BGC0001731 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001731 (Streptomyces paulus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	PKS-like	1	64,000	High	paulomycin	other:other

BGC0001731 - Region 1 - PKS-like

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Location: 1 - 64,000 nt. (total: 64,000 nt) Show pHMM detection rules used

Region on contig edge.

PKS-like: (t2pks2 or ksIII)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 64,001
Label		BGC0001731

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

AIE54174.1: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

AIE54181.1: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

AIE54187.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

AIE54194.1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

AIE54195.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

AIE54206.1: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

AIE54209.1: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

AIE54215.1: aldehyde oxidase and xanthine dehydrogenase

smcogs: SMCOG1293: aldehyde oxidase and xanthine dehydrogenase

Transferases: PPTase acyltransferase aminotransferase glycosyltransferase transferase

AIE54173.1: acyltransferase 3

smcogs: SMCOG1088: acyltransferase 3

AIE54182.1: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

AIE54190.1: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

AIE54191.1: acyltransferase 3

smcogs: SMCOG1088: acyltransferase 3

AIE54192.1: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

AIE54198.1: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

AIE54205.1: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: back translocase hydrolase

AIE54177.1: GTP-binding protein LepA

smcogs: SMCOG1190: GTP-binding protein LepA

AIE54186.1: isochorismatase

smcogs: SMCOG1027: isochorismatase

Lyases: dehydratase

AIE54189.1: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Isomerases: isomerase

AIE54185.1: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthase

AIE54179.1: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

AIE54196.1: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

AIE54201.1: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001731.5	0.91	other (other)	paulomycin	Streptomyces paulus
BGC0001732.5	0.88	other (other)	paulomycin	Streptomyces sp. YN86
BGC0002493.3	0.56	NRPS	parabactin	Paracoccus denitrificans PD1222
BGC0002474.2	0.56	NRPS	agrobactin	Agrobacterium tumefaciens
BGC0001444.5	0.53	other (shikimate-derived)	caboxamycin	Streptomyces sp. NTK 937
BGC0000898.5	0.53	saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae
BGC0000791.3	0.52	saccharide	O-antigen	Cronobacter sakazakii
BGC0001850.4	0.51	other (shikimate-derived)	diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G	Streptomyces sp. F001
BGC0001817.5	0.51	other (other)	vancosamine	Streptomyces sp. WAC2288
BGC0000813.3	0.50	other (other)	K-252a	Nonomuraea longicatena

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001731.5	0.99	other (other)	paulomycin	Streptomyces paulus
BGC0001732.5	0.96	other (other)	paulomycin	Streptomyces sp. YN86
BGC0002493.3	0.56	NRPS	parabactin	Paracoccus denitrificans PD1222
BGC0002474.2	0.56	NRPS	agrobactin	Agrobacterium tumefaciens
BGC0001444.5	0.55	other (shikimate-derived)	caboxamycin	Streptomyces sp. NTK 937
BGC0001817.5	0.54	other (other)	vancosamine	Streptomyces sp. WAC2288
BGC0000898.5	0.53	saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae
BGC0000791.3	0.53	saccharide	O-antigen	Cronobacter sakazakii
BGC0001302.5	0.52	other (other)	lomofungin	Streptomyces lomondensis
BGC0001850.4	0.51	other (shikimate-derived)	diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G	Streptomyces sp. F001

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

NRPS/PKS substrate predictions

AIE54201.1: X

AMP-binding (10..380): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GATVVSYPLK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor