BGC0001735: pentostatine biosynthetic gene cluster from Streptomyces antibioticus
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Location: 1 - 39,550 nt. (total: 39,550 nt).
This entry is originally from NCBI GenBank KJ856912.1.

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core biosynthetic genes
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resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001735
Short description pentostatine biosynthetic gene cluster from Streptomyces antibioticus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (other)
Loci
KJ856912.1
via
Compounds
  • pentostatine
  • vidarabine
Species Streptomyces antibioticus [taxonomy]
References
Chemical products information
pentostatine Evidence:
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C11H16N4O4
vidarabine Evidence:
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C10H13N5O4
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AOE46821.1
 1 - 424 (-) hypothetical protein
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    • AOE46822.1
    		 534 - 1349 (-) hypothetical protein
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      • AOE46823.1
      		 1654 - 1893 (-) hypothetical protein
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        • AOE46824.1
        		 2617 - 3660 (-) hypothetical protein
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          • AOE46825.1
          		 3833 - 4096 (+) HTH-type transcriptional regulator SutR
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            • AOE46826.1
            		 4270 - 5133 (+) hypothetical protein
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              • AOE46827.1
              		 5566 - 7017 (+) F-box DNA helicase protein
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                • AOE46828.1
                		 7288 - 7713 (+) hypothetical protein
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                  • AOE46829.1
                  		 8082 - 8360 (+) hypothetical protein
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                    • AOE46830.1
                    		 9268 - 13995 (+) putative deoxyribonuclease
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                      • AOE46831.1
                      		 13992 - 14672 (+) nucleoid-associated protein Lsr2
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                        • AOE46832.1
                        		 15025 - 15708 (+) nuclear distribution protein
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                          • AKA87333.1
                          		 16004 - 17083 (-) putative LacI family transcriptional regulator
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                            • AKA87334.1
                            • penG
                            		 17327 - 18490 (+) S-adenosyl-L-homocysteine hydrolase, NAD binding
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                              • AKA87335.1
                              • penF
                              		 18484 - 19560 (+) metal dependent phosphohydrolase
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                                • AKA87336.1
                                • penE
                                		 19557 - 20762 (+) major facilitator superfamily protein
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                                  • AKA87337.1
                                  • penD
                                  		 20833 - 22023 (+) adenosylhomocysteinase
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                                    • AKA87338.1
                                    • penC
                                    		 22023 - 22766 (+) saicar synthetase
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                                      • AKA87339.1
                                      • penB
                                      		 22753 - 23457 (+) short-chain dehydrogenase
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                                        • AKA87340.1
                                        • penA
                                        		 23467 - 24375 (+) ATP phosphoribosyltransferase
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                                          • AOE46833.1
                                          • penJ
                                          		 24379 - 24864 (-) phytoene dehydrogenase
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                                            • AOE46834.1
                                            • penI
                                            		 24833 - 25402 (-) phytoene dehydrogenase
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                                              • AOE46835.1
                                              • penH
                                              		 25209 - 25850 (-) phytoene dehydrogenase
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                                                • AOE46836.1
                                                		 25891 - 26655 (-) hydroxybutyryl-CoA reductase
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                                                  • AOE46837.1
                                                  		 26652 - 27287 (-) tubulin alpha-2 chain protein
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                                                    • AOE46838.1
                                                    		 27284 - 29164 (-) hypothetical protein
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                                                      • AOE46839.1
                                                      		 29305 - 29457 (-) hypothetical protein
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                                                        • AOE46840.1
                                                        		 30061 - 32592 (+) nucleoprotein
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                                                          • AOE46841.1
                                                          		 32804 - 33028 (+) hypothetical protein
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                                                            • AOE46842.1
                                                            		 33055 - 34041 (-) polydeoxyribonucleotide synthase
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                                                              • AOE46843.1
                                                              		 34490 - 35203 (-) glycerophosphodiester phosphodiesterase
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                                                                • AOE46844.1
                                                                		 36132 - >39550 (+) tRNA(Glu)-specific nuclease
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                                                                  Biosynthesis information
                                                                  Annotation changelog

                                                                  Entry version: 4

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2022-10-07
                                                                  Update chemical activity to schema version 2.11
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 3

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2022-09-15
                                                                  Updated bioactivity data
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 2

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2019-10-16
                                                                  Migrated from v1.4
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 1

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2018-08-06
                                                                  Submitted
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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