LOCUS       BGC0001747             11156 bp    DNA     linear   BCT 13-MAY-2015
DEFINITION  Tannerella forsythia strain ATCC 43037 contig030, whole genome
            shotgun sequence.
ACCESSION   BGC0001747
VERSION     BGC0001747
KEYWORDS    .
SOURCE      Tannerella forsythia
  ORGANISM  Tannerella forsythia
            Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Tannerellaceae;
            Tannerella.
COMMENT     Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: http://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 16:11:52
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1020
                     /NRPS_PKS="Domain: NAD_binding_4 (8-132). E-value: 1.8e-15.
                     Score: 48.6. Matches aSDomain:
                     nrpspksdomains_Tanf_01185_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 92.1;
                     E-value: 7.1e-28)"
                     /gene_kind="biosynthetic-additional"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_005868112.1"
                     /locus_tag="Tanf_01185"
                     /note="Similar proteins in strain 92A2: TF2075 and
                     BFO_1074; Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="UDP-N-acetylglucosamine 4,6-dehydratase"
                     /protein_id="KKY62496.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 5.2e-16, bitscore:
                     47.8, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 8.1e-99,
                     bitscore: 319.6, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 2.9e-16, bitscore:
                     48.6, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLNNKSILITGGTGSFGKMFVKKILQDYPNVKRIVIFSRGELKQY
                     KMQQMYPANKYPQMRFFIGDVRDAERVKQACEGIDVIIHAAAIKQVDTAEYNPEECIKT
                     NVGGAQNVIRAALYCGVKHVIALSTDKACAPINLYGATKLTSDKLFTAANNIKGGRNIR
                     FSVVRYGNVMGSRGSVIPFFIEKKYQKAAYLPITDQRMTRFNISLEAGVDLVMYAIGHH
                     LGGEIFIPKIPSYRIIDVAQAIAPNIPIKQIGIRPGEKLHEEMITITDALNTLDLGNYY
                     AILPAVSFNHTSAEYIKHHNAKYVPEGFHYSSGENSDWETVESIREKIRKYVDPHFNA"
     subregion       1..11156
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001747"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..11156
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1..1020
                     /locus_tag="Tanf_01185"
     CDS_motif       16..75
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Tanf_01185_0001"
                     /evalue="5.60E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="Tanf_01185"
                     /protein_end="25"
                     /protein_start="5"
                     /score="12.6"
                     /tool="antismash"
                     /translation="SILITGGTGSFGKMFVKKIL"
     aSDomain        25..396
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Tanf_01185_NAD_binding_4.1"
                     /evalue="1.80E-15"
                     /label="Tanf_01185_NAD_binding_4.1"
                     /locus_tag="Tanf_01185"
                     /protein_end="132"
                     /protein_start="8"
                     /score="48.6"
                     /tool="antismash"
                     /translation="ITGGTGSFGKMFVKKILQDYPNVKRIVIFSRGELKQYKMQQMYPA
                     NKYPQMRFFIGDVRDAERVKQACEGIDVIIHAAAIKQVDTAEYNPEECIKTNVGGAQNV
                     IRAALYCGVKHVIALSTDKA"
     gene            1020..2183
                     /locus_tag="Tanf_01190"
     CDS             1020..2183
                     /NRPS_PKS="Domain: Aminotran_1_2 (28-166). E-value:
                     5.9e-14. Score: 43.8. Matches aSDomain:
                     nrpspksdomains_Tanf_01190_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     306.7; E-value: 3.9e-93)"
                     /gene_kind="biosynthetic-additional"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_005801176.1"
                     /locus_tag="Tanf_01190"
                     /note="Similar proteins in strain 92A2: TF1932 and
                     BFO_0923; Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyridoxal-5'-phosphate-dependent protein"
                     /protein_id="KKY62497.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.1e-108,
                     bitscore: 352.9, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 9.5e-15, bitscore:
                     43.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITRPIPYGHQKITVEDIQAVIETLRSDFLTQGPKIKEFENAFAQ
