LOCUS       BGC0001717             19662 bp    DNA     linear   PLN 24-APR-2018
DEFINITION  Penicillium simplicissimum DNA, okaramine biosynthetic gene cluster,
            complete sequence, isolate: AK-40.
ACCESSION   BGC0001717
VERSION     BGC0001717
KEYWORDS    .
SOURCE      Penicillium simplicissimum
  ORGANISM  Penicillium simplicissimum
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Penicillium.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 16:08:15
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 2898
            Orig. end    :: 22560
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(1..6075)
                     /gene="okaA"
     CDS             complement(join(1..147,214..5589,5653..6075))
                     /NRPS_PKS="Domain: AMP-binding (230-624). E-value: 1.5e-87.
                     Score: 285.7. Matches aSDomain:
                     nrpspksdomains_okaA_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (771-835). E-value: 3e-12. Score:
                     38.5. Matches aSDomain: nrpspksdomains_okaA_PCP.1"
                     /NRPS_PKS="Domain: Condensation_DCL (882-1149). E-value:
                     1.8e-28. Score: 91.4. Matches aSDomain:
                     nrpspksdomains_okaA_Condensation_DCL.1"
                     /NRPS_PKS="Domain: PP-binding (1445-1507). E-value:
                     1.1e-10. Score: 33.8. Matches aSDomain:
                     nrpspksdomains_okaA_PP-binding.1"
                     /NRPS_PKS="Domain: Condensation_DCL (1586-1857). E-value:
                     5.3e-27. Score: 86.5. Matches aSDomain:
                     nrpspksdomains_okaA_Condensation_DCL.2"
                     /codon_start=1
                     /gene="okaA"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     258.3; E-value: 1.9e-78)"
                     /gene_kind="biosynthetic"
                     /product="nonribosomal peptide synthetase"
                     /protein_id="BBB04327.1"
                     /sec_met_domain="AMP-binding (E-value: 4.9e-97, bitscore:
                     313.9, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 2.7e-33, bitscore:
                     104.2, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.4e-11, bitscore:
                     33.8, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVNLDFEVEPCLFPSLSTRSVNQSHGKAMAYQHGFEWEVTISEDS
                     VFQGIVLSWNILLAKYTDSTTITFGVISGSEGNKCHDDTTVDEYCTSFHPESCLPTVLP
                     LASRRQYRFHEWKYDARINTCIANGSHKVWLDHWINSPNHGIKLILVVEQGRWPCMSLY
                     GKPSFIDEGSVRLLCTAFQHILDCVLENQMGLLKNIEVTPSHHYQRILDWNSHIPKEPL
                     AECIHDLIQRRCMETPDAEAICAWDGTMSYAALEQESARTMEWLQHHGVGPETIVPLLF
                     EKSKWTVVAVLGVLKAGAAFVLLETSHPIERLKSICHDIGACIILTSALCKEIGSNLAD
                     ITMSVPCDVERKLPCGDGKMKPCIRAQPRNAAYVAYTSGSTGKPKGVIIEHASFCTNAM
                     VSSEAQNLNGCSRVLQFASYAFDVSIHETLVPLMLGGCVCIPSASQRVNSLQEAIVQLR
                     VNWMELTPSVTRLLSPHKIPNVKTLVVGGESISPAELARWAGHIRLNVAYGPAECTVVS
                     MVQSNVTKHGDPLSIGRGCGGSVWIVEPQNHNVLVPIGAPGELLIGGPIVGRGYLNRPE
                     QTAAVFIQNPPWQAENNSRFYKTGDVVRQNSDGSVVFLGRKDTQVKLRGQRIELGEIEY
                     QASGFFPGAAVAVEVGKLYHGHPALVLFVEWKSLENRKRCSGTNCCRTVQNDKTHFMSN
                     AQWAKAGLSQILPSYMVPDIIVPLCTIPLSHSAKVDRKALRAMITRWSKDEVKLYQVTA
                     NSTSCGRYPHHAGQKYDEMVRMVARVLSLDPSEVREHDNFFQLGGDSLSAIMLSREIDT
                     IPLLSLTVADIFQSASIAELFHRSQKTPLPESMEPGIPTKVLPFSLLDPMKIDNYRERA
                     AEHCGVSPSQIEDIYPCSPLQARLMARTSRQPGAFQGHFNFRLSLDTDWDRLHWAWNKA
                     ADFLPILRTRIINTWQLAEGNPLQVVVRDKDIEWVEVAASESEPKSRMSFGSPLIYCVA
                     VRAKHSPVLILNIHHALFDLVVFEQILEAVKAAYQGKPLVWRPFSPFIKYVQDLNRSQA
                     NEFWKREFTGLRAVPFPADITPGRSNLDAIRWTRKSFCLGHQNQAGITLSSLIRLAWAM
                     VLSQYTGSLDVVFGTTVMGRNMPGTADVGGPTIATYPLRITLRGEESIKEALQRIQNHG
                     IAIAPFEQSGIQHIRHSSPESAIACSFRNMLVIQPSSDNSLLAKRDLSPLLVLEERGSW
                     KQKSYVNFSTQALNVVCEPGAGHLDVSAYFDQSILSSQEVEEMLSCMDRLLQLVLQHPD
                     ASMGTILSQSQSPDGDLDRYEERTSLARLEQEACQYLGNGVRVAAVWIIPMASHVPKLA
                     LFVGAMSLNTVSDGRWILAGVKEPLRTRLVQMMHEFQNNPLGRAVPFCCIPVPLQYRPS
                     MPGLFLDRARAQEAASKFTLKTLTSWQNTGDSGFEEPLLPLEATLRRALAKVLSLEPEA
                     IGVNDDLVSLGCDSLVAMQFAAQCDRQSLRLTISEIFQATSLRCLASTLNSRPSGDPTP
                     ALEAFALLKPMYGDRESFEQDIQRSVDGWNIKESIDAFPCTTAHLGLLSGLGTCQSHTI
                     WEIGSPEEQIDLVSFAKAWLNLVNRHAALRTLLLPSRSNPSEWLHVVLKSSPVGVKVVT
                     KLKNASLLKIARKPLLSRDGLGGLPYRFAVYQSTTGRTLCKLEARYAFLDAFSVLVLMK
                     ELRRILDCLPTSDPLLPSYSSWVAYLRRWSEDPLHLQFWDRYLAGLKPCILRASRNHHH
                     HQHEGRQHHGASETNGNRPRLIKSHRQIVVQDAVALRKYCDQRELTITNILQVAWALTL
                     KEQTGIEDICFGALVSGRDVPVDHVGNIVGSLFNVLACRIQMPATDSISSVLLENQQMM
                     RERASHQFCSLQEVTRLVLKARPEASSLFNTCLSVEQPLSDEAETGKGFRALETVEETE
                     YDLIVAATVFPDRIQASIMYWSYFCDPARAATIAETFAQSIERIILCA"
     misc_feature    1..19662
                     /note="okaramine biosynthetic gene cluster"
     subregion       1..19662
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="NRPS"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..19662
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     aSDomain        complement(442..1254)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_okaA_Condensation_DCL.2"
                     /domain_subtypes="Condensation_DCL"
                     /evalue="5.30E-27"
                     /label="okaA_Condensation_DCL.2"
                     /locus_tag="okaA"
