BGC0001700 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001700 (Streptomyces sp. IMB7-145)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	132,350	niphimycin C/niphimycin D/niphimycin E/17-O-methylniphimycin/niphimycin Iα/19-O-malonylniphimycin	PKS	100%

BGC0001700 - Region 1 - T1PKS

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Location: 1 - 132,350 nt. (total: 132,350 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 132,351
Label		BGC0001700

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001700	1.00	Polyketide	niphimycins C-E	Streptomyces sp. IMB7-145
BGC0001523	0.51	Polyketide	azalomycin F3a	Streptomyces sp. 211726
BGC0000041	0.40	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000067	0.34	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001163	0.33	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001164	0.33	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002731	0.32	Polyketide	nanangenine A, nanangenine B, nanangenine C	Aspergillus nanangensis
BGC0002729	0.31	Polyketide	sordarial	Neurospora crassa OR74A
BGC0001749	0.31	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0002211	0.31	Polyketide	HEx-pks1 polyketide	Paraphaeosphaeria sporulosa

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001700	1.00	Polyketide	niphimycins C-E	Streptomyces sp. IMB7-145
BGC0001523	0.79	Polyketide	azalomycin F3a	Streptomyces sp. 211726
BGC0000041	0.72	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000067	0.67	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001163	0.67	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001164	0.66	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002731	0.65	Polyketide	nanangenine A, nanangenine B, nanangenine C	Aspergillus nanangensis
BGC0002729	0.65	Polyketide	sordarial	Neurospora crassa OR74A
BGC0001749	0.64	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0002211	0.64	Polyketide	HEx-pks1 polyketide	Paraphaeosphaeria sporulosa

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 132350:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk - pk) + (Me-ohmal - ccmal) + (pk - pk) + (redmal) + (ohmal - ohmal - ohmal) + (ohmal - ohmal - mal - pk - redmal) + (pk - ohmal) + (pk - ccmal) + (pk)
Non-colinear ordering:: npmB + npmC + npmD + npmA + npmE + npmF + npmG + npmH + npmI

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

npmB

PKS_AT (574..872): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 234.3
Methylmalonyl-CoA: 232.4
Methoxymalonyl-CoA: 191.0
2-Methylbutyryl-CoA: 162.8
trans-1,2-CPDA: 138.2
Malonyl-CoA: 120.0
Propionyl-CoA: 117.9
CHC-CoA: 112.8
Isobutyryl-CoA: 85.1
Benzoyl-CoA: 61.4
inactive: 50.4
3-Methylbutyryl-CoA: 47.9
Acetyl-CoA: 44.8
fatty_acid: 30.9

PKS_AT (2311..2609): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 224.3
Methylmalonyl-CoA: 222.6
Methoxymalonyl-CoA: 180.2
2-Methylbutyryl-CoA: 158.5
trans-1,2-CPDA: 132.3
Propionyl-CoA: 117.2
Malonyl-CoA: 102.0
CHC-CoA: 102.0
Isobutyryl-CoA: 73.0
Benzoyl-CoA: 59.4
Acetyl-CoA: 38.9
3-Methylbutyryl-CoA: 36.0
fatty_acid: 30.6
inactive: 24.0

npmC

PKS_AT (583..881): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 226.3
Ethylmalonyl-CoA: 224.6
Methoxymalonyl-CoA: 184.9
2-Methylbutyryl-CoA: 169.3
trans-1,2-CPDA: 129.9
Propionyl-CoA: 122.1
CHC-CoA: 105.8
Malonyl-CoA: 101.3
Isobutyryl-CoA: 83.5
Benzoyl-CoA: 58.9
3-Methylbutyryl-CoA: 42.7
fatty_acid: 34.5
Acetyl-CoA: 31.5
inactive: 27.5

PKS_AT (2143..2447): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 235.1
inactive: 117.3
Methoxymalonyl-CoA: 74.3
Methylmalonyl-CoA: 68.9
Propionyl-CoA: 36.5
Acetyl-CoA: 33.1
Isobutyryl-CoA: 30.5
Ethylmalonyl-CoA: 23.8
2-Methylbutyryl-CoA: 20.8
Benzoyl-CoA: 17.0
fatty_acid: 14.5
CHC-CoA: 7.9
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

npmD

PKS_AT (565..863): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 218.2
Methylmalonyl-CoA: 216.8
Methoxymalonyl-CoA: 177.1
trans-1,2-CPDA: 133.4
2-Methylbutyryl-CoA: 122.9
Malonyl-CoA: 113.2
Propionyl-CoA: 103.0
CHC-CoA: 91.7
Isobutyryl-CoA: 75.7
Benzoyl-CoA: 53.0
inactive: 36.2
Acetyl-CoA: 34.3
3-Methylbutyryl-CoA: 32.1
fatty_acid: 30.9

