LOCUS       BGC0001701             16220 bp    DNA     linear   BCT 12-SEP-2017
DEFINITION  Blautia obeum strain A2-162 nisin O biosynthetic gene cluster,
            complete sequence.
ACCESSION   BGC0001701
VERSION     BGC0001701
KEYWORDS    .
SOURCE      Blautia obeum
  ORGANISM  Blautia obeum
            Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
            Blautia.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 16:05:54
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16220
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..16220
                     /db_xref="taxon:40520"
                     /mol_type="genomic DNA"
                     /organism="Blautia obeum"
                     /strain="A2-162"
     misc_feature    1..16220
                     /note="nisin O biosynthetic gene cluster"
     protocluster    1..16220
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[9638:15820]"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      9639..15820
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     cand_cluster    1..16220
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..16220
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001701"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..16220
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C))
                     and not (YcaO or TIGR03604))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            775..1479
                     /gene="nsoF"
     CDS             775..1479
                     /codon_start=1
                     /gene="nsoF"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 174.1; E-value:
                     6.3e-53)"
                     /gene_kind="transport"
                     /note="putative LanF immunity transport protein"
                     /product="NsoF"
                     /protein_id="ASY03206.1"
                     /transl_table=11
                     /translation="METLLRTENLTKKFKNQVAIQNISMNVPENSVYGLLGPNGAGKST
                     TLKMIAGILKPTRGSIIFNKHPWKRSDLSNIGALIETPPLYGNLTARENLKVRTELLNI
                     SDGRIDEVLEISGLTGTGKKRAGQFSMGMKQRLGIAIALLNNPKLLILDEPTNGLDPVG
                     IEELRNLIRQFPKQGMTVILSSHILSEVEQIADYIGIICNGKLEYEAPENKEDNLEALF
                     MDIVKRNRREII"
     gene            1479..2198
                     /gene="nsoE"
     CDS             1479..2198
                     /codon_start=1
                     /gene="nsoE"
                     /note="putative LanE immunity transport protein"
                     /product="NsoE"
                     /protein_id="ASY03207.1"
                     /transl_table=11
                     /translation="MRYIRSENLKYKRSFSRKLIFVVPIITAFVAVIFGGIRNFQAQTI
                     YWWYTFLLPGTVAIYCSLSEKKEKSVRYHTFYTLSIDLENAWYARVLVIAWYMLLTGII
                     LVLPAVSMKIWAPAICQISNGKLLLGSICIVVMSLWQIPILLFFNKRIGILLPLIINCM
                     LPLAISPLSNTDLWFLIPYSWVSKSMKSIIGLDVNGTMTTVSSKDSLDFTIGLLLSVLL
                     FIITVIITAKKFREVEG"
     gene            2195..2956
                     /gene="nsoG"
     CDS             2195..2956
                     /codon_start=1
                     /gene="nsoG"
                     /note="putative LanG immunity transport protein"
                     /product="NsoG"
                     /protein_id="ASY03208.1"
                     /transl_table=11
                     /translation="MKSLWYAIKSEVVKLRHTPIFLLHIIVPLLGGLLFAMYFHLYSGQ
                     QSITQRLNLILQATSAFFPLAISIAVSLGINLEEEGHFQALFVGMESKSKLIIAKLILF
                     LGIGAVAIVILFLPILFSVAVMDQELSISVLNTVLYSYVYLVLGNIVTYIIHFWLSLKS
                     GLGASVITGVLESLIVILFSNLPLKLVISWEYIPWAWAVNMCRQEILQFNTQLSTLQPN
                     IIFKVIIITFVLLLVFCIWFEKWEGRKNYEE"
     gene            2946..3782
                     /gene="nsoI"
     CDS             2946..3782
                     /codon_start=1
                     /gene="nsoI"
                     /note="putative LanI immunity protein"
                     /product="NsoI"
                     /protein_id="ASY03209.1"
                     /transl_table=11
                     /translation="MKNSILIKRVILVFCMISIMIIGSGCAAKKTVLENQGKTECYLDE
                     KDATKFIYNGQQYTILNNTVDKNSLGDWIGFIQKYVALDENYNILKKCDMGVNVVGDLS
                     DLIDHTDGTAYYVPYLNVYKTENEGDMNNLVVDVDNDFHKAIPSENAKDGDLKIIFKNQ
                     NDTKDIENDLPQIDKEDVRNLTWEGKTYQITDQVVPNEKIGDYLCTLSGNITFDAETGR
                     ELTHDELNAIDIIPGELSNQKRETWIYDSVYTVIGKDKDSLAVEINYKCVYAILKD"
     gene            3847..4509
                     /gene="nsoR1"
     CDS             3847..4509
                     /codon_start=1
                     /gene="nsoR1"
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 165.4; E-value: 2.4e-50)"
                     /gene_kind="regulatory"
                     /note="putative LanR response regulator protein"
                     /product="NsoR1"
                     /protein_id="ASY03210.1"
