BGC0001716: odilorhabdin NOSO-95A biosynthetic gene cluster from Xenorhabdus nematophila AN6/1
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Location: 2,367,833 - 2,440,325 nt. (total: 72,493 nt).
This entry is originally from NCBI GenBank LN681227.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
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Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC

MIBiG accession | BGC0001716
Short description | odilorhabdin NOSO-95A biosynthetic gene cluster from Xenorhabdus nematophila AN6/1
Status | Quality: questionable The quality level of this entry. Status: active The status of this entry. Completeness: unknown Whether the entry covers everything needed for the pathway producing the compound(s)

Biosynthetic class(es)

- NRPS (Type I)

Loci
LN681227.1
2379690 - 2423130
via
Compounds

- odilorhabdin NOSO-95A
- odilorhabdin NOSO-95B
- odilorhabdin NOSO-95C

Species Xenorhabdus nematophila AN6/1 [taxonomy]
References

- [1] Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site. Pantel L et al., Mol Cell (2018) PMID:29625040

Chemical products information
odilorhabdin NOSO-95A Evidence:
Copy SMILES
C54H101N23O14
Chemical database entries
PubCHEM
odilorhabdin NOSO-95B Evidence:
Copy SMILES
C54H101N23O13
Chemical database entries
PubCHEM
odilorhabdin NOSO-95C Evidence:
Copy SMILES
C54H101N23O12
Chemical database entries
PubCHEM
List of genes involved in compound(s) production

Identifiers | Position | Product | Functions | Evidence | Extra
--- | --- | --- | --- | --- | ---
XNC2_2360 CEK23354.1 | 2379690 - 2380187 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
XNC2_2361 CEK23355.1 | 2380489 - 2380842 (+) | conserved hypothetical protein |  |  | copy AA seq copy Nt seq
XNC2_2362 CEK23356.1 | 2380899 - 2381462 (-) | conserved hypothetical protein |  |  | copy AA seq copy Nt seq
XNC2_2363 CEK23357.1 | 2381416 - 2381721 (-) | conserved hypothetical protein |  |  | copy AA seq copy Nt seq
XNC2_2364 CEK23358.1 | 2381705 - 2381791 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
XNC2_2365 CEK23359.1 | 2381852 - 2384257 (-) | putative Aculeacin A acylase precursor [Contains: Aculeacin A small subunit; Aculeacin A large subunit] |  |  | copy AA seq copy Nt seq
XNC2_2366 CEK23360.1 | 2384254 - 2385213 (-) | putative Clavaminate synthase |  |  | copy AA seq copy Nt seq
XNC2_2367 CEK23361.1 | 2385295 - 2386038 (-) | conserved hypothetical protein |  |  | copy AA seq copy Nt seq
XNC2_2368 CEK23362.1 | 2385975 - 2386235 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
XNC2_2369 CEK23363.1 | 2386114 - 2387742 (-) | putative transport proteins (ABC superfamily, membrane (N-terminal), atp_bind (C-terminal)) |  |  | copy AA seq copy Nt seq
XNC2_2370 CEK23364.1 | 2387833 - 2398761 (-) | putative Phenylalanine racemase (ATP-hydrolyzing) |  |  | copy AA seq copy Nt seq
XNC2_2371 CEK23365.1 | 2398758 - 2402174 (-) | conserved hypothetical protein |  |  | copy AA seq copy Nt seq
XNC2_2372 CEK23366.1 | 2402174 - 2412007 (-) | putative Ornithine racemase |  |  | copy AA seq copy Nt seq
XNC2_2373 CEK23367.1 | 2412004 - 2420325 (-) | putative Ornithine racemase |  |  | copy AA seq copy Nt seq
XNC2_2374 CEK23368.1 | 2420470 - 2420925 (-) | conserved hypothetical protein |  |  | copy AA seq copy Nt seq
XNC2_2375 CEK23369.1 | 2420944 - 2421801 (-) | conserved hypothetical protein |  |  | copy AA seq copy Nt seq
XNC2_2376 CEK23370.1 | 2421823 - 2423130 (-) | Diaminobutyrate--2-oxoglutarate transaminase (Diaminobutyrate--2-oxoglutarate aminotransferase) (L-2,4-diaminobutyric acid transaminase) (DABA aminotransferase) |  |  | copy AA seq copy Nt seq

Biosynthesis information

#### Biosynthetic modules

Name
Unk01
Type
nrps-type1
Genes
XNC2_2370
Substrates
N6-hydroxylysine, lysine (evidence: Structure-based inference [1])
Integrated Monomers
Domains
adenylation
Name
Unk02
Type
nrps-type1
Genes
XNC2_2370
Substrates
beta-hydroxyarginine, dehydroarginine, arginine (evidence: Structure-based inference [1])
Integrated Monomers
Domains
adenylation
Name
Unk03
Type
nrps-type1
Genes
XNC2_2370
Substrates
N6-hydroxylysine, lysine (evidence: Structure-based inference [1])
Integrated Monomers
Domains
adenylation
Name
Unk04
Type
nrps-type1
Genes
XNC2_2371
Substrates
histidine (evidence: Structure-based inference [1])
Integrated Monomers
Domains
adenylation
Name
Unk05
Type
nrps-type1
Genes
XNC2_2372
Substrates
glycine (evidence: Structure-based inference [1])
Integrated Monomers
Domains
adenylation
Name
Unk06
Type
nrps-type1
Genes
XNC2_2372
Substrates
ornithine (evidence: Structure-based inference [1])
Integrated Monomers
Domains
adenylation
Name
Unk07
Type
nrps-type1
Genes
XNC2_2372
Substrates
proline (evidence: Structure-based inference [1])
Integrated Monomers
Domains
adenylation
Name
Unk08
Type
nrps-type1
Genes
XNC2_2373
Substrates
lysine (evidence: Structure-based inference [1])
Integrated Monomers
Domains
adenylation
Name
Unk09
Type
nrps-type1
Genes
XNC2_2373
Substrates
3R-hydroxy-2,4-diaminobutyric acid, 2,4-diaminobutyric acid (evidence: Structure-based inference [1])
Integrated Monomers
Domains
adenylation
Annotation changelog

#### Entry version: 3

Date
Changes
Submitters
Reviewers
2022-09-15
Add compound details

- (ID: SJG3CBEHSM6A3I74YXLH6GLA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

2022-09-15
Added NRP substrate specificities

- (ID: SJG3CBEHSM6A3I74YXLH6GLA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

2022-09-15
Switch to GenBank accessions

- (ID: SJG3CBEHSM6A3I74YXLH6GLA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

#### Entry version: 2

Date
Changes
Submitters
Reviewers
2019-10-16
Migrated from v1.4

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

#### Entry version: 1

Date
Changes
Submitters
Reviewers
2018-08-06
Submitted

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

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