                     /protein_end="1857"
                     /protein_start="1586"
                     /score="86.5"
                     /tool="antismash"
                     /translation="EQIDLVSFAKAWLNLVNRHAALRTLLLPSRSNPSEWLHVVLKSSP
                     VGVKVVTKLKNASLLKIARKPLLSRDGLGGLPYRFAVYQSTTGRTLCKLEARYAFLDAF
                     SVLVLMKELRRILDCLPTSDPLLPSYSSWVAYLRRWSEDPLHLQFWDRYLAGLKPCILR
                     ASRNHHHHQHEGRQHHGASETNGNRPRLIKSHRQIVVQDAVALRKYCDQRELTITNILQ
                     VAWALTLKEQTGIEDICFGALVSGRDVPVDHVGNIVGSLFNVLACRIQM"
     CDS_motif       complement(451..546)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_okaA_0008"
                     /evalue="6.00E-07"
                     /label="C5_DCL_263-294"
                     /locus_tag="okaA"
                     /protein_end="1854"
                     /protein_start="1822"
                     /score="22.0"
                     /tool="antismash"
                     /translation="DICFGALVSGRDVPVDHVGNIVGSLFNVLACR"
     CDS_motif       complement(1180..1251)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_okaA_0007"
                     /evalue="4.40E-05"
                     /label="C2_DCL_024-062"
                     /locus_tag="okaA"
                     /protein_end="1611"
                     /protein_start="1587"
                     /score="15.8"
                     /tool="antismash"
                     /translation="QIDLVSFAKAWLNLVNRHAALRTL"
     aSDomain        complement(1492..1677)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_okaA_PP-binding.1"
                     /evalue="1.10E-10"
                     /label="okaA_PP-binding.1"
                     /locus_tag="okaA"
                     /protein_end="1507"
                     /protein_start="1445"
                     /score="33.8"
                     /tool="antismash"
                     /translation="TLRRALAKVLSLEPEAIGVNDDLVSLGCDSLVAMQFAAQCDRQSL
                     RLTISEIFQATSLRCLA"
     aSModule        complement(1492..3366)
                     /domains="nrpspksdomains_okaA_Condensation_DCL.1"
                     /domains="nrpspksdomains_okaA_PP-binding.1"
                     /incomplete
                     /locus_tags="okaA"
                     /tool="antismash"
                     /type="nrps"
     aSDomain        complement(2566..3366)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_okaA_Condensation_DCL.1"
                     /domain_subtypes="Condensation_DCL"
                     /evalue="1.80E-28"
                     /label="okaA_Condensation_DCL.1"
                     /locus_tag="okaA"
                     /protein_end="1149"
                     /protein_start="882"
                     /score="91.4"
                     /tool="antismash"
                     /translation="EDIYPCSPLQARLMARTSRQPGAFQGHFNFRLSLDTDWDRLHWAW
                     NKAADFLPILRTRIINTWQLAEGNPLQVVVRDKDIEWVEVAASESEPKSRMSFGSPLIY
                     CVAVRAKHSPVLILNIHHALFDLVVFEQILEAVKAAYQGKPLVWRPFSPFIKYVQDLNR
                     SQANEFWKREFTGLRAVPFPADITPGRSNLDAIRWTRKSFCLGHQNQAGITLSSLIRLA
                     WAMVLSQYTGSLDVVFGTTVMGRNMPGTADVGGPTIATYPLRITL"
     CDS_motif       complement(2575..2664)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_okaA_0006"
                     /evalue="1.40E-06"
                     /label="C5_DCL_263-294"
                     /locus_tag="okaA"
                     /protein_end="1146"
                     /protein_start="1116"
                     /score="20.8"
                     /tool="antismash"
                     /translation="DVVFGTTVMGRNMPGTADVGGPTIATYPLR"
     CDS_motif       complement(3193..3279)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_okaA_0005"
                     /evalue="6.10E-01"
                     /label="C2_DCL_024-062"
                     /locus_tag="okaA"
                     /protein_end="940"
                     /protein_start="911"
                     /score="2.5"
                     /tool="antismash"
                     /translation="FRLSLDTDWDRLHWAWNKAADFLPILRTR"
     aSDomain        complement(3508..3699)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_okaA_PCP.1"
                     /evalue="3.00E-12"
                     /label="okaA_PCP.1"
                     /locus_tag="okaA"
                     /protein_end="835"
                     /protein_start="771"
                     /score="38.5"
                     /tool="antismash"
                     /translation="MVRMVARVLSLDPSEVREHDNFFQLGGDSLSAIMLSREIDTIPLL
                     SLTVADIFQSASIAELFHR"
     aSModule        complement(3508..5322)
                     /complete
                     /domains="nrpspksdomains_okaA_AMP-binding.1"
                     /domains="nrpspksdomains_okaA_PCP.1"
                     /locus_tags="okaA"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(4111..4176)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_okaA_0004"
                     /evalue="1.90E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="okaA"
                     /protein_end="634"
                     /protein_start="612"
                     /score="39.0"
                     /tool="antismash"
                     /translation="FLGRKDTQVKLRGQRIELGEIE"
     aSDomain        complement(4141..5322)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_okaA_AMP-binding.1"
                     /evalue="1.50E-87"
                     /label="okaA_AMP-binding.1"
                     /locus_tag="okaA"
                     /protein_end="624"
                     /protein_start="230"
                     /score="285.7"