                     /transl_table=11
                     /translation="MKILVIDDEEAILELVKRGLEKDGFAVDTLTSAKKVDVSKLRQYN
                     LLILDVMMPDIDGFTFCKKIRDIFNAPILFLTAKTLEDEVLYGLGIGGDDYITKPFRIK
                     ELRARVKAHLRRESRENHDYLFSEDGNIKFDLSAKKLLVCEKEIPLTHSEYKICELLIQ
                     NRGHVFSREKIYERVFGFYGESADNTIVVHVKNIRVKLSEAGVNPIQTVWGIGYKWE"
     gene            4500..5858
                     /gene="nsoK1"
     CDS             4500..5858
                     /codon_start=1
                     /gene="nsoK1"
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 131; E-value: 1.2e-39)"
                     /gene_kind="regulatory"
                     /note="putative LanK histidine kinase protein"
                     /product="NsoK1"
                     /protein_id="ASY03211.1"
                     /transl_table=11
                     /translation="MGVKIKKRQYSLKFFFIKFILSLIIGAGVSIALPLVLATLASNMG
                     YITVANYNEIQAEKTAKILETEKNPDYKNIPAGIKYLIISKEFDILNTNMSNGEQKDAL
                     RYANGKFEKTASGKQFILVTRDKEFCILQYYIGSHFTNIWLDIHMPSPDILINAGMILN
                     CLFVFSIMVFLFAKELRKELKPVMDATTKIEEQELEFNISSSRIIEFNDILKSIYNMKN
                     SLKKSLKTQWNIECQQKEQISALAHDLKTPLTIIGGNADLLSETNINQEQEEYINHILE
                     SSKRMENYIAILIDLSKNTGEIPINRESISIGKFIDSIKGQMQSVVAMKKMNLIIAIMD
                     ESFRIEIDTVLMERAIINVLSNAVDHSPTHGEIIFNVTKDKGKCKISIIDSGPGFTPAA
                     LKYGLERFFMDDKSRNYQHHYGMGLYITNSIVTQHGGKVELKNKRGAEVDIII"
     gene            6365..6535
                     /gene="nsoA1"
     CDS             6365..6535
                     /codon_start=1
                     /gene="nsoA1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /note="putative LanA lantibiotic prepeptide"
                     /product="NsoA1"
                     /protein_id="ASY03212.1"
                     /sec_met_domain="TIGR03731 (E-value: 6.6e-19, bitscore:
                     57.8, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKFDDFDLDVTKTAAQGGIEPKYKSKSACTPGCPTGILMTCPLK
                     TATCGCHITGK"
     CDS_motif       6365..6433
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MGKFDDFDLDVTKTAAQGGIEPK"
                     /locus_tag="nsoA1_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       6434..6535
                     /prepeptide="core"
                     /locus_tag="nsoA1_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="12.50"
                     /molecular_weight="3228.9"
                     /monoisotopic_mass="3226.6"
                     /core_sequence="YKSKSACTPGCPTGILMTCPLKTATCGCHITGK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGKFDDFDLDVTKTAAQGGIEPK"
                     /leader_location="[6364:6433](+)"
                     /alternative_weights="3246.9"
                     /alternative_weights="3264.9"
                     /alternative_weights="3282.9"
     gene            6558..6728
                     /gene="nsoA2"
     CDS             6558..6728
                     /codon_start=1
                     /gene="nsoA2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /note="putative LanA lantibiotic prepeptide"
                     /product="NsoA2"
                     /protein_id="ASY03213.1"
                     /sec_met_domain="TIGR03731 (E-value: 8.9e-19, bitscore:
                     57.3, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKFDDFDLDVTKTAAQGGIEPKYKSKSACTPGCPTGILMTCPLK
                     TATCGCHITGK"
     CDS_motif       6558..6626
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MAKFDDFDLDVTKTAAQGGIEPK"
                     /locus_tag="nsoA2_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       6627..6728
                     /prepeptide="core"
                     /locus_tag="nsoA2_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="12.50"
                     /molecular_weight="3228.9"
                     /monoisotopic_mass="3226.6"
                     /core_sequence="YKSKSACTPGCPTGILMTCPLKTATCGCHITGK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAKFDDFDLDVTKTAAQGGIEPK"
                     /leader_location="[6557:6626](+)"
                     /alternative_weights="3246.9"
                     /alternative_weights="3264.9"
                     /alternative_weights="3282.9"
     gene            6752..6922
                     /gene="nsoA3"
     CDS             6752..6922
                     /codon_start=1
                     /gene="nsoA3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /note="putative LanA lantibiotic prepeptide"
                     /product="NsoA3"
                     /protein_id="ASY03214.1"
                     /sec_met_domain="TIGR03731 (E-value: 8.9e-19, bitscore:
                     57.3, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKFDDFDLDVTKTAAQGGIEPKYKSKSACTPGCPTGILMTCPLK
                     TATCGCHITGK"
     CDS_motif       6752..6820