                     YVGAKYAVAVNNATAGLHLAAIALCIKPEDKVIVTPLTFAASANCIRYCGGNVVFCDID
                     KDSYLIDIDKLHNILSSSPMGTYQGVVPVDFAGYPVNLEKLRQLADEYGLWILEDACHA
                     PGGYFVDNQGDIQMCGNGTLADISVFSFHPVKHIATGEGGMITTNSKILYDKLCLYRTH
                     GITKDPLLMQENHGGWYNEMIDLGYNYRLTDFQAALGISQLKRADTGIIRRRQIAENYN
                     QAFKTIQGIKIPYVEERYHHAYHLYVIQVEDRLNLYNYLHKNNILTQVHYIPLHLMPYY
                     QKRGNKKGDFPIVEAYYQHCLSLPMFPSLTEEEQNYIIEKVINFFIK"
     aSDomain        1104..1517
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Tanf_01190_Aminotran_1_2.1"
                     /evalue="5.90E-14"
                     /label="Tanf_01190_Aminotran_1_2.1"
                     /locus_tag="Tanf_01190"
                     /protein_end="166"
                     /protein_start="28"
                     /score="43.8"
                     /tool="antismash"
                     /translation="FLTQGPKIKEFENAFAQYVGAKYAVAVNNATAGLHLAAIALCIKP
                     EDKVIVTPLTFAASANCIRYCGGNVVFCDIDKDSYLIDIDKLHNILSSSPMGTYQGVVP
                     VDFAGYPVNLEKLRQLADEYGLWILEDACHAPGG"
     gene            2324..3190
                     /locus_tag="Tanf_01195"
     CDS             2324..3190
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039:aldo/keto reductase family oxidoreductase (Score:
                     101.6; E-value: 7.4e-31)"
                     /gene_kind="biosynthetic-additional"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_005791069.1"
                     /locus_tag="Tanf_01195"
                     /note="No similar proteins in strain 92A2; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="KKY62550.1"
                     /transl_table=11
                     /translation="MRSLQNKLIIGTVQFGLNYGINNMSGQVSIDEADKILALAKKANV
                     CFIDTSSAYGNSEKILGTILDNYPRGFNVISKYPQSDKSVYDMFKESLKQMKQSRLYGY
                     LVHHFDFYKKNPSIWDSFLRLKEQKLVQKIGFSIYHIEELEFLLNNKVKFDLVQFPYNI
                     FDRQFAPYLSILKNLGVEIHTRSVFLQGLFFKEILSLPQKLLPLKSHLNELHKYCDAHS
                     ISIEKLALGFVTSNPLIDKVLIGVDGIKQFEKNIAICNYCISDKDASFVSSIDVTEKNL
                     LNPVNWN"
     gene            3192..3959
                     /locus_tag="Tanf_01200"
     CDS             3192..3959
                     /codon_start=1
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_005791067.1"
                     /locus_tag="Tanf_01200"
                     /note="No similar proteins in strain 92A2; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="LPS biosynthesis protein"
                     /protein_id="KKY62498.1"
                     /transl_table=11
                     /translation="MKILAITQARYGSTRLPAKILKEVAGKTLLEIHIHRILQSKLINE
                     LKIATTNEEGAKYIINIANILNIGYYQGSVDDVLDRFCKTAEPENPDYIVRFTSDCPLI
                     DPSVIDDVIRFTIDGDYDYVATDSNSYPDGLDTEVFKYSVLKKACEEAKMKSEREHVTP
                     YIWKNGTAKGGDLFKTYHIPCDKGDFSRFRITIDEIEDFEVIKILIEHLGYQKGWTEYI
                     DYLSKERSVFDINNQYRRNEGYLKSINNDLKIR"
     gene            3965..5269
                     /locus_tag="Tanf_01205"
     CDS             3965..5269
                     /NRPS_PKS="Domain: Aminotran_3 (38-339). E-value: 4.3e-40.
                     Score: 129.6. Matches aSDomain:
                     nrpspksdomains_Tanf_01205_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013:aminotransferase class-III (Score: 178.9;
                     E-value: 2.5e-54)"
                     /gene_kind="biosynthetic-additional"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_016834349.1"
                     /locus_tag="Tanf_01205"
                     /note="No similar proteins in strain 92A2; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="aminotransferase class III"
                     /protein_id="KKY62499.1"
                     /sec_met_domain="Aminotran_3 (E-value: 2.6e-38, bitscore:
                     120.9, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKGQNLYKKAKGLIPGGTMLLSKRPEMFLPEFWPAYFSKAKGCK
                     IWDLDGKEYFDLSLMGVGTNTLGYGNDEVDEAVTCTIKNGNLSTLNCPEEVELAEKLIE
                     LNPWADMVRFARTGGEINAIAIRIARVASGKDKVAVCGYHGWHDWYLSANLGNEERLAG
                     HLLPGLDPAGVPRVLQDMTIPFNYNNFQELLDIVNKNNVGVIKMEVCRNMGPEDNFLQK
                     IRQLASERKIILIFDECSSGFRETFGGLYKKYNVEPDMAIFSKTIGNGYAISAVVGKRH
                     IMETAQKTFISSTFWTERIGPTAAIATLKIMKRIKSWEIITKIGLENKKRWQQIADKYG
                     LSITQWGIPALAGFTFNSEKNLAYKTYITQEMLAKGYLAGNSMYTCICHTKDILDGYFY
                     ELDKLFADIRDFEDGRDITKALKGPMCHGGFKRLN"
     aSDomain        4079..4981
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Tanf_01205_Aminotran_3.1"
                     /evalue="4.30E-40"
                     /label="Tanf_01205_Aminotran_3.1"
                     /locus_tag="Tanf_01205"
                     /protein_end="339"
                     /protein_start="38"
                     /score="129.6"
                     /tool="antismash"
                     /translation="SKAKGCKIWDLDGKEYFDLSLMGVGTNTLGYGNDEVDEAVTCTIK
                     NGNLSTLNCPEEVELAEKLIELNPWADMVRFARTGGEINAIAIRIARVASGKDKVAVCG
                     YHGWHDWYLSANLGNEERLAGHLLPGLDPAGVPRVLQDMTIPFNYNNFQELLDIVNKNN
                     VGVIKMEVCRNMGPEDNFLQKIRQLASERKIILIFDECSSGFRETFGGLYKKYNVEPDM
                     AIFSKTIGNGYAISAVVGKRHIMETAQKTFISSTFWTERIGPTAAIATLKIMKRIKSWE
                     IITKIGLENKKRWQQIADKY"
     gene            5302..6046
                     /locus_tag="Tanf_01210"
                     /note="crotonobetainyl-CoA:carnitine CoA-transferase;
                     disrupted; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
     gene            6049..6345
                     /locus_tag="Tanf_01215"
                     /note="hypothetical protein; disrupted; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo=""
     gene            6654..7055
                     /locus_tag="Tanf_01220"
     CDS             6654..7055
                     /codon_start=1
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_009038594.1"
                     /locus_tag="Tanf_01220"
                     /note="No similar proteins in strain 92A2; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="lactoylglutathione lyase"
                     /protein_id="KKY62500.1"
                     /transl_table=11
                     /translation="MLQKFNFHHIGYAVCDIAETAFFYTSEGWSMSKITIDKVQNSQIA
                     FLSKNGQPLIELVSPIDDKSPVCKILEKNGVTPYHICYEVDDIYEAIKIMRKKHFIPLF
                     KPVEAIAFENRPICYIYNKNVGLIELLGS"
     gene            7107..8690
                     /locus_tag="Tanf_01225"
     CDS             7107..8690
                     /NRPS_PKS="Domain: FkbH (172-315). E-value: 4.9e-41. Score:
                     131.8. Matches aSDomain: nrpspksdomains_Tanf_01225_FkbH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1256:FkbH like protein (Score: 337.3; E-value:
                     1.3e-102)"
                     /gene_kind="biosynthetic-additional"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_009124816.1"
                     /locus_tag="Tanf_01225"
                     /note="No similar proteins in strain 92A2; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="KKY62501.1"
                     /transl_table=11
                     /translation="MKYYIYRNMTIENFFSNIEATFSGYEDISTINVDVDRYVWFYLPP
                     LICDIQKMADKIYSYTNMLKMTVFQLPKNKTLICFTMHLVFDINNIISDTRISDAVTQY
                     NKALYHIASQNEQVKVIDFAKFLLRYSDCDQIDWKYYFISQMALNPRLAKPFKSWFEHQ
                     LDAIDLKRKKCLVLDLDNTLWGGILGEDGPNGIALGGDYPGKAFLYFQHCLEELNKQGI
                     ILSVCSKNNIDDVMQLWDEHPDNILNQKHFASCKINWMNKASNIQQIAEDLNISTDSMV
                     FIDDNPAERALIQKMLPEVIVPDFPEQPYLLPPFIKDVAERYFSVYRLTKEDLNKTEQY
                     KANLQRREAKKMFSNMDEYLKSLDIILSVREVNEKTLARIAQMTQKTNQFNLTTRRYTE
                     MDIRDFINNNSKIYTLSVCDKFGDNGITGCSIITFDHNRANIDTFLLSCRILGKNIEME
                     FIHYILNELKKHGLDSVDASYIATAKNSQTSEFYDHAGLSLVREERGIKYYSLNLNLYH
                     YTPSIYYKYQ"
     aSDomain        7623..8051
                     /aSDomain="FkbH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Tanf_01225_FkbH.1"
                     /evalue="4.90E-41"
                     /label="Tanf_01225_FkbH.1"
                     /locus_tag="Tanf_01225"
                     /protein_end="315"
                     /protein_start="172"
                     /score="131.8"
                     /tool="antismash"
                     /translation="KCLVLDLDNTLWGGILGEDGPNGIALGGDYPGKAFLYFQHCLEEL
                     NKQGIILSVCSKNNIDDVMQLWDEHPDNILNQKHFASCKINWMNKASNIQQIAEDLNIS
                     TDSMVFIDDNPAERALIQKMLPEVIVPDFPEQPYLLPPF"
     gene            8696..8914
                     /locus_tag="Tanf_01230"
     CDS             8696..8914
                     /NRPS_PKS="Domain: PP-binding (2-66). E-value: 5.5e-08.
