LOCUS       BGC0001738             24326 bp    DNA     linear   PLN 24-JAN-2019
DEFINITION  Pyrenochaetopsis sp. RK10-F058 DNA, phomasetin biosynthetic gene
            cluster, complete sequence.
ACCESSION   BGC0001738
VERSION     BGC0001738
KEYWORDS    .
SOURCE      Pyrenochaetopsis sp
  ORGANISM  Pyrenochaetopsis sp.
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Dothideomycetes; Pleosporomycetidae; Pleosporales; Pleosporineae;
            Pyrenochaetopsidaceae; Pyrenochaetopsis.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 16:10:48
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 24326
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(1..12300)
                     /gene="phm1"
     CDS             complement(join(1..2882,2939..4765,4836..5530,5584..10156,
                     10222..10860,10922..11134,11188..11616,11673..12300))
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (6-437). E-value:
                     9.5e-164. Score: 537.1. Matches aSDomain:
                     nrpspksdomains_phm1_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (540-858). E-value: 3.7e-87.
                     Score: 284.3. Matches aSDomain:
                     nrpspksdomains_phm1_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (932-1108). E-value: 2.2e-22.
                     Score: 72.0. Matches aSDomain:
                     nrpspksdomains_phm1_PKS_DH.1"
                     /NRPS_PKS="Domain: cMT (1376-1569). E-value: 8.2e-76.
                     Score: 246.7. Matches aSDomain: nrpspksdomains_phm1_cMT.1"
                     /NRPS_PKS="Domain: PKS_KR (2104-2277). E-value: 1.3e-49.
                     Score: 160.5. Matches aSDomain:
                     nrpspksdomains_phm1_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (2387-2460). E-value: 5.7e-11.
                     Score: 34.5. Matches aSDomain:
                     nrpspksdomains_phm1_PKS_PP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (2551-2848). E-value:
                     5.8e-54. Score: 175.0. Matches aSDomain:
                     nrpspksdomains_phm1_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (3021-3432). E-value:
                     5.4e-84. Score: 274.0. Matches aSDomain:
                     nrpspksdomains_phm1_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (3546-3612). E-value:
                     5.7e-11. Score: 34.7. Matches aSDomain:
                     nrpspksdomains_phm1_PP-binding.1"
                     /NRPS_PKS="Domain: TD (3652-3873). E-value: 2.2e-40. Score:
                     130.3. Matches aSDomain: nrpspksdomains_phm1_TD.1"
                     /codon_start=1
                     /gene="phm1"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 206.4; E-value:
                     1.2e-62)"
                     /gene_kind="biosynthetic"
                     /product="PKS-NRPS hybrid"
                     /protein_id="BBC43184.1"
                     /sec_met_domain="itr_KS (E-value: 1.5e-175, bitscore:
                     572.8, seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 4.6e-88, bitscore: 284.3,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 1.6e-45, bitscore:
                     144.2, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 2.8e-40, bitscore:
                     127.1, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 2.8e-91, bitscore:
                     294.9, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 7.2e-12, bitscore:
                     34.7, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 1.9e-32, bitscore:
                     101.2, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSSEPIAIIGSACRFPGGADTPSKLWELLKEPRDLLQKVPEKRR
                     WHSEAFYHKDPEHHGTSNVSSSYFLDDDPASFDNTFFNIQPSECEAIDPQQRMLMETVY
                     DSVCSAGQTIDGLRGSSTAVYVGMMCDDWSAILTKDAESIPQYSATGMGRSIMSNRISY
                     FFDWHGPSITLDTACSSSLVAVHLAVQALRNGDCGTAIAAGVNLCLSPGMYIATSNLHM
                     LSEGARSRMWDKDVDGYARGEGIASVVLKPLSAAIRDGDHIECLIRATGVNQDGKTQGL
                     TMPSATAQTALIRQTYERAGLDIEKPEDRPQFFHAHGTGTPAGDPQEAEAISTAFYSGG
                     LSDKLYVGSIKTVIGHTEGTAGLASLIGTSLALQHGVIPPNLLFNELNPRLIPFYNNLE
                     VPTSAKPWPQLLPGQARRASVNSFGFGGTNAHAIVEAYEPPTSSGAADNVFAPLVFSAA
                     TEKSLRASLSAHGDYLQANPQVPLRNFAYTLQERRSTLAFRAVIPASNTTDAVERINAL
                     LDDADSVELGTKHFATPHPRLLGVFTGQGAQWPRMGAQIVEASPYASKKLGELDTALAT
                     LPPDVRPSWTLREEILADLEVSKVAEAAISQPLCTAVQILLVDLLTAAGIRFDAVVGHS
                     SGEIGAAYAAGFISAETAIRVAYLRGFYAKLAGAAEMKGSMMAVGTSYEDALEFCQLEH
                     FMGRISVAAVNSDSSITLSGNEDAIMEAVEIFKDEGKFARQLKVDTAYHSVHMLPCSEP
                     YLKAMESVTQSTAPRDNTAGPRPTWYSSVLDGAVMGPGEVNSEYWVSNMVNPVLFSAAV
                     AAAVSATGPFNLALEVGPHPALKGPCLDTLAAASGDSIPYSGLLSRSKNDILELSSALG
                     FVWANLGASSVRFGDFEKLISGVSENPRPVKDLPKYAFDHTRSFWQISRASGAQFLAQD
                     PPHPILGKRCLERETSQHVEWRNILSPKELPWLQGHRIQGGMVFPAAGYVAMAIEAMKI
                     AVGKSRMSLIHIENLHIGRAMAFNQETSTMECLFRLNIVNSSPDSMKAKFSCCSGAPYE
                     TGTTMVLNAEGTVTVTLAEPEPDAIPYMKPKNFNMTEIEVDRFYTQIHKLGYEYSAPFR
                     GMLSIQRKNAYALGTMEDQGGSDWEDQLLVHPGMLDTAIQSSSAAFGCPGDGMMWTLYI
                     PTGIQSIIINPYYTTYATEKQEVLPWETISRGMVNTRTSMDINIFSQDNAHTFIQVEGL
                     ELVPFTAARPEDDANIFSSLEYRIDSPSGDLAVINDGWDSHSSEAAIKGERVSFFYLRR
                     LLEEITPEEKEKTLPHYRHLLNWAAHVVARVSAGKNPCVPASCMQDTQEIIDSMWDGVR
                     NRADIRLIESVGRNLIKVVREGSGILEHMDGLFDFYDQGLGLDRANRHLARMVGQLAHR
                     YPHMNIFEIGAGTGGSTRNILSAIREEFSTYTYTDVSSGFFEAAQELFQDYEDRMIYST
                     YNMEHEPTSQGFEEGHYDLLLASNVLHATDKLEEMMLSARKLLKPGGYLIALELTNNDS
                     MRVGLPMGTLPGWWLGAETGRPWGPTVTLPQWDSLLRKCGFGGIDTSTPIQHRLQASTI
                     FAAQAVDDRVNLLRNPLSLVNNLPLTDAPRLVIIGGESLATHAIANNISSLLASHYSEI
                     VRIVSFADLDLDVLPYGTAVLSLADLDEPVFKDISPAKLDALKTLWRQAFNIVWVTQGA
                     RAAEPYSSMMIGLGRAMIHEYPTISLQLMDIDTIADESRATQLIAKEFIRLELLNTFKR
                     GTKSNLDLLWSIESEVTFEGSARLIPRLYLNKEANARYNSARRSIETQVNWKASLVTVA
                     LQGDTYGLSKPSPLRLPISQPSDTKVTSLNVSHFLLQGLKIDGLNPLVLCAGTERSTGK
                     HLLALSHSLESQPEIQTKWSAPLPSGSDPSQIIAAVAAEIIADQITKLHTRSGIMIIHE
                     ATEQLAVALHTRAQTLGCQIVFTTSSKDHAQRGWQFIPQNISRRLIKRTLPADSNVFID
                     LSYSSASVAAGRLISGSVSKSCAKYTSDAFYSASVSSEFDLESSTKVEEAFQQAYDSVT
                     QSKTGLVDPITIPIQEIGDVSVSQKPLAVVVSSATNLAVKVEAIDSGVIFRQDKTYLLI
                     GMSGQVGQSLCQWMVKCGARHVVLTSRRPLVHDDFIESMKDLGANVRTFALDITQRESL
                     HKCYEEIVATMPPIAGVANGAMILRDSMFDGMTFQNLTTVLEPKVAGTRYLDELFYDAP
                     LDFFIVLSSITSLVGNSSQSNYTAANMFMVALVEQRRKRGVPGSAISISALIGIGYVEN
                     SEFTGEYFENIGLRNISEQDLHQQFAEAILAGRPETQGSSEVAIGLIPFYPERDDKAQF
                     HTDIKFNHLMLERKDAQIHGGKGSALPVRVQLAEAKTKDQAATIIKDGFMVRLKRTLMI
                     GLDEVVNEKVPLVEQGIDSLMAVEIRAWFLKELDVDIPVLKVLGGSNITELLQEAMDRT
                     PSTIIDFSSLSNAKAAAPVTNTATPPPEVQVTGSASDSSRSLTPDGLSTSRPSTPVRTP
                     MTEINDPTPSFSLLSVAPDIAPKVPESVSPMSYGQARFWFLSDYLEDKTSFNMTVMFKL
                     TGRLQVPRLERAVRTIAHRHDALRTRFFWGGEGDKRIAMQGISAESSIELEHVRINSEA
                     DAKNELRKMHEFVWDLDSHQAARMVLLTINENEHYFMTSGHHISWDGYGFTVLFIDLDA
                     AYRGEPLSPNGPETQYPAFAAWQRDTYAAGAMKKSIDEYYRPMIDPEARPLPLFPFARA
                     PNRPLLDHFEQFEAKVTLQPHVVSKLKQVSRKNGATMFHLYLAALQALVFRLLPEEQSF
                     YLGVADANRLDKNFMGSLGFFLNLLPVRFDRTAPGTKSSDMIKDTRNKAYKALENSFVP
                     WDVLLHELKIPRTNTEAPIFQLFVDYRQIVRERAQWCGCSMSDEDWLNARNGYDLTLGI
                     TDNPTGESLLSLRFQKKLYSEESTEMFLRSYVNVLEALASGKDLLVDDLPRWAGADVEE
                     ALNVGRGPQLELEWPVTVSHRIDQMIGTYASKPALQDEHNNCMSYEQMGHRINTIAAAL
                     IQAGTTTGTPVGVFQTPSSDWICSMLAIFRVGATYIPLDLRNSVARVSFIVEIAQPLIL
                     LTDRETTLHVAEIQASNATEIIIPDLSTTTMPLSMENQARPDSPAVTLFTSGTTGRPKG
                     VVLTHANLRAQCEGYSRMVNLQSMTSVVLQQTNYNFDVSLDQIFAALAEGGCLYVVPAS
                     KRGDPQAITKIMAEKGVTYTVATPSEYETWFRYAPETLAECKSWGYAFGGGEHLNNGLI
                     GEFAALSTRHIPELRLFNNYGPTEASLAITKGEVDFKRPDLEKHVPAGMTIPNYAVAIV
                     DENLKPVPLETVGEIVAGGPGVAAGYLGQADLTREKFISGHDVHRLAAQHSDRWYRTGD
                     RGYLRPDGALFVHGRILGDTQVKIRGFRVELQEIENVVLETAKGALTHAVVSLRGTGED
                     KFLTAHVVFAPDFAMHLRQDLIRHLEAALPLPSYMQPTVIVPLTKVPVTTNFKIDRNAI
                     QAMPLPQAVAGTDNLANMEGRVAALWRIIIPHLTQELTPESDFFAVGGNSILLVKLQAA
                     IKRELQSSPQLIDLINSSSLEGMARHVRAAFINRIDWDLETAVPADLKEDLEVLTSQPR
                     KHGQDDLTVVITGSTGYLGRHVLAHLVDSSNVRQIICLVRPEHLQTASPLSTSSKIRLV
                     AADISQPSLGLGAQTFAELAQITDIVFHCAANRSFWDGFESLRHVNFDAAKELARLCVA
                     NDAVLHFMSSGAVSKYNDISPPTDGSDGYIASKWAAEEFLRRVAKFGLRVQVHRPLALP
                     SEKVSSLSQEDLKRVQDELPRLIAQIGQRPEFSAIHGHIDVRPVSDVATTLVEDMLVSS
                     VQESGNEATVKNHAAHLRLQIKTFAEQIDADEELSKLPTMDALQWFGAAKRAGFGWLIG
                     AMEMHIEGDDQSGTTTQVLVQR"
     misc_feature    1..24326
                     /note="phomasetin biosynthetic gene cluster"
     protocluster    1..24326
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[0:12300]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..12300
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     protocluster    1..24326
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[0:12300]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      1..12300
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="2"
     cand_cluster    1..24326
                     /SMILES="C([*])C(-O)(C)NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="chemical_hybrid"
                     /product="NRPS"
                     /product="T1PKS"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     subregion       1..24326
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001738"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..24326
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /subregion_numbers="1"
                     /tool="antismash"
     aSDomain        complement(268..930)
                     /aSDomain="TD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_phm1_TD.1"
                     /evalue="2.20E-40"
                     /label="phm1_TD.1"
                     /locus_tag="phm1"
                     /protein_end="3873"
                     /protein_start="3652"
                     /score="130.3"
                     /tool="antismash"
                     /translation="VVITGSTGYLGRHVLAHLVDSSNVRQIICLVRPEHLQTASPLSTS
                     SKIRLVAADISQPSLGLGAQTFAELAQITDIVFHCAANRSFWDGFESLRHVNFDAAKEL
                     ARLCVANDAVLHFMSSGAVSKYNDISPPTDGSDGYIASKWAAEEFLRRVAKFGLRVQVH
                     RPLALPSEKVSSLSQEDLKRVQDELPRLIAQIGQRPEFSAIHGHIDVRPVSDVATTLV"
     aSModule        complement(268..4289)
                     /complete
                     /domains="nrpspksdomains_phm1_Condensation_LCL.1"
                     /domains="nrpspksdomains_phm1_AMP-binding.1"
                     /domains="nrpspksdomains_phm1_PP-binding.1"
                     /domains="nrpspksdomains_phm1_TD.1"
                     /final_module
                     /locus_tags="phm1"
                     /monomer_pairings="X -> X"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(868..933)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_phm1_0012"
                     /evalue="9.60E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="phm1"
                     /protein_end="3673"
                     /protein_start="3651"
                     /score="8.6"
                     /tool="antismash"
                     /translation="TVVITGSTGYLGRHVLAHLVDS"
     aSDomain        complement(1051..1248)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_phm1_PP-binding.1"
                     /evalue="5.70E-11"
                     /label="phm1_PP-binding.1"
                     /locus_tag="phm1"
                     /protein_end="3612"
                     /protein_start="3546"
                     /score="34.7"
                     /tool="antismash"
                     /translation="RVAALWRIIIPHLTQELTPESDFFAVGGNSILLVKLQAAIKRELQ
                     SSPQLIDLINSSSLEGMARHV"
     CDS_motif       complement(1558..1608)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_phm1_0011"
                     /evalue="6.20E-08"
                     /label="NRPS-A_a8"
                     /locus_tag="phm1"
                     /protein_end="3443"
                     /protein_start="3426"
                     /score="25.0"
                     /tool="antismash"
                     /translation="DTQVKIRGFRVELQEIE"
     aSDomain        complement(1591..2823)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_phm1_AMP-binding.1"
                     /evalue="5.40E-84"
                     /label="phm1_AMP-binding.1"
                     /locus_tag="phm1"
                     /protein_end="3432"
                     /protein_start="3021"
                     /score="274.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="GTYASKPALQDEHNNCMSYEQMGHRINTIAAALIQAGTTTGTPVG
                     VFQTPSSDWICSMLAIFRVGATYIPLDLRNSVARVSFIVEIAQPLILLTDRETTLHVAE
                     IQASNATEIIIPDLSTTTMPLSMENQARPDSPAVTLFTSGTTGRPKGVVLTHANLRAQC
                     EGYSRMVNLQSMTSVVLQQTNYNFDVSLDQIFAALAEGGCLYVVPASKRGDPQAITKIM
                     AEKGVTYTVATPSEYETWFRYAPETLAECKSWGYAFGGGEHLNNGLIGEFAALSTRHIP
                     ELRLFNNYGPTEASLAITKGEVDFKRPDLEKHVPAGMTIPNYAVAIVDENLKPVPLETV
                     GEIVAGGPGVAAGYLGQADLTREKFISGHDVHRLAAQHSDRWYRTGDRGYLRPDGALFV
                     HGRILGDTQVKI"
     CDS_motif       complement(1729..1818)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_phm1_0010"
                     /evalue="8.50E-11"
                     /label="NRPS-A_a6"
                     /locus_tag="phm1"
                     /protein_end="3386"
                     /protein_start="3356"
                     /score="34.1"
                     /tool="antismash"
                     /translation="PLETVGEIVAGGPGVAAGYLGQADLTREKF"
     CDS_motif       complement(2356..2415)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_phm1_0009"
                     /evalue="2.20E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="phm1"
                     /protein_end="3177"
                     /protein_start="3157"
                     /score="23.3"
                     /tool="antismash"
                     /translation="AVTLFTSGTTGRPKGVVLTH"
     aSDomain        complement(3399..4289)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_phm1_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="5.80E-54"
                     /label="phm1_Condensation_LCL.1"
                     /locus_tag="phm1"
                     /protein_end="2848"
                     /protein_start="2551"
                     /score="175.0"
                     /tool="antismash"
                     /translation="SPMSYGQARFWFLSDYLEDKTSFNMTVMFKLTGRLQVPRLERAVR
                     TIAHRHDALRTRFFWGGEGDKRIAMQGISAESSIELEHVRINSEADAKNELRKMHEFVW
                     DLDSHQAARMVLLTINENEHYFMTSGHHISWDGYGFTVLFIDLDAAYRGEPLSPNGPET
                     QYPAFAAWQRDTYAAGAMKKSIDEYYRPMIDPEARPLPLFPFARAPNRPLLDHFEQFEA
                     KVTLQPHVVSKLKQVSRKNGATMFHLYLAALQALVFRLLPEEQSFYLGVADANRLDKNF
                     MGSLGFFLNLLPVRFD"
     CDS_motif       complement(3855..3899)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_phm1_0008"
                     /evalue="4.50E-03"
                     /label="C3_starter_134-155"
                     /locus_tag="phm1"
                     /protein_end="2696"
                     /protein_start="2681"
                     /score="10.1"
                     /tool="antismash"
                     /translation="HHISWDGYGFTVLFI"
     CDS_motif       complement(4116..4226)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_phm1_0007"
                     /evalue="6.40E-13"
                     /label="C2_LCL_024-062"
                     /locus_tag="phm1"
                     /protein_end="2609"
                     /protein_start="2572"
                     /score="41.1"
                     /tool="antismash"
                     /translation="SFNMTVMFKLTGRLQVPRLERAVRTIAHRHDALRTRF"
     aSDomain        complement(join(4563..4765,4836..4851))
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_phm1_PKS_PP.1"
                     /evalue="5.70E-11"
                     /label="phm1_PKS_PP.1"
                     /locus_tag="phm1"
                     /protein_end="2460"
                     /protein_start="2387"
                     /score="34.5"
                     /tool="antismash"
                     /translation="ATIIKDGFMVRLKRTLMIGLDEVVNEKVPLVEQGIDSLMAVEIRA
                     WFLKELDVDIPVLKVLGGSNITELLQEA"
     aSModule        complement(4563..12282)
                     /complete
                     /domains="nrpspksdomains_phm1_PKS_KS.1"
                     /domains="nrpspksdomains_phm1_PKS_AT.1"
                     /domains="nrpspksdomains_phm1_PKS_DH.1"
                     /domains="nrpspksdomains_phm1_cMT.1"
                     /domains="nrpspksdomains_phm1_PKS_KR.1"
                     /domains="nrpspksdomains_phm1_PKS_PP.1"
                     /iterative
                     /locus_tags="phm1"
                     /monomer_pairings="pk -> Me-pk"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(join(5182..5530,5584..5753))
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_phm1_PKS_KR.1"
                     /evalue="1.30E-49"
                     /label="phm1_PKS_KR.1"
                     /locus_tag="phm1"
                     /protein_end="2277"
                     /protein_start="2104"
                     /score="160.5"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: (unknown)"
                     /tool="antismash"
                     /translation="KTYLLIGMSGQVGQSLCQWMVKCGARHVVLTSRRPLVHDDFIESM
                     KDLGANVRTFALDITQRESLHKCYEEIVATMPPIAGVANGAMILRDSMFDGMTFQNLTT
                     VLEPKVAGTRYLDELFYDAPLDFFIVLSSITSLVGNSSQSNYTAANMFMVALVEQRRKR
                     GVPGSAISIS"
     CDS_motif       complement(5218..5328)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_phm1_0006"
                     /evalue="1.90E-18"
                     /label="PKSI-KR_m4"
                     /locus_tag="phm1"
                     /protein_end="2265"
                     /protein_start="2228"
                     /score="59.0"
                     /tool="antismash"
                     /translation="LDFFIVLSSITSLVGNSSQSNYTAANMFMVALVEQRR"
     CDS_motif       complement(5652..5750)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_phm1_0005"
                     /evalue="2.20E-14"
                     /label="PKSI-KR_m1"
                     /locus_tag="phm1"
                     /protein_end="2138"
                     /protein_start="2105"
                     /score="45.9"
                     /tool="antismash"
                     /translation="TYLLIGMSGQVGQSLCQWMVKCGARHVVLTSRR"
     aSDomain        complement(7359..7937)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_phm1_cMT.1"
                     /domain_subtypes="cMT"
                     /evalue="8.20E-76"
                     /label="phm1_cMT.1"
                     /locus_tag="phm1"
                     /protein_end="1569"
                     /protein_start="1376"
                     /score="246.7"
                     /tool="antismash"
                     /translation="DFYDQGLGLDRANRHLARMVGQLAHRYPHMNIFEIGAGTGGSTRN
                     ILSAIREEFSTYTYTDVSSGFFEAAQELFQDYEDRMIYSTYNMEHEPTSQGFEEGHYDL
                     LLASNVLHATDKLEEMMLSARKLLKPGGYLIALELTNNDSMRVGLPMGTLPGWWLGAET
                     GRPWGPTVTLPQWDSLLRKCGFGGIDTSTP"
     aSDomain        complement(8742..9269)
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_phm1_PKS_DH.1"
                     /evalue="2.20E-22"
                     /label="phm1_PKS_DH.1"
                     /locus_tag="phm1"
                     /protein_end="1108"
                     /protein_start="932"
                     /score="72.0"
                     /tool="antismash"
                     /translation="HPILGKRCLERETSQHVEWRNILSPKELPWLQGHRIQGGMVFPAA
                     GYVAMAIEAMKIAVGKSRMSLIHIENLHIGRAMAFNQETSTMECLFRLNIVNSSPDSMK
                     AKFSCCSGAPYETGTTMVLNAEGTVTVTLAEPEPDAIPYMKPKNFNMTEIEVDRFYTQI
                     HKLGYEYSAPFRG"
     CDS_motif       complement(9105..9182)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_phm1_0004"
                     /evalue="4.80E-12"
                     /label="PKSI-DH_m2"
                     /locus_tag="phm1"
                     /protein_end="987"
                     /protein_start="961"
                     /score="38.2"
                     /tool="antismash"
                     /translation="WLQGHRIQGGMVFPAAGYVAMAIEAM"
     aSDomain        complement(join(9492..10156,10222..10510))
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_phm1_PKS_AT.1"
                     /evalue="3.70E-87"
                     /label="phm1_PKS_AT.1"
                     /locus_tag="phm1"
                     /protein_end="858"
                     /protein_start="540"
                     /score="284.3"
                     /specificity="substrate consensus: pk"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mmal"
                     /tool="antismash"
                     /translation="VFTGQGAQWPRMGAQIVEASPYASKKLGELDTALATLPPDVRPSW
                     TLREEILADLEVSKVAEAAISQPLCTAVQILLVDLLTAAGIRFDAVVGHSSGEIGAAYA
                     AGFISAETAIRVAYLRGFYAKLAGAAEMKGSMMAVGTSYEDALEFCQLEHFMGRISVAA
                     VNSDSSITLSGNEDAIMEAVEIFKDEGKFARQLKVDTAYHSVHMLPCSEPYLKAMESVT
                     QSTAPRDNTAGPRPTWYSSVLDGAVMGPGEVNSEYWVSNMVNPVLFSAAVAAAVSATGP
                     FNLALEVGPHPALKGPCLDTLAAASGDSIPYSGLLSR"
     CDS_motif       complement(join(10086..10156,10222..10258))
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_phm1_0003"
                     /evalue="2.50E-09"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="phm1"
                     /protein_end="660"
                     /protein_start="624"
                     /score="29.6"
                     /tool="antismash"
                     /translation="GIRFDAVVGHSSGEIGAAYAAGFISAETAIRVAYLR"
     CDS_motif       complement(10463..10507)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_phm1_0002"
                     /evalue="7.10E-04"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="phm1"
                     /protein_end="556"
                     /protein_start="541"
                     /score="12.5"
                     /tool="antismash"
                     /translation="FTGQGAQWPRMGAQI"
     aSDomain        complement(join(10820..10860,10922..11134,11188..11616,
                     11673..12282))
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_phm1_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="9.50E-164"
                     /label="phm1_PKS_KS.1"
                     /locus_tag="phm1"
                     /protein_end="437"
                     /protein_start="6"
                     /score="537.1"
                     /tool="antismash"
                     /translation="IAIIGSACRFPGGADTPSKLWELLKEPRDLLQKVPEKRRWHSEAF
                     YHKDPEHHGTSNVSSSYFLDDDPASFDNTFFNIQPSECEAIDPQQRMLMETVYDSVCSA
                     GQTIDGLRGSSTAVYVGMMCDDWSAILTKDAESIPQYSATGMGRSIMSNRISYFFDWHG
                     PSITLDTACSSSLVAVHLAVQALRNGDCGTAIAAGVNLCLSPGMYIATSNLHMLSEGAR
                     SRMWDKDVDGYARGEGIASVVLKPLSAAIRDGDHIECLIRATGVNQDGKTQGLTMPSAT
                     AQTALIRQTYERAGLDIEKPEDRPQFFHAHGTGTPAGDPQEAEAISTAFYSGGLSDKLY
                     VGSIKTVIGHTEGTAGLASLIGTSLALQHGVIPPNLLFNELNPRLIPFYNNLEVPTSAK
                     PWPQLLPGQARRASVNSFGFGGTNAHAIVEAY"
     CDS_motif       complement(11749..11796)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_phm1_0001"
                     /evalue="4.00E-06"
                     /label="PKSI-KS_m3"
                     /locus_tag="phm1"
                     /protein_end="184"
                     /protein_start="168"
                     /score="18.8"
                     /tool="antismash"
                     /translation="GPSITLDTACSSSLVA"
     gene            complement(12985..15559)
                     /gene="phm2"
     CDS             complement(join(12985..13048,13152..13287,13341..14628,
                     14685..14716,14789..15396,15453..15559))
                     /codon_start=1
                     /gene="phm2"
                     /product="C6 transcription factor"
                     /protein_id="BBC43185.1"
                     /transl_table=11
                     /translation="MSDTASTATGHRKRDKPQLSCNACRKRKYEILPTLSNCASRGLGS
                     TCTFAAISSPTNMPPSHGHSIPVQHRVESARPGPTNSMQTRINQLENLVIELMNQNNTP
                     GMRTGLQNQGSDARSDARCQPTPLSSETEFEYPVAPSPSDHGSINTRLARPTYVSSSHW
                     AAIFDSITELRNHFVQEDIEHGASTVLPSSTVPKPQILYGAWTSETPHAIISSLPPRTT
                     VDRLISRYFNVLDIAPGVVHSTQFLREYENFWMAPQDAPIMWVGLLFAMMCLSAQLQQA
                     SLPAHDSRPSSSRASQQDSIAIYREKTIQCLQLGHYTMGGTHALETLILYFLGECFNLK
                     DMEIGIWILSGTILQIAIHMGYHRDAKNFPSITPFAGEMRRRVWAMIVQLDFSISAQLG
                     LPTLIKASQTDTAEPRNLYDTDFDEDSSALPESRPETEVTPTLYVLAKLRLISIGLRVT
                     NVASESRTRSYSDVLELDRQLREARDALPSSLKWIDLGTSLNVSSQTILQRIWLEVTIQ
                     QLTIVLHKKFLGVSGLQKDFKTSRAACLNAAVKILELQRLVDDETQPDGLLYQSRWRVS
                     SAFSNDFLLATSILCYCLQNRPEGTISNFDESVSVGLDQIRALLETSKSIWSRQCAESK
                     EAHKAVAALRYVLGHSGADVDSGYTVAERQPLPMPTAALSYFPDLTSDYNFAGFDFGSS
                     DTTRWTAFASDELGEENWSRGAGFQQMDMSLKLEAFDRVVPNSIPSRCLS"
     gene            order(15947..16579,16633..16889,16937..17504)
                     /gene="phm3"
     CDS             join(15947..16579,16633..16889,16937..17504)
                     /codon_start=1
                     /gene="phm3"
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 101.7; E-value: 5.9e-31)"
                     /gene_kind="transport"
                     /product="MFS transporter"
                     /protein_id="BBC43186.1"
                     /transl_table=11
                     /translation="MSLQDPTKEHNNTSPSPKDEKTDYVVDWDGAEDAANPRNWTTRTK
                     TAHVLCVSGFTLYSNLAAVMFAPGAPLLVADFHITSTIVASLTVSIYILGFVFGPFLLA
                     SLSELYGRLWLYHICNLIYLAFTVGCALSTNTAMFLAFRFICGCAASGPMTIGGGTIAD
                     LYEAEERGKAMALFGLGPLLGPVIGPVVGGFVTEHLNWRWTFYLVLILAAIIAIAGAVI
                     MRETFEPVLLERKAADERVRTGNRQLRARTSDGTRTANQLLLRAIIRPLKMLCVSPIVL
                     SLSVYCAFLFGLTYLLFTTFPAVFGLTYQFSTEQEGLAFLGLGVGMIFGIALFAILSDK
                     LLHQPRGGTLARPELRLVLMVWSSPLVPIGFFWYGWSAQSTTHWIVPIIGTAVIGIGAF
                     LILMPAQLYLVDAFGTEGAASALAVNTGLRSLFGAVLPLAGPPLYSKLDLGWGNSVLAF
                     IGLAFVPVPFVLYKYGETLRKRFPIDR"
     gene            complement(18097..19185)
                     /gene="phm4"
     CDS             complement(18097..19185)
                     /NRPS_PKS="Domain: PKS_ER (31-241). E-value: 1.7e-28.
                     Score: 91.5. Matches aSDomain:
                     nrpspksdomains_phm4_PKS_ER.1"
                     /codon_start=1
                     /gene="phm4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 212; E-value: 2e-64)"
                     /gene_kind="biosynthetic-additional"
                     /product="trans-enoyl reductase"
                     /protein_id="BBC43187.1"
                     /sec_met_domain="ADH_N (E-value: 1.9e-08, bitscore: 23.2,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.4e-14, bitscore:
                     43.2, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGIIDSSSKQSAIVGNSYGSTELSHNVPIPHAEGDNVVVRTRAV
                     SVNPVDAKMMGPYVTAGAIAGCDFAGEIEAIGPEALSWGFKIGDRVCASIMGMNPLEPD
                     HGAFAQHVATHANALVRIPETMSFEEAAALCTCFMTCGLALFQSLGLPGSPVKPSASAT
                     QVLVYGGATATGTAAIQLLRLAGFTPIATCSPHSNELVKTFGAEATFDYNDPECAAKIR
                     AFTKNGLRYALDCITNRSSMQICYGSLGRVGGRYTALDPYPEDIAATRKIVKAAWVVGP
                     IMLGHDIGWPAPHGRKADPDLFKFGMEWKKLVEGLMAKGVIKPHPLDVRKGGMERVIEC
                     MEAIRAKEVNGKKLVVSLRENH"
     aSDomain        complement(18463..19092)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_phm4_PKS_ER.1"
                     /evalue="1.70E-28"
                     /label="phm4_PKS_ER.1"
                     /locus_tag="phm4"
                     /protein_end="241"
                     /protein_start="31"
                     /score="91.5"
                     /tool="antismash"
                     /translation="HAEGDNVVVRTRAVSVNPVDAKMMGPYVTAGAIAGCDFAGEIEAI
                     GPEALSWGFKIGDRVCASIMGMNPLEPDHGAFAQHVATHANALVRIPETMSFEEAAALC
                     TCFMTCGLALFQSLGLPGSPVKPSASATQVLVYGGATATGTAAIQLLRLAGFTPIATCS
                     PHSNELVKTFGAEATFDYNDPECAAKIRAFTKNGLRYALDCITNRSS"
     CDS_motif       complement(18643..18696)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_phm4_0001"
                     /evalue="1.50E-03"
                     /label="PKSI-ER_m5"
                     /locus_tag="phm4"
                     /protein_end="181"
                     /protein_start="163"
                     /score="11.3"
                     /tool="antismash"
                     /translation="QVLVYGGATATGTAAIQL"
     gene            19591..20691
                     /gene="phm5"
     CDS             19591..20691
                     /codon_start=1
                     /gene="phm5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 139.7; E-value:
                     2.2e-42)"
                     /gene_kind="biosynthetic-additional"
                     /product="methyltransferase"
                     /protein_id="BBC43188.1"
                     /transl_table=11
                     /translation="MAVKSSTVDVRAALQSAGAHYMNLIEFGILKVFIDHQIFDHIPAE
                     GSISVTDLATRTKAEVSLLQRFSDYLVASEVLASPAPHELAHTTRSLSYRSEEIAAGFV
                     SHVYHFFLRPMATWTAYFEENGLREPKDAKTIPLGLATGHPEEDLYGVLDKEPRLAYMF
                     NVAQARSAAIFPMKGLYDFAWLREALEDHIGAESPAIVDIGGSHGLALKELLAENPFIP
                     SKRCAVLDFPQTVEQAQQNLDEDLRDIHFIGGSMLEPLPVALHAAGIYQFRRVLSDFVD
                     KDIILALEQVRRVCAPYSRVLIIEELVKASRDKFAIAQDISVLNFGGKRRSEADWHQLA
                     SQAGLQVRHVFEQTETAFAVVELGLA"
     gene            21386..22771
                     /gene="phm6"
     CDS             21386..22771
                     /codon_start=1
                     /gene="phm6"
                     /product="C6 transcription factor"
                     /protein_id="BBC43189.1"
                     /transl_table=11
                     /translation="MASEQNSPDALLSIRSSCNRCRNHKLKCVVTEAPNGTACCQRCIR
                     AMVPCKFGRRERKKRGSSPRVVPQSPWMHSPWETTSTSMQSIYPNTEAMDVGRADALVV
                     HGTNAFPPPANVPAEQSLTGDHSAILTPGSMNMGIFNHLSLDANNLEADDIHAYKFPHG
                     QLHEAHHTQYWHFQADEWRMDHPNDDSHSDYSATSSSKAATAALLQLAADLQERLDALE
                     NEPSWRRKNASMDKYPIGSVLQLSSKLQQLGRCLQTDDSSSTQSESSRSRASVGATSSV
                     HRLQMPVLESGTSDACLNVSHLTSTTRFDTSVSLMLLSCFVTLLQISTGVLGHFQDYLH
                     AHPKTRARTLSMSAAQSSIVSLGDLDPQQQTHDRIHTAIYVLLNSLEEVEEALCLPPRV
                     RLAITLQASPRSDGSTSEQEKAMSAAFYGGLSAATEGIDDILTEFGRRVNDTKGMLRQH
                     MDL"
     gene            complement(23166..24326)
                     /gene="phm7"
     CDS             complement(23166..24326)
                     /codon_start=1
                     /gene="phm7"
                     /product="Diels-Alderase"
                     /protein_id="BBC43190.1"
                     /transl_table=11
                     /translation="MSEPTSSSSLDITSNCIIETPLQPSDFLPKSANLFPKFPERISVD
                     SWELWEFDTFDTNGSVAFGCSLYRDARGVEQGGFHAEVNALWPDGTHWGETLYFAVSEV
                     VENSDGTTGGKWLSKDGGSITFHIASDYTAAALDFNVPGKVSGTMELRNHANVSPTSNL
                     PASDAEAQLCPGVYYTFPMGPVATSVTATFSSVGANGESRELFISSGYGGMVRGWSARP
                     WPTFMNDAYYVVAQVGPYMLQILRTLGSVFVQHKPFAVARLYLDGSLVSAANTVVGDEL
                     TAHADDVKGDAVRLTKVQPDEKSQGLSGKFRDGNVGYVLEFAKKDSEHGWTFQISHKRA
                     VWSEPTSAPGPDGTGKSGWIEAISGGAKGENYEGHGFGGQLQIPVP"
ORIGIN
        1 tcatcgctgc accaaaactt gtgtcgtggt gccactctgg tcatctccct caatgtgcat
       61 ctccattgct ccgatcagcc atccgaatcc agctctcttt gcagcaccaa accactgcag
      121 agcatccatt gtcggtaact tgctcagctc ctcatctgca tcaatctgct cggcaaaagt
      181 cttgatctga agacggagat gtgcagcgtg attcttgact gtggcttcgt taccgctttc
      241 ttggactgaa gaaacaagca tgtcttcgac aagtgttgtt gccacatcag atactggtct
      301 gacatcaata tgtccatgaa tagctgagaa ttcaggcctc tgcccgattt gagcgatcaa
      361 acgtggaagc tcgtcttgaa ctctcttgag gtcttcttga ctcaaagagc tcaccttctc
      421 cgatggtagc gccagtggac gatggacctg cacgcgcaac ccaaatttcg ccactctgcg
      481 caagaactct tcagctgccc acttactggc gatgtaccca tcgctaccat ctgtgggcgg
      541 cgatatgtcg ttgtacttgc tcacagcacc cgatgacatg aagtgcagga ccgcatcgtt
      601 cgcaacacaa agtctagcaa gctctttggc tgcgtcgaag ttaacgtgac ggagcgactc
      661 gaagccatcc cagaatgagc gatttgcagc gcagtggaac acgatgtctg taatttgagc
      721 gagctcagcg aatgtttgtg cgccgagccc aagagatggc tgcgagatgt ccgcagcgac
      781 taggcggatc ttagaacttg tgctaagagg ggatgccgtt tgaagatgct cgggacgaac
      841 gaggcagatg atttggcgga cattgcttga atcgacgaga tgagcgagaa catggcgacc
      901 gagatatcct gttgatccag taatcacgac agttaggtca tcctgaccgt gcttgcgagg
      961 ttgcgaagtc aatacttcga gatcttcctt caggtctgct ggaacggccg tctcgagatc
     1021 ccagtcaatt cgattgatga acgcagctct cacatggcga gccattcctt caagagagct
     1081 cgagttgatg agatcaatca gctggggaga agattgcaat tcgcgcttga tagcagcctg
     1141 gagtttgacc agcagaatgg aattaccacc cacggcaaag aagtcgcttt caggggtgag
     1201 ctcctgcgtc aaatgaggta ttatgattct ccatagcgct gcaacgcgcc cttccatgtt
     1261 tgccagattg tcggtgccag ccacggcttg tggcagaggc atggcctgga tagcgttgcg
     1321 gtcgatcttg aaattagtag tgactggtac ctttgttaac ggtacgataa cagtaggctg
     1381 catgtacgac ggcaacggaa gagcagcttc aagatggcgg atcaaatctt gtcgaaggtg
     1441 cattgcaaag tcgggcgcaa agacgacgtg cgcagtgagg aatttgtctt caccggtgcc
     1501 tcgcagcgaa acgacggcgt gagtaagcgc gcccttcgcc gtctccaata ccacattttc
     1561 tatttcttgg agctcgacac ggaagcctcg aatcttgacc tgtgtatcac ccagaatgcg
