BGC0001694 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001694 (Streptomyces koyangensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	73,870	High	Neoabyssomicin B/Abyssomicin 2/Abyssomicin 4	PKS

BGC0001694 - Region 1 - T1PKS

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Location: 1 - 73,870 nt. (total: 73,870 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 73,871
Label		BGC0001694

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

AVI57420.1: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

AVI57422.1: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

AVI57432.1: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

AVI57439.1: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

Transferases: PPTase acylase

AVI57413.1: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1060: 4'-phosphopantetheinyl transferase

AVI57433.1: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

AVI57434.1: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

AVI57435.1: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: esterase phosphatase

AVI57427.1: FkbH like protein

smcogs: SMCOG1256: FkbH like protein

AVI57431.1: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: cyclase

AVI57412.1: Diels-Alderase cyclase

extras: DA_cyclase: Diels-Alderase cyclase

Ligases: synthase

AVI57426.1: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

Translocases: permease

AVI57408.1: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001694.4	0.98	PKS	Neoabyssomicin B, Abyssomicin 2, Abyssomicin 4	Streptomyces koyangensis
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000041.3	0.73	PKS	oronofacic acid	Pseudomonas syringae
BGC0002154.2	0.67	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001258.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001694.4	1.00	PKS	Neoabyssomicin B, Abyssomicin 2, Abyssomicin 4	Streptomyces koyangensis
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000041.3	0.73	PKS	oronofacic acid	Pseudomonas syringae
BGC0002154.2	0.67	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001258.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 7313 - 73870:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-ccmal - ccmal - ccmal) + (Me-ccmal - redmal) + (mal)
Non-colinear ordering:: AVI57433.1 + AVI57434.1 + AVI57435.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AVI57433.1: mal - mmal - mal - mal

PKS_AT (550..841): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 185.5
inactive: 90.5
Methylmalonyl-CoA: 64.8
Methoxymalonyl-CoA: 61.2
Propionyl-CoA: 42.0
Ethylmalonyl-CoA: 39.8
CHC-CoA: 26.3
fatty_acid: 25.3
Benzoyl-CoA: 23.5
trans-1,2-CPDA: 22.4
2-Methylbutyryl-CoA: 20.1
Isobutyryl-CoA: 16.9
Acetyl-CoA: 15.9
3-Methylbutyryl-CoA: 2.7

PKS_AT (1563..1864): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 212.3
Ethylmalonyl-CoA: 207.6
Methoxymalonyl-CoA: 170.4
2-Methylbutyryl-CoA: 150.4
trans-1,2-CPDA: 128.7
Propionyl-CoA: 125.2
Malonyl-CoA: 92.3
CHC-CoA: 91.2
Isobutyryl-CoA: 78.9
Benzoyl-CoA: 49.4
fatty_acid: 44.7
3-Methylbutyryl-CoA: 38.6
Acetyl-CoA: 37.9
inactive: 28.5

PKS_AT (3388..3679): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 185.9
inactive: 90.3
Methylmalonyl-CoA: 67.2
Methoxymalonyl-CoA: 62.3
Ethylmalonyl-CoA: 40.9
Propionyl-CoA: 40.0
CHC-CoA: 26.5
fatty_acid: 25.9
Benzoyl-CoA: 24.1
trans-1,2-CPDA: 23.5
2-Methylbutyryl-CoA: 20.8
Acetyl-CoA: 20.1
Isobutyryl-CoA: 17.6
3-Methylbutyryl-CoA: 3.4

PKS_AT (5133..5424): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 190.6
inactive: 91.8
Methylmalonyl-CoA: 69.6
Methoxymalonyl-CoA: 63.7
Propionyl-CoA: 45.8
Ethylmalonyl-CoA: 43.4
fatty_acid: 26.8
CHC-CoA: 26.2
2-Methylbutyryl-CoA: 25.6
Benzoyl-CoA: 23.8
trans-1,2-CPDA: 23.0
Isobutyryl-CoA: 18.6
Acetyl-CoA: 17.5
3-Methylbutyryl-CoA: 3.7

AVI57434.1: mmal - mal

PKS_AT (571..870): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 212.5
Ethylmalonyl-CoA: 207.2
Methoxymalonyl-CoA: 171.4
2-Methylbutyryl-CoA: 149.3
trans-1,2-CPDA: 133.1
Propionyl-CoA: 124.5
Malonyl-CoA: 93.4
CHC-CoA: 91.4
Isobutyryl-CoA: 79.0
Benzoyl-CoA: 50.3
fatty_acid: 45.2
Acetyl-CoA: 38.4
3-Methylbutyryl-CoA: 37.7
inactive: 28.9

PKS_AT (2373..2665): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 185.5
inactive: 89.3
Methylmalonyl-CoA: 71.5
Methoxymalonyl-CoA: 66.3
Propionyl-CoA: 44.0
Ethylmalonyl-CoA: 42.4
CHC-CoA: 33.2
trans-1,2-CPDA: 27.1
fatty_acid: 27.0
Benzoyl-CoA: 26.6
2-Methylbutyryl-CoA: 21.8
Isobutyryl-CoA: 19.8
Acetyl-CoA: 17.3
3-Methylbutyryl-CoA: 7.5

AVI57435.1: mal

PKS_AT (584..874): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 188.8
inactive: 88.0
Methylmalonyl-CoA: 69.8
Methoxymalonyl-CoA: 66.3
Propionyl-CoA: 43.2
Ethylmalonyl-CoA: 42.2
2-Methylbutyryl-CoA: 26.8
CHC-CoA: 25.4
Benzoyl-CoA: 25.2
Isobutyryl-CoA: 24.9
fatty_acid: 23.8
trans-1,2-CPDA: 21.0
Acetyl-CoA: 20.2
3-Methylbutyryl-CoA: 7.4

Link to PARAS substrate predictor