                     Score: 25.1. Matches aSDomain:
                     nrpspksdomains_Tanf_01230_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_005801360.1"
                     /locus_tag="Tanf_01230"
                     /note="No similar proteins in strain 92A2; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="acyl carrier protein"
                     /protein_id="KKY62502.1"
                     /sec_met_domain="PP-binding (E-value: 8.9e-09, bitscore:
                     25.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKIKKIVSSVLKMQNVTDETAQRDCDKWDSLKHLYLIVELEDS
                     FGVSFEPEEIAEMKDIKSIYEIVARKL"
     aSDomain        8702..8893
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Tanf_01230_PP-binding.1"
                     /evalue="5.50E-08"
                     /label="Tanf_01230_PP-binding.1"
                     /locus_tag="Tanf_01230"
                     /protein_end="66"
                     /protein_start="2"
                     /score="25.1"
                     /tool="antismash"
                     /translation="EKIKKIVSSVLKMQNVTDETAQRDCDKWDSLKHLYLIVELEDSFG
                     VSFEPEEIAEMKDIKSIYE"
     gene            8956..9822
                     /locus_tag="Tanf_01235"
                     /note="hypothetical protein; disrupted; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo=""
     gene            10146..11156
                     /locus_tag="Tanf_01240"
     CDS             10146..11156
                     /codon_start=1
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_008663355.1"
                     /locus_tag="Tanf_01240"
                     /note="Similar proteins in strain 92A2: TF2068 and
                     BFO_1066; Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="N-acetylneuraminate synthase"
                     /protein_id="KKY62503.1"
                     /transl_table=11
                     /translation="MKTTIVAELSANHNGSIKIAIETIKSAKRAGADAIKFQTYTAETM
                     TLNCHMPDFKIAQGTLWDGQYLYDLYQKAYTPWEWHDELFRIAKEEGLLCFSTPFDKTA
                     VDFLETLGNPIYKIASFEITDISLIEYTAMKMKPMIISTGVAMLEDIQLAVDTCRAVGN
                     DDITLLKCTSSYPAPIEDANLCMIPDLAKRFGVKSGLSDHTLGSISAITAVALGATMIE
                     KHFIMDRSIGGPDATFSMNEAEFKQMVKDVRDAEKIIGKIKYELTDKMKIGREFSRSLY
                     IAEDIKEGNILTERNVRSVRPGYGLHPKYLKDIIGKRVNRDLKKGMRLDLDYIKK"
ORIGIN
        1 atgctaaata ataaatccat attgattacc gggggcactg ggtcctttgg taaaatgttt
       61 gttaaaaaga tactacaaga ctatccaaac gtaaaacgaa ttgttatttt ttctcgtggc
      121 gaattaaaac aatacaaaat gcagcaaatg tatcctgcaa ataaatatcc tcaaatgcgc
      181 ttttttattg gtgacgtgcg agatgcagag cgtgttaaac aagcttgtga aggtatagat
      241 gtaatcattc atgctgcagc gattaagcaa gttgacacag cagaatacaa tccggaagag
      301 tgtataaaaa caaacgttgg aggagcacag aatgttattc gtgcagcttt atactgtgga
      361 gttaaacatg ttattgcttt atctactgat aaagcttgtg ctccgattaa tttatatgga
      421 gcaacaaaac taacttcaga caagttgttc acggcggcca ataatattaa aggggggcgt
      481 aatatcagat tttcagttgt tcgttatgga aatgtaatgg gatcacgggg ctcagttatt
      541 cctttcttta tagaaaaaaa gtatcaaaaa gcagcatatc tccctataac cgatcaaaga
      601 atgactcgat ttaatatttc tttggaggcc ggggtggatt tggttatgta tgcaattgga
      661 catcatttag ggggagaaat ttttataccc aaaatcccat cttatcgaat tatagatgtt
