BGC0001740: phthoxazolin biosynthetic gene cluster from Streptomyces avermitilis
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Location: 1 - 100,000 nt. (total: 100,000 nt).
This entry is originally from NCBI GenBank LC315614.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001740
Short description phthoxazolin biosynthetic gene cluster from Streptomyces avermitilis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
LC315614.1
via
Compounds
  • phthoxazolin
Species Streptomyces avermitilis [taxonomy]
References
Chemical products information
phthoxazolin Evidence:
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C16H22N2O3
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BBA21050.1
 151 - 1770 (+) putative secreted multicopper oxidase
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    • BBA21051.1
    		 2087 - 3166 (-) putative serine/threonine protein phosphatase
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      • BBA21052.1
      		 3609 - 3860 (+) hypothetical protein
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        • BBA21053.1
        		 3857 - 5974 (+) putative signal transduction histidine kinase
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          • BBA21054.1
          		 5998 - 7512 (-) putative glycerol kinase
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            • BBA21055.1
            		 7554 - 8321 (-) putative IclR-family transcriptional regulator
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              • BBA21056.1
              		 8468 - 8896 (+) putative histidine kinase-like ATPase
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                • BBA21057.1
                		 9184 - 9426 (+) hypothetical protein
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                  • BBA21058.1
                  		 9500 - 10501 (+) putative polyphosphate kinase
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                    • BBA21059.1
                    		 10568 - 11110 (-) hypothetical protein
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                      • BBA21060.1
                      		 11243 - 12688 (+) putative glyceraldehyde 3-phosphate dehydrogenase
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                        • BBA21061.1
                        		 13551 - 13964 (+) putative integrase
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                          • BBA21062.1
                          		 13961 - 15466 (+) putative integrase
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                            • BBA21063.1
                            		 15627 - 16193 (+) putative two-component sensor histidine kinase
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                              • BBA21064.1
                              		 16103 - 16444 (+) putative two-component response regulator
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                                • BBA21065.1
                                		 16553 - 16837 (+) putative LuxR-family transcriptional regulator
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                                  • BBA21066.1
                                  		 17095 - 17604 (-) putative SRPBCC family protein
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                                    • BBA21067.1
                                    • ptxA
                                    		 17716 - 20913 (-) putative di-domain acyl transferase
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                                      • BBA21068.1
                                      • ptxB
                                      		 20910 - 38729 (-) putative non-ribosomal peptide synthetase
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                                        • BBA21069.1
                                        • ptxC
                                        		 38780 - 41413 (-) putative modular polyketide synthase
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                                          • BBA21070.1
                                          • ptxD
                                          		 41434 - 42522 (-) putative OzmP-like protein
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                                            • BBA21071.1
                                            • ptxE
                                            		 42624 - 46088 (-) putative non-ribosomal peptide synthetase
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                                              • BBA21072.1
                                              • ptxF
                                              		 46085 - 60742 (-) putative modular polyketide synthase
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                                                • BBA21073.1
                                                • ptxG
                                                		 61089 - 71717 (-) putative non-ribosomal peptide synthetase
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                                                  • BBA21074.1
                                                  • ptxH
                                                  		 71733 - 80315 (-) putative modular polyketide synthase
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                                                    • BBA21075.1
                                                    		 81458 - 81925 (+) hypothetical protein
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                                                      • BBA21076.1
                                                      		 81964 - 82884 (+) hypothetical protein
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                                                        • BBA21077.1
                                                        		 82974 - 84017 (+) putative inosine-5'-monophosphate dehydrogenase
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                                                          • BBA21078.1
                                                          		 84135 - 85688 (+) putative acetolactate synthase large subunit
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                                                            • BBA21079.1
                                                            		 85721 - 86608 (+) putative D-isomer specific 2-hydroxyacid dehydrogenase
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                                                              • BBA21080.1
                                                              		 86704 - 87936 (-) putative cytochrome P450
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                                                                • BBA21081.1
                                                                		 87883 - 88098 (+) hypothetical protein
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                                                                  • BBA21082.1
                                                                  		 88490 - 90070 (+) putative CoA ligase
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                                                                    • BBA21083.1
                                                                    		 90147 - 91376 (+) putative 5-aminolevulinate synthase
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                                                                      • BBA21084.1
                                                                      		 91424 - 92953 (+) putative 5-aminolevulinate CoA-ligase
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                                                                        • BBA21085.1
                                                                        		 93053 - 93730 (-) putative LuxR-family transcriptional regulator
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                                                                          • BBA21086.1
                                                                          		 94200 - 94946 (-) putative TetR-family transcriptional regulator
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                                                                            • BBA21087.1
                                                                            		 95050 - 96600 (+) putative MFS transporter
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                                                                              • BBA21088.1
                                                                              		 96674 - 97354 (-) putative 4'-phosphopantetheinyl transferase
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                                                                                • BBA21089.1
                                                                                		 98008 - 98508 (+) hypothetical protein
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                                                                                  • BBA21090.1
                                                                                  		 98505 - 98804 (+) hypothetical protein
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                                                                                    • BBA21091.1
                                                                                    		 98804 - 99157 (+) hypothetical protein
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                                                                                      • BBA21092.1
                                                                                      		 99124 - 99942 (+) hypothetical protein
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                                                                                        Biosynthesis information

                                                                                        Biosynthetic modules

                                                                                        Name
                                                                                        Unk01
                                                                                        Type
                                                                                        nrps-type1
                                                                                        Genes
                                                                                        ptxB
                                                                                        Substrates
                                                                                        glycine (evidence: Structure-based inference, Sequence-based prediction)
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        adenylation
                                                                                        Name
                                                                                        Unk02
                                                                                        Type
                                                                                        nrps-type1
                                                                                        Genes
                                                                                        ptxE
                                                                                        Substrates
                                                                                        glycine (evidence: Structure-based inference, Sequence-based prediction)
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        adenylation
                                                                                        Name
                                                                                        Unk03
                                                                                        Type
                                                                                        nrps-type1
                                                                                        Genes
                                                                                        ptxG
                                                                                        Substrates
                                                                                        serine (evidence: Structure-based inference, Sequence-based prediction)
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        adenylation
                                                                                        Name
                                                                                        Unk04
                                                                                        Type
                                                                                        nrps-type1
                                                                                        Genes
                                                                                        ptxG
                                                                                        Substrates
                                                                                        tyrosine (evidence: Structure-based inference, Sequence-based prediction)
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        adenylation
                                                                                        Annotation changelog

                                                                                        Entry version: 4

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2022-10-07
                                                                                        Update chemical activity to schema version 2.11
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                        Entry version: 3

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2022-09-15
                                                                                        Updated bioactivity data
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        2022-09-15
                                                                                        Added NRP substrate specificities
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                        Entry version: 2

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2019-10-16
                                                                                        Migrated from v1.4
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        2019-10-16
                                                                                        Updated compound(s) information (NPAtlas curation)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                        Entry version: 1

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2018-08-06
                                                                                        Submitted
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        Detailed domain annotation
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