BGC0001735: pentostatine biosynthetic gene cluster from Streptomyces antibioticus
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Location: 1 - 39,550 nt. (total: 39,550 nt).
This entry is originally from NCBI GenBank KJ856912.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
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KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001735
Short description pentostatine biosynthetic gene cluster from Streptomyces antibioticus
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Other
Loci NCBI GenBank: KJ856912.1
Compounds
  • pentostatine
  • vidarabine
Species Streptomyces antibioticus [taxonomy]
References
Chemical products information
pentostatine
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C11H16N4O4
vidarabine
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C10H13N5O4
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AOE46821.1
 1 - 424 (-) hypothetical protein
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  • AOE46822.1
 534 - 1349 (-) hypothetical protein
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  • AOE46823.1
 1654 - 1893 (-) hypothetical protein
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  • AOE46824.1
 2617 - 3660 (-) hypothetical protein
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  • AOE46825.1
 3833 - 4096 (+) HTH-type transcriptional regulator SutR
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  • AOE46826.1
 4270 - 5133 (+) hypothetical protein
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  • AOE46827.1
 5566 - 7017 (+) F-box DNA helicase protein
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  • AOE46828.1
 7288 - 7713 (+) hypothetical protein
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  • AOE46829.1
 8082 - 8360 (+) hypothetical protein
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  • AOE46830.1
 9268 - 13995 (+) putative deoxyribonuclease
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  • AOE46831.1
 13992 - 14672 (+) nucleoid-associated protein Lsr2
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  • AOE46832.1
 15025 - 15708 (+) nuclear distribution protein
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  • AKA87333.1
 16004 - 17083 (-) putative LacI family transcriptional regulator
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  • AKA87334.1
  • penG
 17327 - 18490 (+) S-adenosyl-L-homocysteine hydrolase, NAD binding
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  • AKA87335.1
  • penF
 18484 - 19560 (+) metal dependent phosphohydrolase
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  • AKA87336.1
  • penE
 19557 - 20762 (+) major facilitator superfamily protein
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  • AKA87337.1
  • penD
 20833 - 22023 (+) adenosylhomocysteinase
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  • AKA87338.1
  • penC
 22023 - 22766 (+) saicar synthetase
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  • AKA87339.1
  • penB
 22753 - 23457 (+) short-chain dehydrogenase
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  • AKA87340.1
  • penA
 23467 - 24375 (+) ATP phosphoribosyltransferase
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  • AOE46833.1
  • penJ
 24379 - 24864 (-) phytoene dehydrogenase
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  • AOE46834.1
  • penI
 24833 - 25402 (-) phytoene dehydrogenase
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  • AOE46835.1
  • penH
 25209 - 25850 (-) phytoene dehydrogenase
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  • AOE46836.1
 25891 - 26655 (-) hydroxybutyryl-CoA reductase
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  • AOE46837.1
 26652 - 27287 (-) tubulin alpha-2 chain protein
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  • AOE46838.1
 27284 - 29164 (-) hypothetical protein
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  • AOE46839.1
 29305 - 29457 (-) hypothetical protein
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  • AOE46840.1
 30061 - 32592 (+) nucleoprotein
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  • AOE46841.1
 32804 - 33028 (+) hypothetical protein
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  • AOE46842.1
 33055 - 34041 (-) polydeoxyribonucleotide synthase
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  • AOE46843.1
 34490 - 35203 (-) glycerophosphodiester phosphodiesterase
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  • AOE46844.1
 36132 - >39550 (+) tRNA(Glu)-specific nuclease
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Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Similar known gene clusters
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