     1621 gccgtggaca aagagcgctc cgtcggggcg caggtatcct cgatcaccgg tgcgatacca
     1681 tctgtcgcta tgctgagctg caaggcggtg gacgtcatgt ccggagatga atttctctcg
     1741 tgtcaagtct gcctgtccta gatagccagc agcgactcct ggaccgcccg cgacgatctc
     1801 gcccacggtc tcaagaggaa ctggcttcag attctcatca acaatggcaa cggcgtagtt
     1861 gggaatggtc attccggcgg gcacatgctt ttcgagatcc ggtcgcttga agtctacttc
     1921 acccttcgtg atggccaaag atgcttcagt cggtccgtag ttgttgaaaa gccgcagttc
     1981 agggatgtgt cgtgtcgaaa gagcggcgaa ttcgccaatc aatccattgt tgaggtgctc
     2041 tccgccacca aatgcatatc cccacgattt gcactcagcg agcgtctcgg gagcgtaccg
     2101 gaaccatgtc tcgtattctg atggcgtcgc cacggtgtaa gtcacacctt tctctgccat
     2161 gatcttcgtg atagcctgtg gatcgccgcg cttagatgct ggtactacat acagacaacc
     2221 accttctgca agcgccgcga agatttgatc cagagacacg tcgaagttgt agttcgtctg
     2281 ctgaagaaca acagatgtca tggactgcag attcaccatt cgcgagtagc cctcgcactg
     2341 agcacgcaga ttggcatgtg tgagcacaac gccctttggt cgaccggtgg tgccgcttgt
     2401 gaaaagcgtg acagcgggag agtccggcct agcttgattt tccatggaga gtggcatcgt
     2461 tgttgttgaa agatcgggaa ttatgatctc ggttgcgttg ctagcttgaa tctctgcgac
     2521 atgaagtgta gtttcgcggt cagtcaagag tatgagtggc tgagctatct caacaatgaa
     2581 agagacccgt gcgacagagt ttcgaagatc gagcgggatg taagtggctc caacacggaa
     2641 aattgctaac atcgagcata tccaatccga tgaaggtgtc tggaagacac ccacgggagt
     2701 gccggtggtg gtaccagcct gaatgagagc tgcagcgatc gtattgatac ggtggcccat
     2761 ttgctcgtat gacatgcaat tgttgtgctc gtcttgcagc gcaggcttgg aggcgtaggt
     2821 gccgatcatc tggtcgatac ggtgtgagac agtaactggc cattccagtt cgagttgagg
     2881 tcctaaaaat caagaatcag caagtttcat ctagctcaca acaatgagtg acacttacct
     2941 ctaccgacat tcaacgcttc ttcaacatct gcaccagccc accttggcaa atcgtcgacc
     3001 agaagatcct tgccacttgc cagagcctcc agcacattga cgtacgatct aaggaacatc
     3061 tccgtgctct cctcggaata cagcttcttt tggaagcgca gagaaagcag ggactctcct
     3121 gtagggttgt cggtgatacc aagtgtgaga tcgtaaccgt tgcgagcatt cagccagtcc
     3181 tcgtcgctca tgctgcagcc gcaccactga gctcgctccc ggacgatttg acggtaatcg
     3241 acgaacaatt ggaagattgg tgcctctgtg ttcgtgcgcg ggattttgag ctcatggaga
     3301 agaacgtccc atggtacaaa cgagttctcg agcgccttgt atgctttgtt gcgtgtgtcc
     3361 ttgatcatgt cgctcgactt agttcctggt gcagttctgt caaaacggac gggcaaaagg
     3421 ttgaggaaga aacctagact tcccatgaag ttcttatcaa ggcggtttgc atcagcgact
     3481 ccaaggtaga aagactgttc ttcggggagc agacggaaga caagagcttg tagagcagca
     3541 aggtagaggt ggaacattgt tgcaccgttc ttgcgtgaga cttgcttgag cttggagacg
     3601 acgtggggct gaagagtgac ctttgcttcg aattgttcaa agtggtcgag cagaggtctg
     3661 tttggagctc tcgcgaacgg aaacagagga agcggtctcg cttctgggtc aatcattggt
     3721 cggtaatact cgtcgataga cttcttcata gcaccagctg cataggtgtc tcgctgccat
     3781 gcggcaaatg caggatactg cgtctcaggt ccatttggag agagtggttc acctctgtac
     3841 gcggcgtcca ggtcaataaa caatacggtg aatccatatc cgtcccatga gatgtggtgg
     3901 ccgctagtca taaagtagtg ctcgttctcg ttgatagtga gcaggaccat tctcgctgct
     3961 tggtgggagt cgagatccca cacaaactca tgcattttcc tgagttcgtt cttagcatct
     4021 gcttcggagt tgattcgcac atgttcaagc tcaatagaag actctgctga gatgccttgc
     4081 attgcaatgc gtttgtcgcc ttcgccaccc cagaagaagc gtgtacgcag ggcatcgtga
     4141 cgatgggcaa ttgtgcggac agcgcgctca agacgaggta cttgaaggcg cccagtgagt
     4201 ttgaacatga ctgtcatgtt gaaactggtc ttgtcttcaa ggtaatcgct taggaaccag
     4261 aatctggctt ggccataaga catgggcgac actgattcag gaaccttggg agcgatgtcc
     4321 ggggccacag agaggagact gaaagaaggc gttggatcat tgatttcagt catcggagtt
     4381 cggactggtg tacttggacg cgatgttgat aagccatctg gagttagcga tctggaggaa
     4441 tcagacgcgg atcctgtaac ctgaacctct ggaggaggcg tagctgtgtt agtaactgga
     4501 gcagcagctt tggcattaga caaagagcta aagtcaatga tcgtcgatgg tgtacgatcc
     4561 attgcttcct ggagcagttc agttatgttg ctgcctccga gtaccttcag gacagggatg
     4621 tcgacatcca gttcttttag gaaccaggca cgaatttcga cagccatcag cgagtcgatg
     4681 ccttgctcga caagaggcac cttttcattc acaacctcgt cgagaccaat catcaacgta
     4741 cgcttgagac gcaccatgaa gccatctgta gtaaattagc aatgcaacag cttcctggat
     4801 gacaccaaag gtcattcctg gctatcatgg cttacccttg atgattgtcg ctgcttgatc
     4861 tttcgtcttt gcctcggcca gctggacgcg aacaggcaag gcagatcctt tacccccgtg
     4921 aatctgtgcg tctttcctct cgagcatgag atgattaaac ttgatgtcag tatggaattg
     4981 cgctttgtcg tctctctcag ggtagaacgg aattagccca atggccacct ccgagcttcc
     5041 ctgtgtctct ggacgtccgg caaggattgc ttcggcaaat tgctgatgca gatcctgctc
     5101 tgagatgttt ctcagtccga tgttttcgaa atactcgcca gtgaactctg aattctcaac
     5161 gtagccaatg ccaatcagtg cgctaatcga gatcgcagat ccaggcacac cgcgcttcct
     5221 acgttgttcc acaagagcaa ccatgaacat gttggctgct gtatagttgc tctgactact
     5281 gtttccaaca agggatgtga tagatgacag tacgatgaag aagtcaagag gtgcatcgta
     5341 aaacaactcg tccaagtatc gggtgccagc aaccttgggc tccaggaccg ttgtgagatt
     5401 ttggaacgtc atgccatcaa acatggagtc tctcagtatc attgcgccgt tggctacacc
     5461 cgcaattgga ggcattgttg cgactatctc ttcataacat ttatgcagag actcgcgttg
     5521 ggtgatgtcc ctgctcaatt agtctggaat taacaaatgg aggatgagac agatgtgact
     5581 tacagagcaa aagtccggac gtttgccccc aggtccttca tcgattcaat gaagtcatcg
     5641 tggacgagag gccgacggct cgttaagacc acgtgacgag ctccacactt caccatccac
     5701 tgacaaagtg attgcccaac ctgtccactc attccgatga gaagatatgt tttgtcttgt
     5761 cggaatatga caccagagtc gattgcttcc actttgactg cgaggttagt agctgagctg
     5821 acgaccacag caagaggctt ctgggagact gaaacgtccc ctatctcttg gatgggtatc
     5881 gttatcgggt ccacgagacc cgtctttgac tgtgtcactg aatcgtacgc ttgttggaaa
     5941 gcttcttcca ccttcgtaga agactcgaga tcaaactcag aactgactga tgcactatag
     6001 aatgcatccg aggtgtactt tgcacaggat ttcgacacag atccgctgat cagtcgaccg
     6061 gcagcaacag aggctgatga gtacgagaga tcgatgaaga cattcgaatc tgctggaagg
     6121 gtccttttga tcagccttcg agatatattc tgtgggatga attgccaacc acgttgagca
     6181 tggtccttgc ttgaagtggt gaaaacaatc tgacatccaa gagtctgggc ccgagtgtgg
     6241 agagcaaccg caagttgttc agtagcctca tgaattatca ttattcctga ccgcgtatgg
     6301 agtttggtaa tctgatctgc aatgatttca gcagcgacag cagcaataat ctggctcgga
     6361 tcgcttcctg aaggtagtgg cgccgaccac ttagtctgaa tctctggctg agactccaaa
     6421 gaatgagaca aagccaacag atgcttccca gtggaccttt ctgtaccagc gcagagcact
     6481 agcggattga gtccatcgat cttcaaaccc tgaaggagga agtgagacac gttgaggctt
     6541 gtgaccttgg tatcagaagg ctgagatata ggcaaacgta gcggcgatgg cttcgaaagt
     6601 ccgtaagtat ctccctgcag agctaccgtg actaacgatg ctttccagtt aacttgtgtc
     6661 tcgattgaac gacgagcgct attgtatcgc gcattggcct ctttgttcaa atatagtcga
     6721 ggtatgaggc gagcagaacc ttcgaaagta acctcggact caatggacca cagtagatcc
     6781 aagttacttt tcgtgccacg cttgaatgta ttgagaagct ccagccggat gaattctttt
     6841 gcgatcagct gagtagctct gctttcgtcg gcgatagtgt cgatgtccat aagttgtagc
     6901 gagattgttg gatactcgtg gatcatagca cgaccaagac ctatcatcat ggacgagtat
     6961 ggctcagccg ctcgagcgcc ctgagtaacc cagacgatgt tgaaagcttg acgccagagc
     7021 gtcttcaacg catcgagctt tgctggactg atgtccttga atactggctc gtcaagatcg
     7081 gcgagcgaaa gtactgcggt tccatatggc agcacatcca gatccaggtc ggcgaaagag
     7141 acgattcgga cgatttcact atagtgcgaa gcaagcaggg agctgatgtt gttggcaatg
     7201 gcgtgtgttg caaggctctc accgccgatg atgaccaagc gaggagcatc agtcaatggc
     7261 aggttattga caagtgacag tgggtttcgc aaaaggttga cacgatcatc aacagcctga
     7321 gcagcaaaga tggtggaagc ttgcagtctg tgctggatgg gtgttgacgt atcgatacct
     7381 ccgaaaccgc atttgcgaag tagagagtcc cattgcggca aagtcacagt aggtccccac
     7441 ggcctacctg tctccgcacc aagccaccag cctggtaaag tacccatggg aagtccaact
     7501 cgcatgctgt cgttgttggt aagctctagt gcgatcaggt agccgccggg tttgagaagc
     7561 ttccgggcgc taagcatcat ttcctcgagc ttgtcggtgg catgcagcac attggaggcc
     7621 aacaggagat catagtggcc ttcttcaaag ccttgagatg tcggctcgtg ttccatgtta
     7681 tacgtgctgt atatcatgcg atcctcatag tcttggaaca gctcctgagc agcctcgaag
     7741 aatccactag atacatcagt gtaagtgtaa gtagaaaact cttcgcggat agcagagagg
     7801 atgttgcgcg tcgatccacc tgttccggct ccaatctcga agatattcat gtgaggatag
     7861 cgatgtgcaa gttggccaac catacgtgcg aggtggcggt tggctcgatc gagacccaga
     7921 ccttgatcgt agaagtcaaa gagaccgtcc atgtgctcaa ggattccaga gccctcacgg
     7981 acgactttga tcaggttccg gccaactgat tcaatgagac ggatatctgc ccggttcctg
     8041 acaccatccc acatcgaatc aatgatttct tgagtatcct gcatacaact ggcaggtacg
     8101 caaggattct tgccggcgct gacacgggcc acaacatgag cggcccagtt gagaagatgt
     8161 cgataatgtg gcaaagtctt ctctttctcc tctggtgtga tctcttccag caaacgacgc
     8221 aagtaaaaga atgagactct ctcgcccttg attgctgctt ctgagctgtg agaatcccat
     8281 ccatcgttga tgacagcaag gtctccactc ggggaatcaa ttcgatactc aagcgaagaa
     8341 aagatgttcg catcatcctc gggacgtgcg gctgtgaaag gaaccagttc aagaccttcg
     8401 acctgaatga aagtatgcgc attatcctgg gagaaaatat tgatatccat ggaggtgcgt
     8461 gtgttgacca taccacgcga gatggtctcc catggtagta cctcttgctt ctcggtcgca
     8521 tatgtcgtgt aataaggatt gattatgatc gattggatgc cagtcgggat gtagagagtc
     8581 cacatcatgc cgtcgccagg acagccaaac gcagctgatg aagattggat ggcggtatcc
     8641 aacatgcctg gatgaaccag caactggtcc tcccagtctg acccaccctg gtcttccatt
     8701 gtacccagag catatgcatt cttgcgctga atggagagca taccgcgaaa tggagccgag
     8761 tactcgtaac ctagtttgtg aatttgcgta tagaacctgt cgacttcgat ctcggtcata
     8821 ttgaaatttt taggtttcat atatgggata gcatcaggtt caggctccgc aagtgtcacg
     8881 gtaacagtgc cttcggcatt gagcaccatc gtggttccag tctcgtaggg tgctcctgaa
     8941 cagcaagaga acttagcctt catgctatcc ggagaggagt tgacaatgtt caatctgaaa
     9001 agacattcca tggtcgaagt ctcctggttg aatgccatgg ctcggccaat gtgtagattt
     9061 tcgatatgga tgagactcat tcttgacttg ccaacggcga tcttcatcgc ctcgatggcc
     9121 atagcaacat atccagcagc ggggaacacc ataccaccct ggatgcgatg accttgtagc
     9181 catggtaact cctttggaga aagaatgttg cgccactcga cgtgctgaga tgtctcacgc
     9241 tcaaggcatc tcttcccaag gataggatgg ggagggtcct gggccaagaa ttgtgcaccg
     9301 gaagctcttg aaatttgcca gaacgatctt gtgtgatcaa atgcatattt gggcaaatcc
     9361 ttaactggcc gagggttctc ggaaacgcca gagatcaact tctcaaagtc accaaatcgt
     9421 accgatgacg cccctagatt tgcccacaca aatcctagtg cagaagaaag ctccagaatg
     9481 tcgttcttcg atcttgaaag aaggccagag taaggaatcg agtctccaga agctgcagcc
     9541 aaagtatcaa ggcatggacc tttgagcgca gggtgagggc cgacttccag agcgaggttg
     9601 aatggaccag ttgcagacac tgccgccgct acagcagcgg agaacaacac aggattcacc
     9661 atgttgctga cccagtactc cgagttaacc tcaccaggcc ccatgacagc gccgtcaagg
     9721 acactagagt accatgtcgg tctagggccg gcagtattgt cgcgtggtgc agtagattgc
     9781 gtgacagact ccatcgcttt cagatagggc tctgaacatg ggagcatgtg taccgaatga
     9841 taagcggtgt caaccttgag ctgccgcgca aatttgccct cgtctttgaa aatctcgacg
     9901 gcttccatga tggcatcctc gtttccagag agtgtgatac ttgaatcaga attgactgca
     9961 gcgacggaga ttctgcccat gaaatgttcg agttggcaga attcgagggc atcttcgtat
    10021 gatgttccta ccgccatcat actacccttc atctctgcgg cgcctgcgag tttggcatag
    10081 aaacctcgca ggtaggcgac acgaattgct gtttcagctg agataaagcc tgctgcataa
    10141 gcagcaccaa tttcacctat gtgtcgctag atcagccgcc gatcttctct gaagtgcata
    10201 cacaaggagc agactgctta ccggaagagt ggccaacgac tgcatcgaat ctaatgcctg
    10261 cagcagtgag caaatcaaca agtaaaattt ggaccgcagt gcacagaggc tgcgagatcg
    10321 ccgcttctgc cactttcgat acctctagat cagcgagtat ctcctcgcgc aaagtccatg
    10381 atggccgtac gtcgggaggc aatgtagcaa gagccgtgtc aagttcacca agcttcttgg
    10441 acgcataagg tgaggcctcg acaatctgcg cacccatacg cggccactga gccccttgac
    10501 cagtgaacac tccgagaaga cggggatgag gagtggcgaa atgcttcgtg ccgagctcta
    10561 ccgaatctgc atcatcgagc aaagcgttga tcctttctac agcatctgtg gtgtttgatg
    10621 cagggatcac tgcgcggaag gccagtgtag atcttcgttc ttgcagcgtg tatgcaaagt
    10681 tgcgcaatgg gacctgggga ttcgcttgta agtagtctcc atgtgcagac agtgaggctc
    10741 gcagcgactt ctctgtggca gcagagaaga ccagcggggc gaacacgttg tcagctgcac
    10801 cagaagaggt gggcggctcg tacgcctcaa caatggcatg agcgttcgtt ccgccaaatc
    10861 ctgtgcgcac atgccggtca gcctcgacgt tcccgagaag tcaatttgtc atttggctca
    10921 ccgaaactgt tcacgcttgc acgtctcgct tggccaggga gaagctgagg ccacggctta
    10981 gcggaagttg gcacttctag gttattgtaa aatgggatca gtctcggatt gagttcgttg
    11041 aacagtaaat tcggcgggat gacaccatgc tggagcgcca acgacgtgcc tatgagacta
    11101 gcaagtccgg ctgtaccttc tgtgtgtcca atgactgttg cagttagtat ttgcaatttt
    11161 ttttcgacgt atagaatgga ttctgaccgg ttttgattga gccgacatat agcttgtcgg
    11221 acaacccgcc gctatagaaa gcggtggaaa tcgcttcagc ttcttgtgga tctccagccg
    11281 gtgtgccggt accatgagcg tgaaagaatt gcggtcgatc ctctggtttc tcaatatcaa
    11341 gtcctgccct ctcatacgtc tgacgtatga gtgcagtctg cgcagttgca cttggcattg
    11401 tcagaccttg cgttttaccg tcctggttga ctccagtagc gcggataaga cactcaatat
    11461 gatcaccatc acggatagct gcagacagag gcttgagaac cacagaagca attccctcac
    11521 cacgagcgta cccatcaacg tccttgtccc acatacgcga gcgggctcct tccgacaaca
    11581 tgtgcaagtt tgaggttgca atatacatcc cggggcctaa aatagaacat cattagcatc
    11641 gtatctaggt gtactgtgga aattcgactc actcaagcat agattgactc cagccgctat
    11701 cgctgtacca cagtcaccat tcctcagtgc ctgcactgct agatgaacgg cgacaagact
    11761 ggaagagcat gctgtatcaa gcgtgatcga agggccatgc caatcgaaga agtaagagat
    11821 cctgttggac atgatgctgc gacccatgcc agtggcgctg tactgaggaa tggattcggc
    11881 atctttggtg agaatggcac tccagtcgtc acacatcata ccaacgtaca ccgcagtgga
    11941 cgaacctcgc aagccatcga tggtctgccc agcagaacag actgagtcgt atacagtctc
    12001 cataagcatt ctctgctgtg gatcgatagc ttcgcactcg gatggctgga tgttgaaaaa
    12061 tgtattatcg aagcttgcag gatcatcgtc caagaagtaa gacgaagaca cattgctggt
    12121 gccatgatgc tctggatctt tgtggtagaa ggcttctgaa tgccagcgtc gcttttcagg
    12181 aaccttttgg agtagatcac gtggctcttt gagcaattcc cacagcttcg atggggtatc
    12241 ggcgccgccg ggaaagcgac atgcgctgcc aataatggca ataggctctg aggaagtcat
    12301 ttcgaatggt aagctagact ttgttgaaga agctaaaatg gttgaataat gatttgggta
    12361 ggttgaagct aggtgatatg tacttgtcga ttgtattgtg tgtgttccca atctggaatg
    12421 taggtagcct ggcgtgaata catggaccca gtaggatggt tcacaggtca gtgctctgag
    12481 aacatgcact cgcgctccac ttggttgttg gtggcttgag gaagtggctg taggcaccga
    12541 aaatttccga acacatgttg gaatgcttag gtctggaaca acgaggcagc ctcatgaatt
    12601 aagcattcga tgtcgaatcc gcctcaacgc ttacattgca tggcggcatg ttccagagtg
    12661 ggcgcttctc tgggtctcac tcaaaaggtc tagtgacgat cctggccaca tgggaccgca
    12721 ggttgcctgt tggaaagttg ttgtcccggt tgcgcgcggt gatagcatgt gggggtgagc
    12781 tgaacggatg ctgctcatgg tcagcctggt ggttaccttg cagtatgcaa tgcttagcaa
    12841 gaactatgct atctacagaa ctgatatcgt caatccatgg cgtctataga gcggtcctta
    12901 cacgaactaa acggtgcctc ttgagctaaa ctgaccccgg catgtaatgc gaagcccgga