      721 gctcaggcga ttgcccccaa tattccgata aaacagattg gtatacgacc cggagaaaaa
      781 cttcatgaag aaatgattac tatcacagac gctctaaaca cattggattt ggggaattat
      841 tatgccatat taccggcagt atcatttaat catacttcgg cggaatacat aaagcatcat
      901 aatgcgaaat atgttccgga aggatttcac tatagttctg gagaaaactc ggactgggag
      961 actgttgaat caatacgtga gaagataaga aaatatgttg atcctcattt taacgcataa
     1021 tgataacaag accgatacca tatggacatc aaaaaataac ggtggaagat attcaggctg
     1081 ttatagaaac actccgatcg gattttttga cacaagggcc taaaataaaa gaatttgaaa
     1141 atgcttttgc ccaatacgtg ggagcaaaat acgctgttgc agttaataat gcaacggctg
     1201 gattacattt agctgctatt gctttatgta ttaaacctga agacaaagtt attgttacac
     1261 cactaacatt tgcagcaagt gcaaattgca ttcggtactg tggaggtaat gtcgtgtttt
     1321 gtgatattga caaagactct tatttgatag atattgacaa actgcataac atacttagtt
     1381 catctcctat gggaacatac caaggagtcg tgcctgtcga ctttgctgga tatcctgtaa
     1441 atctggagaa acttcgccaa ttagctgatg aatatggctt atggatatta gaagatgctt
     1501 gtcatgcacc aggtggttat tttgttgaca atcaaggaga tatacaaatg tgcggtaatg
     1561 gtacattggc cgatatttca gtattttcat ttcatccagt gaagcatatt gctaccggtg
     1621 aagggggaat gattacaaca aacagtaaga tcttatatga taaactttgt ctttatcgca
     1681 ctcatggaat aactaaagat cctttgttaa tgcaggaaaa tcatgggggg tggtataatg
     1741 aaatgataga ccttgggtat aattatcgtc ttactgattt tcaggcagca ttaggaattt
     1801 cacagcttaa gcgagctgat acgggtataa ttcgcaggcg acaaatagcc gagaactata
     1861 accaggcttt caagacaata caaggtatca agattcctta tgtagaagaa aggtatcatc
     1921 atgcatatca cttatatgtt attcaggtag aagatcgatt aaatttatat aattacctac
     1981 acaaaaataa tattttaaca caagtacact acataccatt acatctaatg ccgtattatc
     2041 aaaagagagg aaataaaaaa ggagattttc cgatcgttga agcatattat caacattgct
     2101 taagtctgcc aatgtttcct tctctaaccg aagaagaaca aaattatatt atagagaaag
     2161 tgattaattt ttttatcaaa tagacaggat ataacaaatc gaaaggaaac gattccccct
     2221 tggggaagca gaacttggca atttgtcaaa aaaaaagaaa gacgaagttg cgaaaaataa
     2281 atcacctctt tctttgataa gaaaaaaaag aattaaagca caaatgagga gtttacagaa
     2341 taaactgatt ataggaacag ttcaatttgg attgaattat ggtattaata atatgtcagg
     2401 tcaagtttca attgatgaag cagataagat ccttgcttta gccaagaaag cgaatgtttg
     2461 tttcatagac acttcatctg catatggaaa tagtgaaaaa atattaggaa ctatattaga
     2521 caattatcca cgaggtttta atgtgatatc taaatatccc caaagtgaca agtctgtata
     2581 tgacatgttt aaagaatcgt taaaacaaat gaaacagagt cggttatatg gatatttggt
     2641 acaccatttt gatttttata aaaaaaatcc gtctatatgg gatagttttc tcaggttaaa
     2701 agagcaaaaa ttggttcaaa aaatagggtt ttctatttat cacatagaag aattggaatt
     2761 ccttcttaac aataaggtaa aattcgatct tgtgcaattc ccttataata tctttgacag
     2821 acaatttgct ccttatctga gtatacttaa aaatctcgga gtggaaatac atactagatc
     2881 cgtatttctt caaggtttgt tctttaaaga aatcctctcc ttgccccaaa aacttctccc
     2941 tcttaaatca catttaaatg aattgcataa atattgtgat gctcattcta taagtataga
     3001 aaaattggca ttggggtttg tgacaagcaa tccgctcata gataaagtct tgataggtgt
     3061 ggatggcatt aaacaatttg aaaagaatat cgctatttgc aattattgca tatcggataa
     3121 agatgcttcc tttgtttcat ccatagatgt tacagaaaag aatttactga accccgttaa
     3181 ttggaattaa aatgaaaata ttggctatta ctcaggcaag atatggttct acacgtttac
     3241 cggcgaaaat attaaaggaa gttgcgggta agacattgtt ggagatacat atacatcgaa
     3301 ttctgcaatc aaaactaatt aatgaattaa aaatagcaac gactaacgaa gagggagcaa
