LOCUS       BGC0001723             10733 bp    DNA     linear   BCT 07-JUN-2017
DEFINITION  Streptomyces antibioticus strain NRRL 3238 oviedomycin biosynthetic
            gene cluster, complete sequence.
ACCESSION   BGC0001723
VERSION     BGC0001723
KEYWORDS    .
SOURCE      Streptomyces antibioticus
  ORGANISM  Streptomyces antibioticus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 16:09:12
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10733
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..10733
                     /db_xref="taxon:1890"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces antibioticus"
                     /strain="NRRL 3238"
     protocluster    1..10733
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[2053:4545]"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /t2pks_malonyl_elongations="8|9 (Score: 736.2; E-value:
                     1.8e-224)"
                     /t2pks_molecular_weights="acetyl-CoA_8 (Da): 381.354"
                     /t2pks_molecular_weights="acetyl-CoA_9 (Da): 423.390"
                     /t2pks_product_classes="angucycline"
                     /t2pks_starter_units="acetyl-CoA (Score: 0.0; E-value: 0)"
                     /tool="antismash"
     proto_core      2054..4545
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /t2pks_malonyl_elongations="8|9 (Score: 736.2; E-value:
                     1.8e-224)"
                     /t2pks_molecular_weights="acetyl-CoA_8 (Da): 381.354"
                     /t2pks_molecular_weights="acetyl-CoA_9 (Da): 423.390"
                     /t2pks_product_classes="angucycline"
                     /t2pks_starter_units="acetyl-CoA (Score: 0.0; E-value: 0)"
     cand_cluster    1..10733
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(t2ks and t2clf)"
                     /kind="single"
                     /product="T2PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..10733
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001723"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..10733
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T2PKS"
                     /region_number="1"
                     /rules="(t2ks and t2clf)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            129..1616
                     /gene="ovmOI"
     CDS             129..1616
                     /codon_start=1
                     /gene="ovmOI"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 592.1; E-value:
                     1.6e-179)"
                     /gene_functions="biosynthetic-additional (t2pks) OXY
                     (Score: 621.1; E-value: 3.2e-189)"
                     /gene_kind="biosynthetic-additional"
                     /product="oxygenase"
                     /protein_id="ARK36153.1"
                     /transl_table=11
                     /translation="MDAALVDVPVVIVGAGPTGLMLAGELRLAGVEIVVIDRLPRPSGE
                     SRGLGFTPRTMEVFDQRGLLPRFGEIVTSKLGHFGGTPVDFGVLDGAHFSVKDVPQHRT
                     EAVLGAWLAELGVQVRRGRELVALTAGEDGVRIDIEGPDGPERLRAGYLVGCDGGRSTV
                     RRLAGFDFPGTTATMEMYLADITDCEVRPRPIGESVPGGMAMSVPIGDGVHRIIVCERD
                     NPPRERTGPPPFAEVAAAWQRLTHQDISGATPVWVSAFGNAARQVTEYRRGRVLLAGDA
                     AHIHLPAGGQGMNTGIQDAVNLGWKLAAVVRGTAPEALLDTYHAERHPVGRRLLTNTQA
                     QGLLYLSGSEMQPLRDVLAELIAYEDVSRHLAGMISGLDIRYDVGATDHPLPGRRMPHL
                     ELVTADGGKTSTTALLHSARGLLLDLADDPGTRRAAAGWADRVDTVTATPHDTAQDRPP
                     HGATAVLVRPDGHVAWAAPGGPAELTAALERWFGPSR"
     misc_feature    129..10733
                     /note="oviedomycin biosynthetic gene cluster"
     gene            1725..2057
                     /gene="ovmC"
     CDS             1725..2057
                     /codon_start=1
                     /gene="ovmC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1225:Polyketide synthesis cyclase (Score: 160.8;
                     E-value: 1.5e-49)"
                     /gene_functions="biosynthetic-additional (t2pks) CYC
                     C4-C17/C2-C19 (Score: 203.9; E-value: 5.3e-63)"
                     /gene_kind="biosynthetic-additional"
                     /product="cyclase"
                     /protein_id="ARK36154.1"