    12961 aatgtcaaga tccagcagca tttcctaact gagacatctt gacggtatgg aattaggcac
    13021 tactcgatcg aaagcttcaa gcttcaagct cgactgtgat cgtggtcaaa gaacattctg
    13081 ctgaggatgt tacgcccttg tgcaaatgaa ggcgtaaggc cgagtcaatt tcccgatact
    13141 caatccatta cgacatgtcc atttgctgaa agccggcccc tcttgaccag ttctcttcac
    13201 ccaattcatc tgacgcaaac gcggtccatc gtgttgtgtc acttgaccca aaatcgaagc
    13261 cagcgaaatt gtagtcagag gtgagatctg aaaggttgac aattagttta tcaattgcaa
    13321 gagaggagtg ctgagcgtac ctgggaaata tgagagcgcc gctgttggca tgggaagcgg
    13381 ttgccgctcc gcaacagtgt aaccgctgtc tacatccgcg ccggaatgcc ccagaacgta
    13441 acgcagggca gccaccgctt tgtgagcttc tttcgattcg gcacattgac ggctccatat
    13501 tgacttggag gtctccagaa gtgctctaat ctgatcaagt ccaacggata cactttcatc
    13561 aaagtttgaa atcgtacctt ctggacgatt ctgaagacag taacagagta tgcttgttgc
    13621 aagaaggaaa tcgttactga aagcagatga gactctccaa cgactttgat atagaagccc
    13681 gtctggttgc gtttcgtcat cgactaagcg ttgcaattcc aagatcttca ctgcagcatt
    13741 gagacaggca gctcgcgatg tcttgaagtc tttctgaagc ccagatactc cgagaaactt
    13801 cttatgcaac acaatggtca attgttggat ggtaacctcc agccagatcc tttgtagaat
    13861 agtctgggat gagacattca gcgatgtgcc cagatcgatc catttcaaac tggatggcaa
    13921 agcatctcgc gcctccctaa gctgccgatc gagctctagt acatcgctat acgatcgagt
    13981 gcgagactcg ctcgccacgt tagtcactct aagtcctata gaaataagcc gaagcttcgc
    14041 gagcacatat aatgtaggcg tcacctcggt ctcaggtcta gattccggga gtgcgctact
    14101 gtcttcatca aagtcggtat cgtacagatt tcggggttct gcggtatcgg tctggcttgc
    14161 tttgatcaac gtcgggagcc caagttgcgc agaaatactg aaatccagct gcactatcat
    14221 cgcccaaaca cgtcgcctca tttcgcctgc gaagggcgta atgcttggga agtttttggc
    14281 atctcgatga tagcccatgt ggatagcgat ctgcagtatt gttccagaaa gtatccatat
    14341 gccaatctcc atgtccttca agttgaagca ctcgcccagg aaatacaaaa tcagagtctc
    14401 taaagcatgg gtgcctccca ttgtatagtg gcctagctgc agacattgaa tcgtcttttc
    14461 ccgataaatg gctatggagt cctgttggga cgcccgagaa gaagatggcc gggagtcgtg
    14521 agcaggaagc gaagcttgct gtagctgggc tgacaagcac atcatggcaa atagcaaccc
    14581 gacccacatg atgggagcgt cctgtggcgc catccagaag ttttcatact gtaaaggcca
    14641 ccctgttaca cactggcaaa atgtctgggc acggctatgc ttacctcacg aagaaattgg
    14701 gtgctgtgga caacacctag ttcatgttag tgctacattt ccttccagga cgtgtgtcta
    14761 tggtacgaga tcggctgctt gtgcttacct ggagcaatat caagcacatt aaagtaacgt
    14821 gatatcagac gatctacagt agtccgggga ggcaaagaag aaatgatcgc atgcggtgtc
    14881 tcggacgtcc atgcaccgta caggatctgc ggcttcggga cagtgctcga gggtaggacc
    14941 gtgctggccc cgtgctctat gtcctcctgc acaaagtgat ttcgcaattc ggtgatacta
    15001 tcaaaaatcg ccgcccaatg agagctgctg acataggtgg gccgtgctag ccgtgtattg
    15061 atgctgccat gatcagatgg ggacggcgca acagggtatt cgaactcagt ttcggatgat
    15121 agtggcgtgg gctgacaacg tgcatcggag cgtgcatcgg agccttgatt ctgcagtcct
    15181 gttcgcattc caggcgtatt gttctggttc ataagttcta ttacgagatt ttccagttga
    15241 ttaatgcggg tctgcatgct gttggtcggg ccgggccttg cggattcgac tcggtgctgt
    15301 acggggatgc tatgcccgtg tgaaggaggc atgttggtcg gcgatgaaat ggcggcaaat
    15361 gtgcaagtcg agcccaaccc ccggctcgca cagttgctac aggggtgcaa ccggtcacaa
    15421 cgcactctac tcaaagctca gcaaagagga acctaagggt tgggagaatc tcgtacttgc
    15481 gctttcgaca tgcgttacag ctgagttgtg gcttgtctcg ttttcgatgg cctgtagctg
    15541 tagacgcagt gtcggacatg gtcgatacct gggtaggggt gtagtgcagc aattccagct
    15601 agagaccttc gagcgcgcgg cgcttgcggg ctcggacacg cttcgtgata tgtagcagac
    15661 tcctccgaac acagcgggcg gcggtcgtga tatagtacca acggggcctt acgatcctcc
    15721 gtcgtccgcg gagctaagtc gcgtttcgga tatgaaatag acctggcccg cgggccgcgc
    15781 cgcataccct ggacccccca tatgccatat gttaccaccg cggacgttag taaggtctgg
    15841 tccgatatgg ccgaaagttg tagtgtattc catgctcatg tacacatcaa aaaggcacgg
    15901 taatcgaggt cgacaattcc tttgcctacc atccagcata tcaaacatgt ctcttcaaga
    15961 tccgaccaaa gaacacaaca acacatcgcc atctccaaag gatgagaaga cggactacgt
    16021 cgtcgattgg gatggcgccg aagatgctgc gaaccctcgg aactggacga cacgcaccaa
    16081 aaccgcccat gtcctttgtg tgagcggctt cacgctatat tcaaatctgg cagcggtcat
    16141 gtttgcacca ggcgctcctt tgcttgtcgc ggacttccac atcaccagta cgatcgtcgc
    16201 ctccttgaca gtctcgatat acatcctagg atttgtcttt ggcccgttcc tccttgcctc
    16261 gctgtctgag ctctatgggc gcctgtggct ctaccacata tgcaacttga tctatctggc
    16321 tttcacagtc ggatgtgcac tcagcacgaa cactgcgatg ttcctggcat tccggttcat
    16381 ctgcggatgt gctgcatccg gcccaatgac cataggcgga ggcactattg cagatcttta
    16441 tgaggctgag gagcgcggaa aggctatggc gttgtttggt cttgggccac tgctggggcc
    16501 agtcatagga ccagttgtgg gtgggttcgt tacggagcat cttaattgga ggtggacctt
    16561 ctacttggtg ctgatacttg taagtgactg gctctccctg tgaatataca gccgtactga
    16621 tgaaatccgt aggctgccat cattgcgatc gctggagctg tgatcatgcg cgaaaccttc
    16681 gaaccggtac tcctagaacg caaggcggcc gatgagcgag tcagaacagg gaatagacag
    16741 ctgcgtgctc gtacatctga tgggacccgt acagcaaatc agctcctgtt gcgtgcaatt
    16801 atacggccgc tgaaaatgct gtgtgtgtcc cctatcgtac tgtcgctctc ggtctattgc
    16861 gccttcctct tcggcctcac atatctactg taagtcttcc ccaaactttt catattcagg
    16921 cgctgatagt acaaagtttc actacctttc ccgcagtgtt cggattgacc tatcagtttt
    16981 cgaccgagca ggagggactg gcgttcctcg gactgggtgt tgggatgatc tttggcattg
    17041 cactctttgc gattctaagc gacaagctac tccaccaacc gcgcggagga acactcgctc
    17101 gccccgaact gcgcctggtg ctcatggtct ggtcttcgcc cctcgttccc attgggttct
    17161 tctggtacgg ttggagtgcc caaagcacta ctcattggat agtgccaatc atcgggacag
    17221 ccgtcatcgg cataggtgct ttcctaatcc tcatgccagc tcagttgtat ctcgtggacg
    17281 cgttcggcac tgaaggggcg gcgtctgcac tggcagtcaa cactggattg cgaagcctgt
    17341 tcggcgcggt gctaccactt gctggaccac cgctgtatag caagctcgac ctaggatggg
    17401 gcaatagcgt acttgctttc attggtttgg catttgtgcc agtacccttt gttctgtaca
    17461 agtacggcga aaccctgagg aaaaggtttc cgatcgacag ataaactgct gtactggcta
    17521 caagtttcac gatcacctgg cagatatctt tagaaggact gtgatgggct gcactgtact
    17581 catagttatt gttgttctga tgatcaagtg ttttggatat ccatgggtcg gacacgaagg
    17641 agaaagtgaa taagcagagg gagtaagtgt aatcaattct gcacacaagt aatggatcaa
    17701 tctatctgtt gacatattcg agagctggtg ttagcttcga gtgtggaaaa ttgatgtttg
    17761 gattaagcgt cgcgtcgcgt ccgactgagg tgatctagcg cgaaacgtat caggcgccga
    17821 tccttcgtgg tgacacctca aagaaacttc gctgctatcc cacatcctac gaacaatacc
    17881 acgatgcatt atcataatgc tacgatgcat caccattatc atgttgaatc tcgagttcgc
    17941 gcacgaagga cttcaattct gcttcttcgg agatatattt cttcagtctt catctcacga
    18001 caaacactcg tggtagatca acaagcatgc caattgatat gataagaaag caagtaaggt
    18061 gcctctatga gaagtgggac ctttacgatt tgtagactaa tggttctcac gcaagctgac
    18121 gaccaacttc ttcccgttga cttccttggc tcgaatcgcc tccatacact caatcactct
    18181 ctccatccct cccttcctca catcgagcgg atgcggcttg atcacgcctt tagccatcag
    18241 accctccact aacttcttcc actccattcc aaacttgaag agatccggat cggctttgcg
    18301 tccatgcggc gcaggccacc caatatcatg cccaagcata atcggtccca ccacccaggc
    18361 agcttttacg atcttgcgcg tcgctgctat gtcttccggg tatggatcca atgcagtgta
    18421 ccgtcctcca acccggccga gcgagccata acaaatttgc atactggagc gatttgtaat
    18481 gcagtccagc gcgtaacgca atccgttttt cgtgaaagcg cgaatctttg cagcgcattc
    18541 gggatcgttg tagtcaaacg tggcctcggc cccaaatgtc ttgacgagct cattgctgtg
    18601 cggtgaacac gttgcaatgg gcgtaaatcc tgccaagcga agtagctgaa tcgcagctgt