                     /tool="antismash"
                     /translation="QRRCMETPDAEAICAWDGTMSYAALEQESARTMEWLQHHGVGPET
                     IVPLLFEKSKWTVVAVLGVLKAGAAFVLLETSHPIERLKSICHDIGACIILTSALCKEI
                     GSNLADITMSVPCDVERKLPCGDGKMKPCIRAQPRNAAYVAYTSGSTGKPKGVIIEHAS
                     FCTNAMVSSEAQNLNGCSRVLQFASYAFDVSIHETLVPLMLGGCVCIPSASQRVNSLQE
                     AIVQLRVNWMELTPSVTRLLSPHKIPNVKTLVVGGESISPAELARWAGHIRLNVAYGPA
                     ECTVVSMVQSNVTKHGDPLSIGRGCGGSVWIVEPQNHNVLVPIGAPGELLIGGPIVGRG
                     YLNRPEQTAAVFIQNPPWQAENNSRFYKTGDVVRQNSDGSVVFLGRKDTQVKLR"
     CDS_motif       complement(4267..4356)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_okaA_0003"
                     /evalue="4.30E-16"
                     /label="NRPS-A_a6"
                     /locus_tag="okaA"
                     /protein_end="582"
                     /protein_start="552"
                     /score="51.0"
                     /tool="antismash"
                     /translation="PIGAPGELLIGGPIVGRGYLNRPEQTAAVF"
     CDS_motif       complement(4840..4899)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_okaA_0002"
                     /evalue="9.00E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="okaA"
                     /protein_end="391"
                     /protein_start="371"
                     /score="30.5"
                     /tool="antismash"
                     /translation="AYVAYTSGSTGKPKGVIIEH"
     CDS_motif       complement(5101..5139)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_okaA_0001"
                     /evalue="1.90E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="okaA"
                     /protein_end="304"
                     /protein_start="291"
                     /score="11.8"
                     /tool="antismash"
                     /translation="LGVLKAGAAFVLL"
     gene            order(6981..7134,7219..7817,7882..8219,8301..8562)
                     /gene="okaB"
     CDS             join(6981..7134,7219..7817,7882..8219,8301..8562)
                     /codon_start=1
                     /gene="okaB"
                     /gene_functions="other (smcogs) SMCOG1087:hypothetical
                     protein (Score: 231.1; E-value: 4.1e-70)"
                     /gene_kind="other"
                     /product="flavin monooxygenase"
                     /protein_id="BBB04328.1"
                     /transl_table=11
                     /translation="MTVHSAESNGSNRIVIIIVGLGIAGLSAAIECHGKGHQVMVFEKY
                     SDLKRTEGDGISIGSNGARVSAKWGDGTFHELIRPLEYQTNKAKVSDYTGYSYGTFELH
                     GYNEGRGYTVNRGQLVYAMHEYARSLGIPIFLNSEVTGYWETEDEAGVVVDGKRISADC
                     VVCAEGIHSSGRLIITGQKMELKETGYAASRGYLDACVTSQDSKLNWILGEEEAEAEDC
                     VYGWLGPGVHFGITTKKRENELFWYCSHKDACTPSKDIDGTINQILHCMEGWAARDQLE
                     TVMRKAKKGRFVSETLAIRTPLATWLSPKRRMIVIGDAAHAALPSSGQGGTQAIEDAAT
                     LAICLELAGKKDVALALSVTEKLRHQRAQIVQQGGLAVLQFVMNHVDFEALRTDPTMVK
                     PPHPAWILDHDCQEYAYREFVKAAEAIQDGEEYVPHNIPRDGKYSMEYNSQ"
     gene            complement(8961..10315)
                     /gene="okaC"
     CDS             complement(join(8961..9111,9177..10315))
                     /codon_start=1
                     /gene="okaC"
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     dmat"
                     /gene_kind="biosynthetic"
                     /product="dimethylallyltryptophan synthase"
                     /protein_id="BBB04329.1"
                     /sec_met_domain="dmat (E-value: 3.6e-123, bitscore: 400.5,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVTKEAPEVMPFEGLTEEINLMSDNERVWWQKTGSMLSRVLSSA
                     DYTWKEQHKHLKFYAQVLLPHLGPYPQSFRSSITRSGLPFELSINYQQNGNPLVVRIGF
                     EPLNALSGTPDDPFNQAPAAEVLSLLDQMHIPGFDSQIWDKAVEHHTVNHTEREALRDS
                     DLGAGYIRSQTAYGFDLLRDGNIAVKGYSFPALKCQITGQSMAQMMAGLVADLAPLVDC
                     SQAFAIVDEYLQDTGYDERAFFSWDFVEPSRSRLKLYTGSSSVTWGKLAEVWTLGNRVQ
                     NPTVARGLEYLRQLFDLIKLSDGQRNIVVAFDDRQDSSKETPLLWNYEMRAGDPTPLTK
                     IYFPVHGENDLQVINGVAEFLCQIGLSHGKTYVEKVKSYYPGIDLSTTERFTSWVSFAY
                     TEKTGVYLSTYYHSSTDNPWKMTTEEDSQL"
     gene            10816..12405
                     /gene="okaD"
     CDS             10816..12405
                     /codon_start=1
                     /gene="okaD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 145.6; E-value: 3.8e-44)"
                     /gene_kind="biosynthetic-additional"
                     /product="cytochrome P450"
                     /protein_id="BBB04330.1"
                     /sec_met_domain="p450 (E-value: 2.9e-58, bitscore: 186.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASEIYRRLPMELPAQHLLASLALVGALLSVGYLLLRPAKYQLPL
                     PPGPRGLPIIGNLHQAPKEKAWEVYKQWSDRYGPIMSVNNGGMITIIVSSHEVVKNFLE
                     KNNAVFSSRPQLLVLERALYGFTTPALPYGEKWLKHRALRGAVLKPAMAVRYRGLQDLE
                     SKQLLRDLLYSEDFTQCMRRQAASLFLGIAYGNRFPEETPEIIDIDQAVAQLGGISESM
                     FQGTGMLREFFPVLKYFPGYDKFLKQLDDVGERLANIYVRRFRDGLSTPAWNWAKEYSK
                     RPEAQGMGELELSFCIGSTYQASLTPYEILRIILLAAICHPEEKARLQKEIDLVVGKDN
                     LPGWEHKDRIQFVQAFIYEALRWHAFSPLGAPRAVSRDIEYKGYFIPKGATLVLNQWAM
                     DHDENVYDNPFTFRPQRWIDNPDLPHVIFGFGLRGCPGQHLARDHLFINTARLFWAFNF
                     GNAYENGKKVELDLDELMQPRGGGSAFNQVPSFKASVIIRSSERRQIVENEWDAVEKDE
                     QKILAEAMPLPE"
     gene            13483..14385
                     /gene="okaE"
     CDS             13483..14385
                     /codon_start=1
                     /gene="okaE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /product="alpha-ketoglutarate-dependent dioxygenase"
                     /protein_id="BBB04331.1"
                     /sec_met_domain="PhyH (E-value: 3.7e-22, bitscore: 68.5,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLTENVMKPQIQRFTRDHDPKVLWQVVEEDGAVIIEGFLPHEVI
                     QKFDCELDVRSKATKGGEMNQEFYQMPVPTTTKWMNDLTATCPTFRHEILNNDILHSLC
                     NVAFEPHGDYWLLNGMAMEMMPGNPTQQIHNDHGTHPILQYLRPDAPAPVFSIITAVTE
                     FTESNGATRVILGSHRWPQGQKAKDDQAVRAALQPGDALVMHRSTKHGGAAHDADNQDH
                     RRLLLTCMGTCQLAPYETNVTVPRPIVESMTPLAQKMIGWRSTRPVISNVTGLNTVRMK
                     HLENQIELKSNVPLNVGGC"
     gap             15554..15745
                     /estimated_length=192
     gene            order(15979..16119,16214..16334,16416..16539,16595..17357)
                     /gene="okaF"
     CDS             join(15979..16119,16214..16334,16416..16539,16595..17357)
                     /codon_start=1
                     /gene="okaF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 183.7; E-value:
                     8.9e-56)"
                     /gene_kind="biosynthetic-additional"
                     /product="methyltransferase"
                     /protein_id="BBB04332.1"
                     /transl_table=11
                     /translation="MEAIAQEIQKLHANTDEAGRGKINHDLSVLLASFDTDWEKILKLA
                     AGPLRLALVKVGVDQGIFHALNERSHTLPELIEKTGVAPYLLERILRGQASFGMIKEEG
                     AKGFAANRFTTLLAGPNTSGAVTYIFDILRPIASAIPGFLSERNNPAITSTHDTVFQRA
                     FNTELGGFEWMTGHPEHYGNLFQFLALRPNCEWVDAFPIEAEIGSFTNDPHVEKVLLVD
                     VGGGTGAQSVAFRKKLPHVKGRVIVQEIAETLIHVGAKAPAGIEFMEYDCFTPQPIRGA
                     KFYYLRYVMHLWQDERCVEALKVIITAMGPESRLIIDEAVIPDRDVPWQAACQSILMTA
                     ALAGAERTLTEWHNLLDAAGLKILNIFPYDLNMQSVIIAVPK"
     gene            complement(17776..19662)
                     /gene="okaG"
     CDS             complement(join(17776..18243,18350..18682,18738..18973,
                     19022..19403,19465..19662))
                     /codon_start=1
                     /gene="okaG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 107.7; E-value: 1.2e-32)"
                     /gene_kind="biosynthetic-additional"
                     /product="cytochrome P450"
                     /protein_id="BBB04333.1"
                     /sec_met_domain="p450 (E-value: 1.2e-35, bitscore: 111.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLISPLAAVLSAMAIVLGLLFFPNMTPQPTLHPRVGWRKEKAST
                     LRAALRSCYKLNDWALEGYNAYAKLNIPYVLPSFDRGPITIIPARLMRRLYTLPDTDLD
                     IRMTQQETNQTRWVAWDKKPAEDTFVWDVLRKQITRNLRQLTPIVASEIELSFNRWWGT
                     DKEWKSIDIWDSCWKIVTGGINTTLCGSPLCRDAEFLQSCQNHSLVLVAGAMAINGAPR
                     LLQPIIGGLVWFVCAILFNTTMKRSKAVVQERLEKTAMLRAEPAYDWKPPQDAIQWIID
                     DLYASDNLTQLNVKTICFRLLLLNDVSIPSTSFSVQTLLLNLFAADPALGFLEALREEC
                     QTVYTESGGVWTYDALKKLKITESAIRESLRLSPVGGIGLHRTVVNPKGISLPDYRLNL
                     PHGTVIASPIESIHYDDDIYPHANDYNAFRFADPEAVRAILDKLSSEPNSNISTGGPRD
                     RESKSAASTANIDEAFLAFGIGKHICPGRFFVMVEMKLILAIILVHYDVKPVKFKPKLV
                     DCLWLKVPWNSGTLVVRRRSN"
ORIGIN
        1 ctacgcacat aaaatgatgc gttcaatcga ctgggcaaat gtctccgcaa ttgtagcagc
       61 acgggctgga tcgcaaaagt aagaccaata catgatgctg gcctggatcc tgtccgggaa
      121 tacagtggcg gcaacaatca agtcgtactg aaatacaatt agcaagggat gtcagcctgt
      181 gcaaatagga cacacgagac tcccgtctct tacctcggtt tcttccacgg tttcgagcgc
      241 tctaaacccc ttgcctgttt cggcctcatc cgacagcggc tgctcgaccg acagacaggt
      301 gttgaataat gacgaggcct cgggcctggc cttgagaact agccgtgtca cttcctgtag
      361 ggagcaaaat tggtgcgaag ctcgttcacg catcatctgt tggttttcca gaagaacgga
      421 gctgatgcta tcggtggccg gcatctgaat gcgacacgcg aggacattga agagtgatcc
      481 aacgatattg ccaacatgat ccacgggcac atcgcggccc gaaaccagcg ctccaaagca
      541 gatgtcctct atcccagtct gctccttcag cgtaagtgcc caggctacct ggaggatgtt
      601 ggttatggta agttcccgtt gatcacaata cttgcgtaag gcgacggcat cttgtactac
      661 aatttggcgg tgagatttta tcaagcgagg gcggtttcca ttggtttcac tggctccatg
      721 atgctggcgg ccttcgtgct ggtgatggtg gtgatttcga gatgcgcgta gaatacaagg
      781 cttgaggcca gcgagatatc ggtcccagaa ttgtagatgc aacggatctt cactccatcg
      841 acgtaaatag gcaacccatg aagaatagga gggtagcaat ggatcagaag tcggaagaca
      901 atcaagaata cgtcgaagtt ccttcatgag gactagcaca gagaatgcgt cgaggaaggc
      961 atacctggcc tcgagcttgc agagagtcct tcccgtggta ctttgataga ctgcgaatct
     1021 gtaaggaaga ccccctagac catctctcga tagaagaggc ttcctagcaa tcttcaaaag
     1081 actggcattc ttcaacttcg ttaccacttt tacaccgacg ggagatgact tcagcactac
     1141 gtgaagccac tcagacgggt ttgaacgact gggaaggaga agggttcgaa gtgcagcatg
     1201 gcgattcacg aggttcagcc aagctttggc aaagcttaca agatcgatct gctcctcagg
     1261 actcccgatc tcccagatcg tatgggattg acaggtgcca agtccagaaa gaagcccgag
     1321 gtgggcggtg gtgcatggga atgcatcaat tgattctttg atattccacc cgtcgacaga
     1381 cctttggata tcttgctcaa atgactctcg gtccccgtac atcggcttca gcaacgcaaa
     1441 agcttccaat gctggtgtgg ggtcaccgga cggacgacta ttcagcgtcg atgcaaggca
     1501 tcttagcgag gttgcctgga agatctctga gatcgttaac ctcaagcttt gtcgatcaca
     1561 ctgagcggca aactgcatgg cgacaagtga atcacatcct agggaaacca gatcgtcgtt
     1621 gaccccaatt gcctcaggct ccagagatag cactttagct aaagcccgtc tcaaagtcgc
     1681 ctcaagaggc aacaagggct cctcgaaacc agaatctcct gtattttgcc atgatgtcaa
     1741 cgtcttcagc gtgaatttcg acgcagcctc ttgtgcacga gcccggtcaa ggaagagacc
     1801 aggcatggac ggtctatact gtaatggcac gggaatacag cagaatggaa ccgctcttcc
