BGC0001692: nematophin biosynthetic gene cluster from Xenorhabdus nematophila ATCC 19061
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Location: 2,151,233 - 2,184,146 nt. (total: 32,914 nt).
This entry is originally from NCBI GenBank NC_014228.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001692
Short description nematophin biosynthetic gene cluster from Xenorhabdus nematophila ATCC 19061
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "Overlaps, and possibly shares genes with rhabdopeptides (BGC0000416)."
Biosynthetic class(es)
  • NRPS (Type I)
Loci
NC_014228.1
2151233 - 2184146
via
Compounds
  • nematophin
Species Xenorhabdus nematophila ATCC 19061 [taxonomy]
References
Chemical products information
nematophin Evidence:
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C16H20N2O2
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • XNC1_RS09375
  • WP_013184315.1
  • pntA
 2151233 - 2152765 (+) Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha
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    • XNC1_RS09380
    • WP_013184316.1
    • pntB
    		 2152776 - 2154164 (+) Re/Si-specific NAD(P)(+) transhydrogenase subunit beta
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      • XNC1_RS20595
      • WP_013184317.1
      		 2154724 - 2159406 (+) non-ribosomal peptide synthetase
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        • XNC1_RS09390
        • WP_013184318.1
        		 2159403 - 2164067 (+) non-ribosomal peptide synthetase
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          • XNC1_RS09395
          • WP_013184319.1
          		 2164064 - 2170060 (+) non-ribosomal peptide synthetase
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            • XNC1_RS22865
            		 2170577 - >2170849 (+) transposase
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              • XNC1_RS09410
              • WP_013184322.1
              		 2170947 - 2175158 (+) non-ribosomal peptide synthetase
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                • XNC1_RS09415
                • WP_230333026.1
                		 2175711 - 2176634 (+) tyrosine-type recombinase/integrase
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                  • XNC1_RS09420
                  • WP_010845792.1
                  		 2176919 - 2177797 (+) DMT family transporter
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                    • XNC1_RS09425
                    • WP_013184323.1
                    		 2178002 - 2179093 (+) amidinotransferase
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                      • XNC1_RS09430
                      • WP_013184324.1
                      		 2179205 - 2180137 (+) fatty acid desaturase
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                        • XNC1_RS09435
                        • WP_010845795.1
                        		 2180220 - 2181083 (+) hypothetical protein
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                          • XNC1_RS09440
                          • WP_010845796.1
                          • uspE
                          		 2181151 - 2182095 (-) universal stress protein UspE
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                            • XNC1_RS09445
                            • WP_010845797.1
                            		 2182223 - 2182987 (-) FNR family transcription factor
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                              • XNC1_RS09450
                              • WP_010845798.1
                              		 2183253 - 2184146 (+) dimethyl sulfoxide reductase anchor subunit
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                                Biosynthesis information

                                Biosynthetic modules

                                Name
                                Unk01
                                Type
                                nrps-type1
                                Genes
                                XNC1_RS20595
                                Substrates
                                leucine (evidence: )
                                Integrated Monomers
                                Domains
                                adenylation
                                Name
                                Unk02
                                Type
                                nrps-type1
                                Genes
                                XNC1_RS09390
                                Substrates
                                valine (evidence: )
                                Integrated Monomers
                                Domains
                                adenylation
                                Name
                                Unk03
                                Type
                                nrps-type1
                                Genes
                                XNC1_RS09395
                                Substrates
                                valine (evidence: )
                                Integrated Monomers
                                Domains
                                adenylation
                                Annotation changelog

                                Entry version: 4

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-10-07
                                Add note about possible overlap with BGC0000416
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 3

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-09-15
                                Added NRP substrate specificities
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 2

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2019-10-16
                                Migrated from v1.4
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 1

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2018-08-06
                                Submitted
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                Detailed domain annotation
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