LOCUS       BGC0001748             18705 bp    DNA     linear   BCT 06-NOV-2017
DEFINITION  Nostoc sp. CENA543 pseudospumigin gene cluster, complete sequence.
ACCESSION   BGC0001748
VERSION     BGC0001748
KEYWORDS    .
SOURCE      Nostoc sp. CENA543
  ORGANISM  Nostoc sp. CENA543
            Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae;
            Nostoc.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 16:11:53
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 18705
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            1..4191
                     /gene="spuA"
     CDS             1..4191
                     /NRPS_PKS="Domain: CAL_domain (352-644). E-value: 7.6e-82.
                     Score: 266.6. Matches aSDomain:
                     nrpspksdomains_spuA_CAL_domain.1"
                     /NRPS_PKS="Domain: PKS_KR (989-1171). E-value: 3e-45.
                     Score: 146.2. Matches aSDomain:
                     nrpspksdomains_spuA_PKS_KR.1"
                     /NRPS_PKS="Domain: PCP (1304-1370). E-value: 8.5e-24.
                     Score: 75.5. Matches aSDomain: nrpspksdomains_spuA_PCP.1"
                     /codon_start=1
                     /gene="spuA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     276.2; E-value: 7e-84)"
                     /gene_kind="biosynthetic"
                     /note="AMP-dependent synthetase"
                     /product="SpuA"
                     /protein_id="ATP76245.1"
                     /sec_met_domain="AMP-binding (E-value: 2.4e-91, bitscore:
                     293.9, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 9.4e-42, bitscore:
                     130.7, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.4e-16, bitscore:
                     48.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQLNDHSQTLATPNDKNFLYRKIEVAILSSLTVSDCIVRERQTQK
                     QKQELVAYVVPSGLFASEQLSSHLQTILPQELIPTIFVPISTIPLTAAGEVDEVTLANL
                     EVIDSELMRSLEKQLESLPEIERVAVVVEPVIKNISPLHLDDLLGETQVNLDTNSQAIQ
                     PNTHSLTIANENSASSKKLAISHGEPLKSSEDAPQTLTAVLKKTSENSTKGIIYIQADG
                     SEQVQSYKELWQDAQRILAGLRKLGLKPQDKVIFQLEDNQDFICAFWACVLGGFVPVPV
                     SIAPNYELANSTASKLQNTWQMLGKPLILTSAALANNIDDFFSLLNLENFQIATINKLR
                     EYQPDLNYHQSQPEDLAILLLTSGSTGIPKCVMLNHHNILSMTTGLILMGDFSSQESVL
                     NWMPLDHVGALVSLSIMAVSLGCQQIHVPTNLIVQKPLLWLDLIDKHQATISWSPNFAF
                     SLICDRTSEINRQNWDLSSMKFIINAGEPIVTKTARNFLKLLSRHGLPTDAIHPAFGMC
                     ETSSGITYSDSFSLESSSDDTSFVELGLPIAGASLRIVDENEQIVAENTIGRLQVKGAS
                     VTNGYYQNPQANQEVFTADGWFNTGDLGFLDQGRLTITGRIKDVIIINGLNYYCHEIEA
                     AVEELAGVEVSYTAACAVRQPGINTDKLAIFFHTSVTDDVSLLNLLREIRTAVVNKAGI
                     NPDYLIPVDKEIIPKTAIGKIQRSQLSQRFQKGEFQSITKRIDILLGNANTIPNWFYRQ
                     VWQLKNPITIDSVFTVTNATLVFLDADGLGSYVCQVLSEHNLPYISVTPGEDFRKINHT
                     HYTITAGQAKDYQLLLESLAADNIIIGQILHLWTYNQYIGEVKSIDTLEQAQEYGIYSL
                     LFLTQALAKVQGADHSVQLLFISSHIQAISSDDSIAYEKSAVLGLLKTIPQELPWLNCR
                     HIDLPFAEAEQNGEFILKEIQIYAKEREVAYRNGQRFVPRLEKVDFISQSPSAITFKQG
                     GMYLITGGLGGIGVEVARYLLQHYQAKLLLVGRTPLTSEKRLKVYQELKQIGGELIYEA
                     VDICNLKQLQITVEKAQAQWGKNLDGILHLAGTFHEQLVIDETQESLKSILRPKVLGAW
                     VLHQLIKHNQDSIFINFSSVNGFFGATAVGAYGAANSFLDSFSHYQNAQSKLASYCLSW
                     SMWDDRGMSQGYQMKNLIRAKGFYIMSASQAISSMIASLQHQQTNILIGLDGSNQNIQC
                     WQSQIFNLQKLTAYFTSRINEVKLSNLRVQDRFGHACNCNLVQIPDIPCRENGEIDRVS
                     LINNIKSQETRERIEPRNEIEIKIAQCWQQVLKVQLLGIHDNFFELGGNSLLAGQVIAL
                     LREYFAVELSLQRLFQAPTIADLSQTILAIQAVTQNKNSLTETLAEDYEEDYL"
     source          1..18705
                     /country="Brazil"
                     /db_xref="taxon:1869241"
                     /isolation_source="saline-alkaline lake"
                     /mol_type="genomic DNA"
                     /organism="Nostoc sp. CENA543"
                     /strain="CENA543"
     misc_feature    1..18705
                     /note="pseudospumigin gene cluster"
     subregion       1..18705
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="NRPS, PKS"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..18705
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     aSDomain        1057..1932
                     /aSDomain="CAL_domain"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spuA_CAL_domain.1"
                     /evalue="7.60E-82"
                     /label="spuA_CAL_domain.1"
                     /locus_tag="spuA"
                     /protein_end="644"
                     /protein_start="352"
                     /score="266.6"
                     /tool="antismash"
                     /translation="PEDLAILLLTSGSTGIPKCVMLNHHNILSMTTGLILMGDFSSQES
                     VLNWMPLDHVGALVSLSIMAVSLGCQQIHVPTNLIVQKPLLWLDLIDKHQATISWSPNF
                     AFSLICDRTSEINRQNWDLSSMKFIINAGEPIVTKTARNFLKLLSRHGLPTDAIHPAFG
                     MCETSSGITYSDSFSLESSSDDTSFVELGLPIAGASLRIVDENEQIVAENTIGRLQVKG
                     ASVTNGYYQNPQANQEVFTADGWFNTGDLGFLDQGRLTITGRIKDVIIINGLNYYCHEI
                     EAAVEELAGVE"
     aSModule        1057..4110
                     /domains="nrpspksdomains_spuA_CAL_domain.1"
                     /domains="nrpspksdomains_spuA_PKS_KR.1"
                     /domains="nrpspksdomains_spuA_PCP.1"
                     /incomplete
                     /locus_tags="spuA"
                     /starter_module
                     /tool="antismash"
                     /type="pks"
     CDS_motif       1069..1128
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuA_0001"
                     /evalue="6.90E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="spuA"
                     /protein_end="376"
                     /protein_start="356"
                     /score="18.7"
                     /tool="antismash"
                     /translation="AILLLTSGSTGIPKCVMLNH"
     CDS_motif       1696..1776
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuA_0002"
                     /evalue="5.90E-06"
                     /label="NRPS-A_a6"
                     /locus_tag="spuA"
                     /protein_end="592"
                     /protein_start="565"
                     /score="18.7"
                     /tool="antismash"
                     /translation="TIGRLQVKGASVTNGYYQNPQANQEVF"
     CDS_motif       1840..1902
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuA_0003"
                     /evalue="5.70E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="spuA"
                     /protein_end="634"
                     /protein_start="613"
                     /score="12.7"
                     /tool="antismash"
                     /translation="TGRIKDVIIINGLNYYCHEIE"
     CDS_motif       2635..2652
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuA_0004"
                     /evalue="3.60E+01"
                     /label="PKSI-KR_m3"
                     /locus_tag="spuA"
                     /protein_end="884"
                     /protein_start="878"
                     /score="-1.0"
                     /tool="antismash"
                     /translation="AKVQGA"
     aSDomain        2968..3513
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spuA_PKS_KR.1"
                     /evalue="3.00E-45"
                     /label="spuA_PKS_KR.1"
                     /locus_tag="spuA"
                     /protein_end="1171"
                     /protein_start="989"
                     /score="146.2"
                     /tool="antismash"
                     /translation="GMYLITGGLGGIGVEVARYLLQHYQAKLLLVGRTPLTSEKRLKVY
                     QELKQIGGELIYEAVDICNLKQLQITVEKAQAQWGKNLDGILHLAGTFHEQLVIDETQE
                     SLKSILRPKVLGAWVLHQLIKHNQDSIFINFSSVNGFFGATAVGAYGAANSFLDSFSHY
                     QNAQSKLASYCLSWSMWDD"
     CDS_motif       2974..3069
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuA_0005"
                     /evalue="2.10E-12"
                     /label="PKSI-KR_m1"
                     /locus_tag="spuA"
                     /protein_end="1023"
                     /protein_start="991"
                     /score="39.6"
                     /tool="antismash"
                     /translation="YLITGGLGGIGVEVARYLLQHYQAKLLLVGRT"
     CDS_motif       3301..3330
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuA_0006"
                     /evalue="8.00E-03"
                     /label="PKSI-KR_m3"
                     /locus_tag="spuA"
                     /protein_end="1110"
                     /protein_start="1100"
                     /score="9.8"
                     /tool="antismash"
                     /translation="PKVLGAWVLH"
     CDS_motif       3361..3459
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuA_0007"
                     /evalue="9.60E-10"
                     /label="PKSI-KR_m4"
                     /locus_tag="spuA"
                     /protein_end="1153"
                     /protein_start="1120"
                     /score="31.0"
                     /tool="antismash"
                     /translation="FINFSSVNGFFGATAVGAYGAANSFLDSFSHYQ"
     aSDomain        3913..4110
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spuA_PCP.1"
                     /evalue="8.50E-24"
                     /label="spuA_PCP.1"
                     /locus_tag="spuA"
                     /protein_end="1370"
                     /protein_start="1304"
                     /score="75.5"
                     /tool="antismash"
                     /translation="EIKIAQCWQQVLKVQLLGIHDNFFELGGNSLLAGQVIALLREYFA
                     VELSLQRLFQAPTIADLSQTI"
     gene            4193..16543
                     /gene="spuB"
     CDS             4193..16543
                     /NRPS_PKS="Domain: Condensation_LCL (72-369). E-value:
                     2.5e-123. Score: 402.7. Matches aSDomain:
                     nrpspksdomains_spuB_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (534-927). E-value:
                     6.2e-118. Score: 385.8. Matches aSDomain:
                     nrpspksdomains_spuB_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1034-1099). E-value: 7.9e-25.