     1861 gagcggattg ttttggaact catgcatcat ctgaaccagg cgagtacgta gaggctcttt
     1921 cacacccgcc agtatccatc taccgtctga tacggtattc aaactcatgg caccgacaaa
     1981 aagcgccagt ttggggacat gggatgccat gggaataatc cacactgcgg ccacccggac
     2041 cccgttcccc agatactggc aagcctcctg ttccaatctt gccaatgatg tgcgttcctc
     2101 atagcgatcc aaatctccat caggagactg gctttgagaa agaattgtcc ccattgaggc
     2161 atcagggtgt tgcaagacga gctggagtag acgatccatg caggaaagca tttcttctac
     2221 ctcttgtgac gacaggatac tttggtcgaa atacgctgac acgtctaaat gaccggcgcc
     2281 cggctcgcac acaacattca acgcctgggt gctgaaattc acatatgact tctgcttcca
     2341 agagccacgt tcctccaata ccaacaatgg tgacaagtcc cgcttcgcca ggaggctgtt
     2401 atccgacgac ggctgaatga ctagcatgtt tcggaaactg caggcgatgg cggactcggg
     2461 gctagagtgt cggatatgtt gaataccaga ctgttcgaaa ggggctatgg caatgccatg
     2521 gttctgaatc ctctgtagtg cttctttgat actttcttcg ccccggagag taatacggag
     2581 gggatatgta gcgatggtgg gcccaccgac atctgcagtg ccaggcatat tgcggcccat
     2641 gacagtggta ccgaacacca cgtcaagaga gccggtatac tgcgagagca ccatggccca
     2701 tgccagacgg atcaaggaag ataatgtgat tcctgcttga ttctgatggc cgagacaaaa
     2761 gcttttgcga gtccagcgga tggcgtcaag atttgacctt ccaggggtaa tgtccgcggg
     2821 aaatggaact gcccggagac cagtgaattc ccgtttccag aattcatttg cttgagatct
     2881 gttcaggtct tgaacgtatt taatgaacgg cgaaaacggt cgccagacaa ggggtttgcc
     2941 ctggtatgcg gctttcactg cctcgaggat ctgctcgaat acaaccaagt cgaataatgc
     3001 gtggtgaata ttgaggatca ggacggggct gtgcttagca cgcactgcaa cacaataaat
     3061 taggggagaa ccgaatgaca tgcgactctt tggttcgctc tcgcttgctg ctacttcgac
     3121 ccactcgatg tctttgtcgc gaacgactac ctgaagagga ttgccttcgg ccagttgcca
     3181 cgtattgata attctagtgc gcaaaatagg caggaaatcg gcagctttgt tccaagccca
     3241 gtgcagtcga tcccaatcgg tgtcgaggga caagcgaaag ttgaaatgcc cttgaaatgc
     3301 gcctggctga cgggaagttc tggccatgag gcgtgcctgc agcggcgagc atgggtatat
     3361 atcctcaatt tgagatgggc ttacaccgca atgctctgct gcacgttccc tgtagttgtc
     3421 gatcttcatc gggtccaaca aggagaatgg caaaactttt gtaggtatgc caggctccat
     3481 agactctggc agaggcgtct tctgtgagcg atgaaaaagc tcggctatcg aagcactttg
     3541 gaaaatatcc gccactgtta aggagagcaa tggaatagtg tctatctccc tagaaagcat
     3601 gatggcggac agcgaatcac cacccaactg gaagaagtta tcatgctccc taacctcgct
     3661 cggatcaagc gatagtacac gagcaaccat tcgaaccatt tcatcgtatt tctgcccagc
     3721 gtgatgtggg tatcggccac agctggtgga gttcgctgtg acctggtata atttcacttc
     3781 gtccttggac cagcgggtta tcatggctcg caaagccttc cggtccactt tggctgaatg
     3841 tgaaagaggg atagtacaca agggaactat aatatcgggg accatatagg aaggcaatat
     3901 ctgcgagagc cctgccttgg cccactgcgc attggacata aaatgagttt tgtcattttg
     3961 gacggtccgg caacaatttg tcccactgca tctttttctg ttctccaacg acttccattc
     4021 cacaaacaga actagagccg gatggccatg gtaaagcttg ccaacctcca cagctaccgc
     4081 agcaccagga aagaagcccg aggcctgata ttcgatctcc cccagttcaa tacgctggcc
     4141 tcgcaatttc acttgcgtat ccttgcggcc tagaaagacg acactgccgt cggaattctg
     4201 acgcaccaca tcgcccgtct tgtagaagcg cgaattgttt tccgcttgcc acggcgggtt
     4261 ttggatgaag acagcggcag tctgttcggg ccgattcagg taacccctgc ccacaatggg
     4321 acctccgatg agaagctcac ccggtgcacc gattggtacc agcacgttgt ggttctgtgg
     4381 ctccacgatc cacacagacc ccccgcatcc ccgaccgata gataacggat cgccatgttt
     4441 cgtcacattc gattgtacca tagagaccac ggtgcattcc gcgggaccgt aagccacgtt
     4501 gagacgaatg tgacctgccc agcgggcgag ctctgccggc gagatggact cgcccccaac
     4561 gaccagtgtc ttgacattgg ggattttgtg gggactcaga aggcgagtta cggagggagt
     4621 aagttccatc caattgacac gcagctggac aatcgcttct tggagactat ttaccctttg
     4681 tgacgccgag ggaatacaaa cacagcctcc gagcatgaga ggaaccaagg tttcatggat
     4741 actaacatcg aacgcgtatg atgcgaattg tagcactctg gagcagccgt tcaggttttg
     4801 agcttcggag ctgaccatcg cattggtgca aaacgaagca tgttcgatga taaccccctt
     4861 cggcttccct gtcgatcctg acgtataagc cacgtacgcc gcatttctcg gttgagcgcg
     4921 aatacaaggt ttcatctttc cgtcaccgca tggtagcttt cgctcgacat cgcaggggac
     4981 tgacattgtg atatcggcca gattcgagcc gatttctttg cagagtgcgg aagtcagaat
     5041 aatacaggcc ccaatatcat ggcagatgct tttaagtcgt tcaatgggat gcgaagtctc
     5101 gagcagtaca aacgcagctc cggctttgag tacccccaat acggccacca ctgtccattt
     5161 gctcttctcg aacaacagcg ggacgattgt ctcgggtcca accccatgat gctgcagcca
     5221 ttccatggtc ctagctgact cctgttccag ggcggcataa gacatggtac catcccaggc
     5281 gcagatggct tctgcatctg gagtttccat gcatcttctc tgaatgaggt catggatgca
     5341 ttctgccaac ggttctttgg gtatatgtga gttccaatcg agaattcgtt gatagtggtg
     5401 actaggagtt acttcgatgt tcttcagcag tcccatctgg ttctccaata cacaatcgag
     5461 aatatgctgg aatgccgtac acaacaagcg aacagatccc tcgtcgatga atgatggttt
     5521 tccatacaag gacatgcatg gccatctccc ctgttctact accaggatca gtttaatccc
     5581 atgattaggc tgagtcaata gacgttagcg tatccaacca aggttatatt ttcctcaatt
     5641 ggtatgactt actgaattaa tccagtgatc cagccagact ttgtgcgaac catttgcaat
     5701 gcaggtatta attcgtgcgt cgtacttcca ctcgtgaaac cgatattgac gcctgctggc
     5761 cagaggaagc acggttggca aacagctctc tgggtgaaag gaagtacaat actcgtccac
     5821 ggtcgtatca tcgtgacatt tattgccctc ggagccagat ataacgccaa atgtgatggt
     5881 agtcgaatcc gtatatttag ccagtaaaat attccaagac agcacgatac cctgaaagac
     5941 agagtcctct gagattgtta cctcccattc gaaaccatgc tggtaggcca ttgccttgcc
     6001 gtgtgattga ttgacagaac gagtagatag gctgggaaag aggcatggct caacctcaaa
     6061 atcaaggtta accatttcgt ccaaacgccc ctttctgatg cttttggtct aattctcacg
     6121 gatggcgaag gtagttagtt cacttgaaaa ttggctgctt tcaatttcta ctccgtctgg
     6181 gagaaaatga caagcgtggt aaagtatgat cagtatcagg ggatgaaaca tttgacctat
     6241 ctcgaatttg cgtatctaag taggtactgg aaatacacgg gatgtatgtg ccgcagttga