     3361 agtatataat taatatcgcg aacatattaa atattggata ttatcaaggt tcagttgatg
     3421 atgttttgga tcgcttttgt aagactgcag agcctgaaaa tccggattat attgttcgtt
     3481 tcacatcaga ttgcccatta atagatccat ctgttattga tgatgtaata agatttacta
     3541 tagatggtga ttatgattat gttgcaacag actcgaacag ttatcctgat ggcctggata
     3601 cggaagtttt caaatattcc gtgttaaaaa aagcttgtga agaggctaag atgaaatcag
     3661 aaagggaaca tgtaactcca tatatatgga aaaatggaac agccaaaggg ggcgatttgt
     3721 ttaagacata ccatatccct tgtgataaag gagatttttc tcggtttcgt attacgatag
     3781 atgaaataga agactttgag gtaatcaaaa ttttaattga acatttagga tatcaaaaag
     3841 ggtggacgga atatattgat tatctatcaa aagaaaggag tgtttttgat attaataatc
     3901 aatacagacg caatgaagga tatttaaagt caataaataa tgatttaaaa ataagataag
     3961 cgcaatgaat aaaggacaga atttatacaa gaaagctaaa ggattgattc ccggtggaac
     4021 aatgttatta tcgaaaaggc ctgaaatgtt tttgccggaa ttttggcccg catattttag
     4081 caaagcaaaa ggatgtaaaa tttgggactt ggatggtaag gaatactttg acctctctct
     4141 tatgggagtt ggaacaaata cattaggtta tggtaatgat gaagttgatg aggccgttac
     4201 ttgtacaatt aaaaatggta atttatcgac actcaattgt ccggaagaag tggagttagc
     4261 agaaaaattg atcgaactga atccatgggc agacatggtt cgttttgcta gaactggagg
     4321 agaaataaat gcaatagcaa ttcgaatagc tcgagttgca agtggaaaag ataaagtggc
     4381 tgtatgtgga tatcatggat ggcatgattg gtatctttcc gctaatttgg ggaatgagga
     4441 aagattagcg ggccacctcc ttcccggatt ggaccctgcc ggcgtaccaa gagtactaca
     4501 agatatgaca atcccattta attataataa cttccaagaa ttacttgaca ttgtcaataa
     4561 gaataatgtt ggagtcatta aaatggaggt ttgtagaaat atggggccgg aagataattt
     4621 tcttcaaaaa atacgccaat tggcatcaga aagaaaaatc attcttattt ttgacgaatg
     4681 ttccagtggg tttagggaaa cgtttggagg attatataag aagtataatg ttgagccgga
     4741 tatggctatt tttagtaaaa caataggaaa tggttatgct atttctgcgg tagtcggtaa
     4801 acgtcatatc atggaaacgg cccaaaaaac atttatcagt agtacctttt ggacagaaag
     4861 aattggtccg accgctgcaa ttgcaaccct gaaaattatg aaaagaataa aatcatggga
     4921 gataataaca aaaattggac ttgaaaacaa aaaaagatgg caacagatag ctgataaata
     4981 tggtttgtct ataacccaat ggggaattcc tgcattggcc ggattcactt ttaacagtga
     5041 gaaaaatctt gcatataaaa catatataac tcaagagatg ttagcaaagg gatatttagc
     5101 aggaaacagc atgtatacat gcatctgcca tacaaaggat attctggacg gatattttta
     5161 tgaattagac aagctttttg cagatattag ggacttcgaa gatggtagag acataacgaa
     5221 agccctgaaa ggtcctatgt gccatggggg atttaaaaga ttgaattgaa cattaagagt
     5281 cctattacaa tacatgttaa aatgaaaaag ataaaaacta tcacagattc tacctccaaa
     5341 gaagaatgta taagagaaaa attctgggat ttgtttgaga gttgtccaat ccctccttct
     5401 gaaagattga acaatatagg attattttta aatcggcaga ccttgtctcg aatttttttt
     5461 atgaataaat tgtatcaaaa aattttgaat atccatgggg ttattatcga atttggcgtt
     5521 agatggggac aaaacctgtc tttgttctcc tcttttcgag ggatgtatga accatacaat
     5581 tacaatagaa caatttatgg gtttgataca ttttcagggt tccccaaaac aaatgttaaa
     5641 gacggggggg gcggtaaaaa cagtaaacta ttcggtaact gaagattata tggaatatct
     5701 tgcaaaaatt cttgaatatc atgagaatga aagtcctatt tctcacatta agaagtttca
     5761 actgatagaa ggtgatgcct ctcaaacgat aaaaactttc ttaaaagaaa gacctgaaac
     5821 agtcatttct ttagcttatt tcgattttga tctataccaa cctactaaag actgccttga
     5881 ggctatactt ccatattgta ccaaaggatc tattttggct tttgatgaat taaattgcaa