                     Score: 78.8. Matches aSDomain: nrpspksdomains_spuB_PCP.1"
                     /NRPS_PKS="Domain: Epimerization (1112-1415). E-value:
                     1.5e-148. Score: 487.7. Matches aSDomain:
                     nrpspksdomains_spuB_Epimerization.1"
                     /NRPS_PKS="Domain: TIGR01720 (1420-1575). E-value: 3.6e-50.
                     Score: 161.6. Matches aSDomain:
                     nrpspksdomains_spuB_TIGR01720.1"
                     /NRPS_PKS="Domain: Condensation_DCL (1593-1895). E-value:
                     1.8e-117. Score: 383.6. Matches aSDomain:
                     nrpspksdomains_spuB_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (2058-2455). E-value:
                     9.9e-118. Score: 385.1. Matches aSDomain:
                     nrpspksdomains_spuB_AMP-binding.2"
                     /NRPS_PKS="Domain: PCP (2564-2632). E-value: 1.6e-27.
                     Score: 87.4. Matches aSDomain: nrpspksdomains_spuB_PCP.2"
                     /NRPS_PKS="Domain: Condensation_LCL (2652-2952). E-value:
                     3.2e-120. Score: 392.5. Matches aSDomain:
                     nrpspksdomains_spuB_Condensation_LCL.2"
                     /NRPS_PKS="Domain: AMP-binding (3117-3524). E-value:
                     8e-115. Score: 375.5. Matches aSDomain:
                     nrpspksdomains_spuB_AMP-binding.3"
                     /NRPS_PKS="Domain: PCP (3632-3699). E-value: 5.2e-22.
                     Score: 69.7. Matches aSDomain: nrpspksdomains_spuB_PCP.3"
                     /NRPS_PKS="Domain: TD (3741-3982). E-value: 6e-89. Score:
                     289.3. Matches aSDomain: nrpspksdomains_spuB_TD.1"
                     /codon_start=1
                     /gene="spuB"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     468.9; E-value: 3.1e-142)"
                     /gene_kind="biosynthetic"
                     /note="non-ribosomal peptide synthetase"
                     /product="SpuB"
                     /protein_id="ATP76246.1"
                     /sec_met_domain="Condensation (E-value: 9.6e-88, bitscore:
                     281.7, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 2.3e-123, bitscore:
                     399.4, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3.9e-17, bitscore:
                     50.4, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 6.3e-09,
                     bitscore: 23.0, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 2.1e-73, bitscore:
                     234.2, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIFEFLSLLNTLDIKIWIEDDQLRYRAPKGAMTAEIKEQLKERK
                     AEIIAFLQEAQTATQLTSLSLDPVSRNKDLPLSFAQQRMWFLSQLDGESTFYNESFQLR
                     IVGKLSVTALEQSINEIIRRHEALRTNFPTVEGIPLQLIRPNLTISIPVIDVQECTETA
                     VQKIITQEVSQSFDLGTDSLVKVTLLRQTPESHLLIITMHHIVVDGWSMGIFFRELEAL
                     YSAFIQGKPNPLPALAIQYADFAVWQREWLTQEVQEKQLEYWTQQLAGAPPLLELPTDY
                     PRPPVQTFAGATIAFQIDEDLTSELVTLSQQSGVTLFMTLLTAFAVLLHRYSGQDDICI
                     GSPFANRDRREIDSLIGFFVNTLVLRTQLEGNPSFSQLLEKVRSVVWDAHAHQDIPFEQ
                     IVEALQPERSLGYNPLFQALFVLENFSLETLELPGISLTPEIIDRGTSKFDLSVSAWQT
                     KKGLKGFWEYNSDLFTPDTITRMIGHFQSLLAAIVKDPQQKVRQLPLLTEKEQHQLLVE
                     WNHTHTDYPQDKCLHQLFEEQVEKTPDAVAVVFENQQLTYHQLNCRANQLAHHLRSLGV
                     KPDVLVSICVERSLEMAIGLLGILKAGGAYLPIDPEYPPERISLMLQDAQVSLLLSQKS
                     LLSQLPLDNRENPCQVICLDQNTFNLALTENPSRQTQPDNLAYVIYTSGSTGRPKGVMI
                     EHRAIVNLSLTWAKTFQVQNHSRLLQFGSFSFDLSVAEITTAFVTGACLYLANKETLLP
                     SQSLVDFLTANKITHSFLSPSALSVLPKASLPDLQCLTAGGEACTTEIVNQWGTERRFY
                     NCYGPTESTVTATIFLCQPNGKKPPIGKPISNLRIYILDAHHQVLPPGIPGELCIAGVG
                     LARGYLNRPEITAEKFIEIDLFGQVERIYKTGDLARWGADGNIEYLGRIDNQVKIRGFR
                     IELDEVETALNRNPEVQTSCVIVREDIPGQKQLVAYVVPHHTVTMSELRQYLKEKLPEY
                     MLPHAFVILESLPVTPNGKIDRRALPAPDSREGLEVSFVAPRNQTEKILAQIWAEVLRV
                     KQVGIYDNFFELGGDSILSIQILAKAKLAGLQLTLKQLFAHQAIADLAAVAGTIEAIEV
                     KQELVTGLVPLTPIQHWFFEQNLVEAHHFNQAFLLSFPCDLQPETLKQVFQQLLVHHDA
                     LRLRFTPSDATWQQIYSAPNDHLAFSYIDLSALPENEQQAAIADQEAVLQANLHLSENL
                     VQVAFFHLGVDKRVKLLIVIHHLVIDGVSWRILLNDLQTAYQQLAQGQTLQLPPKTTSF
                     KDWSEKLTAYAQSPALKSEVAYWLNEARLKVPSIPVDLTKGVNNFAAANTILLSLSESE
                     TRALLHDVPKAYNTQINDVLLTALVLVVSKWIGSRSVLFNLEGHGREDIVDGVDLSRTV
                     GWFTTIFPVLVELPATDKLADVLKSVKEQLRAIPNKGIGYGLLRYLSQDAEIASQLQAF
                     PQAQISFNYLGQFDQQVNTSSWMQPASESAVKMHGLQNNRPYLLEIDSIIAGEQLRIEW
                     TYSKNLHQHATIENLAQEFFQTLQQIIAHCASGENGGYTPSDFSLVRFNQLELDQTLAL
                     VCKHQSGKTHWRNIEDIYPLSPMQEGMLFESLYAPNSPAYFEQSIYNLSGQLNLSAFEQ
                     AWQQVVARHSILRTGFIWEQLPQPLQVVYRQVDVKLQTYDWQHLSPQQQQQKLESLLQS
                     QRQQGFQLSTAPLMHLSLVQLSADRYQFVWNFHHLLLDGWSVPVIFQDLLYFYRAILQG
                     ETQTRPPVLSYRNYIAWLQQQDLTKAQEFWRQKLQGFTAPTPLTVDKPSSQRKQLDASY
                     REQKIQLTATATTALQTFARQHQLTMNNVVQGTWALLLYRYSQETDIVFGATVSGRPAS
                     LIGVESMVGLFINTLPVRVQLGNETEVLALLQDLQTQLVESEQYSYSSLVDIQGLSDVP
                     RGTPLFESLVVFDNYPVNEAAPENNYGFSIDDLHAIEQTNYPLTIIAIPGQQLLVRISY
                     DTSRFDDGAIARLLGHFQTLLTAIVANPNERISQLPLLTAWEKQQLLVDWNNTQAEYPV
                     DQCIHQLFEEQVEKTPDAVAVVFENQHLTYQQLNCRANQLAHYLQDLGVKPDTLVGICV
                     ERSLEMMVGLLGILKVGGAYVPIDPEYPTERLSFMLTDTQVKVLLTQEKLREFLPQYQG
                     RIVCLDSDWNSISLENQNNLNITVSAESLAHVIYTSGSTGTPKGVAVTHQSVNRLVINT
                     NYIQLTANDRIAQAANIAFDAATFEIWGALLHGAVLVIISKSVLLIPEELAVNISSHKV
                     NVLFLTTALFNQLASHLPQAFSSLKYLLFGGEAVDPRWVQEVLEKGTPQKLLHVYGPTE
                     NTTFSSWYWVEKLVGTATTVPIGRPITNTQIYILDQNLQPVPVGVPGELYLGGDGLARG
                     YLNRPELTNEKFIANPFGKSKLYKTGDLARYLPDGNIEYIKRIDNQVKIRGFRIELGEI
                     ETVLSQYPKIKSVVAIAREDSPGNKRLVAYVVPHQDSQPVAQELRSFLKTKLPEHMIPG
                     VFVILESLPLTPNGKIDRRALPQPDLDSTLLEKYVAPHNPIEELLAQVWAQVLKVGQVG
                     IYDNFFELGGHSLLATQLVSRIRNIFQVELPLSELFTAPTVIELAQKIGQLQPEQLELS
                     APQILPRAEISELPMSFAQQRLWFLDQFDQNSVLYNIPTALRLVGKLNLQVLEQSLQEI
                     IHRHEALRTNFITINEQPTQVIQTQINWQLSIVDWQHLPTAEQETSVQQFLQQQALERF
                     DLVRQTLIRATLILLNQTEQILLVCMHHIVSDGWSMGVFVQELTQLYNAYSQGQPSPLA
                     PLAIQYADFALWQRQWLQGEVLQNQLAYWEQQLKDAPTVLSLPTDRPRPAVQTVTGAIH
                     EFALSVELTDQLVKLSQEQGCTLFMTLLAAFDTLLYRYTGQSDILVGSPIANRDRAEVE
                     GLIGFFVNTLVMRSNLAGNPSFSELLTRVRDMALGAYAHQHLPFEMLVEALQPERDLSH
                     TPLFQVMFNLQNAPVSELELNGLTVSSLPIPGVTAAFDMTLFMQNTANGLVGVWEYNTD
                     LFDHSTIERMIGHFVTVLEAVVSNPQAPIDQLPILTAVEQQKLLLEWNDTQADDPVGKC
                     LHELFAQQAELTPDAVAVVFENEQLTYQQLNTQANQLAHYLQSLGVRAEVLVGIYLERS
                     LSMIVALLAVLKAGGGYVPLEVDYPQQRLAYISEDSEISVLITQESLLNSLPVVGVKVI
                     ALHQEWDVLNSQDQENPVSAVVPENLACVLYTSGSTGRPKGVMLTHAALVSHCSAISEA
                     FSLTSSDRVLQFAAFGFDVAVEEIFPTWFKGGTVVLRPAQLFSSFASFAEFIEQQQLSV
                     LTLTSAYWHEWMVAVSQSYATVPQSLRLLTVGGDTVLPETVAMWQQFVGDRITCLNAYG
                     PTEASVTAVVYDVQNFHPEKTNTVPIGRPVANTEIYILDSNLQPVPIGVKGELYIGGVR
                     IARGYLNRPDLTQEKFIPHPFKDKKSHRLYKTGDLARYLPDGNIEFIGRLDDVVKIRGF
                     RVAIGEVESLLVQHPDVICQVVMVREDQPGNKQLVAYVVSDNPSLTQNELQSFLKQKLP
                     SYMVPTAFVMLEGLPVTTNGKVDRRALPAPSQEIDLSNFVFPTTPTQKLIADIWSSVLG
                     TTQLGIRNNFFDIGGNSLRAIQVMSLLREALQLDLPLRYLFENPTIAELAAGVDSLHIS
                     QKNTITRGTIPDLKAEVVLDPNIHIPRQRCDDYHQPQRIFLTGATGFLGIHLLDELLQQ
                     TQADIYCLIRATNAQQAQQRLQSQLKLYKLWEGIDTKRIIPVAGDLAKSYLGLSTSEFQ
                     QLASEIDVIYHCGALINVIYPYSVLKGANVLGTQEIIRLASETTVKPLHFISTTSVLLA
                     SSPNEDGLILESDPLEQYQVLDNGYVQSKWVAEQLVMQARDLGLPVAIYRAARITGHSQ
                     TGVSNTDDLLCRLVKGCLQTKIAPDIDLEDNLTPVDYVSKIIVHLSGQKQSLGKAFHLV
                     NPDSTPLKHLFKLLCALGYPVQLIPVEQWHSEITHHQQMPDPDNLRFLSHIIPKTTADT
                     YKEPEFDYQNTMNGLVNTDIMYPALDQNLLKTYISYFISSGFIDDQLMTEQMAFGNKAN
                     "
     aSDomain        4409..5299
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spuB_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="2.50E-123"
                     /label="spuB_Condensation_LCL.1"
                     /locus_tag="spuB"
                     /protein_end="369"
                     /protein_start="72"
                     /score="402.7"
                     /tool="antismash"
                     /translation="KDLPLSFAQQRMWFLSQLDGESTFYNESFQLRIVGKLSVTALEQS
                     INEIIRRHEALRTNFPTVEGIPLQLIRPNLTISIPVIDVQECTETAVQKIITQEVSQSF
                     DLGTDSLVKVTLLRQTPESHLLIITMHHIVVDGWSMGIFFRELEALYSAFIQGKPNPLP
                     ALAIQYADFAVWQREWLTQEVQEKQLEYWTQQLAGAPPLLELPTDYPRPPVQTFAGATI
                     AFQIDEDLTSELVTLSQQSGVTLFMTLLTAFAVLLHRYSGQDDICIGSPFANRDRREID
                     SLIGFFVNTLVLRTQL"
     aSModule        4409..8917
                     /complete
                     /domains="nrpspksdomains_spuB_Condensation_LCL.1"
                     /domains="nrpspksdomains_spuB_AMP-binding.1"
                     /domains="nrpspksdomains_spuB_PCP.1"
                     /domains="nrpspksdomains_spuB_Epimerization.1"
                     /domains="nrpspksdomains_spuB_TIGR01720.1"
                     /locus_tags="spuB"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       4424..4453
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0001"
                     /evalue="9.70E-03"
                     /label="C1_LCL_004-017"
                     /locus_tag="spuB"
                     /protein_end="87"
                     /protein_start="77"
                     /score="8.7"
                     /tool="antismash"
                     /translation="SFAQQRMWFL"
     CDS_motif       4478..4591
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0002"
                     /evalue="2.00E-15"
                     /label="C2_LCL_024-062"
                     /locus_tag="spuB"
                     /protein_end="133"
                     /protein_start="95"
                     /score="49.2"
                     /tool="antismash"
                     /translation="FYNESFQLRIVGKLSVTALEQSINEIIRRHEALRTNFP"
     CDS_motif       4796..4861
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0003"
                     /evalue="3.20E-12"
                     /label="C3_LCL_132-143"
                     /locus_tag="spuB"
                     /protein_end="223"
                     /protein_start="201"
                     /score="38.8"
                     /tool="antismash"
                     /translation="MHHIVVDGWSMGIFFRELEALY"
     CDS_motif       4910..4948
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0004"
                     /evalue="1.80E-06"
                     /label="C4_LCL_164-176"
                     /locus_tag="spuB"
                     /protein_end="252"
                     /protein_start="239"
                     /score="20.3"
                     /tool="antismash"
                     /translation="QYADFAVWQREWL"
     CDS_motif       5201..5290
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0005"
                     /evalue="5.70E-16"
                     /label="C5_LCL_267-296"
                     /locus_tag="spuB"
                     /protein_end="366"
                     /protein_start="336"
                     /score="50.8"
                     /tool="antismash"
                     /translation="DICIGSPFANRDRREIDSLIGFFVNTLVLR"
     CDS_motif       5339..5458
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0006"
                     /evalue="4.90E-23"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="spuB"
                     /protein_end="422"
                     /protein_start="382"
                     /score="73.6"
                     /tool="antismash"
                     /translation="RSVVWDAHAHQDIPFEQIVEALQPERSLGYNPLFQALFVL"
     aSDomain        5795..6973
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spuB_AMP-binding.1"
                     /evalue="6.20E-118"
                     /label="spuB_AMP-binding.1"
                     /locus_tag="spuB"
                     /protein_end="927"
                     /protein_start="534"
                     /score="385.8"
                     /tool="antismash"
                     /translation="FEEQVEKTPDAVAVVFENQQLTYHQLNCRANQLAHHLRSLGVKPD
                     VLVSICVERSLEMAIGLLGILKAGGAYLPIDPEYPPERISLMLQDAQVSLLLSQKSLLS
                     QLPLDNRENPCQVICLDQNTFNLALTENPSRQTQPDNLAYVIYTSGSTGRPKGVMIEHR
                     AIVNLSLTWAKTFQVQNHSRLLQFGSFSFDLSVAEITTAFVTGACLYLANKETLLPSQS
                     LVDFLTANKITHSFLSPSALSVLPKASLPDLQCLTAGGEACTTEIVNQWGTERRFYNCY
                     GPTESTVTATIFLCQPNGKKPPIGKPISNLRIYILDAHHQVLPPGIPGELCIAGVGLAR
                     GYLNRPEITAEKFIEIDLFGQVERIYKTGDLARWGADGNIEYLGRIDNQVKIR"
     CDS_motif       5981..6022
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0007"
                     /evalue="6.30E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="spuB"
                     /protein_end="610"
                     /protein_start="596"
                     /score="16.2"
                     /tool="antismash"
                     /translation="LGILKAGGAYLPID"
     CDS_motif       6221..6280
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0008"
                     /evalue="4.00E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="spuB"
                     /protein_end="696"
                     /protein_start="676"
                     /score="34.6"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGRPKGVMIEH"
     CDS_motif       6635..6661
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0009"
                     /evalue="1.50E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="spuB"
                     /protein_end="823"
                     /protein_start="814"
                     /score="5.4"
                     /tool="antismash"
                     /translation="YGPTESTVT"
     CDS_motif       6764..6853
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0010"
                     /evalue="2.10E-16"
                     /label="NRPS-A_a6"
                     /locus_tag="spuB"
                     /protein_end="887"
                     /protein_start="857"
                     /score="52.0"
                     /tool="antismash"
                     /translation="PPGIPGELCIAGVGLARGYLNRPEITAEKF"
     CDS_motif       6938..7003
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0011"
                     /evalue="3.90E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="spuB"
                     /protein_end="937"
                     /protein_start="915"
                     /score="34.9"
                     /tool="antismash"
                     /translation="YLGRIDNQVKIRGFRIELDEVE"
     CDS_motif       7211..7237
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0012"
                     /evalue="2.80E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="spuB"
                     /protein_end="1015"
                     /protein_start="1006"
                     /score="4.5"
                     /tool="antismash"
                     /translation="GKIDRRALP"
     aSDomain        7295..7489
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spuB_PCP.1"
                     /evalue="7.90E-25"
                     /label="spuB_PCP.1"
                     /locus_tag="spuB"
                     /protein_end="1099"
                     /protein_start="1034"
                     /score="78.8"
                     /tool="antismash"
                     /translation="EKILAQIWAEVLRVKQVGIYDNFFELGGDSILSIQILAKAKLAGL
                     QLTLKQLFAHQAIADLAAVA"
     CDS_motif       7358..7387
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0013"
                     /evalue="2.40E-01"
                     /label="PCP_mE"
                     /locus_tag="spuB"
                     /protein_end="1065"
                     /protein_start="1055"
                     /score="4.9"
                     /tool="antismash"
                     /translation="NFFELGGDSI"
     aSDomain        7529..8437
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spuB_Epimerization.1"
                     /evalue="1.50E-148"
                     /label="spuB_Epimerization.1"
                     /locus_tag="spuB"
                     /protein_end="1415"
                     /protein_start="1112"
                     /score="487.7"
                     /tool="antismash"
                     /translation="TGLVPLTPIQHWFFEQNLVEAHHFNQAFLLSFPCDLQPETLKQVF
                     QQLLVHHDALRLRFTPSDATWQQIYSAPNDHLAFSYIDLSALPENEQQAAIADQEAVLQ
                     ANLHLSENLVQVAFFHLGVDKRVKLLIVIHHLVIDGVSWRILLNDLQTAYQQLAQGQTL
                     QLPPKTTSFKDWSEKLTAYAQSPALKSEVAYWLNEARLKVPSIPVDLTKGVNNFAAANT
                     ILLSLSESETRALLHDVPKAYNTQINDVLLTALVLVVSKWIGSRSVLFNLEGHGREDIV
                     DGVDLSRTVGWFTTIFPVLVEL"
     CDS_motif       7544..7573
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0014"
                     /evalue="3.10E-04"
                     /label="NRPS-E1"
                     /locus_tag="spuB"
                     /protein_end="1127"
                     /protein_start="1117"
                     /score="13.6"
                     /tool="antismash"
                     /translation="LTPIQHWFFE"
     CDS_motif       7631..7705
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0015"
                     /evalue="4.00E-04"
                     /label="C2_LCL_024-062"