                     /transl_table=11
                     /translation="MKHSTLIVARMEPHASDDVAALFGAFDETEMPHRMGTRRRQLFKY
                     RGLYFHLQDFDTDNGGELIEEAKTDPRFIRISEDLKPFIEAYDPQTWRSPKDAMATRFY
                     HWEASA"
     gene            2054..3325
                     /gene="ovmP"
     CDS             2054..3325
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (5-396). E-value:
                     3.4e-57. Score: 186.1. Matches aSDomain:
                     nrpspksdomains_ovmP_PKS_KS.1"
                     /codon_start=1
                     /gene="ovmP"
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2ks"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 504.3; E-value:
                     4.7e-153)"
                     /gene_functions="biosynthetic-additional (t2pks) KS (Score:
                     795.7; E-value: 2e-242)"
                     /gene_kind="biosynthetic"
                     /product="keto-acyl synthase alpha"
                     /protein_id="ARK36155.1"
                     /sec_met_domain="t2ks (E-value: 7.1e-253, bitscore: 828.3,
                     seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPRRVVITGIGVLAPGGIGVKNFWSLLSEGRTATRGITFFDPAQ
                     FRSRVAAEIDFDPEEHGLNPQETRRMDRAAQLAVVATREAVADSGIELTGIDPYRVGVT
                     VGSAVGATMGLEQEYRVVSNGGLLDLVDHTYAVPHLYNHMVPSSFAAEVAWQVGAEGPS
                     TVVSTGCTSGLDSVGHAVELIREGSADVMIAGSSDAPISPITMACFDAIKATTPRNDDP
                     GHASRPFDGTRNGFVLGEGSAFFVLEELESARARGAHVYAEIAGYATRSNAYHMTGLRP
                     DGAEMAEAIRVALDEARINGDEIDYINAHGSGTKQNDRHETAAFKKSLGDHAYRTPVSS
                     IKSMVGHSLGAIGSIEIAASALAMEHNVVPPTANLHTPDPECDLDYVPLTAREHRTDTV
                     LTVGSGFGGFQSAMVLARPERSVA"
     aSDomain        2069..3241
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ovmP_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="3.40E-57"
                     /label="ovmP_PKS_KS.1"
                     /locus_tag="ovmP"
                     /protein_end="396"
                     /protein_start="5"
                     /score="186.1"
                     /tool="antismash"
                     /translation="VVITGIGVLAPGGIGVKNFWSLLSEGRTATRGITFFDPAQFRSRV
                     AAEIDFDPEEHGLNPQETRRMDRAAQLAVVATREAVADSGIELTGIDPYRVGVTVGSAV
                     GATMGLEQEYRVVSNGGLLDLVDHTYAVPHLYNHMVPSSFAAEVAWQVGAEGPSTVVST
                     GCTSGLDSVGHAVELIREGSADVMIAGSSDAPISPITMACFDAIKATTPRNDDPGHASR
                     PFDGTRNGFVLGEGSAFFVLEELESARARGAHVYAEIAGYATRSNAYHMTGLRPDGAEM
                     AEAIRVALDEARINGDEIDYINAHGSGTKQNDRHETAAFKKSLGDHAYRTPVSSIKSMV
                     GHSLGAIGSIEIAASALAMEHNVVPPTANLHTPDPECDLDYVPLTAREHRT"
     gene            3322..4545
                     /gene="ovmK"
     CDS             3322..4545
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (71-404). E-value:
                     1.6e-28. Score: 91.6. Matches aSDomain:
                     nrpspksdomains_ovmK_PKS_KS.1"
                     /codon_start=1
                     /gene="ovmK"
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2clf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 694.7; E-value:
                     5.1e-211)"
                     /gene_functions="biosynthetic-additional (t2pks) CLF 8|9
                     (Score: 736.2; E-value: 1.8e-224)"
                     /gene_kind="biosynthetic"
                     /product="beta-ketoacyl synthase"
                     /protein_id="ARK36156.1"
                     /sec_met_domain="t2clf (E-value: 1.3e-221, bitscore: 724.7,
                     seeds: 26, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGTATKVVVTGLGVAAPNGLGTQDYWAATRTGKGGIGRITRFDP
                     SQYPSRLAGEVPGFEARDHLPSRLLPQTDHMTRLALVAADWALADAGVKPQELPEFDMG
                     VVTASSSGGFEFGQRELQALWSKGGQHVSAYQSFAWFYAVNSGQISIRNGMKGPSGVVV
                     SEQAGGLDALAQARRQIRKGTRLIVSGGMDASVCTWGWVAQLAGKRLSTSDDPERAYLP
                     FDAGARGHVPGEGGAILILENAEAARSRGARTYGEIAGYGSTFDPKPGSGRPPGLRKAI
                     ELALADAGAAPDEVDVVFADAAAVPELDRIEAEALTAVFGARGVPVTAPKTMTGRLYSG
                     AAPLDVATALLAIEEGLIPPTTNVEPADGYDLDLVTGEARPAEVRTALVLARGFNGFNS
                     ALVVRATH"
     aSDomain        3535..4533
