BGC0001695: neoantimycin biosynthetic gene cluster from Streptomyces conglobatus
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 41,200 nt. (total: 41,200 nt).
This entry is originally from NCBI GenBank MH128122.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001695
Short description neoantimycin biosynthetic gene cluster from Streptomyces conglobatus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MH128122.1
via
Compounds
  • neoantimycin
Species Streptomyces conglobatus [taxonomy]
References
Chemical products information
neoantimycin Evidence:
Copy SMILES
C36H46N2O12
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AWX24481.1
  • natA
 2963 - 3484 (-) RNA polymerase sigma factor
    copy AA seq
    copy Nt seq
    • AWX24482.1
    • natB
    		 3943 - 18042 (+) non-ribosomal peptide synthetase
      copy AA seq
      copy Nt seq
      • AWX24483.1
      • natC
      		 18035 - 22339 (+) type I polyketide synthase
        copy AA seq
        copy Nt seq
        • AWX24484.1
        • natD
        		 22404 - 29786 (+) non-ribosomal peptide synthetase
          copy AA seq
          copy Nt seq
          • AWX24485.1
          • natE
          		 29858 - 30964 (+) NADPH dependent ketoreductase
            copy AA seq
            copy Nt seq
            • AWX24486.1
            • natR
            		 30961 - 31761 (+) type II thioesterase
              copy AA seq
              copy Nt seq
              • AWX24487.1
              • natP
              		 31638 - 32123 (-) phosphopantetheinyl transferase
                copy AA seq
                copy Nt seq
                • AWX24488.1
                • natF
                		 32402 - 33889 (-) acyl-CoA ligase
                  copy AA seq
                  copy Nt seq
                  • AWX24489.1
                  • natG
                  		 33889 - 34137 (-) acyl carrier protein
                    copy AA seq
                    copy Nt seq
                    • AWX24490.1
                    • natH
                    		 34324 - 35313 (+) phenylacetate-CoA oxygenase
                      copy AA seq
                      copy Nt seq
                      • AWX24491.1
                      • natI
                      		 35310 - 35612 (+) phenylacetate-CoA oxygenase subunit
                        copy AA seq
                        copy Nt seq
                        • AWX24492.1
                        • natJ
                        		 35602 - 36381 (+) phenylacetate-CoA oxygenase subunit PaaI
                          copy AA seq
                          copy Nt seq
                          • AWX24493.1
                          • natK
                          		 36378 - 36875 (+) phenylacetate-CoA oxygenase subunit PaaJ
                            copy AA seq
                            copy Nt seq
                            • AWX24494.1
                            • natL
                            		 36883 - 37977 (+) phenylacetate-CoA oxygenase/reductase subunit PaaK
                              copy AA seq
                              copy Nt seq
                              • AWX24495.1
                              • natN
                              		 37991 - 38830 (+) tryptophan 2,3-dioxygenase
                                copy AA seq
                                copy Nt seq
                                • AWX24496.1
                                • natO
                                		 38970 - 39629 (+) lipase-esterase
                                  copy AA seq
                                  copy Nt seq
                                  • AWX24497.1
                                  • natQ
                                  		 39665 - 40927 (+) kynureninase
                                    copy AA seq
                                    copy Nt seq
                                    Biosynthesis information

                                    Biosynthetic modules

                                    Name
                                    Unk01
                                    Type
                                    nrps-type1
                                    Genes
                                    natB
                                    Substrates
                                    threonine (evidence: Structure-based inference, Homology)
                                    Integrated Monomers
                                    Domains
                                    adenylation
                                    Name
                                    Unk02
                                    Type
                                    nrps-type1
                                    Genes
                                    natF
                                    Substrates
                                    anthanillic acid (evidence: Structure-based inference, Homology)
                                    Integrated Monomers
                                    Domains
                                    adenylation
                                    Annotation changelog

                                    Entry version: 4

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2022-10-07
                                    Update chemical activity to schema version 2.11
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 3

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2022-09-15
                                    Updated bioactivity data
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    2022-09-15
                                    Added NRP substrate specificities
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 2

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2019-10-16
                                    Migrated from v1.4
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    2019-10-16
                                    Updated compound(s) information (NPAtlas curation)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 1

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2018-08-06
                                    Submitted
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    Detailed domain annotation
                                    Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                    A domain glossary is available here, and an explanation of the visualisation is available here.
                                    Selected features only
                                    Show module domains
                                    Similar known gene clusters from MIBiG 4.0
                                    Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                    Click on reference genes to show details of similarities to genes within the current region.
                                    Click on an accession to open that entry in the MiBIG database.