BGC0001738 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001738 (Pyrenochaetopsis sp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS,T1PKS	1	28,777	High	phomasetin/wakodecalines A/wakodecalines B	NRPS:Type I+PKS

BGC0001738 - Region 1 - NRPS,T1PKS

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Location: 1 - 28,777 nt. (total: 28,777 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 28,778
Label		BGC0001738

Tailoring functions

Oxidoreductases: dehydrogenase

phm4: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: methyltransferase

phm5: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Ligases: synthase

phm1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001738.3	2.00	NRPS, PKS	phomasetin, wakodecalines A, wakodecalines B	Pyrenochaetopsis sp.
BGC0002192.3	0.94	PKS	FR901512	fungal sp. No.14919
BGC0001268.4	0.94	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001254.3	0.91	PKS	ACT-Toxin II	Alternaria alternata
BGC0002191.2	0.65	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002505.3	0.41	NRPS, PKS	xenoacremone A	Xenoacremonium sp. BF-2018a
BGC0001998.2	0.41	PKS	aspernidgulene A1, aspernidgulene A2, aspernidgulene B1	Aspergillus nidulans FGSC A4
BGC0002139.3	0.40	PKS	burnettiene A, preburnettiene B, preburnettiene A	Aspergillus burnettii FRR 5400
BGC0001400.3	0.39	PKS	citreoviridin	Aspergillus terreus NIH2624
BGC0002538.3	0.38	PKS	chaetolivacine A, chaetolivacine B, chaetolivacine C	Chaetomium olivaceum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001738.3	1.00	NRPS, PKS	phomasetin, wakodecalines A, wakodecalines B	Pyrenochaetopsis sp.
BGC0002192.3	0.77	PKS	FR901512	fungal sp. No.14919
BGC0001268.4	0.77	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001254.3	0.76	PKS	ACT-Toxin II	Alternaria alternata
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002505.3	0.53	NRPS, PKS	xenoacremone A	Xenoacremonium sp. BF-2018a
BGC0001998.2	0.53	PKS	aspernidgulene A1, aspernidgulene A2, aspernidgulene B1	Aspergillus nidulans FGSC A4
BGC0002139.3	0.52	PKS	burnettiene A, preburnettiene B, preburnettiene A	Aspergillus burnettii FRR 5400
BGC0001400.3	0.52	PKS	citreoviridin	Aspergillus terreus NIH2624
BGC0002538.3	0.51	PKS	chaetolivacine A, chaetolivacine B, chaetolivacine C	Chaetomium olivaceum

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 28777:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

phm1: pk - X

PKS_AT (540..858): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 70.8%; Ethylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 82.3
Methoxymalonyl-CoA: 67.2
Ethylmalonyl-CoA: 61.3
Malonyl-CoA: 45.4
Isobutyryl-CoA: 36.7
Propionyl-CoA: 35.2
trans-1,2-CPDA: 32.7
2-Methylbutyryl-CoA: 28.9
Benzoyl-CoA: 21.3
inactive: 16.2
fatty_acid: 13.9
3-Methylbutyryl-CoA: 13.2
Acetyl-CoA: 11.3
CHC-CoA: 6.6

AMP-binding (3021..3432): X

nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVDVFGNLAK
Nearest Stachelhaus code(s):: Tyr DFESFGNIAK (59% 8Å match)
Stachelhaus code match:: 60% (weak)

Link to PARAS substrate predictor