BGC0001742 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001742 (Candidatus Streptomyces philanthi bv. triangulum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	50,415	piericidin A1	PKS:Type I	100%

BGC0001742 - Region 1 - T1PKS

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Location: 1 - 50,415 nt. (total: 50,415 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 50,416
Label		BGC0001742

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001742	1.00	Polyketide	piericidin A1	Candidatus Streptomyces philanthi bv. triangulum
BGC0000124	0.49	Polyketide	piericidin A1	Streptomyces piomogenus
BGC0001169	0.45	Polyketide	piericidin A1	Streptomyces sp. SCSIO 03032
BGC0000041	0.37	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001275	0.31	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000166	0.31	Polyketide	tylactone	Streptomyces fradiae
BGC0001244	0.31	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001273	0.31	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001276	0.30	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0002228	0.27	NRP	CIML B, CIML A, CIML D, CIML C	Colletotrichum incanum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001742	1.00	Polyketide	piericidin A1	Candidatus Streptomyces philanthi bv. triangulum
BGC0000124	0.78	Polyketide	piericidin A1	Streptomyces piomogenus
BGC0001169	0.76	Polyketide	piericidin A1	Streptomyces sp. SCSIO 03032
BGC0000041	0.70	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001275	0.64	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000166	0.64	Polyketide	tylactone	Streptomyces fradiae
BGC0001244	0.64	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001273	0.64	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001276	0.63	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0002228	0.61	NRP	CIML B, CIML A, CIML D, CIML C	Colletotrichum incanum

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 50415:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - Me-ccmal) + (Me-ohmal - Me-ccmal) + (Me-redmal) + (ccmal) + (Me-mal - mal)
Non-colinear ordering:: CSP_7468 + CSP_7467 + CSP_7464 + CSP_7463 + CSP_7462

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CSP_7468

PKS_AT (359..659): mmal

ATSignature: 2-Methylbutyryl-CoA

Top 3 matches:: 2-Methylbutyryl-CoA: 83.3%; Isobutyryl-CoA: 66.7%; Methylmalonyl-CoA: 66.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 162.1
Ethylmalonyl-CoA: 161.8
2-Methylbutyryl-CoA: 141.6
Methoxymalonyl-CoA: 125.9
Propionyl-CoA: 125.2
trans-1,2-CPDA: 110.6
CHC-CoA: 100.6
Malonyl-CoA: 56.2
Isobutyryl-CoA: 48.6
Benzoyl-CoA: 32.5
Acetyl-CoA: 26.2
3-Methylbutyryl-CoA: 26.1
fatty_acid: 21.6
inactive: 0.0

PKS_AT (1363..1658): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.7
Ethylmalonyl-CoA: 196.1
Methoxymalonyl-CoA: 166.6
2-Methylbutyryl-CoA: 133.2
trans-1,2-CPDA: 125.3
CHC-CoA: 103.2
Propionyl-CoA: 100.8
Malonyl-CoA: 99.3
Isobutyryl-CoA: 81.9
Benzoyl-CoA: 70.1
Acetyl-CoA: 43.9
3-Methylbutyryl-CoA: 30.3
inactive: 20.1
fatty_acid: 17.5

CSP_7467

PKS_AT (567..862): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.7
Ethylmalonyl-CoA: 196.1
Methoxymalonyl-CoA: 166.6
2-Methylbutyryl-CoA: 133.2
trans-1,2-CPDA: 125.3
CHC-CoA: 103.2
Propionyl-CoA: 100.8
Malonyl-CoA: 99.3
Isobutyryl-CoA: 81.9
Benzoyl-CoA: 70.1
Acetyl-CoA: 43.9
3-Methylbutyryl-CoA: 30.3
inactive: 20.1
fatty_acid: 17.5

PKS_AT (2141..2436): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.7
Ethylmalonyl-CoA: 196.1
Methoxymalonyl-CoA: 166.6
2-Methylbutyryl-CoA: 133.2
trans-1,2-CPDA: 125.3
CHC-CoA: 103.2
Propionyl-CoA: 100.8
Malonyl-CoA: 99.3
Isobutyryl-CoA: 81.9
Benzoyl-CoA: 70.1
Acetyl-CoA: 43.9
3-Methylbutyryl-CoA: 30.3
inactive: 20.1
fatty_acid: 17.5

CSP_7464

PKS_AT (543..838): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.7
Ethylmalonyl-CoA: 196.1
Methoxymalonyl-CoA: 166.6
2-Methylbutyryl-CoA: 133.2
trans-1,2-CPDA: 125.3
CHC-CoA: 103.2
Propionyl-CoA: 100.8
Malonyl-CoA: 99.3
Isobutyryl-CoA: 81.9
Benzoyl-CoA: 70.1
Acetyl-CoA: 43.9
3-Methylbutyryl-CoA: 30.3
inactive: 20.1
fatty_acid: 17.5

CSP_7463

PKS_AT (610..901): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 79.2%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 201.1
inactive: 97.8
Methoxymalonyl-CoA: 53.6
Methylmalonyl-CoA: 51.8
Propionyl-CoA: 35.9
Benzoyl-CoA: 25.5
Isobutyryl-CoA: 24.4
Ethylmalonyl-CoA: 14.6
2-Methylbutyryl-CoA: 12.9
fatty_acid: 10.3
Acetyl-CoA: 8.5
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

CSP_7462

PKS_AT (568..863): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.7
Ethylmalonyl-CoA: 196.1
Methoxymalonyl-CoA: 166.6
2-Methylbutyryl-CoA: 133.2
trans-1,2-CPDA: 125.3
CHC-CoA: 103.2
Propionyl-CoA: 100.8
Malonyl-CoA: 99.3
Isobutyryl-CoA: 81.9
Benzoyl-CoA: 70.1
Acetyl-CoA: 43.9
3-Methylbutyryl-CoA: 30.3
inactive: 20.1
fatty_acid: 17.5

PKS_AT (1606..1904): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 180.0
inactive: 95.3
Methylmalonyl-CoA: 46.8
Methoxymalonyl-CoA: 46.7
Propionyl-CoA: 21.7
Acetyl-CoA: 14.4
Ethylmalonyl-CoA: 12.1
fatty_acid: 11.6
Benzoyl-CoA: 9.7
CHC-CoA: 7.3
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0