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ovmK_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.60E-28"
                     /label="ovmK_PKS_KS.1"
                     /locus_tag="ovmK"
                     /protein_end="404"
                     /protein_start="71"
                     /score="91.6"
                     /tool="antismash"
                     /translation="QTDHMTRLALVAADWALADAGVKPQELPEFDMGVVTASSSGGFEF
                     GQRELQALWSKGGQHVSAYQSFAWFYAVNSGQISIRNGMKGPSGVVVSEQAGGLDALAQ
                     ARRQIRKGTRLIVSGGMDASVCTWGWVAQLAGKRLSTSDDPERAYLPFDAGARGHVPGE
                     GGAILILENAEAARSRGARTYGEIAGYGSTFDPKPGSGRPPGLRKAIELALADAGAAPD
                     EVDVVFADAAAVPELDRIEAEALTAVFGARGVPVTAPKTMTGRLYSGAAPLDVATALLA
                     IEEGLIPPTTNVEPADGYDLDLVTGEARPAEVRTALVLARGFNGFNSALVVR"
     gene            4626..4898
                     /gene="ovmS"
     CDS             4626..4898
                     /NRPS_PKS="Domain: ACP (22-82). E-value: 1.8e-15. Score:
                     48.9. Matches aSDomain: nrpspksdomains_ovmS_ACP.1"
                     /codon_start=1
                     /gene="ovmS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1129:acyl carrier protein (Score: 109.8; E-value:
                     8.8e-34)"
                     /gene_functions="biosynthetic-additional (t2pks) ACP
                     (Score: 127.7; E-value: 3.1e-40)"
                     /gene_kind="biosynthetic-additional"
                     /product="actinorhodin polyketide synthase"
                     /protein_id="ARK36157.1"
                     /sec_met_domain="PP-binding (E-value: 3e-12, bitscore:
                     36.4, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATKEFTVDDLKRILLEGAGADESVDLDSADFLDSEFEALGYESL
                     ALLETGGRIEREFGITLDDTALTDATTPRALIEVVNAHIGQPTAV"
     aSDomain        4692..4871
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ovmS_ACP.1"
                     /evalue="1.80E-15"
                     /label="ovmS_ACP.1"
                     /locus_tag="ovmS"
                     /protein_end="82"
                     /protein_start="22"
                     /score="48.9"
                     /tool="antismash"
                     /translation="ESVDLDSADFLDSEFEALGYESLALLETGGRIEREFGITLDDTAL
                     TDATTPRALIEVVNA"
     gene            5022..5804
                     /gene="ovmT"
     CDS             5022..5804
                     /NRPS_PKS="Domain: PKS_KR (6-161). E-value: 1e-12. Score:
                     40.2. Matches aSDomain: nrpspksdomains_ovmT_PKS_KR.1"
                     /codon_start=1
                     /gene="ovmT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     260.7; E-value: 2.2e-79)"
                     /gene_functions="biosynthetic-additional (t2pks) KR C9
                     (Score: 490.5; E-value: 2.4e-150)"
                     /gene_kind="biosynthetic-additional"
                     /product="ketoacyl reductase"
                     /protein_id="ARK36158.1"
                     /sec_met_domain="adh_short (E-value: 3.9e-39, bitscore:
                     123.9, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQDKRVALVTGATSGIGLAVARLLAEQGHRVFLGARSAENVAAT
                     VKELQSAGLEADGATLDVRSDADVHAFVRAAVDRFGTVDVLVNNAGRSGGGVTADIADE
                     LWHDVIDTNLNSVFRLTREVLNTGGLRHKSWGRIINIASTAGKQGVVLGAPYSASKHGV
                     VGFTKALGNELAPTGITVNAVCPGYVETPMAQRVRQGYAAAYDTTEDAILEKFQSKIPL
                     GRYSTPEEVAGLVGYLASDTAASITAQALNVCGGLGNF"
     aSDomain        5040..5504
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ovmT_PKS_KR.1"
                     /evalue="1.00E-12"
                     /label="ovmT_PKS_KR.1"
                     /locus_tag="ovmT"
                     /protein_end="161"
                     /protein_start="6"
                     /score="40.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VALVTGATSGIGLAVARLLAEQGHRVFLGARSAENVAATVKELQS
                     AGLEADGATLDVRSDADVHAFVRAAVDRFGTVDVLVNNAGRSGGGVTADIADELWHDVI
                     DTNLNSVFRLTREVLNTGGLRHKSWGRIINIASTAGKQGVVLGAPYSASKH"
     CDS_motif       5046..5117
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ovmT_0001"