                     /locus_tag="spuB"
                     /protein_end="1171"
                     /protein_start="1146"
                     /score="12.8"
                     /tool="antismash"
                     /translation="DLQPETLKQVFQQLLVHHDALRLRF"
     CDS_motif       7913..7978
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0016"
                     /evalue="9.00E-11"
                     /label="NRPS-E2"
                     /locus_tag="spuB"
                     /protein_end="1262"
                     /protein_start="1240"
                     /score="34.0"
                     /tool="antismash"
                     /translation="LLIVIHHLVIDGVSWRILLNDL"
     CDS_motif       8381..8431
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0017"
                     /evalue="2.20E-08"
                     /label="NRPS-E5"
                     /locus_tag="spuB"
                     /protein_end="1413"
                     /protein_start="1396"
                     /score="26.1"
                     /tool="antismash"
                     /translation="DLSRTVGWFTTIFPVLV"
     aSDomain        8453..8917
                     /aSDomain="TIGR01720"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spuB_TIGR01720.1"
                     /evalue="3.60E-50"
                     /label="spuB_TIGR01720.1"
                     /locus_tag="spuB"
                     /protein_end="1575"
                     /protein_start="1420"
                     /score="161.6"
                     /tool="antismash"
                     /translation="LADVLKSVKEQLRAIPNKGIGYGLLRYLSQDAEIASQLQAFPQAQ
                     ISFNYLGQFDQQVNTSSWMQPASESAVKMHGLQNNRPYLLEIDSIIAGEQLRIEWTYSK
                     NLHQHATIENLAQEFFQTLQQIIAHCASGENGGYTPSDFSLVRFNQLELDQ"
     CDS_motif       8474..8536
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0018"
                     /evalue="1.60E-12"
                     /label="NRPS-E6"
                     /locus_tag="spuB"
                     /protein_end="1448"
                     /protein_start="1427"
                     /score="39.4"
                     /tool="antismash"
                     /translation="VKEQLRAIPNKGIGYGLLRYL"
     aSDomain        8972..9877
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spuB_Condensation_DCL.1"
                     /domain_subtypes="Condensation_DCL"
                     /evalue="1.80E-117"
                     /label="spuB_Condensation_DCL.1"
                     /locus_tag="spuB"
                     /protein_end="1895"
                     /protein_start="1593"
                     /score="383.6"
                     /tool="antismash"
                     /translation="EDIYPLSPMQEGMLFESLYAPNSPAYFEQSIYNLSGQLNLSAFEQ
                     AWQQVVARHSILRTGFIWEQLPQPLQVVYRQVDVKLQTYDWQHLSPQQQQQKLESLLQS
                     QRQQGFQLSTAPLMHLSLVQLSADRYQFVWNFHHLLLDGWSVPVIFQDLLYFYRAILQG
                     ETQTRPPVLSYRNYIAWLQQQDLTKAQEFWRQKLQGFTAPTPLTVDKPSSQRKQLDASY
                     REQKIQLTATATTALQTFARQHQLTMNNVVQGTWALLLYRYSQETDIVFGATVSGRPAS
                     LIGVESMVGLFINTLPVRVQL"
     aSModule        8972..12088
                     /complete
                     /domains="nrpspksdomains_spuB_Condensation_DCL.1"
                     /domains="nrpspksdomains_spuB_AMP-binding.2"
                     /domains="nrpspksdomains_spuB_PCP.2"
                     /locus_tags="spuB"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       8981..9016
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0019"
                     /evalue="2.20E-04"
                     /label="C1_dual_004-017"
                     /locus_tag="spuB"
                     /protein_end="1608"
                     /protein_start="1596"
                     /score="14.1"
                     /tool="antismash"
                     /translation="YPLSPMQEGMLF"
     CDS_motif       9044..9160
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0020"
                     /evalue="3.70E-19"
                     /label="C2_DCL_024-062"
                     /locus_tag="spuB"
                     /protein_end="1656"
                     /protein_start="1617"
                     /score="61.0"
                     /tool="antismash"
                     /translation="AYFEQSIYNLSGQLNLSAFEQAWQQVVARHSILRTGFIW"
     CDS_motif       9377..9442
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0021"
                     /evalue="1.70E-09"
                     /label="C3_DCL_135-156"
                     /locus_tag="spuB"
                     /protein_end="1750"
                     /protein_start="1728"
                     /score="30.2"
                     /tool="antismash"
                     /translation="FHHLLLDGWSVPVIFQDLLYFY"
     CDS_motif       9491..9526
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0022"
                     /evalue="4.80E-03"
                     /label="C4_DCL_171-183"
                     /locus_tag="spuB"
                     /protein_end="1778"
                     /protein_start="1766"
                     /score="9.8"
                     /tool="antismash"
                     /translation="YRNYIAWLQQQD"
     CDS_motif       9773..9868
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0023"
                     /evalue="4.50E-20"
                     /label="C5_DCL_263-294"
                     /locus_tag="spuB"
                     /protein_end="1892"
                     /protein_start="1860"
                     /score="64.1"
                     /tool="antismash"
                     /translation="DIVFGATVSGRPASLIGVESMVGLFINTLPVR"
     CDS_motif       9917..10039
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0024"
                     /evalue="3.30E-21"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="spuB"
                     /protein_end="1949"
                     /protein_start="1908"
                     /score="67.8"
                     /tool="antismash"
                     /translation="QTQLVESEQYSYSSLVDIQGLSDVPRGTPLFESLVVFDNYP"
     aSDomain        10367..11557
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spuB_AMP-binding.2"
                     /evalue="9.90E-118"
                     /label="spuB_AMP-binding.2"
                     /locus_tag="spuB"
                     /protein_end="2455"
                     /protein_start="2058"
                     /score="385.1"
                     /tool="antismash"
                     /translation="FEEQVEKTPDAVAVVFENQHLTYQQLNCRANQLAHYLQDLGVKPD
                     TLVGICVERSLEMMVGLLGILKVGGAYVPIDPEYPTERLSFMLTDTQVKVLLTQEKLRE
                     FLPQYQGRIVCLDSDWNSISLENQNNLNITVSAESLAHVIYTSGSTGTPKGVAVTHQSV
                     NRLVINTNYIQLTANDRIAQAANIAFDAATFEIWGALLHGAVLVIISKSVLLIPEELAV
                     NISSHKVNVLFLTTALFNQLASHLPQAFSSLKYLLFGGEAVDPRWVQEVLEKGTPQKLL
                     HVYGPTENTTFSSWYWVEKLVGTATTVPIGRPITNTQIYILDQNLQPVPVGVPGELYLG
                     GDGLARGYLNRPELTNEKFIANPFGKSKLYKTGDLARYLPDGNIEYIKRIDNQVKIR"
     CDS_motif       10553..10594
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0025"
                     /evalue="1.70E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="spuB"
                     /protein_end="2134"
                     /protein_start="2120"
                     /score="14.9"
                     /tool="antismash"
                     /translation="LGILKVGGAYVPID"
     CDS_motif       10787..10846
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0026"
                     /evalue="1.30E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="spuB"
                     /protein_end="2218"
                     /protein_start="2198"
                     /score="27.0"
                     /tool="antismash"
                     /translation="AHVIYTSGSTGTPKGVAVTH"
     CDS_motif       11216..11239
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0027"
                     /evalue="1.70E+00"
                     /label="NRPS-A_a5"
                     /locus_tag="spuB"
                     /protein_end="2349"
                     /protein_start="2341"
                     /score="2.4"
                     /tool="antismash"
                     /translation="YGPTENTT"
     CDS_motif       11354..11443
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0028"
                     /evalue="7.40E-18"
                     /label="NRPS-A_a6"
                     /locus_tag="spuB"
                     /protein_end="2417"
                     /protein_start="2387"
                     /score="56.6"
                     /tool="antismash"
                     /translation="PVGVPGELYLGGDGLARGYLNRPELTNEKF"
     CDS_motif       11522..11587
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0029"
                     /evalue="1.40E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="spuB"
                     /protein_end="2465"