     6301 ataagatgtg tcacaccctg gaagtacatg agccagatgg ctactccact tcacagctca
     6361 gccaccatag caatagcgtg tgtgaaaggg cttgcatgac tgatctaggt taggttttgg
     6421 ggggaaaggc ttgggattct gcagtgcaga tccctgctgc agccgcaggt gaacgacata
     6481 tgtcaaatcc tggatggaca cgagccagat ggctactcca cttcatagct cggctacatt
     6541 caagacagcg tacgtgtagg ggacttgcat ggcggatcta gatcaggtgt gggtaagggg
     6601 tgaggaattt tgcagcgcaa attcctggta caagccctca tatgggaatg ctcgttcact
     6661 agctagaatc acaccaatac ctaatatcta gtctaatcac atcatctttc aattatttcg
     6721 ggtgctgcaa ggtagcatcg cagtaagtta ctgaaatatt atgtattatc ctgcaatttt
     6781 caaataaccc cctgacctta cctcggtatc ggcagcatgg tcccctattc tcaattccaa
     6841 gggtgtcagt agtaatactc atgaagtttt ccaaagatca acccgccacc tgcattcact
     6901 tcactagatt ccattacaac tttcagaaat tcttttactc gggcctaagt ttcttgccaa
     6961 aactagcact tatatcgacc atgactgtcc acagtgcaga gtcgaacggt tctaacagga
     7021 ttgtaatcat tatcgttggt ctggggatcg ctggcttgag tgccgctatc gagtgccatg
     7081 gaaagggcca tcaggtcatg gtatttgaaa aatattctga ccttaaaagg acaggtaagt
     7141 agcgtattca ttggggctac aaggactccc gataagaatg ccatctactt acgaaaatcg
     7201 tcgttccgcc cccaacagaa ggcgacggta tcagcattgg atccaacggc gcgcgagtga
     7261 gcgcgaaatg gggcgatggt accttccacg aattgatccg accgctggag tatcaaacca
     7321 acaaggccaa agtctctgac tacactgggt attcctatgg gacattcgaa cttcacgggt
     7381 acaacgaggg tcgagggtat acggtcaacc gggggcaact ggtgtacgcc atgcacgagt
     7441 atgcccgaag cctcggtatc ccgatctttt tgaattctga agtaacggga tactgggaga
     7501 ccgaggatga ggccggggtt gtggtcgacg ggaaacggat ctcggcggac tgcgtcgttt
     7561 gtgcggaagg cattcacagc tcgggtagat tgatcatcac tggtcagaag atggaactca
     7621 aggaaactgg atatgcggcc tcccgagggt atttggatgc ttgtgtgaca tcccaagact
     7681 caaaactaaa ttggatcttg ggcgaggaag aagctgaagc cgaggattgt gtctatggat
     7741 ggcttggccc cggagtccac tttgggatca cgaccaaaaa gagagaaaat gagctctttt
     7801 ggtactgctc gcataaggta agtggtacta tcgcttttcc ttgtcttgga gtaatccatt
     7861 cacagggcct ttcatcgaca ggacgcatgt accccttcga aagacatcga cgggaccatc
     7921 aaccaaattc ttcattgcat ggagggttgg gctgcccgag accaactcga gaccgttatg
     7981 aggaaagcaa agaaaggccg attcgtgtcg gagactttag ctattcgaac acccttggca
     8041 acctggttgt ctccgaagcg ccgaatgatc gttatcggcg atgcagccca cgccgcgttg
     8101 ccgtccagcg gccagggtgg gacacaggcc atcgaggatg ccgccacact cgctatttgc
     8161 ctagagttgg cgggaaaaaa ggacgttgca ctggcgttgt ccgtcacgga aaagttaagg
     8221 tattacatct cagcatactt cccatcattt ctcattagat ttgttggcta atatcgggtc
     8281 ctctggcaaa aatgagctag gcaccaacga gctcagattg tgcaacaagg tggcctggcg
     8341 gttctgcagt ttgtgatgaa ccatgtcgat ttcgaagctc tgcgaacgga cccgacgatg
     8401 gtgaagccac cgcacccggc ttggatcctg gaccatgact gccaggagta tgcctaccgg
     8461 gaattcgtca aggctgcaga ggcgatccag gatggcgaag agtatgttcc tcataacatt
     8521 cccagggatg gcaagtatag catggagtac aacagccagt agacatgatc tttagctact
     8581 gtctcattgt ggtacttggt atcgagttgg gcgttgcttg ttggatatcg tggccaaatt
     8641 accatggggt taaaggggga atataaagac atagattact gggccaccga atgaagcaag
     8701 aattcggtca agaagtttat gcagaaatgt cgaattttcc agacttgcgt tcctaaataa
     8761 tcaacaggtc accaagcagc tttctctaaa ataagggcct taatttgatc tttcttgaaa
     8821 catacctacc atttggtcta cattcccgtg agacaaaccc ttctatcata tgatgttata
     8881 acactgccca aggacataaa tctttagtta tatttgcctc tgttctgcct ttgttccagc
     8941 tcggactaat atcaccaatt ctaaagctga ctatcctcct cagtcgtcat cttccacggg
     9001 ttatccgtcg aggagtggta gtaggtactc aaatagacac ccgtcttctc agtgtaagcg
     9061 aaagaaaccc acgaggtgaa acgctcggtc gtgctgagat cgattccagg actgcaaatg
     9121 atattgttag tgcaagcttc gtccactgtg aggccctagg gataaaaatg acatactaat
     9181 aagatttgac cttctccaca taggtttttc cgtgactaag accaatctgg caaaggaatt
     9241 cggccactcc attgattact tgcagatcat tctcgccatg aacggggaaa taaatctttg
     9301 tcagtggtgt cggatcgccc gctcgcattt cataattcca gagcaaaggc gtctccttgg
     9361 atgagtcttg gcggtcgtca aaggccacaa caatgttgcg ttgaccatcc gagagcttga
     9421 tgagatcgaa cagctgacga aggtattcca accctcgggc cacggtcggg ttttggaccc
     9481 ggttgccgag cgtccagact tcggccaatt tcccccacgt cacgctgctg gagcccgtgt
     9541 agagcttgag gcgggatcgg gagggttcaa caaagtccca tgagaagaaa gctctctcat
     9601 cgtatccagt gtcctgtaag tactcgtcaa cgatcgcaaa tgcttgcgag cagtcaacaa
     9661 gaggtgcgag atccgcaacc aatccagcca tcatctgggc catggactgt cctgtgattt
     9721 ggcatttcag ggcgggaaaa ctgtagcctt tcacggcaat gttaccatct ctcagaaggt
     9781 cgaagccgta cgcagtttga gatcggatat agccagctcc cagatcactg tcccggagtg
     9841 cttcccgctc tgtatggttc accgtatgat gctcgacggc tttatcccag atctggctat
     9901 cgaagccggg aatgtgcatc tggtccagca acgataggac ttccgcggcg ggagcctggt
     9961 tgaatgggtc atccggggtg cctgacagag cattaagtgg ttcgaagccg atccgcacca
    10021 ccagagggtt tccattttgc tggtaattaa tgctcagctc gaaagggagg ccgctgcggg
    10081 tgatggaact tcggaatgat tgcggatacg gccccagatg ggggagaaga acctgcgcat
    10141 agaacttcag atgcttgtgc tgctccttcc aggtgtagtc ggcagaagac agcactctcg
    10201 agagcatgga gcctgtcttc tgccaccaga ccctttcgtt gtcgctcatg agattgatct
    10261 cttcagtcaa accctcgaag ggcatcacct cgggggcttc tttggtgact gtcattttgg
    10321 gtgagacttg aactgatgat tgcgagagtt caccatctct ctcctgtgat ctaaactact
    10381 tatcctcatg gcggggagaa cggagtaatg atgtcctgag tctttgtgta tcgacgaatt
    10441 gaaaaatact caatacatct ccttgcatgg aatcctaatc agtgaaagcc ttcgtccatc
    10501 acagcaatgt tgacctagtc accggataga acgaaataag caaaaagtga ttattgaagc
    10561 cgtgcatgga gaaacgttac acagcaggat gtcgagacct tagtgtaacg tcaaagtcaa
    10621 ggccgcgagc gtcccgctgc cttgtcactc gcccttgcag caaggagcat gtatgcggaa
    10681 tcgaggtccc aaaatgcaag agtcgagaga cgtgatgggt ttgtttatca tcagatggag
