NRP	nematophin	Xenorhabdus nematophila ATCC 19061
BGC0000416	1.00	NRP	rhabdopeptide 1, rhabdopeptide 2, rhabdopeptide 3, rhabdopeptide 4	Xenorhabdus nematophila ATCC 19061
BGC0001434	0.75	NRP	nematophin	Xenorhabdus budapestensis
BGC0000465	0.70	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0000375	0.67	NRP	indigoidine	Streptomyces chromofuscus
BGC0001133	0.67	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0001249	0.66	NRP	dimethylcoprogen	Alternaria alternata
BGC0000427	0.61	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000979	0.61	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980	0.61	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 32914:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NMe-Leu) + (NMe-Val) + (NMe-Val) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

XNC1_RS20595

Search NORINE for peptide: strict or relaxed

AMP-binding (549..944): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DALVLAVSIK
Nearest Stachelhaus code(s):: Leu DALVLAVSIK (100% 8Å match); Val DALVLAVSIK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

XNC1_RS09390

Search NORINE for peptide: strict or relaxed

AMP-binding (545..941): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DALVLAVSIK
Nearest Stachelhaus code(s):: Val DALVLAVSIK (100% 8Å match); Leu DALVLAVSIK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

XNC1_RS09395

Search NORINE for peptide: strict or relaxed

AMP-binding (549..945): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DALVLAVSIK
Nearest Stachelhaus code(s):: Val DALVLAVSIK (100% 8Å match); Leu DALVLAVSIK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

XNC1_RS09410

AMP-binding (358..758): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: VAIMLGASMK
Nearest Stachelhaus code(s):: Ser DACALGASMK (44% 8Å match)
Stachelhaus code match:: 70% (weak)