BGC0001717 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001717 (Penicillium simplicissimum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	indole,NRPS	1	19,662	okaramine B	NRPS:Type I	100%

BGC0001717 - Region 1 - NRPS,indole

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Location: 1 - 19,662 nt. (total: 19,662 nt) Show pHMM detection rules used

Region on contig edge.

indole: (indsynth or dmat or indole_PTase)
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 19,663
Label		BGC0001717

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001717	2.00	NRP	okaramine B	Penicillium simplicissimum
BGC0001718	1.18	NRP	okaramine D	Aspergillus aculeatus ATCC 16872
BGC0000900	0.68	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.63	NRP	dimethylcoprogen	Alternaria alternata
BGC0002219	0.62	Terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0002248	0.57	Terpene, NRP	flavunoidine	Aspergillus flavus NRRL3357
BGC0002157	0.55	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0002606	0.54	NRP, Polyketide	ochratoxin A	Aspergillus niger
BGC0001775	0.53	Terpene	sespendole	Cordana terrestris
BGC0000293	0.53	NRP	acetylaszonalenin	Aspergillus fischeri NRRL 181

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001717	1.00	NRP	okaramine B	Penicillium simplicissimum
BGC0001718	0.84	NRP	okaramine D	Aspergillus aculeatus ATCC 16872
BGC0000900	0.67	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.65	NRP	dimethylcoprogen	Alternaria alternata
BGC0002219	0.65	Terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0002248	0.62	Terpene, NRP	flavunoidine	Aspergillus flavus NRRL3357
BGC0002157	0.61	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0002606	0.61	NRP, Polyketide	ochratoxin A	Aspergillus niger
BGC0001775	0.60	Terpene	sespendole	Cordana terrestris
BGC0000293	0.60	NRP	acetylaszonalenin	Aspergillus fischeri NRRL 181

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 19662:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Trp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

okaA

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AMP-binding (230..624): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVHEVGAVVK
Nearest Stachelhaus code(s):: Trp DVHEVGAVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)