                     /protein_start="2443"
                     /score="33.2"
                     /tool="antismash"
                     /translation="YIKRIDNQVKIRGFRIELGEIE"
     CDS_motif       11801..11827
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0030"
                     /evalue="2.80E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="spuB"
                     /protein_end="2545"
                     /protein_start="2536"
                     /score="4.5"
                     /tool="antismash"
                     /translation="GKIDRRALP"
     aSDomain        11885..12088
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spuB_PCP.2"
                     /evalue="1.60E-27"
                     /label="spuB_PCP.2"
                     /locus_tag="spuB"
                     /protein_end="2632"
                     /protein_start="2564"
                     /score="87.4"
                     /tool="antismash"
                     /translation="EELLAQVWAQVLKVGQVGIYDNFFELGGHSLLATQLVSRIRNIFQ
                     VELPLSELFTAPTVIELAQKIGQ"
     CDS_motif       11948..11977
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0031"
                     /evalue="1.50E+01"
                     /label="PCP_mE"
                     /locus_tag="spuB"
                     /protein_end="2595"
                     /protein_start="2585"
                     /score="0.2"
                     /tool="antismash"
                     /translation="NFFELGGHSL"
     aSDomain        12149..13048
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spuB_Condensation_LCL.2"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="3.20E-120"
                     /label="spuB_Condensation_LCL.2"
                     /locus_tag="spuB"
                     /protein_end="2952"
                     /protein_start="2652"
                     /score="392.5"
                     /tool="antismash"
                     /translation="ELPMSFAQQRLWFLDQFDQNSVLYNIPTALRLVGKLNLQVLEQSL
                     QEIIHRHEALRTNFITINEQPTQVIQTQINWQLSIVDWQHLPTAEQETSVQQFLQQQAL
                     ERFDLVRQTLIRATLILLNQTEQILLVCMHHIVSDGWSMGVFVQELTQLYNAYSQGQPS
                     PLAPLAIQYADFALWQRQWLQGEVLQNQLAYWEQQLKDAPTVLSLPTDRPRPAVQTVTG
                     AIHEFALSVELTDQLVKLSQEQGCTLFMTLLAAFDTLLYRYTGQSDILVGSPIANRDRA
                     EVEGLIGFFVNTLVMRSNL"
     aSModule        12149..16138
                     /complete
                     /domains="nrpspksdomains_spuB_Condensation_LCL.2"
                     /domains="nrpspksdomains_spuB_AMP-binding.3"
                     /domains="nrpspksdomains_spuB_PCP.3"
                     /domains="nrpspksdomains_spuB_TD.1"
                     /final_module
                     /locus_tags="spuB"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       12161..12193
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0032"
                     /evalue="8.90E-03"
                     /label="C1_LCL_004-017"
                     /locus_tag="spuB"
                     /protein_end="2667"
                     /protein_start="2656"
                     /score="8.8"
                     /tool="antismash"
                     /translation="SFAQQRLWFLD"
     CDS_motif       12215..12325
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0033"
                     /evalue="3.40E-17"
                     /label="C2_LCL_024-062"
                     /locus_tag="spuB"
                     /protein_end="2711"
                     /protein_start="2674"
                     /score="54.8"
                     /tool="antismash"
                     /translation="LYNIPTALRLVGKLNLQVLEQSLQEIIHRHEALRTNF"
     CDS_motif       12545..12610
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0034"
                     /evalue="3.80E-13"
                     /label="C3_LCL_132-143"
                     /locus_tag="spuB"
                     /protein_end="2806"
                     /protein_start="2784"
                     /score="41.7"
                     /tool="antismash"
                     /translation="MHHIVSDGWSMGVFVQELTQLY"
     CDS_motif       12659..12697
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0035"
                     /evalue="9.80E-06"
                     /label="C4_LCL_164-176"
                     /locus_tag="spuB"
                     /protein_end="2835"
                     /protein_start="2822"
                     /score="18.0"
                     /tool="antismash"
                     /translation="QYADFALWQRQWL"
     CDS_motif       12950..13039
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0036"
                     /evalue="1.80E-17"
                     /label="C5_LCL_267-296"
                     /locus_tag="spuB"
                     /protein_end="2949"
                     /protein_start="2919"
                     /score="55.6"
                     /tool="antismash"
                     /translation="DILVGSPIANRDRAEVEGLIGFFVNTLVMR"
     CDS_motif       13088..13207
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0037"
                     /evalue="3.70E-26"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="spuB"
                     /protein_end="3005"
                     /protein_start="2965"
                     /score="83.7"
                     /tool="antismash"
                     /translation="RDMALGAYAHQHLPFEMLVEALQPERDLSHTPLFQVMFNL"
     aSDomain        13544..14764
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spuB_AMP-binding.3"
                     /evalue="8.00E-115"
                     /label="spuB_AMP-binding.3"
                     /locus_tag="spuB"
                     /protein_end="3524"
                     /protein_start="3117"
                     /score="375.5"
                     /tool="antismash"
                     /translation="FAQQAELTPDAVAVVFENEQLTYQQLNTQANQLAHYLQSLGVRAE
                     VLVGIYLERSLSMIVALLAVLKAGGGYVPLEVDYPQQRLAYISEDSEISVLITQESLLN
                     SLPVVGVKVIALHQEWDVLNSQDQENPVSAVVPENLACVLYTSGSTGRPKGVMLTHAAL
                     VSHCSAISEAFSLTSSDRVLQFAAFGFDVAVEEIFPTWFKGGTVVLRPAQLFSSFASFA
                     EFIEQQQLSVLTLTSAYWHEWMVAVSQSYATVPQSLRLLTVGGDTVLPETVAMWQQFVG
                     DRITCLNAYGPTEASVTAVVYDVQNFHPEKTNTVPIGRPVANTEIYILDSNLQPVPIGV
                     KGELYIGGVRIARGYLNRPDLTQEKFIPHPFKDKKSHRLYKTGDLARYLPDGNIEFIGR
                     LDDVVKIR"
     CDS_motif       13730..13768
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0038"
                     /evalue="3.80E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="spuB"
                     /protein_end="3192"
                     /protein_start="3179"
                     /score="13.9"
                     /tool="antismash"
                     /translation="LAVLKAGGGYVPL"
     CDS_motif       13964..14023
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0039"
                     /evalue="4.90E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="spuB"
                     /protein_end="3277"
                     /protein_start="3257"
                     /score="31.3"
                     /tool="antismash"
                     /translation="ACVLYTSGSTGRPKGVMLTH"
     CDS_motif       14411..14437
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0040"
                     /evalue="2.20E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="spuB"
                     /protein_end="3415"
                     /protein_start="3406"
                     /score="4.9"
                     /tool="antismash"
                     /translation="YGPTEASVT"
     CDS_motif       14552..14641
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0041"
                     /evalue="1.00E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="spuB"
                     /protein_end="3483"
                     /protein_start="3453"
                     /score="49.8"
                     /tool="antismash"
                     /translation="PIGVKGELYIGGVRIARGYLNRPDLTQEKF"
     CDS_motif       14729..14794
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0042"
                     /evalue="4.20E-08"
                     /label="NRPS-A_a8"
                     /locus_tag="spuB"
                     /protein_end="3534"
                     /protein_start="3512"
                     /score="25.5"
                     /tool="antismash"
                     /translation="FIGRLDDVVKIRGFRVAIGEVE"
     CDS_motif       15005..15031
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0043"
                     /evalue="2.90E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="spuB"
                     /protein_end="3613"
                     /protein_start="3604"
                     /score="4.4"
                     /tool="antismash"
                     /translation="GKVDRRALP"
     aSDomain        15089..15289
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spuB_PCP.3"