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MAKFDDFDLDVTKTAAQGGIEPK"
                     /locus_tag="nsoA3_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       6821..6922
                     /prepeptide="core"
                     /locus_tag="nsoA3_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="12.50"
                     /molecular_weight="3228.9"
                     /monoisotopic_mass="3226.6"
                     /core_sequence="YKSKSACTPGCPTGILMTCPLKTATCGCHITGK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAKFDDFDLDVTKTAAQGGIEPK"
                     /leader_location="[6751:6820](+)"
                     /alternative_weights="3246.9"
                     /alternative_weights="3264.9"
                     /alternative_weights="3282.9"
     gene            6942..7115
                     /gene="nsoA4"
     CDS             6942..7115
                     /codon_start=1
                     /gene="nsoA4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /note="putative LanA lantibiotic prepeptide"
                     /product="NsoA4"
                     /protein_id="ASY03215.1"
                     /sec_met_domain="TIGR03731 (E-value: 1.8e-11, bitscore:
                     33.9, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKFDDFDLDIIEKKVRRDIIPASITSQHSFCTPNCLTGFLCPPK
                     TQLTCTCKLKGQ"
     CDS_motif       6942..7010
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MAKFDDFDLDIIEKKVRRDIIPA"
                     /locus_tag="nsoA4_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       7011..7115
                     /prepeptide="core"
                     /locus_tag="nsoA4_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="5.70"
                     /molecular_weight="3525.1"
                     /monoisotopic_mass="3522.8"
                     /core_sequence="SITSQHSFCTPNCLTGFLCPPKTQLTCTCKLKGQ"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAKFDDFDLDIIEKKVRRDIIPA"
                     /leader_location="[6941:7010](+)"
                     /alternative_weights="3543.2"
                     /alternative_weights="3561.2"
                     /alternative_weights="3579.2"
                     /alternative_weights="3597.2"
     gene            7259..7924
                     /gene="nsoR2"
     CDS             7259..7924
                     /codon_start=1
                     /gene="nsoR2"
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 162.5; E-value: 1.8e-49)"
                     /gene_kind="regulatory"
                     /note="putative LanR response regulator protein"
                     /product="NsoR2"
                     /protein_id="ASY03216.1"
                     /transl_table=11
                     /translation="MENILVIDDDEKILELVQEVLKNEHYIVETRSYVDNTNIGEFEGF
                     DLILLDIMLPFLDGYEILERIKNIITCPVIFLSAKSSEGAKVKGLMSGADDYITKPFSI
                     RELVARVKVALRRNLKNGSNGILINGLVFNQDSNSIKLDNGEILLTKNEFRICKILVQN
                     SGKIFSKDELYEYLYDLDANAQLRTITEFIYSIRKKFKTLGLDPIKTIWGIGYKWDIK"
     gene            7909..9267
                     /gene="nsoK2"
     CDS             7909..9267
                     /codon_start=1
                     /gene="nsoK2"
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 64.6; E-value: 1.6e-19)"
                     /gene_kind="regulatory"
                     /note="putative LanK histidine kinase protein"
                     /product="NsoK2"
                     /protein_id="ASY03217.1"
                     /transl_table=11
                     /translation="MGYKIITMKRQLLLYLIKLFMGIVIIIICWLALTNIFVECGVIIP
                     ANYSETILEENRKRLDDIQQITDNDLPYGSKYSIFDLDYNYERGTMNKSDIEVTKKILL
                     GKESNLQGNYVYSVIARTEEYCVIKYNIKARFNSDNKIFNYIDYDNLSYITMVLVFLLY
                     VYIMTLHLVGIWKNNFEKIEKITLEIEKQNLDFTYEESKIKEFSNIITALIKMRDALKE
                     SLYQTWKIENEKNEEIAALAHDIKIPLTIISGNTELLKCYSSDEYSLSHLQSIWGAVGK
                     MEEYINLLIKYVKADRIDFHEKESMPCNSFSHKIVSEIKEYISGSEEIIKFNVEKVRGT
                     IKIDYISLERAIFNIIDNAIEYKVYGDKIMCFIGKKDDSYIFTICNEKGEFSSQVLENG
                     TKLFFTSNNNRNSIHYGIGLAYANKVIQSCEGELELYNSKEHGAVVSIKLPIT"
     gene            9639..12698
                     /gene="nsoB"
     CDS             9639..12698
                     /codon_start=1
                     /gene="nsoB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     826.3; E-value: 5.1e-250)"
                     /gene_kind="biosynthetic"
                     /note="putative LanB lantibiotic modification protein"
                     /product="NsoB"
                     /protein_id="ASY03218.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.9e-128,
                     bitscore: 419.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.9e-14,
                     bitscore: 44.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.9e-32, bitscore:
                     101.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNLYYNTQKFMFRIPTDVERKLDFTEDEIKNACLDAKFREKVSI
                     ASPALVDMMDLYIKNPEKLSEKKLVNFQNSIMKYLIRSKNRTTPFGLFSGVGLGKFGDS
                     DTFDVSGAKYQKKVNIDSEWLFGFISQLEKIKSQRLRFKINDACYIKGNRAILLYSTEK
                     EIEEISVRATRVFEIIYESCQEFKEYNQIAGIIEEEYPNVPNEKVTFYLNELISKEILI
                     SDLRPSLNSRDQIAYVIERLRESALFEEAGNIIEIRKMCTSYMNLPVGEGITLYDKIVS
                     KMKLLYSCSSYLQVDTVIENAEFEIKSTVANKINRLASFFVYISNDKNESHTYLDEYRN
                     KFIEKYGVDREVPLLEMLDSNIGIGAPTSYLNPQNDFFEEDSTKPNYNLRLKNYLLNKY
                     ESAITNKTSITLEQDEIEGILKREIKTDEVPISLELYFQLKKKNDELNLCLGPNCGSLV
                     AGKTFGRFSTISDEFADMLEDINKEERRLRDDNIEMCEIGFLPAPARNGNIVRTRTFRE
                     KKTVIFTAADKGTTDVINIKDISIGVFNELFYARDYKTKKLVVFESNNMYNPMLNPNIL
                     RFLQDISHEGKRSWSEFPWTYIFSEFRHVPAIKFEDIVIENEKWKLNLSEMRLEKKNFE
                     EFKCKFLQLIKDKNIPDDIYLTEADNRIKLDLKKELSIRIIFDEFKKHGSRDLILERAE
                     TGENITYSGEGGHTTEIVVPLFRKEKELQNIYPAEKVIIERKKHLELPFENWLYFNLYC
                     NSNREDELIAFDIMDFCEELKKKYDVDYFFMRYVDPKPHVRLRIKGTQEVLLQIYPLII
                     KWQHQLLDDGIIGDLKISIYDREIERYGGLHLMDIAEQVFFIDSFIVESILRMKRLGVL
                     AIDQEDIAIISIIMYTQGFYETFEEQMNFLAINYHTSDFMSEFKKKKQRLVSLCGCEND
                     WKELLSNEEGTSLYNLLNMRTVVLNKYRDEINNINQDPLFKNSIVASVIHLHCNRIIGT
                     DRELERKLMAFSESIMYAKRYIMKRNEDHE"
     gene            12682..14493
                     /gene="nsoT"
     CDS             12682..14493
                     /codon_start=1
                     /gene="nsoT"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 161.5; E-value:
                     4.5e-49)"
                     /gene_kind="transport"
                     /note="putative LanT lantibiotic transport protein"
                     /product="NsoT"
                     /protein_id="ASY03219.1"
                     /transl_table=11
                     /translation="MKIMNNKKVGFKEVWRALKQIPKTITIIRKVDKKGFTLIVMLSMI
                     AGAFPVITLVLSQELINSIVKKSSPLRYTIILFTIYIIVSFLGSILGEAKDYIESKFQY
                     VLQYKLNYLIMDKCTKLTLKDFETPAMYDKIEKITGEVAYKPYQIMIAIIGIITSVVTM
                     LSSAFLLFAWNPYISMLLLVVPIISMLYYLKIGQQEFEIMWNRAKDERKTWYLTYLLTH
                     DFSFKEISLLDLKDYFLKKYWSISALFIRQNTSILKRKTLFNILYELSIQIVSAIIIGV
                     AIMSAYVGEILVGNVMSYIRSVGLVQTNSQAIMSNIYTVYSSTLYMDMLFQFLNYCVKE
                     DSSEKIVMKEPINKIDIKELSFSYNGKTKVLDKINLTLVQGEKVALVGPNGSGKSTFLK
                     ILAGLYNIEEGEILINGRSLKDLDIRSYRSKMSVLFQDFVKYELSLRENIGFGDIQNLN
                     NDEKMVQMLHKLQTKFLQTDNGSYNLDLQLGNWFEDGCQLSQGQWQKIALGRVYFRDAS
                     FYILDEPNAALDTVSEREVFEKFFELSKDKIGVFISHRLNAAKMADKIIVMDKGKIVGI
                     GKHDELLRNCMTYQKLYKAESYEREDM"
     gene            14474..15820
                     /gene="nsoC"
     CDS             14474..15820
                     /codon_start=1
                     /gene="nsoC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140:Lanthionine synthetase C family protein (Score:
                     335.3; E-value: 8.3e-102)"
                     /gene_kind="biosynthetic"
                     /note="putative LanC lantibiotic modification protein"
                     /product="NsoC"
                     /protein_id="ASY03220.1"
                     /sec_met_domain="LANC_like (E-value: 3.1e-67, bitscore:
                     216.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKERTCRKMECDILAMTKNIATNLSDYERMLKIMGRKENQRTWEG
                     IEFEAFSPLTLSHGLPGICLLYGKLMECCPKEDKWGRFAHNYLSLMVEELNKKGFQSLS
                     MFSGAAGVALSVASVSNDFLNYNKLLNTLNDYILNRFEESYSNIVKEEGTHSLYYDVIE
                     GLSGVLSYLGIYRNQRKYYNVITRGLEILVNLTKDIEIQGQVVPGWYIPVQNQFSELEQ
                     DLYPKGNFNTSLSHGIAGPLIILSDMMANGIIVDGQEEAIIKIIKFLFDFKLNDGERDF
                     WKGQIDFDEVVNKKLTDENIIRRDAWCYGNPGICYAIVSAGNALDNQRLIDYGIENLRL
                     TMNNIKGIFSPTFCHGYAGLYQVLNSVEMLLQKEFFSLEKELLKNKIIDFYNPDYIYGF
                     KNMELDNKMEKIKPYDVCGLLEGTTGVCLSLLEGEKKSDNLWKKAFLLA"
ORIGIN
        1 gaatatccac ataaaaacag tgaagtaaag catgtaaatt tgctatctga taaaactgag
       61 tatggaatac agccacaaac ggatggatac tattattgga aagtcgatag taagacgaat
      121 cagggaacaa cttatggttc atggagattg ggacctcagg gtgccggccc aggtacagtt
      181 tctgtaaata aaacagatac agtgactaac acaattagtg gatcatatac cagtgtagga
      241 gatatatccg cttctttagg agctacgatt gggaagagcc agtcctattc tgtacagtac
      301 ccttaatttc cagcctgaga tgcttttagg gctatttcag gctggaaatt aagggatgtg
      361 caggatgttc ttgaattatt gtacacttta acgccagaac aattaaaagc ggtgaaacat
      421 atgatttcat cctatcttga attcaaagaa aatatggaag aacaaaatga gagattaaaa
      481 agtgggatat ccaataaatg gatgtcccct ttctgcttta catatcagca gtcaaaatta
      541 tggaatattt gtttatcatc ttagcatgta agaaaaccgt gaatgtcaac tgatattggg
      601 gtatttgttg aatgctgcaa atttggatac atttatgtgg agaaggatag gaccttacaa