    10741 cagatcttgg gataactata cacaaaggta caggacgcca cgggtttctg cacgccgtac
    10801 tctcttcctg ttgcaatggc gtccgagatc tatcgccgac ttcccatgga gctacctgcg
    10861 cagcatttgc tggcgagtct cgctttggtt ggagctcttt tgtcagttgg ctatctactg
    10921 ttgcgacccg caaaatacca gctacctctt ccccctgggc cccgaggcct gcccatcatt
    10981 ggaaatcttc accaggcccc aaaagagaaa gcctgggaag tctacaagca atggagcgat
    11041 cgctacggcc caattatgtc ggtgaacaat ggcggtatga tcacaatcat cgtcagttcg
    11101 cacgaagttg tgaaaaattt cctagagaaa aacaatgcgg tcttcagcag ccggccccag
    11161 cttcttgtac tcgaacgggc tctatacggc ttcacgactc cggctctgcc ttacggagag
    11221 aagtggctca agcatcgcgc actccgtggc gcagtcttga agccggctat ggccgtgaga
    11281 tacaggggcc ttcaagacct ggagtccaag caactcctca gggaccttct ctatagtgaa
    11341 gatttcacac agtgcatgcg ccgtcaggcc gccagtctgt ttcttggtat cgcatacggg
    11401 aacagatttc ctgaggagac gccggagatc atcgacattg atcaagccgt ggctcagctg
    11461 ggcggcattt ccgagtctat gttccaaggc acgggcatgc ttcgcgaatt tttccccgtt
    11521 ttgaaatact tccccggtta cgataagttc ctgaaacagc tcgatgatgt gggcgagcgg
    11581 ctagcaaata tctacgtgcg tcgcttcaga gacgggttga gcacaccggc gtggaactgg
    11641 gccaaagaat actcgaaaag gcctgaggct cagggtatgg gggagctaga gttgtcgttc
    11701 tgtattggct ccacctatca ggcttcccta actccatacg agattctgcg aattatcctg
    11761 ctggctgcta tctgtcatcc tgaagaaaag gcccggctgc aaaaggagat tgacctggtc
    11821 gtggggaagg acaatctccc cggctgggag cacaaggacc ggatccaatt tgtccaggcc
    11881 ttcatatatg aggctctgcg atggcacgct ttctcgcctc tgggggcccc acgtgccgtg
    11941 agccgagata tcgaatacaa gggatacttc atacccaagg gtgctacact tgttctcaac
    12001 caatgggcta tggaccacga cgagaatgta tacgacaatc cctttacctt ccggcctcag
    12061 cgatggattg acaatcccga tctgccccac gtcattttcg gtttcgggct gcgtggctgc
    12121 cccggacaac atctggctcg tgatcacctg ttcatcaaca ccgctcgtct gttctgggcc
    12181 ttcaatttcg gcaatgctta cgaaaacggc aaaaaggttg agttggacct cgatgagctg
    12241 atgcagccac gtgggggcgg atcggctttc aatcaggttc cttccttcaa ggcttcagtt
    12301 atcattcgaa gttcggagcg gaggcagatt gtcgagaacg agtgggatgc ggttgagaag
    12361 gatgagcaga agattcttgc cgaggcaatg cccttaccgg aataagaatc caaagggggt
    12421 ttccgtccgc agtatctatc ttcatgtacc tttcaaagca tgtttcgccg gtcaatgatg
    12481 acttttctat gtaatgctcg gattcatgcg tagatttaca acttcatagg tttaaaacct
    12541 tcagttggtc catcgatgtt tccaaccaac ttcaatcttt gtgggtatcc gttcattagg
    12601 tacgtttcga ttagaatttg ttactactac cacggctcat ttgtaagtcg ataaatatta
    12661 cactgtttta ccaaaacctg cactggcatc gttacccaac acatatctag gtatttacgt
    12721 agtctcacga cctatgatat gatcgatctc aaagcttaga acattatata cggaaaggaa
    12781 ggtatggaga gagtgagtga gtgagacaat acgatcatat gaaggctccc aaataaattg
    12841 ttgctggtga gttgtcaaat tgtagttatc atcatcactt catggtttcc gtgagggtgg
    12901 ctggttcgtg atggcagatg gcttgtggat aggttacgtt cggcccattt gtgggtagcc
    12961 agaaaattca ttcctctgct gtctggagta gcgtgaactt tcctgggttc tatttctgct
    13021 gtgctaccag tgaaggacgc atggtaagat cgtatctaga ctatcggcca gcatgcatag
    13081 gacaggtgca acgttatgca gtatctatgc acagtcgcta caatgagacc tcaagatcgg
    13141 ccacatgaca ccaacaagta aaggggagct gaagagtcac gcttaccgcc attccagtct
    13201 gtgccaggag gatgtaggta tcttgaagca gatatgcgtg agtttcgaga gccaaacagt
    13261 caccctgacc gccagtccag catgcttcag gaaagtgtgg gtatttcaag caagaccatg
    13321 cttcattggc agcgtcattc ccgagtgata tagccactcc tagtatagaa agctacaccc
    13381 agccatcaaa attctagcct tttcagcgaa agtctacatc catttttcgt cgcttccggg
    13441 ctctagttac cgttttgcag cttgaaatag cccttaagca tcatgactct caccgaaaac
    13501 gtcatgaagc ctcaaattca gcggttcacc cgcgaccacg acccaaaagt tttgtggcaa
    13561 gtggtggaag aagacggggc agtcattatt gaggggtttc ttccccacga agtcattcaa
    13621 aaatttgatt gcgagttgga tgttcgttcc aaagcgacca agggcggcga gatgaatcaa
    13681 gaattctatc agatgccggt ccctaccaca accaaatgga tgaacgatct cacggccacc
    13741 tgcccgacct ttcgacatga gattctcaac aatgatatcc ttcacagtct ctgcaatgtt
    13801 gccttcgagc cccacggtga ctattggttg ttgaacggaa tggcgatgga gatgatgcca
    13861 ggcaacccga cgcagcaaat ccacaacgac catggtacac atcccatcct gcagtatctt
    13921 aggcccgacg caccagctcc cgtcttcagc atcatcacgg cggtgacaga attcactgag
    13981 tccaacggcg ccacacgggt catcctgggc agtcaccgct ggccacaggg acaaaaagca
    14041 aaggatgatc aggcggtgcg tgccgccctg caaccaggag acgcactggt tatgcatcgc
    14101 agcacaaagc atggtggggc cgcgcacgat gcagacaacc aggatcaccg gcggcttttg
    14161 ttgacctgta tgggcacctg ccagctagcg ccatatgaga caaatgtgac cgtgccgcgc
    14221 cctattgttg agagcatgac tcctctggcg cagaagatga ttgggtggcg cagtaccagg
    14281 cccgtgattt ctaatgtgac agggctgaat actgtccgta tgaaacatct ggagaatcaa
    14341 attgagctga agtcgaatgt cccgttgaac gttggaggtt gttgaatctg tttgtagtga
    14401 tccgcgccta tttgaggaat cttgcactag gaccaacgcg gtttaggcca acactacggg
    14461 gggcgatcgc tgccaacctc gccatatcga caatttttgt tagtaatcaa gttttctgct
    14521 aggcagaatt agccatctcc atcgatttca aacttcaaac tctcctctct acatctctct
    14581 gatatcctat tataggaagt aatacatacc cttctcgctc gcgtatacta cctatacata
    14641 atccacgggg ccgcgcgctt gatagctgtt tacgacgtct tcaagacgat ccatggatat
    14701 agtaaacctt agaacttgaa atatacctag gtactcctga ggtctactac aataagactc
    14761 cgagtcttag ccctggagta agtcactaca gtatagtaga gctttaagtt ctaagattca
    14821 aaccttcata ttccaaggtt ctaagattag tatattatca accttggaag ttcaacttga
    14881 agttcgagtt atactagtgt aatcttcaag tttcacatta acttaaacac gtagaaggtt
    14941 caagttagat ctataccagt agtagatata tataatagct ccgactcgga ctcagcatta
    15001 ctagtagtcc acatgttcta tttatttttt ttatttacca gagctactgc gcctttaagt
    15061 tagccattat acctagatag atttgactgt tctactaact gcgtccttta agttcagggc
    15121 tgtacctagg tatgagggca tagtaattgc agtatatatg gaagtttaat aattatatgt
