BGC0001700: niphimycins C-E biosynthetic gene cluster from Streptomyces sp. IMB7-145
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 132,350 nt. (total: 132,350 nt).
This entry is originally from NCBI GenBank MF671979.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001700
Short description niphimycins C-E biosynthetic gene cluster from Streptomyces sp. IMB7-145
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: MF671979.1
Compounds
  • niphimycins C-E
Species Streptomyces sp. IMB7-145 [taxonomy]
References
Chemical products information
niphimycins C-E
Copy SMILES
C59H103N3O18
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AUO16393.1
  • npm1
 1 - 4644 (-) hypothetical protein
copy AA seq
copy Nt seq
  • AUO16394.1
  • npm2
 4791 - 5399 (-) TetR family transcriptional regulator
copy AA seq
copy Nt seq
  • AUO16395.1
  • npm3
 5544 - 6758 (-) cytochrome P450
copy AA seq
copy Nt seq
  • AUO16421.1
  • npm4
 7123 - 8325 (+) cytochrome P450
copy AA seq
copy Nt seq
  • AUO16396.1
  • npm5
 8405 - 8611 (+) ferredoxin
copy AA seq
copy Nt seq
  • AUO16397.1
  • npmB
 8868 - 20711 (+) polyketide synthase
copy AA seq
copy Nt seq
  • AUO16398.1
  • npmC
 20806 - 31188 (+) polyketide synthase
copy AA seq
copy Nt seq
  • AUO16399.1
  • npmD
 31271 - 41392 (+) polyketide synthase
copy AA seq
copy Nt seq
  • AUO16400.1
  • npmE
 41418 - 55661 (+) polyketide synthase
copy AA seq
copy Nt seq
  • AUO16401.1
  • npmF
 55738 - 80562 (+) polyketide synthase
copy AA seq
copy Nt seq
  • AUO16402.1
  • npmG
 80608 - 90225 (+) polyketide synthase
copy AA seq
copy Nt seq
  • AUO16422.1
  • npmH
 90283 - 100647 (+) polyketide synthase
copy AA seq
copy Nt seq
  • AUO16403.1
  • npmI
 100698 - 108452 (+) polyketide synthase
copy AA seq
copy Nt seq
  • AUO16423.1
  • npmA
 108574 - 115494 (+) polyketide synthase
copy AA seq
copy Nt seq
  • AUO16404.1
  • npm6
 115617 - 117053 (+) 4-guanidinobutanoate:CoA ligase
copy AA seq
copy Nt seq
  • AUO16405.1
  • npm7
 117050 - 118084 (+) 4-guanidinobutyryl-CoA:ACP acyltransferase
copy AA seq
copy Nt seq
  • AUO16406.1
  • npm8
 118240 - 118848 (+) TetR family transcriptional regulator
copy AA seq
copy Nt seq
  • AUO16407.1
  • npm9
 118953 - 119837 (+) hydrolase
copy AA seq
copy Nt seq
  • AUO16408.1
  • npm10
 119920 - 120300 (+) HxlR family transcriptional regulator
copy AA seq
copy Nt seq
  • AUO16409.1
  • npm11
 120380 - 120820 (-) endoribonuclease L-PSP
copy AA seq
copy Nt seq
  • AUO16410.1
  • npm12
 120973 - 122403 (-) hypothetical protein
copy AA seq
copy Nt seq
  • AUO16411.1
  • npm13
 122536 - 123816 (-) membrane protein
copy AA seq
copy Nt seq
  • AUO16412.1
  • npm14
 124107 - 124694 (-) XRE family transcriptional regulator
copy AA seq
copy Nt seq
  • AUO16413.1
  • npm15
 124792 - 125091 (+) methyltransferase
copy AA seq
copy Nt seq
  • AUO16414.1
  • npm16
 125126 - 125635 (+) mini-circle protein
copy AA seq
copy Nt seq
  • AUO16415.1
  • npm17
 125642 - 126271 (-) AcrR family DNA-binding transcriptional regulator
copy AA seq
copy Nt seq
  • AUO16416.1
  • npm18
 126515 - 128056 (+) CoA-transferase family III
copy AA seq
copy Nt seq
  • AUO16417.1
  • npm19
 128114 - 128899 (-) GntR-family transcriptional regulator
copy AA seq
copy Nt seq
  • AUO16418.1
  • npm20
 129038 - 129841 (+) 4-guanidinobutyramide hydrolase
copy AA seq
copy Nt seq
  • AUO16419.1
  • npm21
 129835 - 131271 (+) amino acid transporter
copy AA seq
copy Nt seq
  • AUO16420.1
  • npm22
 131314 - 132180 (-) AraC-family transcriptional regulator
copy AA seq
copy Nt seq
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.