BGC0001728: paenilipoheptin biosynthetic gene cluster from Paenibacillus polymyxa E681
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Location: 2,550,215 - 2,616,852 nt. (total: 66,638 nt).
This entry is originally from NCBI GenBank NC_014483.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001728
Short description paenilipoheptin biosynthetic gene cluster from Paenibacillus polymyxa E681
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
NC_014483.2
2550215 - 2616852
via
Compounds
  • paenilipoheptin
Species Paenibacillus polymyxa E681 [taxonomy]
References
Chemical products information
paenilipoheptin Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • PPE_RS11400
  • WP_013310324.1
 2550215 - 2551684 (+) efflux RND transporter periplasmic adaptor subunit
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    • PPE_RS11405
    • WP_013310325.1
    		 2551681 - 2552418 (+) ABC transporter ATP-binding protein
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      • PPE_RS11410
      • WP_013310326.1
      		 2552415 - 2553629 (+) ABC transporter permease
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        • PPE_RS11415
        		 2553739 - 2554505 (+) polysaccharide deacetylase
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          • PPE_RS11420
          • WP_013310330.1
          		 2554546 - 2555022 (+) RNA polymerase sigma factor
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            • PPE_RS11425
            • WP_013310331.1
            		 2555264 - 2556865 (+) alpha-amylase family glycosyl hydrolase
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              • PPE_RS11430
              • WP_013310332.1
              		 2557229 - 2557981 (-) HAD family phosphatase
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                • PPE_RS11435
                • WP_013310333.1
                • gutB1
                		 2558011 - 2559060 (-) 2-amino-2-deoxy-D-mannitol dehydrogenase GutB1
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                  • PPE_RS11440
                  • WP_013310334.1
                  		 2559094 - 2560332 (-) aspartate aminotransferase family protein
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                    • PPE_RS11445
                    • WP_013310335.1
                    		 2560531 - 2561739 (-) MFS transporter
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                      • PPE_RS11450
                      • WP_013310336.1
                      		 2562136 - 2563044 (+) AraC family transcriptional regulator
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                        • PPE_RS11455
                        • WP_013310337.1
                        		 2563162 - 2564226 (+) Gfo/Idh/MocA family oxidoreductase
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                          • PPE_RS11460
                          • WP_013310338.1
                          		 2564658 - 2567498 (+) alpha-amylase family glycosyl hydrolase
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                            • PPE_RS11465
                            • WP_013310339.1
                            		 2568064 - 2568849 (+) S-layer homology domain-containing protein
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                              • PPE_RS11470
                              • WP_013310340.1
                              • fabD
                              		 2569479 - 2570699 (+) ACP S-malonyltransferase
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                                • PPE_RS11475
                                • WP_013310341.1
                                		 2570674 - 2576763 (+) aminotransferase class III-fold pyridoxal phosphate-dependent enzyme
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                                  • PPE_RS11480
                                  • WP_013310342.1
                                  		 2577404 - 2586283 (+) non-ribosomal peptide synthetase
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                                    • PPE_RS24095
                                    • WP_013310343.1
                                    		 2586307 - 2590932 (+) non-ribosomal peptide synthetase
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                                      • PPE_RS24100
                                      • WP_043882190.1
                                      		 2590965 - 2611964 (+) non-ribosomal peptide synthetase
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                                        • PPE_RS11495
                                        • WP_013310345.1
                                        		 2612245 - 2613630 (-) MFS transporter
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                                          • PPE_RS11500
                                          • WP_043882191.1
                                          		 2613741 - 2614628 (+) LysR family transcriptional regulator
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                                            • PPE_RS11505
                                            • WP_013310347.1
                                            		 2614796 - 2615068 (-) helix-turn-helix transcriptional regulator
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                                              • PPE_RS25760
                                              		 2615268 - >2615417 (+) beta-galactosidase
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                                                • PPE_RS11515
                                                • WP_013310350.1
                                                		 2615674 - 2616015 (-) helix-turn-helix domain-containing protein
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                                                  • PPE_RS11520
                                                  		 2616137 - >2616427 (+) arginase family protein
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                                                    • PPE_RS11525
                                                    		 2616460 - 2616852 (+) glycosyl hydrolase
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                                                      Biosynthesis information

                                                      Biosynthetic modules

                                                      Name
                                                      Unk01
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      PPE_RS11480
                                                      Substrates
                                                      serine (evidence: Mass spectrometry, Structure-based inference, Sequence-based prediction)
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Name
                                                      Unk02
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      PPE_RS24095
                                                      Substrates
                                                      2,4-diaminobutyric acid (evidence: Mass spectrometry, Structure-based inference, Sequence-based prediction)
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Name
                                                      Unk03
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      PPE_RS24100
                                                      Substrates
                                                      tryptophan (evidence: Mass spectrometry, Structure-based inference)
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Name
                                                      Unk04
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      PPE_RS24100
                                                      Substrates
                                                      valine (evidence: Mass spectrometry, Structure-based inference, Sequence-based prediction)
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Name
                                                      Unk05
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      PPE_RS24100
                                                      Substrates
                                                      phenylalanine (evidence: Mass spectrometry, Structure-based inference, Sequence-based prediction)
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Name
                                                      Unk06
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      PPE_RS24100
                                                      Substrates
                                                      tyrosine (evidence: Mass spectrometry, Structure-based inference)
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Name
                                                      Unk07
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      PPE_RS24100
                                                      Substrates
                                                      glutamic acid (evidence: Mass spectrometry, Structure-based inference, Sequence-based prediction)
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Annotation changelog

                                                      Entry version: 3

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2022-09-15
                                                      Added NRP substrate specificities
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 2

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2019-10-16
                                                      Migrated from v1.4
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 1

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2018-08-06
                                                      Submitted
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      Detailed domain annotation
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