BGC0001695: neoantimycin biosynthetic gene cluster from Streptomyces conglobatus
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Location: 1 - 41,200 nt. (total: 41,200 nt).
This entry is originally from NCBI GenBank MH128122.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001695
Short description neoantimycin biosynthetic gene cluster from Streptomyces conglobatus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: MH128122.1
Compounds
  • neoantimycin
Species Streptomyces conglobatus [taxonomy]
References
Chemical products information
neoantimycin
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C36H46N2O12
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AWX24481.1
  • natA
 2963 - 3484 (-) RNA polymerase sigma factor
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  • AWX24482.1
  • natB
 3943 - 18042 (+) non-ribosomal peptide synthetase
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  • AWX24483.1
  • natC
 18035 - 22339 (+) type I polyketide synthase
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  • AWX24484.1
  • natD
 22404 - 29786 (+) non-ribosomal peptide synthetase
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  • AWX24485.1
  • natE
 29858 - 30964 (+) NADPH dependent ketoreductase
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  • AWX24486.1
  • natR
 30961 - 31761 (+) type II thioesterase
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  • AWX24487.1
  • natP
 31638 - 32123 (-) phosphopantetheinyl transferase
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  • AWX24488.1
  • natF
 32402 - 33889 (-) acyl-CoA ligase
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  • AWX24489.1
  • natG
 33889 - 34137 (-) acyl carrier protein
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  • AWX24490.1
  • natH
 34324 - 35313 (+) phenylacetate-CoA oxygenase
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  • AWX24491.1
  • natI
 35310 - 35612 (+) phenylacetate-CoA oxygenase subunit
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  • AWX24492.1
  • natJ
 35602 - 36381 (+) phenylacetate-CoA oxygenase subunit PaaI
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  • AWX24493.1
  • natK
 36378 - 36875 (+) phenylacetate-CoA oxygenase subunit PaaJ
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  • AWX24494.1
  • natL
 36883 - 37977 (+) phenylacetate-CoA oxygenase/reductase subunit PaaK
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  • AWX24495.1
  • natN
 37991 - 38830 (+) tryptophan 2,3-dioxygenase
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  • AWX24496.1
  • natO
 38970 - 39629 (+) lipase-esterase
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  • AWX24497.1
  • natQ
 39665 - 40927 (+) kynureninase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
natB
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
  • Homology
natF
Module ?
Specificity: anthanillic acid
Evidence for specificity:
  • Structure-based inference
  • Homology
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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