     5941 gtattttccg ggtgaaacaa ttgccgttcg agaagtatta gacctgacca aatatcgatt
     6001 acaaagagat aggcaaaatc catattgctc atatataaaa ctgtaagtat gacaaaaaaa
     6061 aagatattcg aaattggaga gtttaaatat atcaatttta ctcatctttc tagagattca
     6121 tccttaatag agaatgttag acagtggaga aatcatccag atatcagaaa gtatatgtat
     6181 aatgatgatg aaatttcaga agaggaacat caaattttta tatcatcatt aaataaaagg
     6241 aaagatgtaa catattggtt cgttcactat aaagaaaatc ctattggagt agtatctttg
     6301 gtaaagatag acgaatcaaa taaacaggcg gaattaggtt actatttaat tcccagaata
     6361 ttaaatagcg gattggggct tacttttgct tttcacaact tcttgttctc ctttaaatgt
     6421 ctaatgttta atattttatt tggtgccact catgccgata atagaaatgc tcttctttta
     6481 gataaatatt tgggatgtat tatgggagaa tatttgacaa taaagaagaa tggaaacagc
     6541 cgaaattttt tgagttggac tttgaaaaaa gaagatttca tgagggatgg tttaaaaaaa
     6601 aatgatatta ggctttttgt tcggttttgt agggaatcaa aaatctgata aatatgcttc
     6661 aaaaatttaa tttccatcat ataggatacg ccgtatgtga tattgcagag actgcttttt
     6721 tttacacatc cgaaggatgg tctatgagca aaataacaat agataaggta caaaacagtc
     6781 aaatagcatt tttatcaaag aacggtcaac ctctaatcga gttggtgtct ccaattgatg
     6841 ataagtcgcc agtctgtaag attcttgaaa aaaacggtgt gacaccttat cacatttgtt
     6901 atgaggtgga tgatatatat gaagcgataa aaatcatgcg taagaaacat tttataccat
     6961 tattcaagcc cgtagaggcg attgcttttg agaacagacc tatctgttac atatacaata
     7021 agaatgttgg attgatagaa ctattaggta gttaacctac gtttctgtca tagatggaaa
     7081 atacgattgt tctttgtgct ctcaatatga aatattatat ctatagaaat atgacaatag
     7141 agaatttctt cagcaatatt gaagcaacat tctctggtta tgaggacatt tcaacaataa
     7201 atgtagatgt ggaccgatat gtttggtttt atttgccccc tctcatatgt gatatacaaa
     7261 aaatggccga taagatatac agctatacaa atatgttgaa aatgacagta ttccaactcc
     7321 ctaaaaataa aacgcttatt tgttttacaa tgcatcttgt ttttgatatt aacaatatta
     7381 tatcggatac tcgcattagt gatgctgtca cccaatacaa caaggctctt tatcatatcg
     7441 catcacaaaa tgaacaagta aaagttatcg attttgcaaa atttctttta cgttattccg
     7501 attgtgacca gattgattgg aaatactatt ttatctcaca aatggctctt aatccgcgac
     7561 tggctaaacc gtttaaaagc tggtttgaac atcaactcga tgcaatagac cttaaacgaa
     7621 agaaatgcct tgtcttagac cttgataata ctttgtgggg cggtatatta ggtgaagatg
     7681 gacctaatgg tatagccctt gggggagatt atccgggcaa agcattccta tactttcaac
     7741 actgcctcga agaacttaac aaacaaggaa taattctctc cgtgtgtagt aaaaataaca
     7801 tagacgatgt catgcaacta tgggatgaac atcccgacaa tatccttaat caaaaacatt
     7861 ttgcatcttg taaaataaat tggatgaata aagcttctaa cattcagcag atagcggaag
     7921 atttgaatat cagtacagac agtatggttt ttattgatga taatcctgca gaacgtgcat
     7981 tgattcaaaa aatgttacct gaagtcattg ttcctgattt tcccgaacaa ccctatttat
     8041 tacctccatt tattaaagat gttgcagaga gatatttttc tgtctacaga ttaacaaaag
     8101 aagatttaaa taaaaccgag caatacaaag cgaatttgca acgacgtgaa gctaaaaaga
     8161 tgttttctaa tatggatgaa tatctgaaaa gccttgacat tattctttct gtccgtgaag
     8221 tgaatgaaaa aacactggca cggattgctc aaatgacaca gaaaacaaat caatttaatc
     8281 tgacaacaag gcgttataca gagatggata ttagagactt tattaataat aattcaaaaa
     8341 tatatacact ttcggtctgt gataaatttg gagacaatgg tattacaggc tgttctataa
     8401 taacttttga ccacaataga gcgaatatag atacattttt gttgagttgt agaatattag
     8461 gaaaaaacat cgaaatggaa tttattcatt atattttaaa tgagctcaaa aaacatggcc
     8521 ttgattcagt agatgcttca tatattgcaa cagcaaagaa cagtcaaacc tctgaatttt