    18661 tcccgtagcc gtcgcgccgc cgtaaacgag tacctgagtt gccgatgcac taggtttgac
    18721 cgggctacca ggcagaccaa gactttggaa cagtgcgagc ccacatgtca tgaagcaggt
    18781 gcacagagcg gcagcctctt caaaactcat ggtctcggga attcgaacaa gtgcgttggc
    18841 gtgtgtcgca acatgctggg cgaaagcacc gtggtcgggc tcgagcggat tcattcccat
    18901 gatagacgcg caaacccgat ctccaatctt gaaaccccaa ctcagagctt cagggccgat
    18961 ggcttcgatt tctcccgcga aatcgcagcc tgcgatcgca ccggccgtga catacggacc
    19021 catcattttg gcgtctacgg gattaacaga cacagctctt gtcctgacga caacattgtc
    19081 tccctcagcg tgaggaattg gcacattatg cgaaagctca gtagatccgt acgagttgcc
    19141 aacgatggca ctttgtttgc tggaggagtc aatgattcct ggcatgatgt tggctaggta
    19201 tggtctgggg tgtgagaact cgcacttttg gtgaaagaca atacacaagc tcataatggc
    19261 caatgtgaat gcctggcaca gtaagctgag cgtctatcat gataccgcaa ccgcaacaat
    19321 tcggacatta tcgtaacagg agaggctcat tgccacccta gagcgatgac tgcgcgcatc
    19381 tgcggcgttt ttccaatgcc gaatacttcc gaatgtgcag accggtgcgc attgacaacg
    19441 aattcgcaag agacggatat gtgagtaaga tgaccacaac atgcgacagt atagacagcc
    19501 tgtgcatttg aaggcaaagc cactccccct tcacgtttgt cgatccaaaa tctatctact
    19561 ctttgccgtg tatccacctt caattccgtc atggcagtca aaagttccac tgttgatgtt
    19621 cgggctgcgt tgcaatcggc aggtgcacac tacatgaatc tgatcgaatt tggcatcctt
    19681 aaagtcttca tcgatcacca aattttcgat cacattccag ctgaaggctc catctcggtg
    19741 acagatttag ccactaggac gaaggcagag gtgtcacttc tacagaggtt ctctgactac
    19801 ctggttgctt cagaagtact agcgagcccc gcgcctcatg agctcgctca tactaccagg
    19861 tcgctctctt atcggagtga ggagattgcg gccgggtttg tgtcacacgt ctaccatttc
    19921 ttcctgcgtc ctatggccac atggacagct tactttgaag agaatggtct tcgcgagccc
    19981 aaggacgcaa agactattcc acttggtctc gccacaggcc acccagagga agatctctat
    20041 ggagtcctcg acaaagaacc acgcctggct tacatgttca acgttgctca ggcccgctca
    20101 gcagccattt tcccgatgaa gggattgtac gactttgcgt ggcttcgtga agcactcgag
    20161 gaccatattg gagccgaaag tccagctatc gtggacattg gtggaagcca tggacttgca
    20221 ctcaaggaat tgttggcgga gaatcccttc atcccatcca agcgctgtgc cgttctcgac
    20281 tttccacaga cagtcgagca agcccaacaa aatcttgacg aggacttgcg cgacatccac
    20341 ttcatcggtg gcagtatgtt ggagccactt cctgttgcac tgcatgctgc cggcatctat
    20401 caattcagac gcgtcctcag tgacttcgtc gataaagaca tcattctggc tctcgagcag
    20461 gtcagaagag tgtgtgcccc gtactctcga gttctaatca tcgaagagct tgtcaaagct
    20521 tcacgagata aatttgccat cgcgcaagat atttctgtgc tgaactttgg tgggaagcga
    20581 cgcagtgagg cagattggca ccaattggcg agccaagcag gattacaggt tcgacatgtg
    20641 tttgagcaga cagagacggc gtttgccgtg gtggaactag ggcttgcatg atgtgtggac
    20701 aagctttgcc aatgtcctaa gcttgtagaa gtcacaagcc aaggcattaa atcgaatcca
    20761 gaagccttcg cgaggttgag cttttcacta ggtagccaga ttgaaatgtc acatattgcc
    20821 agcatcatct cgcatatgcc caagtattac atgctacagg cgagcgggca tttactcggg
    20881 tctcggcctg gccatgtacc aagcttgcag cgttaccaat tccaacctaa ttttgttgca
    20941 ccagaaggcc gggtaaatgg cattcatcac gtctccctgc atacattgcc aatgaccgcg
    21001 catcgcccaa attccgcatt tggcaattgg ggctatggcg gggtggcttc gggtaaggcc
    21061 gcgcgccgcc ggggggacgt gccttcggcg tggtgaagga tcctccgatg catgttttac
    21121 ctgttggaca ggctgagcct cgtaaatgac gcctgattgg gatcgaaaga acttccaggt
    21181 tgccgctctg cattgtgaca caacagggta ggcagacgtg catgtaggaa cttgatccat
    21241 ggcttgtgat aagctttcct cgagttccaa caatccttcg ccatatgctt accgccgtaa
    21301 gtacttgtgt gggactcaaa acatctgtgc cacagtataa gtctgtcggt tctccgaagc
    21361 ggctcttaca tcaacgcgat cctcaatggc ctcggaacag aattcgcctg atgcacttct
    21421 ctctatacgc tcatcttgta acagatgccg caaccacaag cttaaatgcg ttgtcaccga
    21481 agctccgaat ggtaccgcat gctgtcaaag atgtatccgc gccatggtac cttgcaagtt
    21541 cggacgtcgt gagaggaaga agcggggatc atcacctcga gtcgttccac aatcaccctg
    21601 gatgcattca ccttgggaga ccacaagcac atccatgcag agtatatatc ccaataccga
    21661 agcaatggac gtgggaagag ccgacgcatt ggtggtccat ggaacaaatg cgtttccacc
    21721 accagccaac gtccccgcgg agcagtctct gactggcgac catagcgcga tcttaactcc
    21781 gggcagtatg aatatgggca tcttcaatca tctctctctg gatgcgaaca atcttgaggc
    21841 cgatgacata cacgcatata aatttcctca tggtcagctg catgaagcac atcacacaca
    21901 atattggcac tttcaggccg acgagtggag gatggatcat ccaaacgacg actctcactc
    21961 agattactcc gcgacgtcga gctccaaggc cgcaacagca gctctgctac agctcgcagc
    22021 tgatctccaa gaaaggctag atgccttaga aaatgaacct tcctggagaa ggaagaacgc
    22081 aagtatggac aaatatccta ttggcagtgt cctacaactc tcaagcaagc tccagcaact
    22141 aggacgatgc ttgcaaaccg acgacagcag cagtacgcag tctgagagta gccgctcgcg
    22201 agcatccgtg ggtgcaactt catccgtaca ccgactgcag atgccggtat tggaaagtgg
    22261 gacatccgat gcttgcctga acgtgtctca cctaacatca acaacccggt ttgatacgtc
    22321 cgtctcgctc atgttgctga gctgctttgt cactctgctc caaatatcca cgggcgtact
    22381 cgggcatttc caagactacc tgcatgcaca tcccaagact agagcaagga cgctaagcat
    22441 gagtgcggct cagagctcca ttgtaagtct tggtgatctt gatccgcaac agcagacaca
    22501 tgaccgcatt catactgcga tctacgtgct tttgaactca ctggaggagg tcgaggaagc
    22561 gttatgcctc cctcctcgag tgagactagc gatcacattg caggcttcac caaggtcaga
    22621 cggctcaacg agtgagcagg agaaggccat gtcggccgca ttctatggtg gactctctgc
    22681 agccaccgaa ggcattgatg atattcttac agaattcggg cgcagggtca acgatacaaa
    22741 agggatgctt cggcagcata tggacttgta gacaaacgca ttagagagag caacatggaa
    22801 ctggctttga ttttaaaatt tcatcacatc atgagtcgat ttgggtcttt ggcatcttca
    22861 agtgacgacg catttgcgca attcttgcca ctcaatttgc caaacaactt ggtctagcac
    22921 ttaaaagcct ctctctatag cctcgtacta gatcaccaag tatcacgcgt tcggtctcga
    22981 ttagggtcac tacctaggta tcccggatca acttcataca ttgcttacta gactatttcc
    23041 tttaacgcta caaagacaga cttgagagct ctagggccgt atcgatttcc aggaaacagg
    23101 ccgttctggt aagcggatgc atggcccata tgccggtctg actatgaaca aggccttcta
    23161 cgcaactagg gtaccgggat ctgcagctga cctccaaatc catggccctc atagttttca
    23221 cctttcgcac cgcccgagat tgcctcaatc caacctgact tgcctgttcc atcaggtcct
    23281 ggtgcgctgg tgggctcgct ccacactgct cgcttatgcg aaatttgaaa agtccaccca
    23341 tgctcactgt ccttctttgc aaattctaag acatatccta cgttgccgtc gcggaatttc
    23401 cctgatagcc cctgcgactt ctcgtctggt tgaactttgg taagtcgcac tgcgtctccc
    23461 tttacatcat ctgcgtgggc agtcaattcg tctccaacga ccgtattcgc ggctgacacg
    23521 agtgatccat cgagatacag ccgtgcaaca gcgaaaggct tgtgttgcac gaacacggag
    23581 cctaaagtgc gaagtatctg cagcatgtac ggaccaactt gtgcgaccac gtaatacgca
    23641 tcgttcatga atgtcggcca aggccttgca gaccatcctc gaaccattcc cccgtagcct
    23701 gatgagatga agagttcccg ggactcccca tttgcgccga cggacgaaaa cgtagcagtg
    23761 actgaggtag ccacagggcc catagggaat gtgtagtaca ccccggggca gagctgcgct
    23821 tcggcatcac tggcaggaag attgctcgtt ggcgagacat tggcatgatt gcgcagctcc
    23881 atggttccgc tcactttgcc tggcacgttg aagtccagtg cggccgctgt gtagtctgaa
    23941 gcaatatgaa aggtgatcga tcctccgtct ttgctcaacc atttccctcc ggttgtgcca
    24001 tcgctgttct ctacgacttc agacacagca aagtagagtg tttcacccca atgagtgccg
    24061 tcgggccaga gagcattgac ttcggcgtgg aagccaccct gttcaacgcc tcgggcatcg
    24121 cggtacaagg aacagccgaa tgcgacagat ccgttggtgt caaatgtgtc gaattcccaa
    24181 agctcccagg agtcgacaga gatgcgctcg gggaatttgg gaaatagatt tgccgactta
    24241 gggaggaagt cagatggttg taatggggtt tcgatgatgc aattgctagt gatgtctagc
    24301 gaagacgagg acgttggttc tgacat
//