      661 gttctatctt ttttgttatg caatttacaa tataaaaaat tttttaatct ttagaaaatc
      721 tttatagtta atcagtatac taaaaaaatc aattaaaagg agatgtataa taatatggaa
      781 acattactga gaacagagaa tttaacaaaa aaattcaaga atcaggtagc aatacaaaat
      841 atttcaatga atgtacctga aaattctgtc tatggccttt taggacctaa tggtgcagga
      901 aaatctacta cattaaaaat gatagctgga atcttgaaac ctaccagggg aagtattatt
      961 tttaataaac atccgtggaa aaggagtgac ttatcaaaca ttggtgcatt gattgaaaca
     1021 cctcctttat atggaaatct aactgcaaga gaaaacctta aggtaaggac tgagctgtta
     1081 aatatttcgg atggtcgtat tgacgaggtc cttgaaatat caggtttgac tggtacagga
     1141 aaaaagagag caggacagtt ttctatggga atgaagcaaa gacttggcat tgcaatagca
     1201 ttattgaata accccaaatt actaatatta gacgaaccta caaatggcct tgatcctgta
     1261 ggtattgaag agctgcgaaa tttaataagg cagtttccga agcaaggtat gacagttatt
     1321 ctatctagcc atatactatc ggaagtggaa cagattgcag attatatagg gataatatgt
     1381 aatgggaaat tggaatacga agcaccagag aacaaagaag ataatcttga agctttgttt
     1441 atggacatcg taaaaagaaa tagaagggag attatttaat gagatatata agatcagaaa
     1501 atttgaaata taaacggtct ttcagcagaa aattaatatt tgtggtaccc atcattacag
     1561 cttttgtagc tgttatattt ggtggaatta gaaattttca agcacaaact atatattggt
     1621 ggtatacatt tctcttaccg gggacggttg ccatatactg ttcattgtct gagaagaaag
     1681 aaaaaagtgt acgctatcac accttttata ccctatctat tgatttagaa aatgcttggt
     1741 atgctcgagt gttagttata gcatggtata tgcttttgac aggtattata ttagttcttc
     1801 cggcagtatc aatgaaaata tgggcaccgg ccatttgcca aatatctaac ggaaaattat
     1861 tacttggcag tatatgtatt gtagttatgt cattatggca aattcctatt ttgctttttt
     1921 ttaataaaag aataggtata cttttgccgc ttataattaa ttgtatgttg ccattggcta
     1981 tttctccgtt atctaatact gatctatggt tcttgatacc ttatagttgg gtctcaaaat
     2041 ctatgaaaag tattatcgga ttagacgtaa acggaacaat gacgaccgtt tcctcaaaag
     2101 attcattaga ctttactatt ggactcttat tatctgtttt actatttatt ataactgtta
     2161 ttattactgc aaaaaaattc agagaggtgg aaggatgaaa agtctttggt atgcaattaa
     2221 gtcggaagtt gtaaaattac gacatacccc tatttttttg ttgcacataa ttgtaccgct
     2281 tctaggaggg ttattatttg caatgtattt tcacttatat tcaggacaac aaagtataac
     2341 acaaagactg aatctaattt tacaggcaac atcagcattt ttccctcttg caatttctat
     2401 tgctgttagt ctaggtataa acttagaaga agaagggcat tttcaggcac tttttgtagg
     2461 tatggagagt aagagtaaat taattattgc aaagttaatt ctattcttag gaataggtgc
     2521 agtagccatt gtgattctct ttttaccaat tttattttca gtagcagtta tggatcaaga
     2581 gcttagtatt tctgttctta atacagtatt gtatagttat gtttatttag ttttaggtaa
     2641 cattgtaact tatataatcc atttttggtt atctctgaaa tcagggcttg gagcttcagt
     2701 tataacaggg gtgttggaaa gccttattgt tattttgttt agcaatcttc cgttgaagtt
     2761 agttattagt tgggaatata ttccttgggc gtgggcagta aatatgtgta gacaagaaat
     2821 tttgcaattt aacactcaac tctctactct tcaacccaat attatattta aagttatcat
     2881 tataacattt gtgttattgt tggtgttttg tatatggttt gagaaatggg aaggaagaaa
     2941 aaattatgaa gaatagtata ttaataaaaa gggtgattct ggtattttgt atgatatcta
     3001 taatgatcat tggttcaggt tgtgctgcta aaaagacagt tttagaaaac caaggtaaaa
     3061 cagaatgtta tttagacgag aaagatgcaa cgaaatttat atataatgga caacaataca
     3121 caatattaaa taatacagtg gataagaatt cattaggtga ttggattgga tttattcaaa
     3181 agtatgttgc acttgatgaa aattataaca tactaaaaaa atgtgatatg ggagtcaacg
     3241 tagtaggaga tttaagcgac ttaatagatc atacagatgg taccgcatat tatgtgccat
     3301 atttgaatgt atataagaca gaaaatgagg gggatatgaa taatttagtt gtagatgtag
     3361 ataacgattt ccataaagca attccatcag aaaatgcgaa agatggtgat ttaaagataa
     3421 tttttaaaaa tcaaaatgac accaaagata tagaaaatga tttaccacaa attgataaag
     3481 aagatgtgag gaatttgact tgggaaggta aaacatatca aattacagat caagttgtac
     3541 caaatgaaaa aataggcgat tatctatgta ctttatccgg aaatattact tttgatgcag
     3601 aaacaggcag ggaacttaca catgatgagt taaatgctat tgatataatt ccgggcgaac
     3661 tgtcaaacca aaaacgggag acttggatat atgattcggt atacaccgtt attggaaagg
     3721 ataaggatag tttggcagtt gaaattaatt ataaatgtgt atatgctata ttaaaagatt
     3781 agtatgggtc aaacttgtga ctataatatc taacaaataa aaattttaaa aggagaggat
     3841 atcttgatta aaattctagt tatagatgat gaagaggcaa tacttgagct tgtcaaacgt
     3901 ggactagaaa aggatggatt tgctgttgac actttgactt ctgcaaaaaa ggtggatgtt
     3961 agtaaactgc ggcaatataa tttgttgatt ttggatgtta tgatgccgga tattgatggt
     4021 ttcacatttt gcaaaaaaat ccgtgacata ttcaatgcac caattttatt tctgacagct
     4081 aaaacactgg aagacgaagt attatatggt ttaggtattg ggggagacga ttatattaca
     4141 aaacccttcc ggattaagga gttaagagct cgtgtaaaag cacacttaag gcgagagtcc
     4201 agagaaaatc atgattattt attttcagaa gatggaaata ttaagtttga tttgtcagca
     4261 aaaaagctat tggtttgtga aaaggaaatt cctttgacac atagcgaata caaaatatgt
     4321 gaattgctga tacagaatag aggacacgtt ttttccagag agaaaatata tgaacgagtt
     4381 tttggatttt atggagaatc agcagataat acaatagttg ttcatgttaa aaatatacga
     4441 gtgaaactaa gtgaagctgg tgtgaatcct atacagacag tgtgggggat aggatataaa
     4501 tgggagtaaa aataaaaaaa aggcagtatt ctctaaagtt tttttttata aagtttatat
