BGC0001718 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001718 (Aspergillus aculeatus ATCC 16872)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	indole,NRPS	1	15,216	okaramine D	NRPS:Type I	100%

BGC0001718 - Region 1 - NRPS,indole

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Location: 1 - 15,216 nt. (total: 15,216 nt) Show pHMM detection rules used

Region on contig edge.

indole: (indsynth or dmat or indole_PTase)
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 15,217
Label		BGC0001718

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001718	2.00	NRP	okaramine D	Aspergillus aculeatus ATCC 16872
BGC0001717	1.02	NRP	okaramine B	Penicillium simplicissimum
BGC0000900	0.68	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.64	NRP	dimethylcoprogen	Alternaria alternata
BGC0000293	0.57	NRP	acetylaszonalenin	Aspergillus fischeri NRRL 181
BGC0002248	0.57	Terpene, NRP	flavunoidine	Aspergillus flavus NRRL3357
BGC0002157	0.55	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0002606	0.53	NRP, Polyketide	ochratoxin A	Aspergillus niger
BGC0002272	0.53	NRP	asterrelenin, epi-aszonalenin A	Aspergillus terreus NIH2624
BGC0002710	0.52	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001718	1.00	NRP	okaramine D	Aspergillus aculeatus ATCC 16872
BGC0001717	0.79	NRP	okaramine B	Penicillium simplicissimum
BGC0000900	0.67	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.65	NRP	dimethylcoprogen	Alternaria alternata
BGC0000293	0.62	NRP	acetylaszonalenin	Aspergillus fischeri NRRL 181
BGC0002248	0.62	Terpene, NRP	flavunoidine	Aspergillus flavus NRRL3357
BGC0002157	0.61	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0002606	0.60	NRP, Polyketide	ochratoxin A	Aspergillus niger
BGC0002272	0.60	NRP	asterrelenin, epi-aszonalenin A	Aspergillus terreus NIH2624
BGC0002710	0.60	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23

Similar known gene clusters from MIBiG 4.0

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 15216:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Trp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ASPACDRAFT_115976

Search NORINE for peptide: strict or relaxed

AMP-binding (232..621): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVHEVGAVVK
Nearest Stachelhaus code(s):: Trp DVHEVGAVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)