                     /evalue="9.60E-08"
                     /label="PKSI-KR_m1"
                     /locus_tag="ovmT"
                     /protein_end="32"
                     /protein_start="8"
                     /score="24.7"
                     /tool="antismash"
                     /translation="LVTGATSGIGLAVARLLAEQGHRV"
     gene            5832..6779
                     /gene="ovmA"
     CDS             5832..6779
                     /NRPS_PKS="Domain: Polyketide_cyc2 (4-146). E-value:
                     7.3e-18. Score: 57.2. Matches aSDomain:
                     nrpspksdomains_ovmA_Polyketide_cyc2.1"
                     /NRPS_PKS="Domain: Polyketide_cyc2 (155-302). E-value:
                     3.5e-10. Score: 32.3. Matches aSDomain:
                     nrpspksdomains_ovmA_Polyketide_cyc2.2"
                     /codon_start=1
                     /gene="ovmA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1128:cyclase/dehydrase (Score: 467.6; E-value:
                     3e-142)"
                     /gene_functions="biosynthetic-additional (t2pks) CYC C7-C12
                     (Score: 500.0; E-value: 4.6e-153)"
                     /gene_kind="biosynthetic-additional"
                     /product="cyclase"
                     /protein_id="ARK36159.1"
                     /transl_table=11
                     /translation="MTTREVEHEITIAAPAEAVYRLLADVENWPRIFPPTIFADRLEGG
                     ETEERIRIWATANGEAKNWTSRRTLEPRGLVITFRQEVSAPPVAAMGGTWIIEPAGESA
                     ARVRLLHDYRAVDDDPAGLAWIDEAVDRNSRTELASLKTNVEFAHAAREITFSFEDTVR
                     IDGSAKDVYDFINDAHLWSERLPHVASVRCEEEYPGLQTLEMDTRAKDGSTHTTKSYRV
                     CFPHRKIAYKQVTLPALMNLHTGYWTFTEDADGVSASSQHTVVLNTDNITRILGPDAGI
                     PEARAYVQSALSTNSRATLGHAKDYAEARRNHAD"
     aSDomain        5844..6269
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ovmA_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="7.30E-18"
                     /label="ovmA_Polyketide_cyc2.1"
                     /locus_tag="ovmA"
                     /protein_end="146"
                     /protein_start="4"
                     /score="57.2"
                     /tool="antismash"
                     /translation="EVEHEITIAAPAEAVYRLLADVENWPRIFPPTIFADRLEGGETEE
                     RIRIWATANGEAKNWTSRRTLEPRGLVITFRQEVSAPPVAAMGGTWIIEPAGESAARVR
                     LLHDYRAVDDDPAGLAWIDEAVDRNSRTELASLKTNVE"
     aSModule        5844..6737
                     /domains="nrpspksdomains_ovmA_Polyketide_cyc2.1"
                     /domains="nrpspksdomains_ovmA_Polyketide_cyc2.2"
                     /incomplete
                     /locus_tags="ovmA"
                     /tool="antismash"
                     /type="unknown"
     aSDomain        6297..6737
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ovmA_Polyketide_cyc2.2"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="3.50E-10"
                     /label="ovmA_Polyketide_cyc2.2"
                     /locus_tag="ovmA"
                     /protein_end="302"
                     /protein_start="155"
                     /score="32.3"
                     /tool="antismash"
                     /translation="FSFEDTVRIDGSAKDVYDFINDAHLWSERLPHVASVRCEEEYPGL
                     QTLEMDTRAKDGSTHTTKSYRVCFPHRKIAYKQVTLPALMNLHTGYWTFTEDADGVSAS
                     SQHTVVLNTDNITRILGPDAGIPEARAYVQSALSTNSRATLGH"
     gene            6769..8241
                     /gene="ovmOII"
     CDS             6769..8241
                     /codon_start=1
                     /gene="ovmOII"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 550.8; E-value:
                     5.6e-167)"
                     /gene_functions="biosynthetic-additional (t2pks) OXY
                     (Score: 605.7; E-value: 1.5e-184)"
                     /gene_kind="biosynthetic-additional"
                     /product="oxidoreductase"
                     /protein_id="ARK36160.1"
                     /transl_table=11
                     /translation="MRTDVLVVGAGPVGLMLAGELRLGGAEVVVLDRLPRPTTESRATT
                     LHARTMEILAARGLLEALGTPPNDVMGHFGGVPLDLTLPTPYPGQWKVPQTRTEELLQA
                     WALSLGATVRRAHELRALTVTDTGAEAEATGPDGRPVRVSARYVVGCDGERSTVRELTG
                     ADFPGQDATRELIRADVAGIDIPDRRFQRLQRGLAIAARRPDGVTRVMVHEFGRAARPR
                     TGAPAFAEVVDVWKRVTGEDIGGGTPLWLNAFGDASRQVARYRDGRVLFAGDAAHVQMP
                     VGGQALNLGLQDAVNLGWKLAAEIRGRAPDGLLDTYHSERHAVGERVLSTIRAQSTFLL
                     GGPDVEALREVFRELIDPAHTRHTRAHLAGLISGLDIRYDVGPGDHPLLGARMPYGELD
                     QAPDAACRKARGVLLDLAPGSPSAAELHAVAAGWADRVDVVTAGFRTADGPSALSGARA
                     VLVRPDGHVVWTDSGAGRPETALRRWFGAPVS"
     gene            8261..9781
                     /gene="ovmOIII"
     CDS             8261..9781
                     /codon_start=1
                     /gene="ovmOIII"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 432.3; E-value:
                     4.7e-131)"
                     /gene_functions="biosynthetic-additional (t2pks) OXY
                     (Score: 428.4; E-value: 9.3e-131)"
                     /gene_kind="biosynthetic-additional"
                     /product="hypothetical protein"
                     /protein_id="ARK36161.1"
                     /transl_table=11
                     /translation="MSKSAPRPPAGPRTATGPEVLVVGAGPTGLLLAGDLAAAGTRVTV
                     LEKRGRKLSNLTRSFTVHARTLEQLQARGVAEDIIATGTKLPTLPLFGDLDIHFAHLRT
                     RYPYVLITPQFHVEQVLERRAVSLGVEFRHDTEVTGLRQDAHGVELDAVTADGTRETHR
                     AAYAVGTDGVRSTVRRLLDIPFPGDSVLRSVILADVLMKEAPADLLTVDANEHGFAFVA
                     PFGDGYYRVLAWNRHTDSSADESVDFEELRRLCRAILGRDFGMHEPRWVSRFHSDERQA
                     TRYREGRFFLAGDAAHVHSPAGGMGMNTGLQDAMNLAWKLAAAVRGHGDDALLDTYEAE
                     THPVGEEVLRTSGSLVRAAIRQSGRTRLAQQAMVWFAGHLGPLGEALGRREGLAVSGTG
                     ITYGRQRGDHRLVGRFFHGRLTGGRLDGALGTGRFVLLSPDEAVRTAVADWSDRVVTAP
                     ADVRTTLLIRPDGYVAWAADGPGPAAVRDALNRWAGPAEPRIRLAYAG"
     gene            9855..10733
                     /gene="ovmF"
     CDS             9855..10733
                     /NRPS_PKS="Domain: ACPS (146-208). E-value: 2.7e-09. Score:
                     28.8. Matches aSDomain: nrpspksdomains_ovmF_ACPS.1"
                     /codon_start=1
                     /gene="ovmF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012:4'-phosphopantetheinyl transferase (Score: 151.6;
                     E-value: 3.3e-46)"
                     /gene_kind="biosynthetic-additional"
                     /product="hypothetical protein"
                     /protein_id="ARK36162.1"
                     /transl_table=11
                     /translation="MPDGRRVDLWLLRCPGPGTPPGPHVRPDSHVRADTRVRPDPDVRP
                     DPDPLADPGVLDVLDAAERKRAASLRRPADRALYVASHLALRTLLGAYLRVPAREVVLV
                     REPCPGCGGPHGRPAVPGTPPPLHFSLSHSHGLALIGVAAVPVGVDVQRVPGPGTVDAC
                     APSLHPAERAELERLPPGARPGAFAQLWARKEAYLKGIGTGLSRPASADYLGADTRSRP
                     HGWTVTDLPRADGHTAAVAVLGTAPPTPAVRRLPVRLTSPHLTSPTDDHAPGRQRPRAH
                     RPVGKATGGYP"
     aSDomain        10293..10478
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ovmF_ACPS.1"
                     /evalue="2.70E-09"
                     /label="ovmF_ACPS.1"
                     /locus_tag="ovmF"
                     /protein_end="208"
                     /protein_start="146"
                     /score="28.8"
                     /tool="antismash"
                     /translation="VGVDVQRVPGPGTVDACAPSLHPAERAELERLPPGARPGAFAQLW
                     ARKEAYLKGIGTGLSRP"
ORIGIN
        1 ccctttcgtc tgtcgcctcc gcccgcccgg aaccacgtac ccccggcggg cggcgacatg
       61 acgtgccctc agccacctca ccggcgtctc cccgtcccgg gacgtacgca acaggaaagg
      121 aggcgcggat ggacgctgcc ctcgtcgacg ttcccgtggt catcgtggga gcaggcccca
      181 cggggctgat gctcgccggt gaactgcgcc tcgccggagt cgagatcgtc gtcatcgacc
      241 gccttccccg gcccagcgga gagtcccgcg ggctcggttt cacccctcgc accatggagg
      301 tcttcgacca gcgcggactg ctgccccgct tcggcgagat cgtcaccagc aagctcggcc
      361 acttcggcgg cacccccgtc gacttcggcg tgctcgacgg cgcccacttc agcgtcaagg
      421 acgtgcccca acaccgtacg gaggcggtgc tcggcgcatg gctcgccgaa ctcggcgtcc
      481 aggtgcggcg cggccgcgaa ctcgtcgccc tcacggccgg cgaggacggc gtccgcatcg
      541 acatcgaggg ccccgacggc cccgaacggc tgcgcgccgg ctacctggtg ggctgcgacg
      601 gcggccgcag cacggtccgc agactcgccg ggttcgactt ccccggcacc accgcgacca
      661 tggagatgta cctcgccgac atcaccgact gcgaggtgcg gccccgcccc atcggcgagt