                     /evalue="5.20E-22"
                     /label="spuB_PCP.3"
                     /locus_tag="spuB"
                     /protein_end="3699"
                     /protein_start="3632"
                     /score="69.7"
                     /tool="antismash"
                     /translation="KLIADIWSSVLGTTQLGIRNNFFDIGGNSLRAIQVMSLLREALQL
                     DLPLRYLFENPTIAELAAGVDS"
     CDS_motif       15149..15178
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spuB_0044"
                     /evalue="2.70E+01"
                     /label="PCP_mE"
                     /locus_tag="spuB"
                     /protein_end="3662"
                     /protein_start="3652"
                     /score="-0.4"
                     /tool="antismash"
                     /translation="NFFDIGGNSL"
     aSDomain        15416..16138
                     /aSDomain="TD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spuB_TD.1"
                     /evalue="6.00E-89"
                     /label="spuB_TD.1"
                     /locus_tag="spuB"
                     /protein_end="3982"
                     /protein_start="3741"
                     /score="289.3"
                     /tool="antismash"
                     /translation="IFLTGATGFLGIHLLDELLQQTQADIYCLIRATNAQQAQQRLQSQ
                     LKLYKLWEGIDTKRIIPVAGDLAKSYLGLSTSEFQQLASEIDVIYHCGALINVIYPYSV
                     LKGANVLGTQEIIRLASETTVKPLHFISTTSVLLASSPNEDGLILESDPLEQYQVLDNG
                     YVQSKWVAEQLVMQARDLGLPVAIYRAARITGHSQTGVSNTDDLLCRLVKGCLQTKIAP
                     DIDLEDNLTPVDYVSKIIV"
     gene            16702..18705
                     /gene="spuF"
     CDS             16702..18705
                     /codon_start=1
                     /gene="spuF"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 119; E-value:
                     4.5e-36)"
                     /gene_kind="transport"
                     /note="ABC transporter"
                     /product="SpuF"
                     /protein_id="ATP76247.1"
                     /transl_table=11
                     /translation="MQAQISRDQPITNSYSALTQFWENIKALTEPYWYPTKAGGRAFSA
                     VIRSWGMLITLILLIIGLVSLNVFTNFLYRYLVDITITGRDVSKFFDTVLIYSVALIFV
                     TAFVGFSKFVRKQISLDWYQWLNNHILAKYLYGRAYYKINFKSDIDNPDQRLSQEIEPV
                     INNALTFVTTFLEKILEIIAYIVIIWTISHQVAIILVIYTVIGNVVAVYLTQHLNNINQ
                     EELQSKADYNYCLTHVRVHAESVAFFRGEKQESNIIGKRFTKLVKNVQRRIDWERNQDI
                     FNRGYQAVIEIFPFLILGPLYITNQLGFGEISQASLCAYLFANSLAELINEFGVSGRFS
                     IYVERLSEFSSALEEVAKEPTNVSTIKTVEENHLTFENVTLQTPNYEQVIVEDLSLSVQ
                     PGEGLLIVGPSGRGKSSLLRAIAGLWNAGTGRLVRPPLEEVLFLPQRPYIILGTLREQL
                     LYPNTNLQLTDAQLKEVLQKVNLQNVLNRVEGFDTEVPWENILSLGEQQRLAFARLLIT
                     HPSFTILDEATSALDLTNEGHLYQQLQETKTTFISVGHRESLFQYHQWVLELSENSTWQ
                     LVTVEDYQKQKQIVNNPPPENVPITINNLPKETTVITNIITGFSHKEMQTLTDYSLGTI
                     RSRASQGKSITTKDGVTYRYNKDPKVLKWLRV"
ORIGIN
        1 atgcagttaa atgatcatag tcaaacttta gcaaccccca atgacaaaaa ttttctctat
       61 agaaaaatag aagttgctat tttgtcgagt ttgactgtca gtgattgtat agtccgagaa
      121 agacaaacgc aaaagcaaaa acaggaatta gttgcttatg tagtgccatc aggtttattt
      181 gcatcagaac aattatcatc tcatctgcaa acaattctgc ctcaagaatt gatacctaca
      241 atatttgtgc caatctctac cataccccta acagccgcag gggaagtaga tgaagtaact
      301 ctagccaatt tagaagtaat tgactctgag ttaatgcgta gtttagaaaa gcaattagag
      361 tcattaccag aaattgagcg tgtcgcggtt gttgtcgaac ctgttattaa aaatatttcc
      421 cctctacatt tagatgattt actaggtgag actcaagtaa atctcgatac aaatagccaa
      481 gcgatacaac caaacaccca tagtctgaca atagcaaacg aaaattctgc ttcatcaaaa
      541 aagttagcta ttagtcacgg tgaaccccta aaatcttctg aagatgcgcc tcagacttta
      601 acagcagtat taaaaaaaac ctcggaaaat tccactaaag ggattattta cattcaagct
      661 gacggcagtg agcaagttca atcttacaaa gaattatggc aagatgctca acgcatttta
      721 gctgggttga gaaaactagg actcaaaccc caagataaag taatttttca actagaagat
      781 aatcaagatt ttatctgtgc tttttgggct tgtgttctgg ggggttttgt tcctgtacca
      841 gtatccattg ccccaaacta tgaattagct aatagtaccg ccagcaaact gcaaaatact
      901 tggcaaatgt tggggaaacc tctgattttg acgagtgctg ctttagctaa caatattgat
      961 gattttttca gcttgttaaa cttagaaaat tttcaaattg caactattaa taaattacgt
     1021 gaatatcaac cagatttaaa ttaccatcaa agtcagccag aggatttagc aatattgctt
     1081 ttgacttcag gcagcactgg aatacccaag tgtgtgatgt tgaatcatca caacattttg
     1141 agtatgacga ctggattaat tttaatgggt gatttttcca gtcaggaaag cgttttaaac
     1201 tggatgcctt tagatcatgt gggtgcgcta gtttcgctga gtattatggc tgtgagttta
     1261 ggttgtcagc aaattcatgt acctactaac ctaattgtgc agaaaccact cctgtggcta
     1321 gatttgattg ataaacatca agctaccatt agttggtctc ctaactttgc tttttcctta
     1381 atttgcgatc gcacttctga aatcaatcgt cagaattggg atttatcctc aatgaagttt
     1441 atcatcaacg ctggggagcc gattgtcact aaaacagcca gaaatttctt aaaattacta
     1501 agtcgtcacg gtttaccgac tgatgctatt cacccagctt ttggaatgtg tgaaacttct
     1561 tcaggtatta cctattctga tagtttttcc cttgaatctt catcggatga cacttcattt
     1621 gtagaattag gactaccaat tgctggagct tcattacgca ttgttgatga aaatgaacaa
     1681 atagtggcag aaaatactat tggtcgttta caggtaaaag gtgcgtctgt tactaatggt
     1741 tattatcaaa atccccaagc aaatcaagaa gtttttacgg ctgatggttg gtttaacaca
     1801 ggagatttag gttttcttga tcaaggacgt ttaactatta ccggaagaat caaagatgtc
     1861 attattatta atggattgaa ctactactgt cacgaaattg aggctgctgt tgaagaatta
     1921 gcaggagtag aagtttcata tacggcagct tgtgcagtca gacaacctgg aattaataca
     1981 gataaactag caatcttttt ccatacttct gtgactgatg atgttagttt gttaaatctg
     2041 ctcagagaaa ttcgtactgc tgttgtcaac aaagcaggaa taaatcctga ttatttaatt
     2101 ccagtagata aagaaattat tccaaaaact gccataggaa aaattcagcg atcgcaactc
     2161 agccaacgct tccaaaaagg tgagtttcaa tcaattacta aacgcattga tatattactc
     2221 ggtaatgcca ataccattcc aaactggttc taccgtcaag tatggcaact caaaaatccc
     2281 attactattg attctgtttt cactgttact aatgccacat tagtattttt agatgctgac
     2341 ggtttgggtt cttatgtatg tcaagtattg tcagaacata acctgccata cataagtgtt
     2401 acacctggag aagatttccg caaaatcaat cacacacact acaccattac agcaggacaa
     2461 gccaaagatt accaactttt acttgaatca ctagcagcag ataatattat cattgggcaa
     2521 attcttcacc tatggactta taaccaatat attggcgaag tcaaaagcat tgatacttta
     2581 gaacaagcac aagaatacgg catatatagt ttattgtttt tgactcaagc tttagccaaa
     2641 gttcaaggtg cggatcattc agtccaatta ctatttattt cttctcatat ccaggctatt
     2701 tcctcagatg actccatagc ttatgagaaa tcagcagtat tagggctact aaaaaccatt
     2761 ccccaagaat taccttggtt gaattgtcgc cacattgatt taccctttgc tgaagcggaa
     2821 caaaatggag aatttatctt aaaagaaatc caaatttatg ccaaggaacg agaagtggct
     2881 tatagaaatg ggcagcgttt tgttccccgg ctagaaaaag ttgattttat cagccaatct
     2941 ccatctgcaa ttaccttcaa acaaggtggg atgtatttaa tcaccggcgg acttggtggt
     3001 ataggagtcg aagtcgcgcg gtatttattg cagcattatc aagccaaatt actgttagtg
     3061 ggcagaaccc cattaacttc agaaaaacgc ctcaaagtct atcaagaatt aaaacaaatt
     3121 gggggagagt taatctacga agctgtggat atttgtaatt taaaacagtt acaaatcaca
     3181 gttgaaaaag ctcaagccca atggggtaaa aacctggatg gcatactgca tttagctgga
     3241 acttttcatg agcaacttgt aattgatgaa actcaagaaa gcttaaagtc tatacttcgt
     3301 ccaaaagttt tgggagcttg ggtgctgcat caattaatta aacacaatca agacagtatt
     3361 tttattaact tttcttcagt aaatggtttt tttggtgcta ctgctgtcgg agcttatggt
     3421 gctgctaata gttttttgga tagtttttct cattaccaaa atgcccagag taaattagcc
     3481 agctattgtc ttagttggag tatgtgggat gacagaggca tgagccaagg atatcagatg
     3541 aagaatctca tccgcgctaa aggtttctat atcatgtctg cttcccaagc catatcttca
     3601 atgattgcta gtctacaaca tcaacaaaca aatatattga taggtttgga tgggagtaat
     3661 caaaacattc aatgttggca gtctcaaatc tttaacttac aaaagttaac tgcttatttt
     3721 acttctagaa ttaacgaagt taaattatca aatttacgag tgcaagaccg ctttggtcat
     3781 gcttgtaatt gcaacttggt acaaattcca gacattcctt gccgggaaaa tggtgaaatt
     3841 gatcgtgtta gccttattaa caacattaag tctcaggaaa ctagagagcg aatagaacca
     3901 cgcaacgaaa tagagattaa aattgctcaa tgttggcagc aagttctgaa agtgcaactg
     3961 ctaggcattc acgacaactt tttcgagtta ggaggaaatt ccttattagc tggtcaagtg
     4021 attgctctgt tgcgcgaata tttcgctgtg gaattatctt tacagcgttt gtttcaagca
     4081 cctaccattg ctgatttatc tcagacaatt ctagcaattc aagcagtaac tcaaaataaa
     4141 aattccttga ctgaaacact cgcagaagat tacgaagagg attatttata aaatggctat
     4201 atttgaattc ttatctttac taaatacttt agatattaaa atctggattg aggatgatca
     4261 gttacgctat cgcgctccta aaggagcaat gacagcagag ataaaagagc aacttaagga
     4321 acgtaaagca gaaattatcg cttttttaca ggaagcacaa acagctacac aattaacttc
     4381 gttatcttta gatccagttt ctagaaataa agatttacct ttatcttttg cccagcagag
     4441 aatgtggttt ctttcgcaat tagatggaga aagcacattt tataatgaga gtttccagtt
     4501 aagaattgtt ggtaaactat ctgtcacagc tttagaacag agcattaacg aaattattcg
     4561 tcgtcatgaa gctttacgta ctaactttcc gacggtagaa ggtattcccc ttcagcttat
