BGC0001693 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001693 (Micromonospora echinospora)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	66,848	High	nenestatin	PKS

BGC0001693 - Region 1 - T2PKS

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Location: 1 - 66,848 nt. (total: 66,848 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 66,849
Label		BGC0001693

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

ARD70861.1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

ARD70864.1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

ARD70865.1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

ARD70866.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

ARD70870.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

ARD70872.1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

ARD70874.1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

ARD70875.1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

ARD70896.1: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Transferases: acylase aminotransferase glycosyltransferase methyltransferase sulfotransferase transferase

ARD70858.1: Sulfotransferase domain

extras: Sulfotransfer_4: Sulfotransferase domain

ARD70871.1: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

ARD70889.1: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

ARD70890.1: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

ARD70893.1: methyltransferase

smcogs: SMCOG1248: methyltransferase

ARD70894.1: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

ARD70898.1: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

ARD70899.1: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

ARD70904.1: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

ARD70908.1: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

ARD70909.1: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

Hydrolases: amidase hydrolase

ARD70854.1: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

ARD70881.1: amidase

smcogs: SMCOG1105: amidase

Lyases: cyclase dehydratase lyase

ARD70869.1: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

ARD70873.1: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

ARD70882.1: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

ARD70892.1: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

ARD70900.1: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

ARD70901.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ARD70902.1: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001693.3	0.92	PKS	nenestatin	Micromonospora echinospora
BGC0000241.5	0.73	PKS, saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora tropica CNB-440
BGC0000240.5	0.71	PKS, saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora pacifica
BGC0001817.5	0.67	other (other)	vancosamine	Streptomyces sp. WAC2288
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001160.5	0.63	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0002175.3	0.62	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000231.5	0.61	PKS	griseusin A, griseusin B	Streptomyces griseus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001693.3	1.00	PKS	nenestatin	Micromonospora echinospora
BGC0000241.5	0.80	PKS, saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora tropica CNB-440
BGC0000240.5	0.78	PKS, saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora pacifica
BGC0000231.5	0.69	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001817.5	0.65	other (other)	vancosamine	Streptomyces sp. WAC2288
BGC0001160.5	0.65	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.62	PKS	YWA1	Aspergillus oryzae RIB40

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

ARD70904.1: mal

PKS_AT (30..308): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 60.7
Methylmalonyl-CoA: 32.2
Propionyl-CoA: 27.7
inactive: 26.3
Methoxymalonyl-CoA: 24.7
Ethylmalonyl-CoA: 17.1
2-Methylbutyryl-CoA: 17.1
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 22122 to 66848
Starter unit(s):: propionyl-CoA (Score: 305.0; E-value: 5.84e-106)
Malonyl elongations:: 8|9 (Score: 663.6; E-value: 2.1e-202)
Product class(es):: angucycline
anthracycline
aureolic acid
tetracycline
Product molecular weight(s):: propionyl-CoA_8: 815 Da
propionyl-CoA_9: 857 Da

ARD70871.1: MET (Score: 265.7; E-value: 1.3e-81)
ARD70872.1: OXY (Score: 551.1; E-value: 5.4e-168)
ARD70873.1: CYC C7-C12 (Score: 466.9; E-value: 5.4e-143)
ARD70874.1: OXY (Score: 460.0; E-value: 2.4e-140)
ARD70875.1: OXY (Score: 543.7; E-value: 9.6e-166)
ARD70889.1: GT (Score: 339.7; E-value: 7.1e-104)
ARD70890.1: MET (Score: 245.4; E-value: 2e-75)
ARD70898.1: GT (Score: 262.1; E-value: 2.7e-80)
ARD70901.1: KS (Score: 750.6; E-value: 9.8e-229)
ARD70902.1: CLF 8|9 (Score: 663.6; E-value: 2.1e-202)
ARD70903.1: ACP (Score: 109.8; E-value: 1.1e-34)
ARD70904.1: AT (Score: 380.6; E-value: 1.4e-116); AT AAF70110.1_Aclacinomycin_propionyl-CoA (Score: 305.0; E-value: 5.84e-106)
ARD70906.1: ACP (Score: 79.0; E-value: 4.7e-25)