     8581 atgatcatgc aggtctatca ttagtaagag aggaaagggg cattaaatat tattcattga
     8641 atttaaactt atatcattat actcccagta tatattataa atatcaataa aaaaaatgaa
     8701 agagaagata aaaaaaattg tatcctctgt cttaaagatg caaaatgtga cagatgaaac
     8761 tgcacaaaga gattgtgata agtgggattc tctaaaacat ttatatctca ttgtcgaact
     8821 tgaagattca tttggagttt catttgaacc ggaagaaata gcagaaatga aggatatcaa
     8881 gtctatttat gaaatcgttg caagaaaatt ataatatttc tgcaaaatat tatatcttgt
     8941 aaaacgtaca aaaggatggg caaacgtcag attatatttc gtgcagatgc cggcaagagg
     9001 attggatacg ggcattttgt acgtacattg gctttggcgg atatgctaaa agaagagttt
     9061 gaatgtgtat tcgttacgca agacccaaca gaataccaaa aaagagaagt tgaacgaatt
     9121 tgccctctaa taggacttcc ttctgacaac agtaaatttt cattgttttt aagaatgctt
     9181 tctggcaaag agatagtggt attagataat tatttttatt caactgatta tcaaaaaaaa
     9241 ataaagtcta aagggtgtaa attggtctgt attgatgata tgcatgataa gcattatatt
     9301 gcagatgctg tgattaatca tggattagat aacccaaaat tgtttgatgt tgagccatat
     9361 acaaggttgc ttcttgggtt ggattgggct ttgatacgta aaccgtttcg atgttctggt
     9421 tccattcggg atcgagaaaa agggcatatt gctatttctt ttggtggcgc tgattggaat
     9481 aatcttacaa caaaattctc tgaaaaaatc acgaatgact gtgaaataga cagaattaca
     9541 gcaattgtgg gggatgcatt tccatttgaa aagaagctga aaaaggttgg taaagtccaa
     9601 attgtcaaaa atctaagtgc ttttcagatg gctgacttat ttcgtaaggt tgaatttgta
     9661 atacttccat caagtacagt ttgtattgaa gcattagctt gtaaatgtcc cgtaattgca
     9721 ggatggtata caaaaaacca aaaagaaatg tatcattctc tattaaaaaa taaaagaata
     9781 gttggtttgg gttttctaaa tgagcggacg atccatggtt tatgtaatgt gtcacaaata
     9841 aagagagggg ataatgatgt taaaatctgg gaaatacaag atatctcaaa aaaatatatc
     9901 catgcttttc acggaatata acaatgttgt tttttaagat attcttccta cggaaacaca
     9961 aagtagacgc aatagtaatt gatgaagggt gaaaaatttc gcaaaaaaac aatagaaaat
    10021 tctcttgatt tacttttggt gaatgtgaca gtaaataatt gagataattt aacaataaac
    10081 gtatgatatt tgcagtcttg taaaaatatg caaagccaat tcaaacaaat aattcgtaat
    10141 acaatatgaa gacaacaatt gtagcagaac tatcagccaa tcacaatgga agtataaaaa
    10201 tcgctattga aacaattaaa tcggcaaaac gcgctggtgc tgacgcgatt aagtttcaaa
    10261 cttacactgc tgagacaatg actttgaatt gtcatatgcc ggattttaaa atagcacaag
    10321 gtactttatg ggatgggcag tatctatatg atttgtatca gaaagcatat acaccatggg
    10381 agtggcatga tgaacttttt cgaatagcaa aagaagaagg gcttctctgt ttttccactc
    10441 cttttgataa gacggctgtt gattttttag agacattagg aaacccgatt tataaaatag
    10501 cttcatttga gattacagat atatcgttaa tcgaatatac ggcaatgaaa atgaaaccaa
    10561 tgattatatc aacgggcgtt gcaatgctcg aagatattca attggcggtt gacacctgtc
    10621 gcgcagtcgg taatgatgat ataacacttt taaagtgtac ctcttcttat ccagccccaa
    10681 tagaggatgc aaacttatgc atgattccag atttagctaa gcgctttggt gtaaaatctg
    10741 gattatcgga tcatacatta gggtctatct ctgctattac ggcagttgct cttggagcaa
    10801 caatgattga aaagcatttt attatggatc ggtctatagg aggccctgat gcgacattct
    10861 ccatgaatga agcagagttc aaacaaatgg tgaaagatgt tcgtgatgcc gaaaagatta
    10921 ttggaaaaat aaaatacgaa ttaactgata aaatgaaaat agggcgtgaa tttagtcgtt
    10981 cattatatat tgctgaagat ataaaagaag ggaatatact tacagaacga aacgtgcgat
    11041 ctgttcgtcc tgggtatggt ttacatccca aatatctaaa agatataatt ggaaagagag
    11101 tgaatcgaga cttaaaaaaa ggaatgcggt tggacttaga ttacattaag aaatga
//