     4561 tgtcattgat tataggagct ggagtgagta ttgccttacc gctggtcttg gcaacacttg
     4621 caagtaatat gggatatata actgttgcaa attataatga gatacaggct gagaaaacgg
     4681 caaaaatttt agaaacagaa aaaaatcctg actataagaa tattccagca gggataaaat
     4741 acttaataat tagcaaagaa ttcgatatct taaatactaa tatgagcaat ggggaacaaa
     4801 aagacgcatt gagatatgca aatggtaagt ttgagaaaac agcatcaggt aaacaattta
     4861 ttttagttac aagagataaa gaattctgta ttttacaata ttatattggt tctcatttca
     4921 ccaatatatg gttagatata catatgccat ctccagatat tttgattaat gcaggaatga
     4981 ttttaaattg tttatttgta tttagtatta tggtcttttt gtttgcaaaa gaactaagaa
     5041 aagagttgaa gccagtaatg gatgcgacta caaaaataga agagcaggag ctggaattta
     5101 atatttcatc atcgaggata atagaattta atgatatatt aaaatctatt tataatatga
     5161 aaaatagttt aaaaaagtct ttgaaaacgc aatggaatat agagtgtcag cagaaagaac
     5221 aaatttcggc attagcgcac gatttgaaga caccgttgac gatcataggt ggtaatgctg
     5281 atttattatc tgaaacaaat attaatcagg agcaagaaga gtatattaac catattttag
     5341 agagctctaa acgcatggaa aattacattg ctatattgat tgatctatcc aagaatactg
     5401 gtgagattcc gataaataga gaaagcatat ctattggaaa gtttattgat agtataaaag
     5461 gacagatgca gtctgtagtt gcaatgaaaa aaatgaattt aataattgca attatggatg
     5521 aatcttttag gatagagatt gatacagtat taatggaaag ggcgattata aatgttttat
     5581 caaatgccgt agatcattct cctacacatg gggagattat ttttaacgtg acgaaggata
     5641 aaggaaaatg taagattagt attatagatt caggtcctgg ttttacgccg gcagcattaa
     5701 aatatggttt agaaagattt tttatggatg ataagagtag aaattatcaa caccattatg
     5761 gaatggggtt atatattaca aattctattg tgacacagca tggtggaaaa gtagaattaa
     5821 aaaataaaag aggagcagaa gtagatatta ttatatagga aaaattcata gttcaggtta
     5881 gctctggtgg aatacaccag agttttttta ctttatagga ttagggtgtc aaaagcccat
     5941 tttaatattt gattttgctt gtaccttgaa aatttaacac gaatttgtga aagatataat
     6001 ttttgcgcct ataatttatt gatattttga aactgtggtt cattgatttt atgctgtttt
     6061 cttatttgaa gcatacgaat ccaagctatt gatataatct aatagctttt gaaaatctaa
     6121 tgctgctatt ttaaatccga agaataaccg ggtacgtttt ttgccatgca caggtatctt
     6181 gtccacatga tatcttcgac gaagaagaga gggaattgct tctactccat ttctaaattt
     6241 tgcgtattca gaatatagct agaaacgaca ttgtaaaaaa atatattaaa tttaggaacg
     6301 attttgatat tttgctgatt tttatattgt ataactaatt tatcaaaaag aaaggaggca
     6361 ccaaatggga aaatttgatg atttcgattt ggatgtaaca aagacagcag cacagggcgg
     6421 gatcgagccg aagtataaga gcaaatcagc gtgtacccca ggatgcccga caggaatcct
     6481 tatgacatgc ccacttaaga cagcaacatg cggatgccat atcacaggta aataataaag
     6541 aatacggagg aaaaaagatg gcaaaatttg atgatttcga tttggatgta acaaagacag
     6601 cagcacaggg cgggatcgag ccgaagtata agagcaaatc agcatgtacc ccaggatgcc
     6661 cgacaggaat ccttatgaca tgcccactta agacagcaac atgcggatgc catatcacag
     6721 gtaaataata aagaatacgg aggaaaaaaa gatggcaaaa tttgatgatt tcgatttgga
     6781 tgtaacaaag acagcagcac agggtgggat cgagccgaag tataagagca aatcagcatg
     6841 taccccagga tgcccgacag gaatccttat gacatgccca cttaagacag caacatgcgg
     6901 atgccatatc acaggtaaat aaagtttgga agtgaagcgt aatggcaaaa tttgatgatt
     6961 ttgatttgga tattatcgaa aaaaaagtaa gaagagatat tatacctgcg agtattacaa
     7021 gtcaacactc tttttgtacc cccaattgcc taacaggatt tctttgtcca ccaaaaactc
     7081 agcttacatg cacatgtaaa ttaaagggtc aataaatctg ttttagtgta catacataaa
     7141 aaagctctat tttgataata gagctttttt tacgagtaaa tgagtatttt ttacatgttg
     7201 ggtgattaat tactaatttt tgttattatt agttagtaaa aacataaagg agcagataat
     7261 ggaaaatata cttgtgattg acgatgacga aaagatttta gaattagtac aagaagtttt
     7321 gaaaaatgaa cattatatag tggaaacaag aagctatgtt gacaatacta atattggtga
     7381 atttgaaggg tttgacttaa tattattgga tattatgtta ccgtttttag atggttatga
     7441 aattttggag agaataaaaa acataataac atgtccggtg atctttttat ctgctaagtc
     7501 tagtgaagga gcaaaagtga aaggcctgat gagtggagca gatgattata ttaccaaacc
     7561 ttttagtatc agagagttag tagccagagt gaaagttgca ttaagaagaa atttgaaaaa
     7621 tgggagtaac gggattttaa tcaatggatt ggtgtttaat caagattcaa actcaataaa
     7681 attagataat ggtgaaattt tattaacgaa aaatgagttt cgcatatgta aaattcttgt
     7741 tcagaatagc ggaaagattt tttcaaaaga tgagctatat gaatacttat atgacttaga
     7801 tgccaatgca caattaagga ctataacaga gtttatttac tcaatcagaa aaaagttcaa
     7861 aacacttggt cttgatccaa taaaaactat ttgggggata ggttataaat gggatataaa
     7921 ataataacga tgaagagaca gttattactg tacttgataa aattgtttat gggaatcgtg
     7981 attataataa tctgttggtt ggctttaact aatatatttg tggaatgcgg agtgataatt
     8041 ccagcaaatt atagcgaaac tattttggaa gagaatagaa agcgtttaga tgatatacaa
     8101 cagataacag ataatgattt accatatgga agtaagtatt caatctttga tttagattat
     8161 aattatgaac gtgggactat gaataaatca gatatagaag taactaaaaa aatattatta
     8221 gggaaagaaa gtaatcttca agggaattat gtttactcag taattgctag aacagaagaa
     8281 tattgcgtta taaagtataa tattaaagca cgttttaact ctgacaataa aattttcaat
     8341 tatatagatt atgacaattt gtcgtatatc acaatggtat tagtgttttt actatatgtg
     8401 tatattatga cattacactt agttggcatc tggaaaaata attttgaaaa gatagagaaa