     4621 tagacctaat ttaactatca gcattcctgt aatagatgtg caggaatgca cagaaactgc
     4681 tgtacaaaaa atcatcactc aggaagtaag tcagtctttt gatttaggta cagattcctt
     4741 agtaaaagtc actttactac ggcaaacacc agaatctcac ctattgatta tcaccatgca
     4801 ccacatcgtt gtagatggtt ggtcaatggg gatattcttc cgagaattag aagcactgta
     4861 ttcagccttt attcaaggaa agcccaatcc cttaccggca ttagcaatac aatatgctga
     4921 tttcgctgtg tggcagcgtg aatggttaac tcaagaagtt caagaaaagc aactagaata
     4981 ctggacacaa cagttagctg gcgcaccgcc tttgttggag ttaccaacag attatccccg
     5041 tcccccagtg cagacttttg ctggtgcgac gattgcattt caaattgatg aagatttaac
     5101 ctctgagctt gttaccctga gccaacagtc aggtgtcacc ttgtttatga cgctgctgac
     5161 agcttttgct gttttactgc atcgttatag tggtcaggat gatatttgca ttggttcgcc
     5221 ttttgctaac cgcgatcgcc gagaaattga ttcactaatt ggcttttttg tcaatacctt
     5281 ggttttgcgt acccagttag aaggcaatcc tagtttctca cagttgctag aaaaagtccg
     5341 gtctgtggtt tgggatgccc acgcacacca agacatccca tttgaacaaa tagtagaagc
     5401 attacagcca gaacgttctc tgggctataa tcccttgttt caggcgttat ttgttctaga
     5461 aaatttctcc ctggaaactt tagagttacc tggtattagt ctgactccag aaatcattga
     5521 ccggggtacg tccaagttcg acttgagtgt ctcagcttgg cagactaaaa agggattaaa
     5581 ggggttttgg gaatataaca gtgacctatt cacacccgac acaattacca ggatgattgg
     5641 tcatttccag agtttgttag cagcaatagt caaagatccc caacaaaaag tgcgacaatt
     5701 gcctttgctg actgaaaaag aacagcatca attgttagtg gagtggaatc acactcatac
     5761 agattatccc caagataaat gtctgcatca gttatttgag gaacaggtag agaaaacacc
     5821 ggatgctgtg gctgtggtgt ttgaaaatca gcaattaact taccaccaat tgaattgtcg
     5881 ggctaatcaa ttagcacatc acctgcggtc tttgggtgta aaaccagacg tactagtaag
     5941 tatttgtgtg gagcgatcgc tagaaatggc gatcggactg ttggggattc ttaaagctgg
     6001 tggggcttat ctgccaattg acccagaata tcctcctgag cgtataagct tgatgttgca
     6061 agatgctcaa gtgtctttgt tgctgtctca aaagtcacta ttaagtcaat tacccttaga
     6121 taaccgagaa aacccttgtc aggtcatttg tttagaccaa aacactttta acttagcgtt
     6181 aactgaaaat cccagtcgcc aaactcagcc tgataattta gcctacgtaa tttatacctc
     6241 cggttctaca ggaagaccca agggggtaat gattgagcat cgcgccattg tcaatttaag
     6301 tttgacatgg gctaaaacct tccaagttca aaaccacagc cgtttgttgc aatttggttc
     6361 ttttagtttt gatttatctg tagctgaaat taccacggct ttcgtcacag gtgcttgttt
     6421 gtatttggcc aataaagaaa ctttattgcc tagtcaaagc ttagttgact ttttaacagc
     6481 aaacaaaatt acccatagct ttttatctcc ttcggcctta tctgtcttac cgaaagcgag
     6541 tttacctgat ttgcaatgtc tcacagccgg tggtgaggct tgtacaactg aaatagttaa
     6601 tcagtgggga acggagagac gtttctacaa ttgctacggg ccaacagaat ccacagtgac
     6661 ggctactata tttctttgtc aacccaatgg caaaaaacca cccatcggta aaccaatatc
     6721 taatctccgc atctatattt tagatgcaca tcatcaagta ttaccgccag gaataccagg
     6781 ggaattgtgt attgctgggg ttggtttagc tagaggctat ttaaatcgtc ccgaaattac
     6841 tgctgaaaaa tttattgaaa ttgatctatt tggtcaagtt gagcgcattt acaaaactgg
     6901 cgacctagca agatggggtg ctgatggcaa catcgaatac ttgggtcgca ttgataatca
     6961 agtaaaaata cgtggattcc gcattgagtt ggacgaagtc gaaaccgcac tcaaccgcaa
     7021 tcctgaagta cagacatcct gtgtcattgt gcgtgaagat atccctgggc agaagcaact
     7081 agtcgcctac gtggtgccac accatacagt aaccatgagt gaactgcgcc aatatctcaa
     7141 agaaaaactc ccagagtata tgctgcctca tgcttttgtc attctagagt ctttacctgt
     7201 gactcctaac ggtaagatag accggcgcgc cttaccagca ccagactctc gtgagggact
     7261 tgaagtcagt tttgtcgctc cacgtaatca aaccgaaaaa atcctagcgc agatttgggc
     7321 agaagtgctg agggtaaagc aagtaggtat ttacgataac ttctttgaac ttggtggcga
     7381 ttccattctc agtattcaaa ttctggctaa agccaagctt gcagggctgc aactgacact
     7441 taaacaattg tttgcccatc aagcgatcgc tgatttagcc gcagtagcag gtacaattga
     7501 ggcgatcgag gtcaaacagg aattagtcac aggcttagtc cctctaactc ccattcaaca
     7561 ctggtttttt gaacagaatt tagtagaagc acaccatttc aaccaagcat ttttactctc
     7621 atttccttgt gacctccagc cagaaacatt aaagcaagta ttccagcaat tactggtaca
     7681 tcatgatgct ctacgcctac gcttcacacc atctgatgca acctggcaac aaatttattc
     7741 tgcgcctaat gatcaccttg ctttctctta catagattta tcggcactcc cagagaatga
     7801 gcaacaagca gccattgcag atcaagaagc tgtcttgcag gcaaatttgc atctgtcaga
     7861 aaatctagtg caagtagcct tttttcattt gggggttgac aaaagagtaa aattactcat
     7921 agtcatccac cacttggtaa ttgatggtgt atcgtggcgg attttattaa atgatttgca
     7981 aaccgcttac cagcaacttg ctcaaggtca aacccttcag ttgcctccta aaaccacttc
     8041 ttttaaggat tggtctgaga aattaacagc ttatgcacaa tccccagccc tcaaatctga
     8101 agtagcttat tggctcaacg aagctcgcct caaagttcct tctatccccg tagacttgac
     8161 aaaaggagtc aataattttg cagccgccaa caccatatta ttatctttaa gtgagtcaga
     8221 aactcgtgct ttactccacg atgtgccgaa agcttacaac actcaaatca acgacgtgct
     8281 gttaactgcc ttggtgttgg ttgtgagcaa atggattggc tctcgcagtg tcctgtttaa
     8341 tttagaaggt cacgggcgag aagatattgt tgatggtgta gatttatcac gcactgtcgg
     8401 ttggtttacg actatcttcc ccgtgcttgt agaacttcca gccacagaca agctagcaga
     8461 tgtcttaaaa tccgtgaaag aacaactgcg ggctattccc aataaaggta ttggctatgg
     8521 tttattacgc tatctgagcc aagatgcaga aattgctagc caactacagg catttcccca
     8581 agctcaaatc agttttaatt atttgggtca atttgatcaa caagtcaata catcttcttg
     8641 gatgcagcca gctagtgagt cggcggtaaa aatgcacggg ttacagaaca accgccctta
     8701 tctactagaa atagacagca ttattgcggg agaacagtta cgaatagagt ggacttacag
     8761 caaaaatctg caccagcacg cgacaatcga aaatctggca caagagtttt tccagacatt
     8821 gcagcaaata attgctcatt gtgcatctgg tgagaatgga ggttatacac cttcagattt
     8881 ctcactcgtg aggtttaacc agctagaact agaccaaacc ttggctttag tttgcaaaca
     8941 tcaatcaggc aaaactcact ggcgaaatat tgaagatatt tatccactct cgccgatgca
     9001 agaggggatg ctatttgaga gtctttatgc tcccaattct ccggcgtatt ttgagcagtc
     9061 aatttacaat ttgagtggtc agctaaacct gtcagccttt gaacaagctt ggcagcaagt
     9121 ggtagcaaga cactcaattt tgcggactgg ttttatttgg gaacaattgc cacagccact
     9181 gcaagtagtg tatcggcaag tagatgttaa actacagacc tatgattggc agcacctatc
     9241 tccacaacag caacaacaaa aactagaatc tttattgcag tcccagcgac aacagggttt
     9301 ccaactttct actgcaccat taatgcactt gagtcttgta caattgagtg cagatcgcta
     9361 tcaatttgtg tggaattttc atcatttatt gcttgatggt tggtcagtac ctgtaatttt
     9421 ccaagactta ttgtattttt atcgagcaat tctccagggt gaaactcaga caagaccacc
     9481 agttttaagc taccgcaact atattgcttg gttacagcag caagacttga ccaaagccca
     9541 agaattttgg cggcaaaaac tccaaggttt taccgcacct actcctttaa cagtcgataa
     9601 accctcatcc cagcgtaaac agttagacgc tagttacagg gaacagaaaa ttcaactaac
     9661 cgcgacagcg acaaccgccc tacagacttt tgcccgacag catcaattga cgatgaataa
     9721 cgttgtgcag gggacttggg cattactgct gtatcgctac agtcaagaaa cagatatagt
     9781 ttttggtgct actgtgtccg gccgtcccgc atctttgatt ggtgttgagt cgatggtagg
     9841 actatttatc aatactttgc cagtgcgagt tcagttggga aatgaaactg aagttttggc
     9901 tttgttgcag gatttgcaga ctcaacttgt cgagtctgag cagtattcat atagctcatt
     9961 agtagatatt caagggctaa gtgatgttcc tagaggaaca cctttatttg agagtctggt
    10021 tgtttttgat aattatccag ttaatgaagc tgccccagag aacaattatg gtttctcaat
    10081 agacgatctt cacgccattg agcaaactaa ttatccccta acaatcatag cgattcctgg
    10141 tcagcaatta ctagtgagga ttagctatga tactagccga tttgatgatg gggcgatcgc
    10201 tcgtttgtta ggacatttcc aaacattgct gacagcaatt gttgctaacc ccaatgagcg
    10261 aatttctcaa ttaccattgc tgacagcctg ggaaaaacag cagttgttag ttgactggaa
    10321 taatactcaa gcagaatatc ctgttgatca gtgcatccat cagttattcg aggaacaggt
    10381 ggagaaaaca ccggatgctg tggctgtggt gtttgaaaat caacatctca cctatcagca
    10441 attgaattgt agggcgaatc aattagctca ttatttgcag gacttgggtg taaaaccaga
    10501 tacactggtg ggtatttgtg ttgagcgttc cttagaaatg atggtgggac tattggggat
    10561 tctcaaagtt ggtggtgctt atgtaccaat tgacccagag tatccgactg aacgcttaag
    10621 ctttatgctg acagacactc aggtcaaagt tttgctaact caagagaaat taagagagtt
    10681 ccttcctcaa tatcaagggc gtatagtttg cttagacagc gactggaaca gcatatctct
    10741 ggaaaatcag aataatctca acatcacagt cagtgcagaa agtctagccc atgtaattta
    10801 tacatcaggt tcgacaggca cacccaaagg agtcgccgtc actcatcagt ctgtaaatcg
    10861 acttgtgatc aacacaaatt acatccaact cacagctaat gaccgtattg cacaagccgc
    10921 aaatattgct tttgatgccg ccacctttga aatttgggga gcattattac acggagcagt
    10981 gctagtgatc atcagtaaat ccgtgttgtt gattcccgaa gaattagccg tcaatatcag
    11041 ttcacacaaa gtcaatgtct tatttttaac tacagcgtta ttcaatcaac tagccagtca
    11101 tctcccgcaa gcgtttagct cattaaaata cttactgttt ggcggggaag cagttgatcc
    11161 tagatgggtg caggaagtcc tagaaaaagg aactcctcaa aaattactcc atgtttatgg
    11221 gccaaccgaa aatactactt tttcttcttg gtactgggta gagaaattag taggaacagc
    11281 tacaactgtt cccatcggtc gcccaattac taatacgcaa atttatatcc ttgaccaaaa
    11341 tttacaacca gtacctgttg gtgtaccagg ggaattatac cttggcggtg acggactagc
    11401 acgaggctat ctcaaccgcc ctgaattgac caacgaaaaa tttatcgcca acccctttgg
    11461 caagtcaaaa ttgtataaaa ctggagattt agcccgttat ttaccagatg ggaatattga
    11521 gtacataaaa cgcattgata atcaagtaaa aattcgggga ttccgcatcg aattgggaga
    11581 aatcgaaacc gtcctcagcc aatatcctaa aattaaatca gttgtagcga tcgcccgtga
    11641 agatagccct ggtaacaaac gtttagtcgc ttatgttgta ccacatcaag actctcaacc
