BGC0001741 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001741 (Phyllosticta cirsii)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS	1	42,946	phyllostictine A/phyllostictine B	NRPS:Type I+PKS	100%

BGC0001741 - Region 1 - NRPS,T1PKS

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Location: 1 - 42,946 nt. (total: 42,946 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 42,947
Label		BGC0001741

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001741	2.00	NRP, Polyketide	phyllostictine A, phyllostictine B	Phyllosticta cirsii
BGC0001264	0.70	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001254	0.70	Polyketide	ACT-Toxin II	Alternaria alternata
BGC0002192	0.69	Polyketide	FR901512	fungal sp. No.14919
BGC0002258	0.69	Polyketide	shimalactone A, shimalactone B	Aspergillus stellatus
BGC0001268	0.68	NRP, Polyketide	fusarin C	Fusarium fujikuroi
BGC0000064	0.68	NRP, Polyketide	fusarin	Fusarium verticillioides
BGC0001136	0.65	NRP, Polyketide	desmethylbassianin	Beauveria bassiana
BGC0000992	0.63	NRP, Polyketide	fusaridione A, (3R,5S)-5-(4-hydroxybenzyl)-3-methyl-3-((2E,4E,6E,8E,10E)-4,8,10-trimethyldodeca-2,4,6,8,10-pentaenoyl)pyrrolidine-2,4-dione	Fusarium heterosporum
BGC0001049	0.62	NRP, Polyketide	tenellin	Beauveria bassiana

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001741	1.00	NRP, Polyketide	phyllostictine A, phyllostictine B	Phyllosticta cirsii
BGC0001264	0.68	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001254	0.68	Polyketide	ACT-Toxin II	Alternaria alternata
BGC0002192	0.68	Polyketide	FR901512	fungal sp. No.14919
BGC0002258	0.67	Polyketide	shimalactone A, shimalactone B	Aspergillus stellatus
BGC0001268	0.67	NRP, Polyketide	fusarin C	Fusarium fujikuroi
BGC0000064	0.67	NRP, Polyketide	fusarin	Fusarium verticillioides
BGC0001136	0.66	NRP, Polyketide	desmethylbassianin	Beauveria bassiana
BGC0000992	0.65	NRP, Polyketide	fusaridione A, (3R,5S)-5-(4-hydroxybenzyl)-3-methyl-3-((2E,4E,6E,8E,10E)-4,8,10-trimethyldodeca-2,4,6,8,10-pentaenoyl)pyrrolidine-2,4-dione	Fusarium heterosporum
BGC0001049	0.65	NRP, Polyketide	tenellin	Beauveria bassiana

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 4681 - 42946:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

phyS

PKS_AT (548..873): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 70.8%; Ethylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 82.3
Methoxymalonyl-CoA: 68.1
Malonyl-CoA: 41.5
Isobutyryl-CoA: 38.3
fatty_acid: 35.1
trans-1,2-CPDA: 31.6
Benzoyl-CoA: 25.2
Propionyl-CoA: 23.1
CHC-CoA: 15.2
3-Methylbutyryl-CoA: 8.9
Acetyl-CoA: 4.5
2-Methylbutyryl-CoA: 4.3
inactive: 0.0
Ethylmalonyl-CoA: -1.1

AMP-binding (3081..3482): X

nrpys: Orn, Lys, Arg

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DFDKFGSIAK
Nearest Stachelhaus code(s):: Phe NHDKFGSISK (76% 8Å match); MalAc NHDKFGSISK (74% 8Å match); Ser DFDTFGGILK (59% 8Å match); Tyr DFESFGNIAK (53% 8Å match)
Stachelhaus code match:: 70% (weak)