     8461 attacgctgg aaatagaaaa acagaatctg gatttcactt acgaagaaag taagataaaa
     8521 gaattttcta atattattac agcattaatt aagatgaggg atgcattaaa agagtcattg
     8581 tatcaaacct ggaagataga aaatgaaaaa aatgaggaaa tagcagcatt ggctcatgat
     8641 ataaaaatac cgcttacaat tatcagtgga aatacagagc ttttaaaatg ttattcatct
     8701 gatgagtaca gtttatctca tctgcaaagt atttggggag ctgtgggcaa gatggaggaa
     8761 tacattaatt tattaattaa atatgtgaaa gctgatagaa ttgattttca cgaaaaggaa
     8821 agtatgccct gcaacagttt ttctcataaa atagtctctg agattaaaga gtatatcagc
     8881 ggatctgaag aaataattaa atttaatgtt gaaaaagtga ggggcactat taagatagac
     8941 tacatatctt tagaaagggc aatttttaac attattgata acgcaataga atataaggta
     9001 tatggtgaca aaataatgtg ttttattgga aaaaaagatg attcttatat atttaccata
     9061 tgtaatgaaa aaggagagtt tagtagtcag gttcttgaga atggaactaa attatttttt
     9121 acttcaaata ataatagaaa ttcaattcac tatggtattg gcctagctta tgcgaataaa
     9181 gttattcaat cttgtgaagg ggaattggaa ctatacaatt ctaaagagca tggtgctgtg
     9241 gtaagcataa aattaccgat cacatagagg aaaaggggga aaccgtaaat ttggtcatcc
     9301 ccttttctta cttttacata tccgtgtcac tttctaatat aataagtaac tcttctaatg
     9361 atgcttcgtc tataaatttt ccttcgggag tatatgagta gccatataag atggttcctt
     9421 cgttttgcaa tgacatatgt gtgtacacta acttgtcttt tccaaatgct tcaatgtctt
     9481 ccttaacaga aagtagaagt tcttcttttg ttttcatgga aagggcgcct ttatcttttt
     9541 cttaagtata tcatatttta ggaatatgtt caaaaaatct tgatattttt ttgataattc
     9601 cactttatag ttgacttata acagattagg aggtagaaat gaaaaattta tactataata
     9661 ctcaaaagtt tatgtttcgt ataccaactg atgtagagag aaaacttgac tttacggaag
     9721 atgagataaa aaatgcgtgt ttagatgcaa agttccgtga aaaagtcagt atagcaagtc
     9781 ctgcattagt tgatatgatg gatttgtaca ttaaaaatcc agagaaatta tctgagaaga
     9841 agttagtaaa cttccaaaat tcaattatga aatatttgat taggagcaaa aatagaacta
     9901 caccatttgg gcttttttca ggtgtcggtc tgggaaaatt cggagatagt gatacttttg
     9961 acgtatcagg ggctaaatat caaaagaaag tcaatattga ttcagaatgg ctttttggat
    10021 ttatatctca gttagaaaag attaagtcac aaagacttag gtttaaaata aatgatgcat
    10081 gttatattaa aggaaataga gctattcttt tatattctac tgaaaaggaa atagaagaaa
    10141 ttagtgtaag agcgactagg gtctttgaaa ttatttatga gtcatgccag gaattcaaag
    10201 aatataacca gattgctgga atcattgaag aagagtatcc taatgtgcca aatgaaaaag
    10261 ttacttttta tttaaatgag cttatttcaa aagaaatact aatttcagac cttaggccgt
    10321 cgttaaattc aagagatcaa atagcatatg taattgagcg attaagagaa agtgcgcttt
    10381 ttgaggaagc aggaaatatt atagagataa gaaagatgtg tacctcctac atgaatttac
    10441 cagtaggtga agggataact ctgtacgata aaatagtatc taaaatgaag ctactgtatt
    10501 cttgctcatc ttacttacaa gtagatacag taattgaaaa tgctgagttt gaaataaaat
    10561 caacagttgc aaataagatt aataggttgg caagcttttt tgtttatata agcaatgata
    10621 agaatgagag tcacacttat ttagatgaat ataggaataa gtttattgaa aagtatggag
    10681 ttgacagaga agtaccatta ttagaaatgt tagattcaaa tattggaata ggagcaccga
    10741 cttcatatct taatccccaa aatgattttt tcgaggaaga ttctactaaa cctaattaca
    10801 atttaaggtt aaaaaattat ttgctgaata aatatgaatc tgctattacc aataaaacat
    10861 ctatcacttt agaacaggac gaaattgagg ggattctaaa aagagaaatt aaaacggacg
    10921 aagtccccat atcgttagag ctgtatttcc aacttaaaaa gaaaaatgat gaattaaatc
    10981 tttgtttagg tcctaattgt ggttcgcttg tagctggtaa aacttttggt cgattctcca
    11041 caatctccga tgaatttgcg gatatgttgg aagatattaa taaggaagaa agaagattac
    11101 gtgatgataa tattgaaatg tgtgagattg ggtttcttcc tgcaccggcc agaaatggaa
    11161 atattgttag aacccgcaca tttagagaaa agaaaacggt tatttttaca gcagcagata
    11221 aaggaactac tgatgttatc aatataaaag atatttccat aggggttttt aatgagttgt
    11281 tttacgcaag agattataaa acaaagaaat tagtcgtctt tgaatctaat aatatgtaca
    11341 atccgatgct aaatcctaat atattaaggt ttttacagga catatcacat gaagggaaga
    11401 gatcttggtc agaatttcct tggacatata tattctcaga gttccgccat gtaccagcca
    11461 taaagtttga ggatattgta attgaaaatg aaaaatggaa attaaacctt agtgagatgc
    11521 gattagaaaa gaaaaatttt gaggaattta aatgcaagtt tttacaactt ataaaagata
    11581 aaaacatacc ggatgatatt tatttaacag aagctgataa cagaataaag ctggacttaa
    11641 aaaaagaatt gtcaattagg attatttttg atgaatttaa gaaacatggt agtcgtgatc
    11701 tgattcttga aagagctgaa actggtgaaa atattactta tagtggtgaa gggggtcata
    11761 caactgaaat tgtagttcct cttttcagaa aagaaaagga actacagaat atttatccgg
    11821 cggagaaagt gattattgaa agaaagaaac atttagaatt accttttgaa aattggttat
    11881 attttaacct atattgcaat agtaatcgtg aagatgaatt gattgccttt gatatcatgg
    11941 atttctgcga agagcttaaa aagaaatatg atgtagatta tttctttatg cgttatgtag
    12001 atcctaaacc acatgtacgg ctacggataa aaggaacaca agaagtattg ttacagatat
    12061 atccgctaat tattaaatgg cagcaccaat tattggatga tggtataatt ggtgatttaa
    12121 aaatttctat atatgataga gagattgaac ggtatggcgg tttgcatctt atggatattg
    12181 cagagcaagt attttttatc gacagcttta ttgttgaaag tatcctcaga atgaagcgat
    12241 taggggtatt agctattgat caggaggata tagcaattat ctcaatcatt atgtatactc
    12301 agggatttta tgaaaccttt gaagaacaaa tgaattttct ggcaataaat tatcatacat
