BGC0001708 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001708 (Aspergillus novofumigatus IBT 16806)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	32,997	novofumigatonin	PKS+terpene	100%

BGC0001708 - Region 1 - T1PKS

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Location: 1 - 32,997 nt. (total: 32,997 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 32,998
Label		BGC0001708

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001708	1.00	Polyketide, Terpene	novofumigatonin	Aspergillus novofumigatus IBT 16806
BGC0001360	0.36	Polyketide	mycophenolic acid	Penicillium roqueforti FM164
BGC0000104	0.32	Polyketide, Terpene	mycophenolic acid	Penicillium brevicompactum
BGC0002619	0.30	Polyketide	mycophenolic acid	Penicillium brevicompactum
BGC0002616	0.28	Polyketide	mycophenolic acid	Penicillium roqueforti
BGC0001677	0.28	Polyketide	mycophenolic acid	Penicillium roqueforti
BGC0002734	0.23	Polyketide	2,4-dihydroxy-5,6-dimethyl benzaldehyde	Aspergillus terreus NIH2624
BGC0001219	0.23	Polyketide	shanorellin	Chaetomium globosum CBS 148.51
BGC0002290	0.22	Other	biscognienyne B, eutypinic acid, compound 3, 4-hydroxy-3-prenylbenzoic acid, prenylhydroquinone, compound 15, compound 8, compound 7, compound 6, compound 11, compound 12, pestalodiol E	Biscogniauxia sp.
BGC0000156	0.21	Polyketide	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001708	1.00	Polyketide, Terpene	novofumigatonin	Aspergillus novofumigatus IBT 16806
BGC0001360	0.69	Polyketide	mycophenolic acid	Penicillium roqueforti FM164
BGC0000104	0.66	Polyketide, Terpene	mycophenolic acid	Penicillium brevicompactum
BGC0002619	0.63	Polyketide	mycophenolic acid	Penicillium brevicompactum
BGC0002616	0.62	Polyketide	mycophenolic acid	Penicillium roqueforti
BGC0001677	0.62	Polyketide	mycophenolic acid	Penicillium roqueforti
BGC0002734	0.56	Polyketide	2,4-dihydroxy-5,6-dimethyl benzaldehyde	Aspergillus terreus NIH2624
BGC0001219	0.56	Polyketide	shanorellin	Chaetomium globosum CBS 148.51
BGC0002290	0.55	Other	biscognienyne B, eutypinic acid, compound 3, 4-hydroxy-3-prenylbenzoic acid, prenylhydroquinone, compound 15, compound 8, compound 7, compound 6, compound 11, compound 12, pestalodiol E	Biscogniauxia sp.
BGC0000156	0.54	Polyketide	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 5866 - 32997:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

P174DRAFT_455569

PKS_AT (887..1172): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 58.3%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 67.2
inactive: 41.4
Methoxymalonyl-CoA: 39.6
Methylmalonyl-CoA: 30.9
fatty_acid: 18.0
Propionyl-CoA: 16.1
2-Methylbutyryl-CoA: 12.9
Benzoyl-CoA: 10.9
CHC-CoA: 10.6
Ethylmalonyl-CoA: 10.5
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0