BGC0001722 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001722 (Aspergillus nidulans FGSC A4)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	46,781	High	aspernidine A	PKS

BGC0001722 - Region 1 - T1PKS

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Location: 1 - 46,781 nt. (total: 46,781 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 46,782
Label		BGC0001722

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

ANIA_03225: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

ANIA_03226: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Ligases: synthase

ANIA_03230: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001722.3	1.00	PKS	aspernidine A	Aspergillus nidulans FGSC A4
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0000037.4	0.64	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0001244.3	0.62	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.62	PKS	asperlactone	Aspergillus ochraceus
BGC0001258.3	0.62	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002191.2	0.62	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001257.3	0.62	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000107.3	0.62	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002175.3	0.62	PKS	YWA1	Aspergillus oryzae RIB40

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001722.3	1.00	PKS	aspernidine A	Aspergillus nidulans FGSC A4
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0000037.4	0.64	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0001244.3	0.62	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.62	PKS	asperlactone	Aspergillus ochraceus
BGC0001258.3	0.62	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002191.2	0.62	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001257.3	0.62	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000107.3	0.62	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002175.3	0.62	PKS	YWA1	Aspergillus oryzae RIB40

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 46781:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ANIA_03230: mal

PKS_AT (875..1168): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; Ethylmalonyl-CoA: 54.2%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 68.4
Methoxymalonyl-CoA: 56.7
inactive: 46.1
Methylmalonyl-CoA: 46.0
Ethylmalonyl-CoA: 24.0
Propionyl-CoA: 23.3
CHC-CoA: 21.2
Acetyl-CoA: 19.6
fatty_acid: 18.7
trans-1,2-CPDA: 17.5
2-Methylbutyryl-CoA: 16.7
Benzoyl-CoA: 15.4
Isobutyryl-CoA: 13.5
3-Methylbutyryl-CoA: 11.9

Link to PARAS substrate predictor