BGC0001694 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001694 (Streptomyces koyangensis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	73,870	Neoabyssomicin B/Abyssomicin 2/Abyssomicin 4	PKS	100%

BGC0001694 - Region 1 - T1PKS

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Location: 1 - 73,870 nt. (total: 73,870 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 73,871
Label		BGC0001694

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001694	0.92	Polyketide	neoabyssomicin, abyssomicin	Streptomyces koyangensis
BGC0000041	0.41	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000016	0.33	Other	amphotericin B	Streptomyces nodosus
BGC0001124	0.32	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0001283	0.31	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0002227	0.31	NRP	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0001913	0.31	Polyketide	phomoidride	fungal sp. ATCC 74256
BGC0002731	0.31	Polyketide	nanangenine A, nanangenine B, nanangenine C	Aspergillus nanangensis
BGC0001273	0.31	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000120	0.31	Polyketide	patulin	Penicillium expansum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001694	1.00	Polyketide	neoabyssomicin, abyssomicin	Streptomyces koyangensis
BGC0000041	0.73	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000016	0.66	Other	amphotericin B	Streptomyces nodosus
BGC0001283	0.66	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0001124	0.65	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0002227	0.65	NRP	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0001913	0.65	Polyketide	phomoidride	fungal sp. ATCC 74256
BGC0002731	0.64	Polyketide	nanangenine A, nanangenine B, nanangenine C	Aspergillus nanangensis
BGC0001273	0.64	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000120	0.64	Polyketide	patulin	Penicillium expansum

Similar known gene clusters from MIBiG 4.0

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 7313 - 73870:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-ccmal - ccmal - ccmal) + (Me-ccmal - redmal) + (mal)
Non-colinear ordering:: AVI57433.1 + AVI57434.1 + AVI57435.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AVI57433.1

PKS_AT (550..841): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 185.5
inactive: 90.5
Methylmalonyl-CoA: 64.8
Methoxymalonyl-CoA: 61.2
Propionyl-CoA: 42.0
Ethylmalonyl-CoA: 39.8
CHC-CoA: 26.3
fatty_acid: 25.3
Benzoyl-CoA: 23.5
trans-1,2-CPDA: 22.4
2-Methylbutyryl-CoA: 20.1
Isobutyryl-CoA: 16.9
Acetyl-CoA: 15.9
3-Methylbutyryl-CoA: 2.7

PKS_AT (1563..1864): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 212.3
Ethylmalonyl-CoA: 207.6
Methoxymalonyl-CoA: 170.4
2-Methylbutyryl-CoA: 150.4
trans-1,2-CPDA: 128.7
Propionyl-CoA: 125.2
Malonyl-CoA: 92.3
CHC-CoA: 91.2
Isobutyryl-CoA: 78.9
Benzoyl-CoA: 49.4
fatty_acid: 44.7
3-Methylbutyryl-CoA: 38.6
Acetyl-CoA: 37.9
inactive: 28.5

PKS_AT (3388..3679): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 185.9
inactive: 90.3
Methylmalonyl-CoA: 67.2
Methoxymalonyl-CoA: 62.3
Ethylmalonyl-CoA: 40.9
Propionyl-CoA: 40.0
CHC-CoA: 26.5
fatty_acid: 25.9
Benzoyl-CoA: 24.1
trans-1,2-CPDA: 23.5
2-Methylbutyryl-CoA: 20.8
Acetyl-CoA: 20.1
Isobutyryl-CoA: 17.6
3-Methylbutyryl-CoA: 3.4

PKS_AT (5133..5424): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 190.6
inactive: 91.8
Methylmalonyl-CoA: 69.6
Methoxymalonyl-CoA: 63.7
Propionyl-CoA: 45.8
Ethylmalonyl-CoA: 43.4
fatty_acid: 26.8
CHC-CoA: 26.2
2-Methylbutyryl-CoA: 25.6
Benzoyl-CoA: 23.8
trans-1,2-CPDA: 23.0
Isobutyryl-CoA: 18.6
Acetyl-CoA: 17.5
3-Methylbutyryl-CoA: 3.7

AVI57434.1

PKS_AT (571..870): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 212.5
Ethylmalonyl-CoA: 207.2
Methoxymalonyl-CoA: 171.4
2-Methylbutyryl-CoA: 149.3
trans-1,2-CPDA: 133.1
Propionyl-CoA: 124.5
Malonyl-CoA: 93.4
CHC-CoA: 91.4
Isobutyryl-CoA: 79.0
Benzoyl-CoA: 50.3
fatty_acid: 45.2
Acetyl-CoA: 38.4
3-Methylbutyryl-CoA: 37.7
inactive: 28.9

PKS_AT (2373..2665): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 185.5
inactive: 89.3
Methylmalonyl-CoA: 71.5
Methoxymalonyl-CoA: 66.3
Propionyl-CoA: 44.0
Ethylmalonyl-CoA: 42.4
CHC-CoA: 33.2
trans-1,2-CPDA: 27.1
fatty_acid: 27.0
Benzoyl-CoA: 26.6
2-Methylbutyryl-CoA: 21.8
Isobutyryl-CoA: 19.8
Acetyl-CoA: 17.3
3-Methylbutyryl-CoA: 7.5

AVI57435.1

PKS_AT (584..874): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 188.8
inactive: 88.0
Methylmalonyl-CoA: 69.8
Methoxymalonyl-CoA: 66.3
Propionyl-CoA: 43.2
Ethylmalonyl-CoA: 42.2
2-Methylbutyryl-CoA: 26.8
CHC-CoA: 25.4
Benzoyl-CoA: 25.2
Isobutyryl-CoA: 24.9
fatty_acid: 23.8
trans-1,2-CPDA: 21.0
Acetyl-CoA: 20.2
3-Methylbutyryl-CoA: 7.4