    15181 gatgaagatg cagtggatat aattggccga caggagggca ccattaccta ggtagtagcg
    15241 gtgagggtac ttagaataca attgcgatat ggcgaagttg gcagcgattg cccctcgtag
    15301 tgtaaacgca tttttcgata ttcgattagg attatgtagt ttcagacata ccgtcacata
    15361 caaaacaggt atcagataca tagttacagt tcaggaattt atgaattttt gtcagcagat
    15421 ttatgcatct caattaggga aagcacatat acgagtcata tgtgaagggt cgcttggcgg
    15481 gtgatcctcc agcagtgagg gtcgtcagta tgcgacccta ccctccacat tatgacacct
    15541 acaccagtgt agtnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    15601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    15661 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    15721 nnnnnnnnnn nnnnnnnnnn nnnnntcaaa aagcagggaa atgcaaaatc acctagactg
    15781 ttaacgaata ccaaaagcac aggaacaaac acgtcgaaaa ataagtaacc gggtagtgct
    15841 gtcgctggac gatcaccacc ctgtctacag tgtagacaat tgttcttaag cccaagataa
    15901 cacctgccct catcatcgct accttttcaa catcgcagag cgcatacttg aagactccgc
    15961 ttgtcaccaa gttccaagat ggaagctatt gctcaagaaa tccaaaagct gcacgctaac
    16021 acggacgagg cgggccgtgg aaagatcaac cacgacctta gtgttcttct agcgtccttt
    16081 gacacagact gggagaaaat cctgaagctg gcagccgggg tgagtcagat gcaagtcatg
    16141 ttatccccac accctcgcca cttcaaagta tgggaagaga ataaaacctc taactatgtg
    16201 agaaattcaa cagcctctcc ggttggcttt ggtgaaagta ggcgtcgacc aaggcatttt
    16261 ccatgctctg aatgaacgct ctcacaccct gcccgagctt atcgagaaga ctggagtggc
    16321 accatatttg ctaggtagag tgtcctattt gctttcttta ttatcatcct gctgccagtg
    16381 gtttgaatgg ctactgacgg agttgtctgg cttagagcgc atcttacgcg gccaagcatc
    16441 gttcggcatg ataaaggaag agggcgccaa aggatttgca gcaaaccgat ttaccacact
    16501 cctagctgga ccaaatacat ccggcgcagt gacctacatg taagaatagg atatataatc
    16561 aggaatgaat gtacaatact gatcctcacg ctagcttcga cattctcagg ccaattgcct
    16621 ctgccatccc gggattcctg agcgagcgaa acaaccctgc tatcacatct acccatgaca
    16681 ccgttttcca gagagcattc aacacggagc tcggcgggtt tgaatggatg actgggcacc
    16741 ccgagcatta tgggaatctc ttccagttcc ttgccctacg gccgaactgt gagtgggttg
    16801 acgcattccc cattgaagcc gaaatcggct catttaccaa tgatccacat gtggaaaagg
    16861 tgctcttggt ggacgtgggc ggtggcacag gagcccagtc cgtcgctttc aggaagaagc
    16921 tcccgcacgt caaaggccgg gtcatcgtgc aggagattgc agagactcta attcatgtgg
    16981 gtgcaaaggc acccgctggc attgagttta tggaatacga ctgcttcaca ccgcagccga
    17041 tccggggtgc gaaattctat tacttgcggt atgttatgca tctctggcag gatgagagat
    17101 gtgtggaagc attgaaggtg atcatcactg ctatgggccc tgagtctcgc cttataattg
    17161 acgaggctgt tattccggac cgtgatgttc cctggcaggc agcgtgtcag agcattctca
    17221 tgacagctgc tttggcaggg gcagagcgga ccttgactga gtggcataac ttgcttgatg
    17281 cagcggggtt gaagattctg aatattttcc cctatgactt gaacatgcag tcagtcatta
    17341 tcgctgttcc gaaataagaa ttgggagtag tacatacata atgagctagt tgtttgagca
    17401 ccgcgaaaga gctgtaattg acatttgatg ttttagtctc agggctccat cccgtccacc
    17461 cgtaacttcc gaatatgctc tgaatatggt attcatacta cattcgccga atatgatatc
    17521 ttactgaata ccgtgttaac ttcgtatata tctaggtaga ctgttttgga aaaaatctcg
    17581 tggcgaatat ggtgtgagta tcatatccag accatattca aagcatattc atagcatatt
    17641 cggaagttgc tggcgggtgg gatggctgtc tgtgagcttt ggcctattca gcattattat
    17701 aaagaattgc atacaccaat ataagtgaca atataagtct ataagcagca agctactctg
    17761 ctcactgcta tcttattaat tagaccgtct ccgtacaact aacgtcccac tattccaagg
    17821 aaccttaagc cataaacaat ctactagctt tggcttaaac ttcaccggct tgacatcata
    17881 atggaccaga ataatagcta agatgagctt catttcaacc atcacaaaga atcgccccgg
    17941 acatatatgc tttccaatgc caaacgcaag gaaggcttca tcaatgttgg ctgtgctggc
    18001 tgcactcttg gactctctgt cgcgtggccc tccagtgctg atgttgctat tcggctccga
    18061 cgacaatttg tccaatatcg ctcggaccgc ctcgggatcg gcgaagcgaa atgcgttgta
    18121 gtcattggcg tgcgggtaga tgtcatcgtc gtagtggatt gattctatcg gggaagcaat
    18181 gactgtcccg tgggggaggt tcagtcggta gtcggggagt gatatgcctt tagggttgac
    18241 gacctggagt ttgttctcta ttagcctaga acggcagcat ttcatcgcaa agaattggct
    18301 cgagacaaat tggtggaatg cagggatagg taaaaggagt tgaaattaca gttcgatgta
    18361 agccaatccc cccaaccggt gacagcctga gagactctcg aattgcagac tcggtgattt
    18421 tcaacttttt gagcgcgtca taggtccata ctccgcctga ctctgtgtac acagtctggc
    18481 actcttcgcg caatgcttcg aggaagccaa gggcaggatc agcggcaaac aagttgagca
    18541 gcaatgtctg cactgaaaat gaggttgaag gtatggagac atcgttcagg agaagcaggc
    18601 ggaagcagat ggtctttaca ttcaactgcg tcagattatc cgaagcatac aagtcatcga
    18661 taatccactg aatggcatct tgctgcatcg agaaaagtta gtctaacagc aaacaacgac
    18721 tgagccgggt atcttaccgg aggtttccag tcgtaggccg gttcagcacg taacatcgca
    18781 gtcttctcca gtctctcttg caccactgct ttagacctct tcatggttgt gttgaagaga
    18841 atagcgcaca caaaccagac gaggccccct ataataggct gcagcagtct cggggcaccg
    18901 ttgatcgcca tcgcgcccgc cacaagaacc agcgaatggt tctgacagct ctgcaagaac
    18961 tccgcatcgc ggcctgggga gaatgtcaga agatttcttt gcttggagaa gagaaacaca
    19021 caaagcgggc taccacaaag tgtagtgttg attccaccag tcactatttt ccagcaggaa
    19081 tcccagatgt cgatcgactt ccactccttg tccgtccccc accagcgatt aaagcttagc
    19141 tcaatttcag atgcgacaat tggtgtaagt tgtctcaggt tccgggtaat ctgcttgcgc
    19201 agcacatccc acacaaacgt atcctcggcg ggcttcttgt cccaggcaac ccatctcgtc
    19261 tggttggttt cctgctgggt catccgtatg tccaagtcag tgtccggcag ggtgtatagc
    19321 cttctcatca ggcgcgctgg aataatcgta attggccccc gatcaaagct ggggagtacg
    19381 tagggaatat tcaatttagc atactattga atttgtggat tagctggtga gtgtcgtaat
    19441 atcactgggg gcgcggctct ttactgcatt gtaaccctca agtgcccaat cgttcaactt
    19501 gtagcatgag cgcagcgcag cgcgcaacgt cgacgccttc tcctttctcc aaccaacccg
    19561 tgggtgtaag gtgggctgcg gcgtcatgtt ggggaagaag aggagaccca gtacaatcgc
    19621 catggcagat aatactgcgg caagagggga tatcaatgac at
//