    12361 cagactttat gtcggaattt aaaaagaaaa agcaaagatt agtttcatta tgcgggtgtg
    12421 agaatgattg gaaagaatta ttaagtaatg aagaaggaac ttctctatat aatttattaa
    12481 atatgagaac agttgtactt aataaatata gggatgaaat caacaatata aaccaggatc
    12541 cgttgtttaa aaatagtata gttgcaagcg taattcatct acattgtaat agaataattg
    12601 gaacggatcg tgaactggag agaaaattga tggcattttc tgaaagtata atgtatgcta
    12661 agcgatacat aatgaagagg aatgaagatc atgaataata agaaagtagg ttttaaagaa
    12721 gtttggaggg ctttaaagca gatacctaaa actataacta taattagaaa agttgataaa
    12781 aaaggattta cacttatagt aatgctaagt atgatagcgg gagcttttcc tgtaataaca
    12841 ttggtattat cacaggaatt aattaactca atagttaaga aaagctcacc attacgatat
    12901 accatcattc tatttacgat ttatattatc gtttcatttt taggaagtat tcttggagaa
    12961 gcaaaagatt atattgaaag caaatttcaa tatgttcttc agtacaaatt gaattacttg
    13021 attatggata agtgtacaaa actgacatta aaagattttg agacgcctgc catgtatgat
    13081 aaaattgaaa aaatcaccgg agaagtggca tataagccat atcaaattat gattgcaatt
    13141 ataggaatta ttacttcggt tgtaacaatg ctatcttcag cctttttatt atttgcatgg
    13201 aatccatata tatctatgct attactcgta gttcctatta tatcaatgct atattactta
    13261 aaaatagggc aacaggaatt tgaaataatg tggaatagag ctaaagatga acgaaaaaca
    13321 tggtatctaa cgtatttact gacgcatgat ttttcattca aagagatatc cttattggat
    13381 ttgaaagact attttcttaa aaagtattgg agtattagtg ctcttttcat tcgccaaaac
    13441 acctccatcc tgaaaagaaa aacgttattc aatattctat atgagttatc tatacaaatt
    13501 gtgagtgcaa tcattatagg agtggctata atgtcagcat atgttggtga gattcttgtt
    13561 ggtaatgtta tgagttatat taggagtgta gggttagtac aaacaaattc tcaggcaata
    13621 atgtcaaata tttatacagt atatagtagt acattgtata tggatatgct ttttcaattt
    13681 ttgaattact gtgtaaaaga agatagttca gaaaaaatag tgatgaagga accaattaat
    13741 aaaatagata ttaaagaact ttcattttca tataatggaa aaacaaaagt attggacaaa
    13801 attaatctga cattggtaca aggcgaaaag gtcgctcttg taggtcctaa cggatcagga
    13861 aaaagcactt ttttgaaaat tttagccggg ctctataaca tcgaagaagg agaaatattg
    13921 ataaatggta gatcgttaaa agatttggat atcagaagtt atagatcaaa gatgtctgtt
    13981 ttatttcaag attttgtaaa atatgagctt agtttaaggg aaaatatcgg ctttggagat
    14041 attcaaaatc taaacaatga tgaaaaaatg gttcaaatgc ttcacaagtt acaaactaag
    14101 tttttgcaaa cggataatgg aagttataat ttggatttgc agctaggaaa ttggtttgaa
    14161 gatggatgtc aattgtctca aggacagtgg cagaaaatag cattaggaag agtttatttt
    14221 agagatgcat ctttttatat tttagatgag ccaaatgctg cacttgatac agtatctgaa
    14281 agagaagttt ttgaaaagtt ttttgaatta tcaaaagata aaattggcgt ttttatttct
    14341 catcgcctta atgcagcaaa aatggcagat aaaattatag ttatggataa gggcaaaatt
    14401 gttggaatag gcaaacatga tgagctactg cgaaactgta tgacatatca aaagctatat
    14461 aaagcggaat catatgaaag agaggacatg taggaaaatg gaatgcgata ttttagctat
    14521 gaccaagaac attgctacaa atttaagtga ttacgaaaga atgttaaaaa taatggggag
    14581 aaaagaaaac caacgaactt gggaaggaat agaatttgaa gcattttcac cacttacttt
    14641 gagtcatggt cttccgggga tttgtttatt gtacggaaaa ttaatggaat gttgtccaaa
    14701 agaagacaaa tggggacgat ttgctcataa ttatttatca ctaatggtag aagagctaaa
    14761 taaaaaggga tttcaaagtc tgtctatgtt ttcaggtgct gccggtgtgg ctctatcagt
    14821 agctagtgtt tccaatgatt ttttaaacta taacaaatta ctaaatacgt tgaatgacta
    14881 tattctaaat cggtttgaag agtcatacag taatatagta aaagaggaag ggacacattc
    14941 actctattac gatgtaattg aagggctgag cggtgttttg agttatctag gaatttatag
    15001 aaatcaaaga aagtattata atgtcatcac aagaggattg gagattcttg taaatttgac
    15061 taaagacatt gagattcaag gtcaagttgt tccgggttgg tatattccgg ttcaaaacca
    15121 atttagtgaa ttagaacaag atctttatcc aaaaggcaat ttcaatacca gtttatctca
    15181 tggtattgca ggaccattaa taattctttc agatatgatg gctaatggga ttattgtgga
    15241 tggacaagaa gaagctataa taaaaataat taaattcctt tttgatttta agttgaatga
    15301 tggtgaacgt gatttctgga aagggcagat agattttgat gaagtagtaa acaaaaaatt
    15361 aaccgatgaa aatattattc ggcgagatgc atggtgttat ggaaatccgg gaatatgtta
    15421 tgcaattgta tcggccggta atgctttaga caatcagcgt ttgattgatt acggaataga
    15481 aaatttgaga cttacaatga acaatattaa aggtattttt tcacctacat tttgtcatgg
    15541 atatgctggt ctataccaag tattaaattc ggtagaaatg ttgttacaaa aggagttttt
    15601 ttctttagaa aaggaactct tgaagaataa aataattgat ttttataatc cggattatat
    15661 atatggattt aaaaatatgg agcttgacaa taaaatggag aaaataaaac catatgatgt
    15721 atgtggactg ttagaaggaa cgaccggcgt atgtctctct cttcttgaag gagagaagaa
    15781 gagcgataat ttatggaaga aagctttttt attggcataa aaagatagga taggagtaaa
    15841 cggtgaatag taagtactaa gattttcgct agttttcatg agataattac tttgaaaaat
    15901 ctaagatttt ttagagaaat tatctcatgg ataaaataac tcataaagtt cgatgtgaac
    15961 aatggacaaa tatcatcaaa gaatgtcttg ctagtggaat gcccaaaatg acttggttcc
    16021 gagagcatgg tatttcagat aaatcatttt tttactggca acgaattctc cgagaagaag
    16081 catacctctc tacattagag aacaccttga cgccagctgt taaagaaaat tcagttccaa
    16141 caactacaga tttcgttgaa atcaaaatga ctgatcacac aagttcatct gccagtcctt
    16201 ttaaaccgga tgttgttatt
//
