BGC0001692 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001692 (Xenorhabdus nematophila ATCC 19061)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS	1	60,435	High	nematophin	NRPS:Type I

BGC0001692 - Region 1 - NRPS

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Location: 1 - 60,435 nt. (total: 60,435 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 60,436
Label		BGC0001692

Tailoring functions

Ligases: ligase

XNC1_RS09390: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

XNC1_RS09395: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

XNC1_RS09410: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

XNC1_RS20595: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001692.5	0.97	NRPS	nematophin	Xenorhabdus nematophila ATCC 19061
BGC0000416.5	0.97	NRPS	rhabdopeptide 1, rhabdopeptide 2, rhabdopeptide 3, rhabdopeptide 4	Xenorhabdus nematophila ATCC 19061
BGC0001249.5	0.74	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001434.3	0.73	NRPS	nematophin	Xenorhabdus budapestensis
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti
BGC0000307.4	0.68	NRPS	AbT1	Aureobasidium pullulans
BGC0000465.4	0.68	NRPS	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0002164.2	0.67	NRPS	peramine	Epichloe festucae
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.66	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001692.5	0.97	NRPS	nematophin	Xenorhabdus nematophila ATCC 19061
BGC0000416.5	0.97	NRPS	rhabdopeptide 1, rhabdopeptide 2, rhabdopeptide 3, rhabdopeptide 4	Xenorhabdus nematophila ATCC 19061
BGC0001249.5	0.74	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001434.3	0.73	NRPS	nematophin	Xenorhabdus budapestensis
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti
BGC0000307.4	0.68	NRPS	AbT1	Aureobasidium pullulans
BGC0000465.4	0.68	NRPS	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0002164.2	0.67	NRPS	peramine	Epichloe festucae
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.66	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 60435:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NMe-Leu) + (NMe-Val) + (NMe-Val) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

XNC1_RS20595: Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (549..944): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DALVLAVSIK
Nearest Stachelhaus code(s):: Leu DALVLAVSIK (100% 8Å match); Val DALVLAVSIK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

XNC1_RS09390: Val

Search NORINE for peptide: strict or relaxed

AMP-binding (545..941): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DALVLAVSIK
Nearest Stachelhaus code(s):: Val DALVLAVSIK (100% 8Å match); Leu DALVLAVSIK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

XNC1_RS09395: Val

Search NORINE for peptide: strict or relaxed

AMP-binding (549..945): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DALVLAVSIK
Nearest Stachelhaus code(s):: Val DALVLAVSIK (100% 8Å match); Leu DALVLAVSIK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

XNC1_RS09410: X

AMP-binding (358..758): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: VAIMLGASMK
Nearest Stachelhaus code(s):: Ser DACALGASMK (44% 8Å match)
Stachelhaus code match:: 70% (weak)

Link to PARAS substrate predictor