      721 ccgtgcccgg cgggatggcc atgtcggtgc ccatcggcga cggcgtccac cgcatcatcg
      781 tctgcgagcg cgacaacccc ccgcgcgaac gcaccggacc gccgcccttc gcggaggtcg
      841 ccgccgcctg gcagcgcctg acccaccagg acatcagcgg cgccacaccg gtgtgggtca
      901 gcgccttcgg caacgccgcc cgccaggtca ccgagtaccg ccgcggacgc gtcctgctgg
      961 ccggcgacgc ggcgcacatc cacctgcccg ccggcggcca gggcatgaac accggcatcc
     1021 aggacgccgt caacctgggc tggaagctcg ccgccgtcgt acgcggcacg gcccccgagg
     1081 cgctgctcga cacgtaccac gccgagcgcc acccggtcgg ccgccggctg ctgaccaaca
     1141 cgcaggccca gggcctgctc tacctcagcg gcagcgagat gcagccgctg cgcgacgtgc
     1201 tcgccgagct gatcgcgtac gaggacgtca gccgccacct cgccggaatg atcagcggcc
     1261 tggacatccg ctacgacgtc ggcgcgaccg atcacccgct gcccggccgc cgcatgccgc
     1321 acctggaact cgtgaccgcc gacggcggca agaccagcac caccgccctg ctgcacagcg
     1381 cgcgcggcct gctgctcgac ctcgccgacg accccgggac ccggcgcgcc gccgccggct
     1441 gggcggaccg cgtggacacc gtcaccgcga ccccgcacga caccgcccag gaccggccgc
     1501 cgcacggcgc caccgccgta ctggtgcgcc ccgacggcca tgtggcctgg gccgcgcccg
     1561 gcggtcccgc ggagctgacc gccgccctgg agcgctggtt cggcccgtcc cgctgacggc
     1621 cccgcccgcc ccctcaccac cccatctctt gcgtcacccg cccgagcaac tccggccgcg
     1681 cccggccgcg tccggtcgcg aaccgtcgtg aggagacacc caccatgaag cacagcacgt
     1741 tgatcgtggc ccggatggag ccgcacgcca gtgacgacgt cgcggccctc ttcggcgcct
     1801 tcgacgagac cgagatgccc caccgcatgg gcacccgccg ccgtcagctg ttcaagtacc
     1861 ggggcctgta cttccacctc caggacttcg acaccgacaa cggcggcgag ctgatcgagg
     1921 aggccaagac cgacccgcgc ttcatccgga tcagcgagga cctcaagccg ttcatcgagg
     1981 cgtacgaccc gcagacgtgg cgctcgccca aggacgcgat ggccacgcgc ttctaccact
     2041 gggaggcctc cgcatgacgc cccggcgcgt cgtcatcacc ggcatcggcg tgctcgcgcc
     2101 gggcggcatc ggtgtgaaga acttctggag cctgctgagc gagggccgca ccgcgacccg
     2161 cggcatcacc ttcttcgacc ccgcccagtt ccgctcgcgg gtcgccgccg agatcgactt
     2221 cgatccggag gaacacgggc tgaacccgca ggagacacgg cgcatggacc gcgccgccca
     2281 gctcgccgtc gtggccaccc gcgaggcggt cgccgacagc ggcatcgagc tgaccggcat
     2341 cgacccgtac cgcgtcggcg tcaccgtggg cagcgcggtc ggcgcgacca tggggctgga
     2401 acaggagtac cgggtcgtca gcaacggcgg cctgctcgac ctggtcgacc acacgtacgc
     2461 ggtcccgcac ctgtacaacc acatggtccc cagctccttc gccgccgagg tcgcctggca
     2521 ggtgggcgcg gagggcccca gcacggtggt ctccaccggc tgcacctccg gcctggactc
     2581 ggtcggccac gcggtggagc tgatccgcga gggctcggcg gacgtcatga tcgccggctc
     2641 gtcggacgcg ccgatctcgc ccatcaccat ggcgtgcttc gacgcgatca aggcgacgac
     2701 cccgcgcaac gacgaccccg ggcacgcctc ccgccccttc gacggcaccc gcaacggctt
     2761 cgtgctcggc gagggctccg ccttcttcgt actggaggag ctggagagcg cccgcgcgcg
     2821 cggcgcccac gtctacgccg agatcgccgg ctacgccacc cgctccaacg cgtaccacat
     2881 gaccgggctg cgccccgacg gcgccgagat ggccgaggcc atccgcgtcg cgctcgacga
     2941 ggcccggatc aacggcgacg agatcgacta catcaacgcg cacggctccg gcaccaagca
     3001 gaacgaccgg cacgagacgg ccgcgttcaa gaagagcctc ggcgaccacg cgtaccgcac
     3061 cccggtctcc tccatcaagt cgatggtggg ccactcgctg ggcgcgatcg gctccatcga
     3121 gatcgccgcg tccgccctgg ccatggagca caacgtcgtg cccccgacgg ccaacctgca
     3181 cacccccgac ccggagtgcg acctggacta cgtgccgctc accgcccgcg agcaccgcac
     3241 ggacaccgtc ctgacggtcg gcagcggatt cggcggattc cagagcgcca tggtgctcgc
     3301 ccggcccgag aggagcgtgg catgaccggc acggccacga aggtggtggt caccggactg
     3361 ggcgtcgcgg cccccaacgg cctgggcacc caggactact gggcggcgac ccggaccggc
     3421 aagggcggca tcggccgcat cacccgcttc gacccctcgc agtacccctc ccggctggcc
     3481 ggcgaggtcc ccggcttcga ggcccgcgac cacctgccca gccggctgct gccgcagacc
     3541 gaccacatga cgcggctcgc gctcgtggcc gccgactggg cgctcgccga cgccggggtc
     3601 aagccgcagg agctgcccga gttcgacatg ggcgtggtca ccgccagctc ctcgggcggc
     3661 ttcgagttcg gccagcgcga actccaggcg ctgtggagca agggcggcca gcacgtcagc
     3721 gcctaccagt ccttcgcctg gttctacgcg gtcaactccg gccagatctc gatccgcaac
     3781 ggcatgaagg ggcccagcgg cgtcgtcgtc agcgagcagg cgggcggcct cgacgcgctc
     3841 gcccaggccc gccggcagat ccgcaagggc acccggctga tcgtctccgg cggcatggac
     3901 gcgtccgtgt gcacctgggg ctgggtcgcc cagctggccg gcaagcggct gagcaccagc
     3961 gacgaccccg agcgcgccta cctgccgttc gacgccgggg cgcgcgggca cgtcccgggc