PKS_AT (2291..2589): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 227.6
Methylmalonyl-CoA: 225.9
Methoxymalonyl-CoA: 182.7
2-Methylbutyryl-CoA: 153.0
trans-1,2-CPDA: 135.7
CHC-CoA: 116.3
Propionyl-CoA: 116.2
Malonyl-CoA: 111.5
Isobutyryl-CoA: 82.6
Benzoyl-CoA: 56.2
inactive: 49.1
3-Methylbutyryl-CoA: 45.8
Acetyl-CoA: 37.8
fatty_acid: 30.1

npmE

PKS_AT (573..876): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 252.9
inactive: 124.1
Methoxymalonyl-CoA: 76.9
Methylmalonyl-CoA: 67.3
Propionyl-CoA: 39.0
Isobutyryl-CoA: 34.4
Ethylmalonyl-CoA: 26.2
Acetyl-CoA: 23.1
Benzoyl-CoA: 19.0
2-Methylbutyryl-CoA: 16.4
fatty_acid: 12.6
trans-1,2-CPDA: 10.2
CHC-CoA: 7.2
3-Methylbutyryl-CoA: 0.0

PKS_AT (2123..2424): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 247.1
inactive: 114.5
Methoxymalonyl-CoA: 77.6
Methylmalonyl-CoA: 67.4
Propionyl-CoA: 42.5
Isobutyryl-CoA: 32.4
Ethylmalonyl-CoA: 30.8
Acetyl-CoA: 22.9
Benzoyl-CoA: 17.7
2-Methylbutyryl-CoA: 17.5
trans-1,2-CPDA: 15.3
fatty_acid: 14.6
CHC-CoA: 10.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (3669..3972): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 218.5
inactive: 112.9
Methoxymalonyl-CoA: 66.5
Methylmalonyl-CoA: 52.9
Propionyl-CoA: 31.6
Isobutyryl-CoA: 27.2
Acetyl-CoA: 23.8
Benzoyl-CoA: 14.6
fatty_acid: 12.4
2-Methylbutyryl-CoA: 12.4
CHC-CoA: 6.9
Ethylmalonyl-CoA: 6.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

npmF

PKS_AT (569..870): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 247.7
inactive: 113.5
Methoxymalonyl-CoA: 76.9
Methylmalonyl-CoA: 67.6
Propionyl-CoA: 41.0
Isobutyryl-CoA: 36.3
Ethylmalonyl-CoA: 33.5
Benzoyl-CoA: 24.5
Acetyl-CoA: 24.2
2-Methylbutyryl-CoA: 18.7
trans-1,2-CPDA: 18.1
fatty_acid: 13.8
CHC-CoA: 12.4
3-Methylbutyryl-CoA: 0.0

PKS_AT (2120..2422): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 244.1
inactive: 116.9
Methoxymalonyl-CoA: 72.9
Methylmalonyl-CoA: 66.1
Propionyl-CoA: 37.8
Isobutyryl-CoA: 28.0
Ethylmalonyl-CoA: 27.4
Acetyl-CoA: 21.0
Benzoyl-CoA: 18.5
fatty_acid: 13.4
2-Methylbutyryl-CoA: 12.6
trans-1,2-CPDA: 9.0
CHC-CoA: 8.3
3-Methylbutyryl-CoA: 0.0

PKS_AT (3671..3972): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 249.5
inactive: 130.0
Methoxymalonyl-CoA: 82.2
Methylmalonyl-CoA: 74.1
Propionyl-CoA: 41.6
Isobutyryl-CoA: 40.3
Ethylmalonyl-CoA: 32.9
2-Methylbutyryl-CoA: 24.1
Acetyl-CoA: 23.8
Benzoyl-CoA: 19.6
fatty_acid: 18.8
CHC-CoA: 14.6
trans-1,2-CPDA: 11.2
3-Methylbutyryl-CoA: 0.0