    11701 cgtagcccaa gaactgcgta gcttcctgaa aaccaaacta ccagaacaca tgataccggg
    11761 tgtgtttgtc atcctcgaat ctctacctct gacacccaac ggcaaaatcg accgccgcgc
    11821 cttaccacaa ccagacttag acagcacact gctagaaaaa tacgtcgccc cacacaaccc
    11881 aattgaagaa ctgttagccc aagtttgggc gcaggtgctg aaagtagggc aagtgggtat
    11941 ttatgataac ttctttgaat tggggggaca ctccttactc gcaacacaat tggtttcacg
    12001 catccgcaat atttttcaag tagaactacc cttgtctgag ttgtttactg cccccacagt
    12061 cattgaattg gcacaaaaaa ttgggcagtt acagccagaa cagctagaac tatctgcacc
    12121 gcagatttta ccgagggcag agatttccga gttaccaatg tcttttgctc aacagcgttt
    12181 gtggttcttg gatcaattcg accagaatag tgtcctatac aatatcccca ctgctttgcg
    12241 tctggtaggg aaactgaatc ttcaggtact cgaacaaagc ttacaagaaa ttattcatcg
    12301 ccacgaagct ttacgtacca acttcatcac cattaacgaa caaccaactc aagttattca
    12361 aacacaaatt aattggcaac tatcaattgt tgactggcaa catctaccca ctgctgaaca
    12421 agaaacatct gtacaacaat tcttgcaaca gcaagcactt gaacgatttg acctggtaag
    12481 acaaacgtta attagagcga cattaatact actgaaccag acagagcaaa tcttgttagt
    12541 gtgtatgcac cacattgttt ctgatggttg gtcaatgggt gtgtttgttc aagaactaac
    12601 acaactatat aacgcttatt ctcaaggtca gccttcacct ctagcaccac tagcaattca
    12661 gtacgcagat tttgcattgt ggcaaagaca gtggctacaa ggggaggtgt tacaaaacca
    12721 actcgcgtac tgggaacagc aattaaaaga cgcaccaact gtattatcgc tacccactga
    12781 ccgtcccaga cctgcggtgc aaactgtgac tggcgcgatt catgaatttg ccttgtcagt
    12841 ggagttaact gatcaattag tgaaactcag ccaggagcaa ggttgtaccc tgttcatgac
    12901 actgttggca gcatttgata ccctactgta tcgctacacg ggacaatcag atattttggt
    12961 gggttcaccc attgcaaacc gcgatcgcgc ggaggtagaa gggttaattg gcttttttgt
    13021 caatactttg gtcatgcgga gcaatttggc aggtaatccc agctttagtg aattgctgac
    13081 tcgtgtgcgg gacatggctt tgggtgctta tgctcatcaa cacctgccct ttgaaatgtt
    13141 ggtggaagca ttgcaaccag aacgggattt atcccataca ccactattcc aagtcatgtt
    13201 taacttgcaa aatgcccctg tgtcggagtt ggagttaaat gggttaactg ttagttcact
    13261 gccaattcca ggggtgacag ctgcatttga tatgacctta ttcatgcaga acactgctaa
    13321 cggactagtg ggagtatggg aatacaacac tgatttattt gaccacagca ctattgagag
    13381 gatgattggt cattttgtga ctgtgttaga agcagtggtg agtaaccccc aagcacccat
    13441 tgaccagttg cccatattaa cagcagttga gcaacaaaag ttactacttg agtggaatga
    13501 tactcaggct gatgatcctg tcggtaaatg tctgcatgaa ttatttgcac agcaagcaga
    13561 actgacacca gatgctgtgg ctgtggtgtt tgagaatgaa caactgactt accaacagct
    13621 aaacacccaa gctaatcaat tagctcatta cctacagtct ttaggtgtga gagcagaggt
    13681 attagtggga atttatttag agcgttcgct ctccatgata gtggcactgt tagccgtcct
    13741 caaagcaggt ggcggttatg ttcccctaga agttgattat ccccaacagc gattagctta
    13801 catctcggaa gattcagaaa tttcagtatt gattacacag gaaagtttac tcaactcctt
    13861 gccagttgta ggggtgaaag tgattgcctt acatcaagag tgggatgtac taaattctca
    13921 agatcaagaa aatcccgtga gtgcagtagt accagaaaac ttagcttgtg tattgtacac
    13981 ttctggttcg accggcagac ccaaaggtgt gatgttgacc catgccgcct tagtaagtca
    14041 ttgtagtgct attagtgaag cctttagtct cacaagtagc gatcgcgttt tacaatttgc
    14101 ggcattcggt tttgatgtcg cagtcgaaga aattttcccc acctggttta aaggtggaac
    14161 agtcgtgtta agaccagcgc aattgttttc ttccttcgcc agttttgctg agtttattga
    14221 acaacaacag ctgagtgtct tgactctcac ttccgcctat tggcatgaat ggatggtagc
    14281 agtatctcaa tcctatgcca cagtaccgca aagtctacgt ttattgactg taggagggga
    14341 tacagtttta ccagaaacag tggctatgtg gcagcaattt gtaggtgata gaatcacttg
    14401 tctcaatgcc tacggcccca ctgaagcttc ggtgacagcc gtagtctatg atgtgcagaa
    14461 cttccaccca gaaaaaacca atacagtccc cattggtcgt cctgtcgcta atacagaaat
    14521 ttacatcttg gattctaatc tgcaaccagt accaattggg gttaaaggcg aattatacat
    14581 tggtggtgtg cggatagcac ggggttatct caaccgccca gacttgacac aagaaaaatt
    14641 tattcctcac ccgtttaaag ataaaaaatc ccatcgcctc tataaaactg gagatttggc
    14701 acgttattta cctgatggta acatcgagtt tattggtcgc cttgatgatg tggtgaaaat
    14761 ccgaggtttt cgtgttgcga tcggagaagt cgaaagtttg ttagttcagc atcctgatgt
    14821 gatttgtcag gtggtcatgg tcagagaaga ccaaccaggt aataaacagt tggttgctta
    14881 tgttgtctct gataacccat ccttaaccca aaatgaatta caaagcttct tgaaacaaaa
    14941 gctacctagt tacatggttc ccacagcttt tgtgatgctg gagggtttgc cagtcacgac
    15001 taatggcaaa gttgaccgtc gcgccctccc cgcaccctcc caagagattg acctgagcaa
    15061 ctttgttttc cccaccactc ccacacaaaa actgatagca gatatttgga gcagtgtttt
    15121 aggcacaaca cagctaggta ttcgcaacaa cttttttgac ataggaggaa attctttacg
    15181 agcgatacag gtgatgtctc tattaagaga agctttgcaa ctagatttac ccctacgtta
    15241 tctgtttgaa aaccccacaa tcgcagaact ggcagcaggg gttgatagct tacacatcag
    15301 ccagaagaat accattacca gaggcactat cccagattta aaagcagaag ttgtcttaga
    15361 tcccaacatt cacatcccca gacagcgttg tgatgattac caccagcccc agcgtatatt
    15421 tttaacgggg gccacaggtt ttctaggaat tcatttgctt gatgaacttc tacaacaaac
    15481 ccaggctgat atttattgct tgattcgagc taccaatgct caacaagcac aacagaggtt
    15541 gcaaagtcaa cttaagttgt acaaactctg ggaaggaatt gacacaaagc ggatcattcc
    15601 tgtagctgga gacttagcaa aaagctattt aggtctttcc acatcagagt ttcagcagtt
    15661 ggctagtgag atagatgtga tctatcactg tggtgctttg atcaatgtga tctatcctta
    15721 ctctgtttta aaaggagcca atgtcctggg gacacaagaa attatccgat tagctagtga
    15781 aaccacagtc aaacctttgc atttcatttc cacaacatct gttttattag catcgtctcc
    15841 caatgaagat ggattaattc tggaatcaga cccccttgag caatatcaag ttcttgataa
    15901 cggctatgtc caaagcaagt gggtagcaga gcagttagtg atgcaagccc gtgatttggg
    15961 acttcctgtg gctatttatc gagctgcaag aatcacagga cacagccaaa ctggggtgag
    16021 taacacagat gatttattgt gcaggctagt gaaaggttgt ttacaaacaa aaatagcccc
    16081 tgatattgat ttagaagata atctgacccc cgtagactat gtcagcaaaa tcattgttca
    16141 tctatcaggg caaaagcaat ctctaggaaa agcatttcac ctagttaatc cagactctac
    16201 tcctcttaag catttgttta aattgctttg tgctttagga taccctgtgc aactgattcc
    16261 tgtagagcaa tggcattcag agattacaca tcatcaacag atgcctgatc cagataactt
    16321 aagattcttg tctcatatca tacccaaaac tacagcagat acttacaaag aaccagaatt
    16381 cgactatcaa aacactatga acgggttagt aaatactgat atcatgtatc ctgcattaga
    16441 ccaaaaccta ctgaaaactt acatttctta cttcataagt agtggtttta tcgatgacca
    16501 attgatgaca gagcaaatgg catttggtaa taaggctaac taactataaa taaacagtag
    16561 tttgacaacc tcaaattacc aaatgaaggt ggacagggga gcagggtaaa gtcttttatt
    16621 accctttccc ctgttcactt tgacaaacaa ggattaaatt gcttcccata catcaaatca
    16681 aaatcacaag atttttagaa tatgcaagct caaatttccc gcgatcaacc cataacaaac
    16741 tcttattcag ctttaactca attttgggaa aatatcaaag ccctgactga accttactgg
    16801 tatccgacca aggcgggagg aagagcattt tcagcagtga ttcgttcctg gggaatgctg
    16861 attaccctca tcctactaat aattggactt gtgagtctaa atgtatttac taattttctt
    16921 tatcgatatt tagttgatat tactattaca ggcagggatg tttctaagtt ttttgatacc
    16981 gtattgattt atagtgtagc cctgatattt gtcacagcct ttgtcgggtt ttctaaattt
    17041 gtgaggaagc aaatttccct tgattggtat caatggctta ataatcacat cctcgcaaaa
    17101 tatttgtatg gaagagcata ctacaaaata aattttaaat ctgatattga taatcctgac
    17161 caacggttgt ctcaagaaat cgaaccggtt attaataatg ctttgacttt tgtcactact
    17221 ttcttggaaa aaatcttaga aatcatagct tatatcgtaa ttatttggac aatctctcat
    17281 caagtcgcca ttatcttagt tatttataca gttataggta atgtggttgc tgtatacttg
    17341 actcaacatt taaataatat taatcaagaa gaactacaat ctaaagctga ctataactat
    17401 tgcctgactc atgttagagt ccatgctgaa tcagtggctt tttttcgggg agagaaacaa
    17461 gagtctaata tcattggtaa aagatttact aaattggtca aaaatgttca gcgcaggatt
    17521 gactgggaaa gaaatcaaga catttttaat agaggctatc aggctgtaat tgaaatattt
    17581 ccatttctta tcttaggccc cttgtatatt acaaatcaac taggctttgg agaaattagt
    17641 caagcttcat tgtgtgcata tttgtttgct aattctcttg cggaattaat caacgaattt
    17701 ggggtttccg gtcgattttc tatatatgtt gagaggttat ctgagttttc ttctgcttta
    17761 gaagaagtgg cgaaagagcc aacaaatgtt agtacaatca aaacagtaga agaaaaccat
    17821 cttacttttg aaaatgtcac cttacaaaca cccaattatg aacaagtgat tgttgaggat
    17881 ttatcacttt ctgtgcagcc aggagaaggt ttattaatcg tggggccgag tggtcgtggt
    17941 aaaagttctt tattgagagc gatcgcaggt ttatggaacg ccggaacagg tcgtttagtc
    18001 cggccgcctc tagaagaggt cttattttta ccccaacgtc cttacatcat tttaggcact
    18061 ctgcgggaac agttacttta tcctaatacc aatcttcaat tgaccgatgc ccaactaaaa
    18121 gaggttttac aaaaagttaa cctacaaaat gtgttaaatc gcgtcgaagg ctttgataca
    18181 gaagtgcctt gggagaatat attatcgctg ggagaacagc aacggctagc atttgcaaga
    18241 ctattaatta ctcatcctag cttcactata ttagatgaag caacgagtgc tttagattta
    18301 actaatgaag ggcatttata tcaacaattg caagagacaa aaacaacgtt tattagtgtt
    18361 ggacaccgag aaagtttatt tcaatatcat caatgggttc tagaactatc ggaaaattct
    18421 acttggcaac ttgtgactgt ggaagattat caaaagcaga aacaaatcgt caataatcct
    18481 cctccagaaa atgttccaat tactatcaat aacctgccta aagaaaccac tgtaataaca
    18541 aacataatca caggtttttc tcacaaagaa atgcagacat taacagacta ttcactcggc
    18601 acaattagaa gccgagccag tcaaggaaaa tccatcacta ctaaggacgg cgtgacttac
    18661 cgctataaca aagaccccaa agtattgaaa tggttgagag tttag
//