     4021 gagggcggcg cgatcctcat cctggagaac gccgaggccg cccggtcccg gggcgcccgg
     4081 acctacggcg agatcgcggg ctacggctcc acgttcgacc ccaagccggg cagcggccgt
     4141 ccgccgggcc tgcgcaaggc gatcgagctg gccctcgcgg acgcgggcgc ggccccggac
     4201 gaggtggacg tggtgttcgc cgacgccgcc gccgtcccgg agctggaccg tatcgaggcc
     4261 gaggcgctca ccgccgtctt cggcgcccgc ggcgtcccgg tcaccgcgcc caagaccatg
     4321 accggccgcc tgtactccgg cgccgccccg ctggacgtgg ccaccgcgct gctcgccatc
     4381 gaggaggggc tgatcccgcc caccacgaac gtcgagccgg ccgacggcta cgacctggac
     4441 ctggtcaccg gcgaggcccg cccggccgag gtgcgcacgg cgctcgtgct ggcccgcggc
     4501 ttcaacgggt tcaactccgc gctcgtggtc cgcgccaccc actgaccatc cctcggcggg
     4561 gccttcccgc ttgttcgaac aagcgcgggc gccgtcccgc tcgtacacgg aagaaggaga
     4621 tccccatggc caccaaggaa ttcaccgtcg acgacctcaa gcgcatcctc ctcgaaggcg
     4681 ccggcgccga cgagagcgtc gacctcgaca gcgccgactt cctcgactcc gagttcgagg
     4741 cgctgggcta cgagtccctg gcgctgctgg agaccggcgg ccgcatcgag cgcgagttcg
     4801 gcatcacgct ggacgacacc gcgctgaccg acgccaccac cccgcgtgcc ctcatcgagg
     4861 tcgtcaacgc gcacatcggt cagcccaccg cggtctgacc cgggcgccgt cgcccgacac
     4921 cggtcgcgaa cgaccctcgc ggccccgccg ccggaccggc cgggaagcac ccccggtccg
     4981 gcggcggccc ttttccgcat cgagatccgc aggaggaaac aatggcgcag gacaagcggg
     5041 tcgccctggt gaccggggcg accagcggca tcggtctggc cgtggcccgg ctgctggccg
     5101 agcaggggca ccgggtgttc ctgggcgcgc gcagcgccga gaacgtggcc gcgaccgtga
     5161 aggaactgca gagcgccggc ctggaggcgg acggcgccac gctggacgtc cgctccgacg
     5221 ccgacgtcca cgccttcgtg cgggcggccg tggaccggtt cggcacggtg gacgtgctgg
     5281 tgaacaacgc cggccgcagc ggcggcggag tgaccgcgga catcgccgac gagctgtggc
     5341 acgacgtgat cgacacgaac ctcaacagcg tgttccggct gacccgcgag gtgctgaaca
     5401 ccggtggcct caggcacaag agctggggcc ggatcatcaa catcgcctcc accgcgggca
     5461 agcagggcgt cgtcctgggc gccccgtact cggcgtccaa gcacggcgtg gtcggcttca
     5521 ccaaggccct cggcaacgag ctggccccga ccgggatcac cgtcaacgcg gtctgcccgg
     5581 gctacgtcga gacgccgatg gcccagcggg tgcgccaggg ctacgccgcc gcctacgaca
     5641 ccaccgagga cgcgatcctg gagaagttcc agtccaagat cccgctcggc cgctactcca
     5701 cccccgagga ggtcgccggg ctggtcggct acctggcctc cgacaccgcc gcctccatca
     5761 ccgcccaggc gctcaacgtc tgcggcggcc tcggcaactt ctgatccccc gccttcctag
     5821 gagctaccgc gatgaccacc cgtgaggtcg agcacgagat caccatcgcc gccccggccg
     5881 aggcggtgta ccggctgctg gccgacgtgg agaactggcc gcgcatcttc ccgcccacca
     5941 tcttcgccga ccgcctggag ggcggggaga ccgaggagcg gatccggatc tgggccaccg
     6001 ccaacggcga ggccaagaac tggacgtccc gccgcaccct ggaaccgcgg ggccttgtga
     6061 tcaccttccg ccaggaggtg tccgccccgc cggtcgcggc catgggcggc acctggatca
     6121 tcgagccggc cggcgagtcc gcggcccggg tgcggctgct gcacgactac cgcgccgtcg
     6181 acgacgaccc ggccggcctg gcctggatcg acgaggccgt cgaccgcaac tcccgcaccg
     6241 agctggcctc gctgaagacc aacgtggagt tcgcgcacgc cgcgcgggag atcaccttct
     6301 ccttcgagga caccgtccgc atcgacgggt cggccaagga cgtgtacgac ttcatcaacg
     6361 acgcccacct gtggtccgag cggctgccgc acgtggccag cgtgcgctgc gaggaggagt
     6421 acccgggcct gcagaccctg gagatggaca cccgggccaa ggacggctcg acccacacca
     6481 ccaagtcgta ccgggtctgc ttcccgcacc ggaagatcgc ctacaagcag gtcacgctgc
     6541 ccgcgctgat gaacctgcac accggctact ggaccttcac cgaggacgcg gacggggtgt
     6601 cggcctcctc ccagcacacc gtcgtcctca acaccgacaa catcacgcgg atcctcggcc
     6661 ccgacgccgg catccccgag gcccgcgcct acgtgcagag cgcgctgagc accaacagcc
     6721 gcgccaccct cggccacgcc aaggactacg ccgaagcacg gcggaaccat gcggactgac
     6781 gtcctcgtcg tcggcgcggg cccggtcggg ctgatgctcg ccggtgaact gcgcctcggc
     6841 ggcgccgagg tggtcgtgct ggatcggctg ccccggccca ccaccgagtc ccgcgcgacg
     6901 accctgcacg cccgcaccat ggagatcctc gccgcccgcg gcctgctcga ggcgctcggc
     6961 accccgccga acgacgtgat gggccacttc ggcggcgtcc cgctggacct caccctgccc
     7021 acgccgtacc ccggccagtg gaaggtcccg cagacccgca ccgaggaact gctccaggcc
     7081 tgggcgctct ccctcggcgc caccgtccgc cgcgcccacg aactgcgcgc gctgaccgtc
     7141 acggacaccg gtgccgaggc cgaggccacc ggccccgacg gccggcccgt ccgggtgagc
     7201 gcccgctacg tcgtcggctg cgacggcgag cgcagcaccg tgcgcgagct gaccggagcc
     7261 gacttccccg ggcaggacgc cacccgcgag ctgatccgcg ccgacgtcgc cggcatcgac
     7321 atccccgacc ggcgcttcca gcggctccag cggggcctgg ccatcgccgc ccgccggccc
     7381 gacggcgtca cccgggtgat ggtgcacgag ttcggccgcg cggcccggcc gcgcaccggc
     7441 gcccccgcct tcgccgaggt cgtcgacgtg tggaagcgcg tgaccggcga ggacatcggc
     7501 ggcggcaccc cgctgtggct caacgccttc ggtgacgcct cccggcaggt ggcgcgctac
     7561 cgcgacggcc gcgtgctgtt cgccggggac gccgcgcacg tccagatgcc cgtgggcgga
     7621 caggccctca acctcggtct ccaggacgcg gtcaacctcg gctggaagct cgccgccgag
     7681 atccggggcc gggccccgga cggcctgctg gacacgtacc actccgagcg gcacgccgtc
     7741 ggcgagcggg tgctgagcac catccgcgcc cagtcgacgt tcctgctcgg cggcccggac
     7801 gtcgaggcgc tgcgcgaggt cttccgcgag ctgatcgacc ccgcgcacac ccgtcacacc
     7861 cgcgcccacc tggccggcct gatcagcggc ctggacatcc ggtacgacgt cggcccgggc
     7921 gaccatccgc tgctgggcgc ccgtatgccc tacggcgagc tggaccaggc ccccgacgcg
     7981 gcctgccgca aggcgcgcgg ggtgctgctg gacctcgcac ccggcagccc gtccgcggcg
     8041 gagctgcacg ccgtcgccgc cggctgggcg gaccgggtgg acgtcgtcac ggccgggttc
     8101 cgtaccgccg acggcccttc cgctctctcg ggggcgcgtg ccgtcctggt gcggcccgac
     8161 ggccacgtgg tctggaccga ttccggcgcg ggacggccgg agacggccct gcgccgctgg
     8221 ttcggcgcac cggtgtcttg agttcgaggg agtgaccgac atgtcgaagt ccgcaccgcg
     8281 gcccccggcg ggcccccgca cggcgaccgg ccccgaggtc ctggtcgtcg gggcgggccc
     8341 caccggcctg ctgctggcgg gagacctcgc cgccgccggc acccgggtca ccgtcctgga
     8401 gaagcgcggc cggaaactga gcaacctgac ccgctcgttc accgtgcacg cgcgcaccct
     8461 ggagcagctt caggcgcgcg gcgtcgccga ggacatcatc gccaccggca ccaagctgcc
     8521 caccctgccg ctcttcggcg acctggacat ccacttcgcg cacctgcgca cccgctaccc
     8581 gtacgtgctg atcaccccgc agtttcacgt ggaacaagtg ctggagcgac gggccgtctc
     8641 cctcggggtg gagttccgcc acgacaccga ggtgaccggg ctgcgccagg acgcgcacgg
     8701 ggtcgagctg gacgccgtca ccgccgacgg cacccgggag acccaccgtg cggcctacgc
     8761 ggtcggcacc gacggggtgc gcagcaccgt gcggcggctg ctggacatcc ccttccccgg
     8821 cgactccgtg ctgcgctcgg tgatcctcgc cgacgtgctg atgaaggagg cgcccgccga
     8881 cctgctcacc gtggacgcca acgagcacgg gttcgccttc gtcgccccct tcggcgacgg
     8941 ctactaccgc gtgctcgcct ggaaccggca caccgacagc tcggcggacg agtccgtgga
     9001 cttcgaggag ctgcgccggc tgtgccgggc cattctgggc cgggacttcg gcatgcacga
     9061 gccgcgctgg gtctcgcgct tccacagcga cgagcgccag gccacccggt accgcgaggg
     9121 ccgcttcttc ctggccggcg atgccgcgca cgtccactcg ccggccggcg gcatgggcat
     9181 gaacaccggc ctgcaggacg cgatgaacct cgcctggaag ctggcggcgg cggtgcgcgg
     9241 ccacggcgac gacgccctgc tcgacaccta cgaggcggag acccatccgg tcggcgagga
     9301 ggtgctgcgc acgtcgggct ccctggtccg cgcggccatc cggcagagcg gacgcacccg
     9361 gctcgcccag caggcgatgg tctggttcgc cggacacctc ggcccgctcg gcgaggcact
     9421 gggccgccgg gagggcctgg ccgtctccgg caccggtatc acctacggcc ggcagcgcgg
     9481 cgaccaccgg ctcgtcggcc ggttcttcca cgggcggctg accggcggac ggctcgacgg
     9541 cgccctgggc accggccggt tcgtgctgct cagccccgac gaggccgtgc gcacggcggt
     9601 ggcggactgg tccgaccgcg tcgtgaccgc ccccgcggac gtccgcacca cgctgctcat
     9661 ccggccggac gggtacgtcg cctgggcggc cgacggcccc ggcccggcgg cggtccgcga
     9721 cgccctgaac cgctgggcgg gcccggcgga accccggatc cggcttgcgt acgcgggctg
     9781 aggaacgctg ggcggtaccg gtaccggacg ccgtaccggt accggacgcc gtaccggtac
     9841 cggaaacgct cccggtgccg gacggccggc gcgtggacct gtggctgctg cgctgccccg
     9901 gaccgggcac cccgccgggc cctcacgtac ggccggactc tcacgtacgg gccgacaccc
     9961 gcgtacgccc cgacccggac gtacgccccg acccggaccc tctcgccgac ccgggcgtcc
    10021 tcgacgtact cgacgcggcg gagcggaagc gggcggcctc cctgcgccgg cccgccgacc
    10081 gggccctcta cgtcgcctcg cacctcgccc tgcgcaccct gctcggcgcc tacctgcgcg
    10141 tccccgcgcg ggaggtggtc ctcgtccgcg agccgtgccc ggggtgcggc ggcccgcacg
    10201 gccgcccggc ggtcccgggc accccgcccc cgctgcactt ctccctctcg cacagccacg
    10261 gcctggccct gatcggggtg gcggcggtcc ccgtcggcgt cgatgtgcag cgggtgccgg
    10321 gtcccggcac cgtcgacgcc tgcgcccctt cgctgcaccc ggccgaacgc gccgaactgg
    10381 agcggctgcc gcccggcgca cgccccggcg cgttcgccca gctgtgggcg cgcaaggagg
    10441 cgtacctcaa gggcatcggc accggcctga gccgccccgc gtccgccgac tacctcggcg
    10501 ccgacacccg gtcccggccg cacggctgga cggtcaccga cctgccccgc gccgacggcc
    10561 acaccgcggc ggtcgccgtc ctcggcacgg cgcccccgac cccggccgta cgccggctgc
    10621 ccgtgcgcct cacctcacct cacctcacct caccgactga cgaccatgca ccaggccgcc
    10681 aacgaccacg agcccaccga ccagttggca aggcaaccgg agggtaccca tga
//