PKS_AT (5044..5342): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 231.1
Methylmalonyl-CoA: 229.2
Methoxymalonyl-CoA: 184.3
2-Methylbutyryl-CoA: 160.7
trans-1,2-CPDA: 135.6
CHC-CoA: 121.1
Malonyl-CoA: 116.4
Propionyl-CoA: 116.0
Isobutyryl-CoA: 84.4
Benzoyl-CoA: 57.5
inactive: 48.6
3-Methylbutyryl-CoA: 47.2
Acetyl-CoA: 38.6
fatty_acid: 30.4

PKS_AT (6618..6922): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 91.7%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 230.7
inactive: 113.8
Methoxymalonyl-CoA: 70.0
Methylmalonyl-CoA: 61.9
Propionyl-CoA: 33.9
Isobutyryl-CoA: 30.9
Acetyl-CoA: 26.0
Ethylmalonyl-CoA: 21.7
Benzoyl-CoA: 20.4
fatty_acid: 13.3
CHC-CoA: 9.7
2-Methylbutyryl-CoA: 8.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

npmG

PKS_AT (566..864): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 233.2
Methylmalonyl-CoA: 228.8
Methoxymalonyl-CoA: 185.7
2-Methylbutyryl-CoA: 152.8
trans-1,2-CPDA: 139.2
Propionyl-CoA: 119.7
Malonyl-CoA: 115.9
CHC-CoA: 108.9
Isobutyryl-CoA: 85.5
Benzoyl-CoA: 62.5
inactive: 42.2
3-Methylbutyryl-CoA: 42.1
Acetyl-CoA: 38.2
fatty_acid: 29.9

PKS_AT (2117..2418): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 241.8
inactive: 113.6
Methoxymalonyl-CoA: 77.8
Methylmalonyl-CoA: 66.4
Propionyl-CoA: 36.6
Isobutyryl-CoA: 35.6
Ethylmalonyl-CoA: 29.4
2-Methylbutyryl-CoA: 23.8
Acetyl-CoA: 21.4
Benzoyl-CoA: 19.6
fatty_acid: 14.2
trans-1,2-CPDA: 14.1
CHC-CoA: 11.4
3-Methylbutyryl-CoA: 0.0

npmH

PKS_AT (569..867): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 231.4
Methylmalonyl-CoA: 228.8
Methoxymalonyl-CoA: 185.1
2-Methylbutyryl-CoA: 156.9
trans-1,2-CPDA: 135.5
CHC-CoA: 118.7
Propionyl-CoA: 116.3
Malonyl-CoA: 113.2
Isobutyryl-CoA: 83.9
Benzoyl-CoA: 59.7
3-Methylbutyryl-CoA: 49.5
inactive: 47.9
Acetyl-CoA: 39.5
fatty_acid: 32.0

PKS_AT (2139..2442): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 242.6
inactive: 112.1
Methoxymalonyl-CoA: 72.3
Methylmalonyl-CoA: 65.0
Propionyl-CoA: 38.3
Isobutyryl-CoA: 27.6
Acetyl-CoA: 20.8
Ethylmalonyl-CoA: 18.8
Benzoyl-CoA: 16.8
2-Methylbutyryl-CoA: 13.8
CHC-CoA: 13.4
trans-1,2-CPDA: 12.9
fatty_acid: 11.0
3-Methylbutyryl-CoA: 0.0

npmI

PKS_AT (578..876): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 230.9
Methylmalonyl-CoA: 230.7
Methoxymalonyl-CoA: 183.8
2-Methylbutyryl-CoA: 167.1
trans-1,2-CPDA: 132.8
Malonyl-CoA: 125.5
CHC-CoA: 122.9
Propionyl-CoA: 120.6
Isobutyryl-CoA: 89.1
Benzoyl-CoA: 61.9
inactive: 51.9
3-Methylbutyryl-CoA: 45.7
Acetyl-CoA: 42.8
fatty_acid: 32.1

npmA

PKS_AT (672..980): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 234.6
inactive: 135.7
Methoxymalonyl-CoA: 72.4
Methylmalonyl-CoA: 62.7
Propionyl-CoA: 36.1
Isobutyryl-CoA: 36.1
Benzoyl-CoA: 25.8
Ethylmalonyl-CoA: 23.0
Acetyl-CoA: 21.1
2-Methylbutyryl-CoA: 20.9
trans-1,2-CPDA: 20.3
fatty_acid: 11.9
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

npm6

AMP-binding (8..375): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: QYSDCGSNVK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

npm7

PKS_AT (31..308): pk

ATSignature: (unknown)

No matches above 50%

minowa: CHC-CoA

Prediction, score:

CHC-CoA: 10.4
trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0